Pedro Friedmann Angeli
@angelifriedmann.bsky.social
📤 1354
📥 163
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🇧🇷 expat living in 🇩🇪 Tweets in English sometimes in Portuguese - Impressum:
http://bit.ly/14S4Z8k
Kids today will never know the pain of waking up early on Saturday, running to the TV for your favourite cartoon… …only to realise it’s a repeat you already watched five times 😭📺 Streaming killed a very specific kind of character building experience
about 3 hours ago
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Pedro Friedmann Angeli
Julius-Maximilians-Universität Würzburg
3 days ago
We are delighted to announce our
#HighlyCited2025
researchers: Ronny Thomale,
@angelifriedmann.bsky.social
, Georg Gasteiger,
@dominicgrun.bsky.social
, and Christoph Wanner. Congratulations! ➡️
www.uni-wuerzburg.de/en/news-and-...
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Pedro Friedmann Angeli
Forbes
about 19 hours ago
Billionaires are more publicly involved in politics than ever—and Americans aren’t loving it.
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Americans Want Billionaires Out Of Politics—And Think They’re A Threat To Democracy, Poll Shows
Billionaires are more publicly involved in politics than ever—and Americans aren’t loving it.
http://www.forbes.com/sites/maryroeloffs/2025/11/14/americans-want-billionaires-out-of-politics-and-think-theyre-a-threat-to-democracy-poll-shows/?utm_campaign=forbes&utm_medium=social&utm_source=bluesky
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Andrea Musacchio
1 day ago
1/ It is no secret that I view the unchecked rise of liquid–liquid phase separation (LLPS) in biology as a profound distortion of molecular biology. It conflicts with its principles, it is logically incompatible with them, and the claims made in its name have been, with rare exceptions,... –>2
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Every single time I apply with a colleague to a bilateral grant that involves the
#CNPq
🇧🇷is a chance for one its reviewers to tell me how I have a mediocre scientific carreer - not sure why the personal swings but this is anything but professional 🧐
1 day ago
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🚨We have just launched a search to fill a new Jr group leader position!🚨 Great conditions to kickstart your own independent carreer - happy to answer any questions you might have. please spread the word and repost!
www.uni-wuerzburg.de/en/rvz/jobs-...
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Job Offers - Rudolf Virchow Center for Integrative and Translational Bioimaging
https://www.uni-wuerzburg.de/en/rvz/jobs-and-career/job-offers/
3 days ago
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Pedro Friedmann Angeli
Pedro Beltrao
4 days ago
957 proposals were submitted in the latest round of ERC Synergy applications. They expect to fund 50 which means around 5% success rate. This is really not sustainable and a lot of people are likely avoiding doing this knowing how poor the chances are.
erc.europa.eu/news-events/...
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Applications for ERC Synergy Grants 2026: Facts and figures
The ERC Synergy Grants 2026 call closed for applications on 5 November 2025. These are the preliminary data on the submitted proposals:
https://erc.europa.eu/news-events/news/applications-erc-synergy-grants-2026-facts-and-figures
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Can Senkal
4 days ago
We have a post-doctoral fellow position in our laboratory. Please spread the news and encourage applications. Thank you!
vcujobs.com/jobs/post-do...
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Post-Doctoral Fellow - Department of Cellular, Molecular, and Genetic Medicine - MCV Main Campus, Virginia, United States
Advertising Summary: Virginia Commonwealth University (VCU) School of Medicine is a premier academic medical center located in the heart of Richmond. Accounting for almost half of VCU’s sponsored rese...
https://vcujobs.com/jobs/post-doctoral-fellow-department-of-cellular-molecular-and-genetic-medicine-mcv-main-campus-virginia-united-states-b663b296-a3c4-4f65-805f-3c93e57d1e6b
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Pedro Friedmann Angeli
Ubellacker Lab
10 days ago
Excited to share our work
@nature.com
! Postdoc
@mariopalma.bsky.social
, with major contributions from
@retickerflynn.bsky.social
and collaborators, discovered melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits progression.
