Recent work by Richards et al. of the Devenport lab (rupress.org/jcb/article/...) reports that melanoblast migration through epithelial layers requires cell–cell adhesion via E-cadherin junctions of potential atypical composition. More in @natcellbio.nature.com: www.nature.com/articles/s41...

🔬 from our February issue shows live imaging of fission yeast mating cells where the P-cell is labeled with the myosin V Myo52-mScarlet-I and the formin Fus1-sfGFP, and the M-cell is labeled with Myo52-mTagBFP2 and a cytosolic mRaspberry. From @sophiemartinlab.bsky.social doi.org/10.1083/jcb....

🌈 Download JCB's CELLULAR DIVERSITY poster! 📩 Sign up to receive our future special collections and download this beautiful artwork by Bianca Dunn to display at home or in the lab 👉 info.rupress.org/jcb-collecti...

New video summary from on the study "MIM triggers formin to Arp2/3-based actin assembly in membrane remodeling in #Drosophila embryos" from Debasmita Mitra, Georgina K. Goddard, Sanjana S, Aparna K, Richa Rikhy & colleagues rupress.org/jcb/article/... youtu.be/En_BWljN47I

#InMemoriam: Dr. Robert Bruce Nicklas, who spent over 50 years unraveling the mysteries of how #chromosomes move during #CellDivision, died on February 19, 2025, at the age of 92. Leocadia Paliulis commemorates his life and work. rupress.org/jcb/article/...

Cullin-3 adaptor SHKBP1 inhibits SQSTM1/p62 oligomerization and Keap1 sequestration. New study from Lin Luan, Jeremy Baskin @jeremybaskin.bsky.social and colleagues @weillinstitute.bsky.social: rupress.org/jcb/article/... #CellSignaling #Biochemistry

Soffer, Bhosale, Niessen, Luxenburg, Rübsam @unicologne.bsky.social et al. identify #spectrin as a central component of epithelial cortical #actomyosin networks to control cortex mechanics and signaling. rupress.org/jcb/article/... #CellSignaling #Cytoskeleton #Development

Honored to see our work featured in a JCB Spotlight by Pacheco and @drericabiophd.bsky.social (@UCSF). The piece discusses our study revealing distinct force-generating mechanisms in epithelial and mesenchymal collective migration 🔬🐸 Thank you for your careful review of our work! hubs.la/Q042GFYY0

Made a bluesky account especially for this - our new spotlight on a really interesting new paper is now available to read! Findings that go against what "should" be based on current knowledge are always some of my favourite discussions to have, one of the great joys of being in Biology. 🧬

🌐 Join @keystoneSymposia.bsky.social meeting #Neuroinflammation in Health & Disease, this June in Whistler 🚠 Our Executive Editor Tim Spencer is attending! Scholarship, abstract & discount reg deadlines are approaching 👉 www.keystonesymposia.org/conferences/... #KSNeuroInflam26

🌐 Deadlines are approaching for @keystoneSymposia.bsky.social #Neurodegeneration: Neurocentric to Systems Perspectives, this June in Whistler 🚠 Our Executive Editor Tim Spencer is attending! See scholarship, abstract & discount reg dates 👉 www.keystonesymposia.org/conferences/... #KSNeurodegen26

Our take on a really interesting new study by the Franz lab at UCL, a version of epithelial polarity where you would not expect it! Read our Spotlight and the original paper!

We had the privilege of contributing a @jcb.org Spotlight about the exciting new work from @mayorlab.bsky.social ! Check them out! Spotlight: rupress.org/jcb/article/... Featured article: rupress.org/jcb/article/...

Pacheco & @drericabiophd.bsky.social discuss new study from @jorgediazfuentes.bsky.social & @mayorlab.bsky.social (rupress.org/jcb/article/...) which reveals the distinct force-generating mechanisms used by epithelial and mesenchymal cells during collective cell migration rupress.org/jcb/article/...

Spotlight: Ball and Röper @pdncambridge.bsky.social discuss recent findings by Almasoud, Franz et al. (rupress.org/jcb/article/...) describing how apical–basal polarity regulates cell–cell adhesion in the #Drosophila fat body. rupress.org/jcb/article/... #Adhesion #Cytoskeleton #Development

Early resolution of sister chromatids during #Celegans #meiosis. New study from Antonia Hamrick and Ofer Rog @theroglab.bsky.social @uofubiology.bsky.social: rupress.org/jcb/article/... #Chromatin #epigenetics #Genetics #CellCycle #CellDivision

Yinyin Zhuang, @xyshi.bsky.social et al. introduce land-ExM, a superresolution approach that simultaneously maps protein and #lipid ultrastructure to reveal 3D interactions of #membrane #organelles and condensates. rupress.org/jcb/article/... #ExM #Microscopy #StructuralBiology

🌈 Download JCB's CELLULAR DIVERSITY poster! 📩 Sign up to receive our future special collections and download this beautiful artwork by Bianca Dunn to display at home or in the lab 👉 info.rupress.org/jcb-collecti...

