Colarusso, Wirshing and Lew @mit.edu find that the multibudding yeast Aureobasidium pullulans can position cytokinetic machinery at most bud necks even in the absence of #septins, revealing a novel pathway to mark #cytokinesis sites. rupress.org/jcb/article/... #CellDivision #Cytoskeleton

Spotlight: New study by Begar et al. from @cytolabkoc.bsky.social (doi.org/10.1083/jcb....) reveals how PCM1 multimerization drives assembly of centriolar satellites and recruitment of client proteins. Kearney, Sharma, and Morrison highlight the findings: rupress.org/jcb/article/... #Cilia

Growth-dependent concentration gradient of the oscillating Min system in Escherichia coli. From Claudia Morais Parada, Ching-Cher Sanders Yan, Cheng-Yu Hung, Yu-Ling Shih et al. rupress.org/jcb/article/... 📕 Part of "Collective Behaviors and Self-Organization in Cells" rupress.org/jcb/collecti...

I feel honored that my Perspective article with @mayorlab.bsky.social on collective cell migration has been featured in this special collection. Many thanks to the curators, @wumin-lab.bsky.social and Gabriele Stephan, as well as @jcb.org rupress.org/jcb/article/... #CellBio #CellMigration

Inorganic phosphate rapidly switches the stability of Arp2/3 induced #actin branches. New study from Jiu Xiao, Guillaume Romet-Lemonne, Antoine Jégou @romet-jegou-lab.bsky.social @ijmonod.bsky.social and colleagues: rupress.org/jcb/article/... #Cytoskeleton #Biophysics

Unattached #kinetochores cluster in budding #yeast to promote #microtubule capture. Darren R. Mallett, @suebiggins.bsky.social et al. dissect the molecular mechanisms of this pathway, showing Mps1 kinase regulates an interaction between Stu1 and Slk19 to drive clustering. rupress.org/jcb/article/...

Arp2/3-dependent #endocytosis ensures #Cdc42 oscillations by removing Pak1-mediated negative feedback. from Marcus Harrell, Ziyi Liu, @daslabpombe.com and colleagues: rupress.org/jcb/article/... 📕 Part of "Collective Behaviors and Self-Organization in Cells" rupress.org/jcb/collecti...

This collection explores emergent phenomena in #CellBiology incl. how cellular events are rapidly coordinated by waves of chemical & electrical signals, how tissue patterning is governed at the cellular level & how cellular interfaces guide cellular migration & morphology rupress.org/jcb/collecti...

Skin without #fibroblasts: Rethinking epidermal–dermal dependence. Emanuel Rognoni @qmul.bsky.social highlights work from @isabella-gaeta.bsky.social, @shuangshuangdu.bsky.social, @valentatormenta.bsky.social et al. (doi.org/10.1083/jcb....) in Spotlight: rupress.org/jcb/article/... #StemCells

New study led by Lei Wang from the Institute of Biophysics of the Chinese Academy of Sciences (rupress.org/jcb/article/...) has revealed two coordinated molecular mechanisms that maintain efficient protein phosphorylation in the Golgi apparatus during lactation. 👉

The Rab GEF VINE couples phosphatase recruitment to GAP-mediated Rab5 inactivation. New study from Mia S. Frier, Elizabeth Conibear @lizconibear.bsky.social and colleagues (University of British Columbia): rupress.org/jcb/article/... #Trafficking #Organelles #Genetics #GTPases

Spotlight: Alba Muniesa-Vargas, Hannes Lans et al. (rupress.org/jcb/article/...) provide insight into the mechanisms that regulate the dynamics of XPG recruitment & release during nucleotide excision repair. Opresko and @orlandoscharer.bsky.social highlight the findings: rupress.org/jcb/article/...

Intercellular mitochondrial transfer and trans-#mitophagy in response to protein import dysfunction. New study from Emily Glover, Kevin Wilkinson, Ian Collinson @ianofbristol.bsky.social @collinsonlab.bsky.social @bristoluni.bsky.social and colleagues: rupress.org/jcb/article/... #Mitochondria

aPKC exclusion from the apical cortex in enteroblasts maintains stem cell homeostasis in #Drosophila. New study from Yasushi Izumi and Mikio Furuse (National Institute for Physiological Sciences, Tokyo): rupress.org/jcb/article/... #Adhesion #StemCells #Development #Polarity

Yang et al. show that the secretory pathway kinase Fam20C is retained in the #Golgi via Fam20A-mediated membrane anchoring. Mislocalizing Fam20C alters #secretome phosphorylation, leading to reduced milk quality and subsequent growth retardation in pups. rupress.org/jcb/article/...

Hanbing Xue, Xingwen Hu, Zhenni Yang, Yan G. Zhao et al. reveal that during nutrient scarcity, the lipid droplet–localized PISD isoform, PISD-LD, ensures survival by bridging #LipidDroplets to #mitochondria for β-oxidation while simultaneously inhibiting #lipophagy rupress.org/jcb/article/...