#TeamFSP1
www.nature.com/articles/s41...
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Lymph node environment drives FSP1 targetability in metastasizing melanoma | Nature
https://www.nature.com/articles/s41586-025-09709-1
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pubs.acs.org/doi/abs/10.1...
Congrats
@theprattgroup.bsky.social
for this thought provocative study. Still some unexpected observations in the autoxidation of lpids 👀
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Intramolecular Hydrogen Atom Transfer Enables Hydroperoxyl Radical Formation during the Peroxidation of Unsaturated Lipids
Lipid peroxidation (autoxidation) is among the most well-studied free radical chain reactions and drives a cell death modality (ferroptosis) implicated in neurodegeneration and the damage resulting fr...
https://pubs.acs.org/doi/abs/10.1021/jacs.5c14856
14 days ago
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Pedro Friedmann Angeli
Alicia Kowaltowski
15 days ago
Muito animada com o futuro da pesquisa metabólica USPiana!!
jornal.usp.br/ciencias/nov...
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Novo centro da USP vai investigar como o metabolismo “define a vida” e influencia doenças
Projeto de R$ 50 milhões será hospedado pelo Hospital Universitário e reunirá quatro grupos de pesquisa que hoje operam em unidades distintas da Universidade
https://jornal.usp.br/ciencias/novo-centro-da-usp-vai-investigar-como-o-metabolismo-define-a-vida-e-influencia-doencas/
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Pedro Friedmann Angeli
Nature Metabolism
18 days ago
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IPA brews metabolic balance in gut immunity
Nature Metabolism, Published online: 21 October 2025; doi:10.1038/s42255-025-01401-yMicrobiota-derived metabolites shape intestinal health by modulating T cell metabolism. Li et al. show that indole-3-propionic acid (IPA) promotes mitochondrial respiration to suppress pro-inflammatory T cell differentiation, thereby alleviating inflammatory bowel disease in humans and mice.
https://bit.ly/4htIIrk
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calling "Acetylysine" the 21st amino acid is a declaration of war
22 days ago
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(1) New preprint from our lab! HMOX1 controls a heme/ferritin switch that protects cells from ferroptosis. Loss of HMOX1 stabilizes heme, boosts ferritin, and suppresses ferroptotic death. 👉
doi.org/10.1101/2025...
#ferroptosis
#heme
#ironmetabolism
#preprint
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HMOX1 controls a heme/ferritin switch that protects cells from ferroptosis
Modulating the intracellular labile iron pool (LIP) has emerged as a promising strategy to induce ferroptosis in cancer cells, offering a way to overcome resistance to apoptosis-based therapies. One o...
https://doi.org/10.1101/2025.10.14.682408
about 1 month ago
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Pedro Friedmann Angeli
Nature Reviews Cancer
24 days ago
REVIEW🚨 The authors discuss the regulation and interplay of the metabolic #CellDeath pathways #ferroptosis, #disulfidptosis and #cuproptosis and explore how these mechanisms can be harnessed for cancer therapies. @mdanderson.bsky.social 📖 ⬇️
https://bit.ly/3L3vN...
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Pedro Friedmann Angeli
Julius-Maximilians-Universität Würzburg
24 days ago
Bayern und die Max-Planck-Gesellschaft
@maxplanck.de
haben sich darauf verständigt, in Würzburg ein Max-Planck-Institut 🔬 aufzubauen. Unipräsident Paul Pauli: "Das ist ein starkes Zeichen für den Wissenschaftsstandort Würzburg."
go.uniwue.de/mpg-wue
📷 Mindcore
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Pedro Friedmann Angeli
Holthuis Lab
29 days ago
🚨🚨🚨 We are launching the 2nd application round for the Erasmus Mundus Joint Master’s Program MemBioMed, offering cutting-edge training on exploring the complex behavior of cellular membranes & unlocking their therapeutic potential. Students can apply here:
life.univ-cotedazur.eu/internationa...
