In this intriguing paper published from the lab of @amartinezarias.bsky.social , they looked at the effects of size on morphology, tissue composition, and gene expression of gastruloid development. They found that AP elongation dynamics is size-dependent! Check it out here: doi.org/10.1016/j.cd...

Epithelial-to-mesenchymal transition or EMT is an integral part of development in animals. In this beautifully illustrated review from the lab of Magali Suzanne, they describe and compare and contrast the cellular mechanism of EMT across the different model organisms. doi.org/10.1016/j.cd...

Our September issue cover is now online. You can check out the issue here: www.sciencedirect.com/journal/cell...

Just posted (bioRxiv): A novel #mechanobiology model revealing how #immune #Tcells combine a #nucleus as a #piston, an #uropod, and #microenvironment to power #amoeboid #cellmigration in #cellconfinement via a hydraulic cell engine. #CellBiophysics #ImmuneMigration www.biorxiv.org/content/10.1...

For decades, living embryos were the favourite tool to study development. However, their complexity hindered precise dissection of many processes. This comprehensive review provides a comparison between embryos and the power of gastruloids, opening up a new wave of dev bio. doi.org/10.1016/j.cd...

A cryosection from an embryo stained for the neural crest (🟠) using HCR, and DAPI (⚪). Can you guess what embryo this is? #FluorescenceFriday Image credit: Ines Fernandez Mosquera, PhD student at @ucl.ac.uk

Many phenotypes from cells on plastic dishes just don't seem to translate to cells in vivo, particularly isolated primary cells. @raimonsunyer.bsky.social et al discussed how cells mechanically adapt, and the different ways we can mitigate this in this very helpful review: doi.org/10.1016/j.cd...

Striking new study from @archaeon-alex.bsky.social's lab just out in @science.org on multicellular development induced by compression in Archaea: www.science.org/doi/10.1126/...

My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...

Automated optogenetic control of hundreds of cells in parallel. Each cell is individually steered, collectively acting as a "tissue printer". Preprint & code out! www.biorxiv.org/content/10.1...

fyi, if you weren't aware bsky.app/profile/pape...

Yet I still see many of the biggest scientists, universities, institutes still post their new research there? I barely ever find any papers to read on bluesky or is it just the algorithm works differently?

YO, what's up with all these almost-witchcraft techniques?? In this paper, they develop a way to freeze cells so quickly that it preserves Calcium waves midway!! WHAT??? HELLO??? So now you can do 3D reconstruction of calcium waves with just a normal confocal. www.nature.com/articles/s41...

🐤Promise you this is one you'll want to say you were a part of... Help us get our 'ducks in a row' and IMPEACH AND REMOVE THAT DANG QUACK!!!! 📣🦆📣🦆📣🦆📣🦆 Link here: tinyurl.com/sufsci

Embryonic induction of fate is a core concept in developmental biology. But, cells can also modify the physical state of surrounding tissues a process we call 'actuation'. I reviewed with @mayorlab.bsky.social 3 excellent papers that show how actuation and feedback can drive changes in the embryo.

What are the physics behind lumen formation? In this interesting and interdisciplinary review, Guillaume Salbreux et al described the physical laws from osmotic pressure to electrical potential that govern this biological process. Check it out here: doi.org/10.1016/j.cd...

A fascinating paper! I think in hindsight, us scientists are all expecting this to happen when we knockout something. But to actually characterise its effects and see it happening in real time is still eye opening. Watch out for Transcriptional Adaptation!

For something as classic as the Spemann-Mangold organizer first discovered in amphibians, the existence of such an organiser in mammals remains elusive. In this thought provoking review by Kate Mcdole et al, they discuss the evidence for and against such organiser in mouse. doi.org/10.1016/j.cd...

A classical neural crest migration. Even if the movie is a little bit shaky, their migration is still somehow mesmerising. It must be the stripes! 🤔 #fluorescencefriday Movie by Kai Weissenbruch

VACANCY - We’re recruiting for a visionary group leader to lead fundamental research on Discovery Plant Science as part of our vibrant research community Successful candidate will be offered a six-year tenure-track position with the opportunity to apply for tenure: www.jic.ac.uk/vacancies/gr...

This is so cool! A good way for early career scientists to put your name out there and network too! Beautiful images are always eye catching. Register and we would love to see them too at ISDB!

Interesting review about the role of ECM in development!

1000% YES !!! Also works for cancer, immunology and every other cellular process: differentiation, adhesion, migration, proliferation, survival etc. Cell biology is cool, but it's like studying plants without their soil. I wish more studies would try to put their findings in perspective of the ECM

Maybe it's time we rethink the idea that development is a cell centric process? In this beautiful review, María-del-Carmen and @stramerlab.bsky.social discussed how the ECM underlies and influences many morphogenesis processes from wing unfolding to mammary gland development. doi.org/10.1016/j.cd...

Something Im also wondering too. Like why are we not posting on here more? I want to see more academics, more cool papers, more news.

AKAP14 is of those genes that is highly expressed, yet when knocked down by 60% even in a mouse model shows no apparent effects on the organism, no effects on meiotic progression, sperm count, motility and morphology. How weird?Check out this intriguing paper here: doi.org/10.1016/j.cd...