@sonideshwal.bsky.social et al (rupress.org/jcb/article/...) reveal a system by which mitochondria prioritize CoQ retention when the mevalonate pathway is impaired, preserving respiration at the expense of antioxidant defenses, highlight @angelifriedmann.bsky.social et al rupress.org/jcb/article/...

Weikang Fan, Youheng Wei et al. reveal how nutrient sensing in #Drosophila intestinal epithelial cells controls stem cell activity. Inhibition of Rag GTPases or mTORC1 in enterocytes non-cell autonomously promotes ISC proliferation via Upd3–JAK–STAT signaling. rupress.org/jcb/article/...

Happy that our team - aka @aschahl.bsky.social 😆 - helped a little on this really cool project! Congratulations @romet-jegou-lab.bsky.social team!

Spotlight: @isabella-gaeta.bsky.social, @shuangshuangdu.bsky.social, @valentatormenta.bsky.social et al. (doi.org/10.1083/jcb....) revealed that dermal #fibroblast depletion does not affect epidermal #StemCell proliferation in the skin. Rognoni highlights the findings: rupress.org/jcb/article/...

Xiao et al. @romet-jegou-lab.bsky.social show that #actin branch junctions whose Arp2/3 complex contains inorganic phosphate are mechanically more stable & protected from GMF-induced destabilization, but are not stabilized further by cortactin. rupress.org/jcb/article/... #Cytoskeleton #Biophysics

A pan-vertebrate signaling motif controls the molecular function of intracellular AQP12. New study from François Chauvigné, Joan Cerdà and colleagues @uab.cat: rupress.org/jcb/article/... #Physiology #CellSignaling #Trafficking #Aquaporins

“We greatly appreciated JCB’s support in highlighting the significance of our study. The outreach efforts helped communicate our findings to a broader scientific audience.” — Wu-Min Deng Why publish in JCB? 👉 hubs.la/Q04kxlH90

Synergistic assembly, disassembly, and protection of complex forms of bundled F-actin. New study from Sudeepa Rajan, Jimok Yoon, Jonathan R. Terman (UT Southwestern Medical Center), Emil Reisler (UCLA) and colleagues: rupress.org/jcb/article/... #Migration #Development #Cytoskeleton #Actin

A bit delayed, but proud to present our latest publication in @jcb.org extending the sphere of influence of the lipid kinase PIKfyve beyond the endo-lysosomal system and into the endoplasmic reticulum doi.org/10.1083/jcb....

Recruitment and release of XPG during NER is controlled by pre‑ and post‑incision factors and EXO1. New study from Alba Muniesa-Vargas, Hannes Lans and colleagues @erasmusmc.bsky.social: rupress.org/jcb/article/... #DNAbiology #Genetics #DNArepair

Glover, Wilkinson, @ianofbristol.bsky.social et al. show that cells subject to mitochondrial protein import failure induce Intercellular Mitochondrial Transfer via tunnelling nanotubes. rupress.org/jcb/article/... #Organelles #Biochemistry #Mitochondria

Izumi and Furuse show that the exclusion of apical aPKC by septate junction proteins in #Drosophila enteroblasts is required for stem cell homeostasis via the Kibra–Yorkie pathway. rupress.org/jcb/article/... #Adhesion #StemCells #Development #Polarity

Frier, @lizconibear.bsky.social et al. show that the VPS9 GEF complex VINE unexpectedly recruits a phosphatase that stimulates GAP-mediated Rab5 inactivation, revealing dual control of Rab signaling by a single complex. rupress.org/jcb/article/... #GTPases #Organelles #Trafficking

Meiotic CENP-C supports #centromere assembly and #kinetochore recruitment in #spermatogenesis. New study form Rachel S. Keegan, Dina Malkeyeva, Meg B. Weever, and Elaine M. Dunleavy @uniofgalway.bsky.social: rupress.org/jcb/article/... #CellCycle #CellDivision #Development #Meiosis #Drosophila

Our July issue is here! rupress.org/jcb/issue/22... The cover shows an immunofluorescence image of a TNFα-inflamed mouse cremaster muscle acquired w/ a Nikon A1 confocal microscope. Green, cortactin; magenta, CD31 (vessels); cyan, MRP-14 (neutrophils). Guerrero-Fonseca et al. doi.org/10.1083/jcb....

