⏰ Voting closes TOMORROW, December 31! Explore 12 breathtaking images submitted by our talented authors and vote for your favorite. Have your say in celebrating the beauty of science 👉 www.surveymonkey.com/r/JCB2025Cov... #ScienceArt

Shout out to @jcb.org again for recognition of my work...being the recipient of this year's Allan Hall Travel Award..truly honoured and humbled🙏🙏

Keeping a stiff upper lip: p120ctn and tissue fusion. Jeff Hardin @uwmadison.bsky.social discusses recent work by @xsciteng.bsky.social et al. of the @jeffbush.bsky.social lab (rupress.org/jcb/article/...) in Spotlight: rupress.org/jcb/article/... #Adhesion #Development

SynSeg: A synthetic data-driven approach for robust subcellular structure segmentation, developed by Zhengyang Guo, Guangshuo Ou and colleagues @tsinghuauniversity.bsky.social: rupress.org/jcb/article/... #Technology #Cytoskeleton

A crucial step towards understanding tip growth in plants. Ivan Radin @radinbio.bsky.social (University of Minnesota) highlights work from Ryken et al. of the Bezanilla lab (rupress.org/jcb/article/...) in Spotlight: rupress.org/jcb/article/... #CellSignaling #PlantBiology #PlantCellBiology

Very nice highlight on Camilla’s new paper! @xsciteng.bsky.social

It's such an honor to be featured in @jcb.org The Year in Cell Biology 2025 Collection!! 🤩 Huge thanks to my amazing PI @nanigrotjahn.bsky.social and my wonderful lab mate @nitishdua.bsky.social for bringing the hard copy of the magazine back from #cellbio1025 for me. It truly made my day! 🥰

Steady and escort cyst cells regulate #Drosophila germline stem cell differentiation and death, say Aya Ben-Hamo-Arad, Hila Toledano and colleagues (University of Haifa): rupress.org/jcb/article/... #CellDeath #StemCells

Maspardin/SPG21 controls #lysosome motility and TFEB phosphorylation through RAB7 positioning, say Thomas Jacqmin, Marielle Boonen and colleagues (University of Namur): rupress.org/jcb/article/... #Trafficking #Organelles #Disease

Check this out! Camilla is awesome! @xsciteng.bsky.social

On the first day of the Christmas holidays, I got... a new preprint out! Challenging the reproducibility of our manual presynaptic actin nanostructure identification: www.biorxiv.org/content/10.6... (data from Bingham et al. @jcb.org 2023 doi.org/10.1083/jcb....) with @flevet.bsky.social

JCB’s Cover of the Year voting is open! I’ll just say… they are all gorgeous, but April has my heart 😍❄️🔬 #teamtomo @attychang.bsky.social

Vote for JCB’s cover of the year! Explore 12 breathtaking images submitted by our talented authors and pick a favorite. Voting closes on Wednesday, December 31! 👉 www.surveymonkey.com/r/JCB2025Cov... #ScienceArt

🎥 New video summary of a recent paper by @xsciteng.bsky.social et al. of the @jeffbush.bsky.social lab @ctbatucsf.bsky.social (rupress.org/jcb/article/...), revealing cellular mechanisms of tissue fusion in the developing face.

Spotlight: Jeff Hardin highlights recent work from @xsciteng.bsky.social et al. of the @jeffbush.bsky.social lab (rupress.org/jcb/article/...), studying the function of p120-catenin and #cadherin-mediated #adhesion in upper lip fusion in mammalian embryos. rupress.org/jcb/article/... #Development

Zhengyang Guo, Guangshuo Ou et al. @tsinghuauniversity.bsky.social introduce SynSeg, a method that eliminates manual annotation by training #DeepLearning models on synthetic data from abstracted “primitives” to robustly segment diverse subcellular structures rupress.org/jcb/article/... #Technology

Perinuclear non-centrosomal #microtubules direct nuclei dispersion during epithelial #morphogenesis, say Rashmi Budhathoki et al. @blankenshiplab.bsky.social rupress.org/jcb/article/... #Drosophila #Cytoskeleton #Development #Organelles

Independent nuclear and organellar mechanisms determine #apicoplast fate in #malaria #parasites, say Michal Shahar, Anat Florentin et al. @florentin-lab.bsky.social rupress.org/jcb/article/...