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Valentina Piano
about 1 month ago
We’re thrilled to announce this workshop! 🌟 Are you a junior PI in the process of building your lab? Join us in Regensburg for an inspiring workshop where we’ll exchange ideas and strategies on how to develop a motivated and harmonious team. 👉 Check it out! There are sponsored spots available!
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(1) New preprint from our lab! HMOX1 controls a heme/ferritin switch that protects cells from ferroptosis. Loss of HMOX1 stabilizes heme, boosts ferritin, and suppresses ferroptotic death. 👉
doi.org/10.1101/2025...
#ferroptosis
#heme
#ironmetabolism
#preprint
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HMOX1 controls a heme/ferritin switch that protects cells from ferroptosis
Modulating the intracellular labile iron pool (LIP) has emerged as a promising strategy to induce ferroptosis in cancer cells, offering a way to overcome resistance to apoptosis-based therapies. One o...
https://doi.org/10.1101/2025.10.14.682408
about 1 month ago
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Pedro Friedmann Angeli
Kat Tenbarge
about 1 month ago
One of the crazy things about the AI bubble bursting is that consumer sentiment toward AI has always leaned skeptical to outright negative but it’s an industry propped up by pure billionaire greed, sycophancy, and childish fantasy
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André Nadler
about 1 month ago
This is going to be fun - we are really pleased with the program - there is some really exciting science on the menu! Do sign up!
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This is madness... pure madness
www.theguardian.com/world/ng-int...
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Young lives cut short on an unimaginable scale: the 18,457 children on Gaza’s list of war dead
Every name on a list compiled by health authorities in Gaza of the child victims of Israel’s offensive
https://www.theguardian.com/world/ng-interactive/2025/oct/08/young-lives-cut-short-on-an-unimaginable-scale-the-18457-children-on-gazas-list-of-war-dead
about 1 month ago
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Pedro Friedmann Angeli
Humboldt-Stiftung
about 1 month ago
✨✨✨ Huge congratulations to the winners of the
#NobelPrize
in Physics: John Clarke, Michel H. Devoret and John M. Martinis. Clarke and Martinis are both members of the Humboldt Network – as hosts for Feodor Lynen Research Fellows! 💚 Picture: Ill. Niklas Elmehed © Nobel Prize Outreach
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www.theguardian.com/world/2025/o...
will be too late when people realise that is not about left and right
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‘One rule for the rich’: the Salzburg mansion, the Porsche heir and the writer Stefan Zweig
The car magnate, who is restoring the Jewish author’s former villa, has been given permission to dig out a 500-metre road leading to a garage, causing consternation in the city
https://www.theguardian.com/world/2025/oct/04/salzburg-mansion-tunnel-porsche-heir-jewish-writer-stefan-zweig
about 1 month ago
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Pedro Friedmann Angeli
Lisa Heinke
about 2 months ago
Check out this new Roadmap, a fantastic team effort by a consortium of ER researchers. Glad we could provide the space for this synthesis, which came out of discussions at a fruitful meeting, see below:
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Pedro Friedmann Angeli
🚨Preprint alert 🚨 We identify riboflavin (vitamin B₂) as a key modulator of ferroptosis sensitivity via stabilizing FSP1 & recycling lipid-soluble antioxidants.
www.biorxiv.org/content/10.1...
. pls check
@olzmannlab.bsky.social
www.biorxiv.org/content/10.1...