PIKfyve influences inter-organelle contacts with lysosomes to modulate the endoplasmic reticulum. New study from Nicala Jenkins, Roberto J. Botelho et al. @botelholabcanada.bsky.social @torontomet.bsky.social: rupress.org/jcb/article/... #Organelles #Membrane #lipid #ER_literature #phospholipids

Phosphatidylserine and RhoB connect PI4P and PA #metabolism to maintain plasma #membrane identity. New study from Shiying Huang, Tamas Balla, Jeremy M. Baskin @jeremybaskin.bsky.social, @weillinstitute.bsky.social and colleagues: rupress.org/jcb/article/... #lipid

The discovery of a novel trafficking domain in unorthodox AQP12 by Chauvigné, Cerdà et al. @uab.cat yields insight into the channel’s native membrane function and its molecular regulation in intracellular yolk platelets and pancreatic zymogen granules. rupress.org/jcb/article/... #CellSignaling

Role of the nonhelical tailpiece of #myosin-II in regulating filament architecture and function. New study from Kangji Wang, Shi Shu, Xiong Liu, and Erfei Bi @upenn.edu rupress.org/jcb/article/... #Cytoskeleton #Biochemistry #CellMigration #motility #Physiology

Sequential changes in calcium transients during M phase regulate #cardiomyocyte proliferation. New study from Honghai Liu, Bernhard Kühn and colleagues @weillcornell.bsky.social: rupress.org/jcb/article/... #Development #CellCycle #CellDivision #Mitosis

My contribution to this work was demonstrating in vivo, using Drosophila bristle cells as a model system (shown in the attached image, Figure 8 in the paper), that espin and fascin work together to protect F-actin bundles against Mical-mediated disassembly and cellular remodeling.

Rajan, Yoon, Terman, Reisler et al. identify mechanisms for assembling & disassembling complex networks of multi-protein–bundled F-actin, including a synergism between different bundlers and disassemblers in these processes. rupress.org/jcb/article/... #Migration #Development #Cytoskeleton #Actin

Thanks a lot to Andreas Boland for writing this kind and succinct Highlight of our recent work!

Alba Muniesa-Vargas, Hannes Lans et al. @erasmusmc.bsky.social use live-cell imaging to uncover how XPG activity is dynamically controlled during nucleotide excision repair. rupress.org/jcb/article/... #DNAbiology #Genetics #DNArepair

Keegan, Dunleavy et al. show that, in #Drosophila, a new pool of constitutive #centromere protein CENP-C is loaded at the centromere in prophase of #meiosis I. This pool is critical for #kinetochore assembly and meiotic chromosome segregation. rupress.org/jcb/article/... #Spermatogenesis

Small-number effects limit chromosome segregation synchrony. Andreas Boland @biology-unige.bsky.social highlights a new study from Williams, @kamenzlab.bsky.social, @silkehauflab.bsky.social and colleagues (rupress.org/jcb/article/...) in Spotlight: rupress.org/jcb/article/... #CellDivision

Thrilled to share this #lipidtime mechanism story in @jcb.org where, led by Shiying Huang and in collaboration with Tamas Balla’s lab, we uncover plasticity in phospholipid metabolism to preserve plasma membrane identity and integrity in the face of disease-relevant perturbations!

How does the plasma #membrane preserve its #lipid identity under stress? The Baskin and Balla labs report a homeostatic circuit linking PI4P, phosphatidylserine, RhoB, and phospholipase D-driven phosphatidic acid. rupress.org/jcb/article/... @jeremybaskin.bsky.social

Jenkins et al. @botelholabcanada.bsky.social show that the PIKfyve #lipid kinase extends its sphere of influence to modulate the architecture & dynamics of the ER by balancing phosphoinositide species at their inter-organellar sites. rupress.org/jcb/article/... #Organelles #Membrane #ER_literature

Honghai Liu et al. from the Bernhard Kühn lab (Department of Pediatrics @weillcornell.bsky.social) show that #cardiomyocytes suppress calcium transients during #CellDivision. rupress.org/jcb/article/... #Development #CellCycle #Mitosis

Kangji Wang, Shi Shu, Xiong Liu, and Erfei Bi @upenn.edu show that deletion of the nonhelical tailpiece (NHT) in #myosin-II results in enlarged bipolar filaments with reduced bare zones, decreased disassembly, and impaired #CellMigration rupress.org/jcb/article/... #Cytoskeleton #Biochemistry

When Neuroligin2 sticks around, #astrocytes take shape. Sneha Ray and Aakanksha Singhvi @singhvilabglia.bsky.social @basicsci.fredhutch.org discuss work from Sakers, @caglaeroglu.bsky.social et al. (rupress.org/jcb/article/...), in Spotlight: rupress.org/jcb/article/... #Neuroscience

Publishing in JCB enables authors funded by National Institutes of Health (NIH), Howard Hughes Medical Institute (HHMI), and other funders an easy pathway to compliance. Learn more: 👉 rupress.org/pages/nih-hh...

ICYMI: this collection highlights how #microtubule nucleation is regulated by spindle matrix proteins, how spindle assembly affects microtubule organization, how #centriole cap proteins cooperatively regulate microtubule elongation, and more: 👉 rupress.org/jcb/collecti... #Microtubules #Cytoskeleton