Spotlight: Ivan Radin discusses new work from Ryken and colleagues (rupress.org/jcb/article/...) which shows how localization and function of autoinhibitory calcium ATPases maintains the strength of the tip-focus Ca2²⁺ gradient during polarized plant growth. rupress.org/jcb/article/... #PlantBiology

Ben-Hamo-Arad, Toledano et al. reveal that #Drosophila cyst cells exist in two functionally distinct subpopulations: transient escort cells derived from #StemCell divisions & long-lived steady cyst cells that persist at the testis apex & mediate phagoptosis rupress.org/jcb/article/...

Jacqmin, Boonen et al. report that the loss of maspardin, which is deficient in spastic paraplegia 21, results in RAB7 hyperactivation due to mislocalization. This abnormal RAB7 localization leads to defects in #lysosome #trafficking & disruption of the mTOR–TFEB pathway. rupress.org/jcb/article/...

TMEDs mediate versatile cargo transport in vesicle-dependent unconventional secretion, say Jianfei Zheng, Haodong Wang, Min Zhang, Liang Ge and colleagues @tsinghuauniversity.bsky.social: rupress.org/jcb/article/... #Biochemistry #Membrane #lipid

Thanks to @jcb.org for featuring our paper on their webpage!

JCB's The Year of Cell Biology: 2025 features new advances in plasma membrane repair, autophagy, protein homeostasis, and organelle-dependent cell signaling. Find the original research articles that have garnered exceptional interest from our readership this year 👉 rupress.org/jcb/collecti...

Macrophage fireworks 🎆 from Miller et al. of the @mmorrissey.bsky.social lab (doi.org/10.1083/jcb....) showing a #macrophage expressing Vav1-mCherry (magenta) interacting with IgG (yellow) on a supported lipid bilayer containing ICAM-1. More in JCB's December issue: rupress.org/jcb/issue/22...

Congratulations to Amanda Bentley-DeSousa of the Ferguson lab for her paper being selected as one of JCB’s most impactful papers of 2025! @shawnferguson.bsky.social

This might be my favorite piece of conference swag ever. My 5yo is obsessed with it. #cellbio2025 @jcb.org

In a paper out this month in @jcb.org we present evidence implicating intrinsically disordered regions (IDRs) as key to junctional assembly and function 2/n 🧪 pubmed.ncbi.nlm.nih.gov/41099653/

📣 “An interkinetic envelope is assembled during oocyte meiosis” published by Layla El Mossadeq et al. (Dumont Lab) is one of the 13 most influential articles of @jcb.org of 2025! More infos ➡️ www.ijm.fr/the-year-in-... Find here the scientific article🔗 rupress.org/jcb/article/...

Happy to see Rashmi’s latest on embedded ncMTs at the nucleus and how they enable intercalation out @jcb.org. Congrats to her and many thanks to the constructive editors/reviewers at JCB! doi.org/10.1083/jcb....

Loss of ErbB3 redirects Integrin β1 from endosomal recycling to secretion in extracellular vesicles, say Dorival Mendes Rodrigues-Junior, Ana Rosa Sáez-Ibáñez, Ingvar Ferby and colleagues @uu.se: rupress.org/jcb/article/... #Cancer #Biochemistry #Trafficking #CellSignaling

Help choose JCB’s cover of the year! Explore 12 breathtaking images submitted by our talented authors and vote for your favorite. Don’t miss your chance to have your say in celebrating the beauty of science. Voting closes on December 31! 👉 www.surveymonkey.com/r/JCB2025Cov... #ScienceArt

Rashmi Budhathoki et al. @blankenshiplab.bsky.social show that nuclear dispersion relies on a transition from centrosomal to embedded nucleus-associated, non-centrosomal #microtubules during #Drosophila tissue extension. rupress.org/jcb/article/... #Cytoskeleton #Development #Organelles

LncRNA EGFR-AS1 promotes DNA damage repair by enhancing PARP1-mediated PARylation, say Kun Gao, Changying Guo (Xinjiang University), Liang Jin (China Pharmaceutical University) and colleagues: rupress.org/jcb/article/... #Biochemistry #Cancer #DNAbiology #RNAbiology

Michal Shahar, Anat Florentin et al. @florentin-lab.bsky.social reveal how the #malaria parasite's #apicoplast develops through four distinct stages linked to nuclear replication, including a unique “Crown” stage critical for organelle inheritance rupress.org/jcb/article/...