#ferroptosis
#FSP1
#antioxidants
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Riboflavin metabolism shapes FSP1-driven ferroptosis resistance
Membrane protection against oxidative insults is achieved by the concerted action of glutathione peroxidase 4 (GPX4) and endogenous lipophilic antioxidants such as ubiquinone and vitamin E. Deficienci...
https://www.biorxiv.org/content/10.1101/2025.08.05.668651v1#:~:text=Furthermore%2C%20we%20show%20that%20the,membrane%20tolerance%20to%20lipid%20peroxidation
3 months ago
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very interesting study from Gonzalo Cosa's lab adding to the discussion of ferroptosis initiations and propagation
www.nature.com/articles/s41...
will there be a consensus? does it really matter? more studies definitely needed to settle this
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Live-cell imaging with fluorogenic radical-trapping antioxidant probes reveals the onset and progression of ferroptosis - Nature Chemistry
Spatiotemporal information on ferroptosis progression is highly desired to develop new therapies. Now, the development of organelle-targeting fluorogenic radical-trapping antioxidants has enabled dissection of the dynamic subcellular evolution of ferroptosis through real-time live-cell fluorescence imaging.
https://www.nature.com/articles/s41557-025-01966-x
about 2 months ago
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very interesting study from Gonzalo Cosa's lab adding to the discussion of ferroptosis initiations and propagation
www.nature.com/articles/s41...
will there be a consensus? does it really matter? more studies definitely needed to settle this
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Live-cell imaging with fluorogenic radical-trapping antioxidant probes reveals the onset and progression of ferroptosis - Nature Chemistry
Spatiotemporal information on ferroptosis progression is highly desired to develop new therapies. Now, the development of organelle-targeting fluorogenic radical-trapping antioxidants has enabled dissection of the dynamic subcellular evolution of ferroptosis through real-time live-cell fluorescence imaging.
https://www.nature.com/articles/s41557-025-01966-x
about 2 months ago
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meteoroptosis
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about 2 months ago
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Pedro Friedmann Angeli
Max-Planck-Gesellschaft
2 months ago
Early-career researchers: want to run your own lab? 🌟Max Planck Research Groups offer 6+ years, up to €2.7M in funding, open-topic freedom, team support & tenure-track opportunities. Intrigued? 😃Apply by Oct 14, 2025!
www.mpg.de/max-planck-r...
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Preach freedom of speech overseas, but ignore that weak institutions are what give clowns the spotligh
2 months ago
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Pedro Friedmann Angeli
André Nadler
2 months ago
This is an really amazing opportunity. If you get it, you can essentially pick you institute. The package really is rather competitive.
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Emmanuel Saliba
2 months ago
🔔PhD position open. Interested in building competencies in computational biology in spatial transcriptomics? Malte Luecken's lab and I have an open PhD position, part of the Munich School of Data Science. Application deadline: Sept 26 Link:
www.mu-ds.de
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MUDS - Helmholtz Information & Data Science Academy
https://www.mu-ds.de/
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Pedro Friedmann Angeli
Bettina Böttcher
3 months ago
🧪❄️🔬 We were very surprised to find out that the MscS-like channel YnaI does not tilt its paddle helices to open.... almost overlooked the huge pore in our cryo-EM maps Very proud that this is finally out:
rdcu.be/eB3FF
Well done, Vanessa
@uni-wuerzburg.de
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Markus Elsner
3 months ago
uuhh, wohl keine Müller Milch für mich mehr 🤮
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Pedro Friedmann Angeli
eLife
3 months ago
Membrane Biology: Nothing can replace polyunsaturated lipids Genetic studies reveal that polyunsaturated lipids do more than simply increase the fluidity of the cell membrane.
buff.ly/qcLJNUN
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Pedro Friedmann Angeli
bioRxiv Biochemistry
3 months ago
SLC26A11 is an atypical solute carrier with dual transport-channel function mediating lysosomal sulfate transport
https://www.biorxiv.org/content/10.1101/2025.08.17.670773v1
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Garry Kasparov
3 months ago
By the way, if you don't protest Trump weaponizing the Justice Department against his critics because they are people you don't like or agree with, you are assisting this fascist takeover. Wait until it happens to someone you like and it's too late.
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André Nadler
3 months ago
Out today in
@nature.com
: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
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Hart
3 months ago
Können wir bitte zuerst die Bahn sanieren 🫢
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André Nadler
3 months ago
This.
@erc.europa.eu
, this is the way to go!