RCC1 depletion drives protein transport defects and rupture in #micronuclei. New study from Molly G. Zych, Maya Contreras, Anna E. Mammel, and Emily M. Hatch @fredhutch.org: rupress.org/jcb/article/... #disease #chromatin #epigenetics #cancer

So proud to share my paper on collective chemotaxis and force coordination in epithelial and mesenchymal cells, developed in the Mayor Lab and now published in JCB. Deeply grateful for everything I learned from Xenopus NC and the amphibian world, where adaptation is everything🐸

GRIPAP1 is an endosomal tethering factor mediating platelet α-granule biogenesis. New study from Andrea L. Ambrosio, Hallie P. Febvre, Gabrielle H. Schusler, & Santiago M. Di Pietro (Colorado State University): rupress.org/jcb/article/... #Biochemistry #Disease #Organelles #Trafficking #Platelets

NRZ complex facilitates virus infection via enhancing ER-LDs contacts, say Zhifang Li, Yifan Xing, Xinyi Huang, Buyun Tian, Jie Mei, Xinyue Fu, Xiaobao Cao, Yanhong Xue, Zonghong Li, Tao Xu, Yaming Jiu (Shanghai Institute of Materia Medica) and colleagues: rupress.org/jcb/article/... #Virology

Join the #EMBL conference "Cellular mechanisms driven by phase separation" 🗓️ May 19-22! Register now for in-person at @embl.org Heidelberg or Virtual 👉 www.embl.org/about/info/c... #EESPhaseSeparation @events.embl.org

Articles in our latest collection focus on the roles of ATG9 and LC3 interacting regions, plus mechanisms of selective #autophagy involving Rab GTPases, #mitophagy, and #pexophagy. 👉 rupress.org/jcb/collecti...

New paper in @jcb.org! We found a new regulator of p62 phase separation, autophagy, and antioxidant signaling. It is an E3 ligase adaptor called SHKBP1, but the effect is via direct p62 binding, not ubiquitination. Congrats to Lin Luan & team! @weillinstitute.bsky.social

Lin Luan, @jeremybaskin.bsky.social and colleagues @weillinstitute.bsky.social identify the Cullin-3 adaptor SHKBP1 as a non-canonical regulator of p62 phase behavior limiting p62 body formation and affecting Keap1/Nrf2 antioxidant signaling. rupress.org/jcb/article/... #CellSignaling

Energy stress activates AMPK to arrest #mitochondria via phosphorylation of TRAK1. New study from Jill E. Falk, Thomas L. Schwarz and colleagues @bostonchildrens.bsky.social: rupress.org/jcb/article/... #Metabolism #Neuroscience #Organelles #CellMetabolism #Cytoskeleton

Actomyosin cortex integration with complex plasma membrane topography in the early #Drosophila embryo. New study from Rowan K. Naidoo, Rebecca Tam, and Tony J.C. Harris @uoftcellsysbiol.bsky.social: rupress.org/jcb/article/... #Development #Cytoskeleton

ATG9A facilitates closure of mammalian autophagosomes. From Ruheena Javed, Vojo Deretic and colleagues: rupress.org/jcb/article/... 📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti... #KSAutophagy26

The #mitophagy receptors BNIP3 and NIX mediate tight attachment and expansion of the isolation membrane to #mitochondria. From Shun-ichi Yamashita, Ritsuko Arai, Tomotake Kanki, Satoshi Waguri et al. rupress.org/jcb/article/... 📕 In #Autophagy 2026 👉 rupress.org/jcb/collecti... #KSAutophagy26

🌈 Download JCB's CELLULAR DIVERSITY poster! 📩 Sign up to receive our future special collections and download this beautiful artwork by Bianca Dunn to display at home or in the lab 👉 info.rupress.org/jcb-collecti...

Trachsel-Moncho, @annesimonsen.bsky.social et al. identify the endosomal protein SNX10 as a modulator of piecemeal #mitophagy of OXPHOS machinery components and mitochondrial homeostasis. rupress.org/jcb/article/... 📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti... #KSAutophagy26

In this Perspective, North, @doroteaartscience.bsky.social, Shoemaker et al. highlight the rapidly expanding role of LC3-interacting regions in autophagy. rupress.org/jcb/article/... 📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti... #KSAutophagy26

Real time imaging reveals new mechanisms for pancreatic ductal establishment and remodeling. New study from Abigail Laura Jackson, Silja Heilmann @ucph.bsky.social, Pia Nyeng @roskildeuni.bsky.social and colleagues: rupress.org/jcb/article/... #Polarity #Development

A key finding of our last study is that soluble and immobilized CCL21 gradients cooperate to fine-tune different steps of lymphatic migration, revealing a new layer in leukocyte guidance. This work was only possible thanks to an amazing team effort!