High resolution mapping of the #actin fusion focus reveals #myosin V-dependent formin transport for aster formation. New study from Valentine Thomas (@valthomas.bsky.social), Sophie Martin (@sophiemartinlab.bsky.social) et al: rupress.org/jcb/article/... #Cytoskeleton #Microbiology #Spombe #Yeast

📢 Yu Deng, winner of the JCB 2025 Norton B. Gilula Travel Award, is presenting ⏰ TODAY at 9:00AM - 11:00AM! Be sure to catch Yu's talk if you're attending #CellBio2025!

DUX4-induced HSATII RNA accumulation drives protein aggregation impacting RNA processing pathways, say Tessa Arends, Sean Bennett, and Stephen Tapscott @fredhutch.org: rupress.org/jcb/article/... #Disease #RNAbiology

Regulation of cell dynamics by rapid #integrin transport through the biosynthetic pathway. New study from Martina Lerche, Mathilde Mathieu, Johanna Ivaska @johannaivaska.bsky.social @ivaskalab.bsky.social @turkubioscience.bsky.social and colleagues: rupress.org/jcb/article/... #Adhesion #Cancer

#Phosphatidylserine exposure and #annexin A5 weaken the #actin cortex in #osteoclast fusion, say Evgenia Leikina, Michael Kozlov, Leonid Chernomordik and colleagues (National Institutes of Health): rupress.org/jcb/article/... #Membrane #lipid #CellSignaling #Biophysics

GARLH regulates neuroligin preference for excitatory versus inhibitory synapses, say Tokiwa Yamasaki, Kohtarou Konno, Susumu Tomita @yaleschoolofmed.bsky.social and colleagues: rupress.org/jcb/article/... #Adhesion #Neuroscience

Rivero-Ríos, Sutton, Weisman and colleagues show that PI(3)P coordinates SNX17- and SNX27-dependent protein recycling for long-term synaptic plasticity. rupress.org/jcb/article/... 📕 From The Year In Cell Biology: rupress.org/jcb/collecti... #CellBio2025

Zheng et al. uncover that p24/TMED family proteins mediate selective cargo translocation and release in vesicle-dependent UcPS. The switch of TMED hetero-oligomers at the ER to the UcPS cargo–stabilized homo-oligomers at the ERGIC is critical for their functions in UcPS. rupress.org/jcb/article/...

Jiasheng Li, Ye Tian et al. show that TMBIM-2 orchestrates systemic mitochondrial stress response via facilitating Ca2⁺ oscillations. rupress.org/jcb/article/... 📕 Part of The Year In Cell Biology: rupress.org/jcb/collecti... #CellBio2025

Proud of two covers from India this year in JCB....both so beautiful, @rpadinjat.bsky.social and @spindlebehavior.bsky.social

Our final day at #CellBio2025! Be sure to stop by Journal of Cell Biology in the Exhibit Hall to chat about the journal and pick up a copy of The Year in Cell Biology: 2025 magazine, our annual collection of the year’s most impactful papers 📕 📍 Booth #1224

What an honor to see @attychang.bsky.social’s work featured in @jcb.org The Year in Cell Biology 2025 collection! Even more special that it coincides with my first #cellbio2025 conference 🙂 s/o to co-authors @baradlab.com @hamid13r.bsky.social @zidlab.bsky.social #teamtomo #cellbio25

Attending #CellBio2025 and interested in discussing your research with JCB editors? Our editorial team will be available TODAY, Tuesday, Dec. 9, 12:00 pm–3:00 pm 📍 Booth #1224

Gameiro et al. establish genome-wide libraries of conditional auxin-inducible degron alleles in budding yeast and demonstrate how these resources can be applied to uncover gene functions. rupress.org/jcb/article/... 📕 From The Year In Cell Biology: rupress.org/jcb/collecti... #CellBio2025

El Mossadeq, Dumont et al. show that an interkinetic envelope surrounds chromosomes between #meiosis I and II in #Celegans oocytes. rupress.org/jcb/article/... 📕 From The Year In Cell Biology: rupress.org/jcb/collecti... #CellBio2025