A cryosection immunofluorescence image of a Xenopus embryo showing fibronectin in 🔵, DAPI in ⚪, and Sox9 - a marker of the neural crest in 🟠. Image credit: Kai Weissenbruch from UCL #FluorescenceFriday #devbio

I was looking through my old microscopy videos, and found this perfect shot of a macropinosome forming through the collapse of an actin-driven membrane ruffle (cyan). Immediately, CRYI-A (orange) is recruited to the vesicle to finish the job. Still in awe with this process after all those years!

Continuing with the theme of organiser biology, Alexandra Neaverson and Benjamin Steventon discussed in this beautifully illustrated review the idea that "neural specification and patterning occur before organiser formation" in Xenopus, zebrafish, chick, and mouse. doi.org/10.1016/j.cd...

This is very impressive! My former highschool in Vietnam is the one with the most number of IMO winners (including Ngo Bao Chau) and I know many students there have to solve problems that are almost alien like. For an AI to be able to do the same, that's so nervously cool!

It's one of those experiments where you don't really know if it's worth doing it but you're also curious to know what happens if you do it. I adapted another Optogenetic tool in 🐸 that allows one to change the migration direction of immune cells. It works beautifully, but is it useful for me, Idk 😅

Check out this insightful review by Alfonso Martinez Arias et al where they show how studying the organiser in amphibian embryos helps us understand the development of the body axis in mammalians, and the use of gastruloids to study the Primitive Streak. doi.org/10.1016/j.cd...

This comprehensive review by Manuel Zúniga-García and Juan Rafael Riesgo-Escovar focuses on the evolutionarily conserved fos gene family in different species of invertebrates (🪰,🪱). The authors argued that fos genes were coopted from stress responses to development. doi.org/10.1016/j.cd...

OMG, this is such a cool paper from Patrick Caswell's lab. They express Rab25-mCherry-GFP-nanobody in cells, microinject GFP-magnetic particles, then use a magnet to pull Rab25 to the plasma membrane to show that it can trigger actin protrusions! I want this system. www.science.org/doi/10.1126/...

Our June cover is here. This image shows SALL1 protein (green) in a slice section of mouse embryonic external genitalia. New research shows that SALL1 is involved in tubulin acetylation and is important for urethral masculinization. doi.org/10.1016/j.cd...

TUMOR SUPPRESSOR RASSF8 CONTROLS COLLECTIVE CELL MIGRATION New findings in the Drosophila model shed light on cancer mechanisms, see press release Marburg Universiy: www.uni-marburg.de/de/aktuelles.... Original PNAS publication: doi.org/10.1073/pnas...

One our postdocs, Kai Weißenbruch, just won the Prize for Best Talk at the Cambridge-London Cell Motility conference for his talk on Frictiotaxis - how cells migrate toward regions of higher friction. This video shows a cell repolarises itself in a uniform friction channel. doi.org/10.1038/s414...

@gounismichalis.bsky.social‬ et al. show that cells that seed early lung #metastasis in #BreastCancer have altered #metabolism. These metabolic alterations lead them to release extracellular vesicles which engender a microenvironment conducive to invasive growth. rupress.org/jcb/article/...

Who would have thought inverting colors would be so tricky ? jordan.yoonbuck.com/post/contras...

A fantastic review written by Jan Stundl and Marianne E. Bronner on the development of the neural crest. The paper explores how neural crest interacts with their tissue, the genes involved in their development, and their differentiation identity. Check it out: www.sciencedirect.com/science/arti...

oh haha this is in Vietnam. So rare to see an international conference organised in sunny Vietnam 😄

Rosettes are cell-scale structures found in epithelial tissue. This unique structure allows for a dynamic bio-mechanical adaptation during development and morphogenesis. In this review, Neahring et al describes the interesting facets of rosettes found in various organs. doi.org/10.1016/j.cd...

Haha what is my BSCB image Drops of Colours doing on an @embo.org tote bag? The original image was inspired by Andy Warhol's Marilyn Monroe pop art so the black and white doesn't quite do it justice, but it was still a pleasant surprise! 🥰

We are sponsoring the Scottish Cell Biology Meeting on 18th Sept. Save the date!

After the success of our 2023 Imaging Cell Dynamics conference, we’ll be hosting a second #JCSImaging meeting in 2026, organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social‬, @drmichaelway.bsky.social‬ & Giulia Zanetti. To register your interest: www.biologists.com/meetings/jcs...

1/I'm excited to share my review with CSHL exploring the concept of neighbouring cells as substrate to guide the collective migration of other cells. We tend to focus on cell-matrix interactions, but forget that within tissue, cell-cell interactions exist. cshperspectives.cshlp.org/content/earl...

The deadline to registre for the 20th International Congress of Developmental Biology in Sheraton Puerto Rico, San Juan, PR is on the 21st of May. The meeting is co-chaired by Marianne Bronner, Carole LaBonne, and Juan Riesgo. More information here: www.sdbonline.org/2025icdb

Check out this collection of articles on organiser biology as part of our Spemann and Mangold centennial special issue.Part II: Self-Organization in Biology doi.org/10.1016/j.cd... doi.org/10.1016/j.cd... doi.org/10.1016/j.cd... doi.org/10.1016/j.cd... doi.org/10.1016/j.cd... doi.org/10.1016/j.cd...

Our special issue contains some very interesting articles on organiser biology, ranging from cnidarians to amphibian to mammals. Check them out.

A cluster of neural crest cell migrating on some micro patterns (📹 Kai Weißenbruch). Also congratulations to former postdoc Adam Shellard, Kai Weißenbruch, and PhD student Peter A. E. Hampshire on their recent paper on friction-based migration. www.nature.com/articles/s41...