MIM triggers formin to Arp2/3-based actin assembly in membrane remodeling in #Drosophila embryos, say Debasmita Mitra, Georgina K. Goddard, Sanjana S, Aparna K, Richa Rikhy (Indian Institute of Science Education and Research Pune) & colleagues: rupress.org/jcb/article/... #Cytoskeleton #Development

Andrea L. Ambrosio, Santiago M. Di Pietro et al. discover GRIPAP1 is a component of the cellular machinery that produces the #platelet α-granule, a member of the #lysosome-related organelle family. rupress.org/jcb/article/... #Biochemistry #Disease #Organelles #Trafficking

Molly Zych, Emily Hatch et al. @fredhutch.org demonstrate that reduced RCC1 levels in #micronuclei impair protein export, causing persistent micronuclear growth, nuclear lamina gap expansion, and rupture. rupress.org/jcb/article/... #disease #chromatin #epigenetics #cancer

Wei Zou & Qiming Sun labs uncover Rab #GTPases as evolutionarily conserved signals mediating selective #autophagy, targeting damaged #mitochondria, #LipidDroplets, and #pathogens for degradation. rupress.org/jcb/article/... 📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti... #KSAutophagy26

Antonia Hamrick and Ofer Rog @theroglab.bsky.social define the organization of the sister chromatids during #meiosis in #Celegans. Sisters are found to occupy distinct volumes when meiotic exchanges form. rupress.org/jcb/article/... #Chromatin #epigenetics #Genetics #CellCycle #CellDivision

Zhifang Li et al. reveal that the NRZ tethering complex is a critical regulator of virus-induced ER–LD interactions by enhancing ER–LD contacts, thereby facilitating efficient viral infection. rupress.org/jcb/article/... #Organelles #Virology #Membrane #lipid #ER_literature #LipidDroplets

The p97 ATPase and its adaptor UBXD8 maintain #peroxisome pools by preventing #pexophagy. From Iris Montes, Malavika Raman @maliramanlab.bsky.social and colleagues: rupress.org/jcb/article/... 📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti... #KSAutophagy26

uPA-mediated remodeling of CCL21 gradients regulates lymphatic migration of dendritic cells. New study from Victor Collado-Diaz, Maria-Nefeli Christakopoulou, Philipp Schineis, Cornelia Halin @halinlab.bsky.social @ethz.ch and colleagues: rupress.org/jcb/article/... #Immunology #Migration #motility

Landscape expansion microscopy reveals interactions between membrane and phase-separated organelles. New method developed by Yinyin Zhuang et al. of the Xiaoyu Shi lab @xyshi.bsky.social @ucirvine.bsky.social: rupress.org/jcb/article/... 🎥 See video summary by Xiaoyu Shi: youtu.be/OFNd0Yq8A_A

Part of the JCB Autophagy 2026 special issue

The #autophagy protein ATG-9 regulates #lysosome function and integrity. From Kangfu Peng, Hong Zhang and colleagues (Institute of Biophysics, CAS): rupress.org/jcb/article/... 📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti... #KSAutophagy26

SOD1 is delivered to #lysosomes via #autophagy to maintain lysosomal function and integrity. From Yanzhe Zheng, Ruilin Tian, Yan Zhao and colleagues: rupress.org/jcb/article/... 📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti... #KSAutophagy26

JCB’s February issue is here! rupress.org/jcb/issue/22... 🔬 The cover shows the organelle organization of #Plasmodium falciparum while infecting a human red blood cell. From Shahar et al. @florentin-lab.bsky.social: rupress.org/jcb/article/...

Naidoo, Tam, and Harris @uoftcellsysbiol.bsky.social show that, over the early #Drosophila embryo, a composite of actomyosin and plasma membrane folds conveys cortical tension, and regulation involves PM topography modulation by Arp2/3. rupress.org/jcb/article/... #Actin #Cytoskeleton #Development

Schwarz lab @bostonchildrens.bsky.social identify a mechanism coupling mitochondrial movement to energy demand. When energy levels are low, the energy-sensing kinase AMPK phosphorylates the motor/adaptor protein TRAK1, arresting #mitochondria via the #actin #cytoskeleton. rupress.org/jcb/article/...