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Pedro Friedmann Angeli
Harvard Molecular Metabolism
3 months ago
Jessalyn Ubellacker
@ubellackerlab.bsky.social
was honored with a FASEB Journal Early Career Researcher Award at the first FASEB Ferroptosis, Oxidative Stress, and Lipid Metabolism meeting, co-organized by James Olzmann
@olzmannlab.bsky.social
and Scott Dixon, to support early career researchers.
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Pedro Friedmann Angeli
Trends in Biochemical Sciences
3 months ago
Don't miss out on other great Review content! 📝 A Review from
@angelifriedmann.bsky.social
,
@k-hadian.bsky.social
, et al details the metabolic code of ferroptosis 📝
@damelab.bsky.social
et al describe how prokaryotes and viruses possess histone-mediated chromatin organization (1/n)
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Pedro Friedmann Angeli
James Olzmann
3 months ago
Excited to share our new preprint, led by Kirandeep Deol! 🤩 Genetic screens uncover mechanisms regulating FSP1 abundance in cancer. Vitamin B2 metabolism promotes FSP1 stability via FAD synth / binding, further linking nutrient metabolism to ferroptosis.
www.biorxiv.org/content/10.1...
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Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis
Ferroptosis, a regulated form of cell death driven by excessive lipid peroxidation, has emerged as a promising therapeutic target in cancer. Ferroptosis suppressor protein 1 (FSP1) is a critical regul...
https://www.biorxiv.org/content/10.1101/2025.08.05.668752v1
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Pedro Friedmann Angeli
bioRxiv Cell Biology
3 months ago
Riboflavin metabolism shapes FSP1-driven ferroptosis resistance
https://www.biorxiv.org/content/10.1101/2025.08.05.668651v1
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🚨Preprint alert 🚨 We identify riboflavin (vitamin B₂) as a key modulator of ferroptosis sensitivity via stabilizing FSP1 & recycling lipid-soluble antioxidants.
www.biorxiv.org/content/10.1...
. pls check
@olzmannlab.bsky.social
www.biorxiv.org/content/10.1...
#ferroptosis
#FSP1
#antioxidants
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Riboflavin metabolism shapes FSP1-driven ferroptosis resistance
Membrane protection against oxidative insults is achieved by the concerted action of glutathione peroxidase 4 (GPX4) and endogenous lipophilic antioxidants such as ubiquinone and vitamin E. Deficienci...
https://www.biorxiv.org/content/10.1101/2025.08.05.668651v1#:~:text=Furthermore%2C%20we%20show%20that%20the,membrane%20tolerance%20to%20lipid%20peroxidation
3 months ago
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Gabrielle Brewer
3 months ago
Exercise induces microbiota to produce formate which in turn enhances CD8+ T cell anti-tumour functionality. 💪
#gains
Check out my research highlight below for more deets 🤓🐛🧫
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Pedro Friedmann Angeli
Elizabeth McKenna
3 months ago
Now online in Cancer Discovery
@aacrjournals.bsky.social
: Mitochondrial Glutathione Import Enables Breast Cancer Metastasis via Integrated Stress Response Signaling - by Hsi-wen Yeh, Nicole Del Gaudio, Kivanç Birsoy, and colleagues
doi.org/10.1158/2159...
@rockefelleruniv.bsky.social
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A new postdoc position in our group will open early next year — looking for candidates with a proven track record & relevant experience. If
#CRISPRscreens
,
#syntheticlethality
,
#smallmolecules
&
#celldeath
excite you, let’s talk! DMs welcome. pls share 🙏
3 months ago
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Pedro Friedmann Angeli
Ubellacker Lab
4 months ago
Huge thank you to
@olzmannlab.bsky.social
and Scott Dixon for a phenomenal 1st FASEB Ferroptosis conference! I’m grateful to be part of such a collaborative community and it was especially great to meet all the brilliant trainees whose insights are clearly shaping the exciting future of the field! 🎉
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