This project started with confusion 🤔 www.nature.com/articles/s41... Loss of LUBAC or OTULIN causes severe inflammatory disease. But patients also show clear metabolic defects. Neither LUBAC nor OTULIN had been linked to metabolic regulation. So where do these metabolic manifestations come from?

This project started with confusion 🤔 www.nature.com/articles/s41... Loss of LUBAC or OTULIN causes severe inflammatory disease. But patients also show clear metabolic defects. Neither LUBAC nor OTULIN had been linked to metabolic regulation. So where do these metabolic manifestations come from?

🧐 What if metabolic defects are not just a consequence of inflammatory disease - but actively contribute to it? Inflammation and metabolism are deeply intertwined, but the molecular links remain unclear. Our new paper in Cell Death & Differentiation uncovers one. 🧵👇 nature.com/articles/s41...

M1-linked ubiquitination by LUBAC regulates AMPK signalling and the response to energetic stress www.nature.com/articles/s41...

🧐 What if metabolic defects are not just a consequence of inflammatory disease - but actively contribute to it? Inflammation and metabolism are deeply intertwined, but the molecular links remain unclear. Our new paper in Cell Death & Differentiation uncovers one. 🧵👇 nature.com/articles/s41...

M1-linked ubiquitination by LUBAC regulates AMPK signalling and the response to energetic stress #Drosophila

Interesting article and accompanying spotlight on the cross-talk between ciliary homeostasis and ubiquitination (written by Jonathan Pruneda and @rbdamgaard.bsky.social). www.nature.com/articles/s41... www.nature.com/articles/s41...

💡 Ciliary homeostasis turns out to depend on an unexpected tug-of-war between UFMylation and ubiquitination. In a recent editorial in Cell Death & Differentiation, @jnpruneda.bsky.social and I highlight new work from Wang et al. 🧵👇

💡 Ciliary homeostasis turns out to depend on an unexpected tug-of-war between UFMylation and ubiquitination. In a recent editorial in Cell Death & Differentiation, @jnpruneda.bsky.social and I highlight new work from Wang et al. 🧵👇

🚨 Postdoc position in my lab! A project on protein binder discovery for K6-linked #ubiquitin to investigate their role in infection is available. 📍 DTU, Copenhagen, Denmark ⏰ Deadline: 18 December 2025 Apply here: efzu.fa.em2.oraclecloud.com/hcmUI/Candid...

🚨 Postdoc position in my lab! A project on protein binder discovery for K6-linked #ubiquitin to investigate their role in infection is available. 📍 DTU, Copenhagen, Denmark ⏰ Deadline: 18 December 2025 Apply here: efzu.fa.em2.oraclecloud.com/hcmUI/Candid...

A #postdoc position in atypical #ubiquitin signalling and protein binder engineering is opening soon in my lab at DTU Bioengineering! Get in touch if you are interested.

🚀 Off to our Research Retreat with the Section for Medical Biotechnology, DTU Biotechnology and Biomedicine. Two days of science, ideas & innovation 🧬💡 12 faculty pitches, 30+ PhDs & postdocs, and endless opportunities for new collaborations 🔬🤝✨

A few months ago, our review “The Molecular Toolbox for Linkage Type-Specific Analysis of Ubiquitin Signaling” 🧬🧰🛠️ came out in ChemBioChem. Time to give it a spotlight! chemistry-europe.onlinelibrary.wiley.com/doi/full/10....

A few months ago, our review “The Molecular Toolbox for Linkage Type-Specific Analysis of Ubiquitin Signaling” 🧬🧰🛠️ came out in ChemBioChem. Time to give it a spotlight! chemistry-europe.onlinelibrary.wiley.com/doi/full/10....

Is it still useful to insist that authors spell out every protein name in research papers? Many names are long, obscure, and say nothing about function... we might as well call them James, Joan, and John.

The goal of a PhD is not to learn some facts or read a few papers or learn a bunch of techniques. The goal of a PhD is to learn independence, problem solving, how to finish things you start, resilience, & gain the ability to adapt & think creatively. Learning these things is hard.

Jeg er godt træt af måden regeringens spareplan rammer universiteterne.

the really key number to remember is that biorxiv serves the entire global science community, posting thousands of papers per month for millions of readers, and it's entire running costs ( a few $M/year) are less than some single labs....

it’s a global contest, whether we want to compete or watch from the sidelines

Special day for our group @cbmr.science as we celebrate the successful defense of our (first) freshly minted PhD, Dr. Conchita Bringas 🥳 Her thesis was based on characterizing novel #AMPK inhibitors. Special thanks to the great committee @rbdamgaard.bsky.social ,Dave Carling & Lykke Sylow.

We have a 4-year postdoc position open in our Research Unit on proteostasis! The project explores inter-tissue regulation using advanced proteomics approaches. Collaborative & interdisciplinary environment. More details & application here: jobs-uk-koeln.onlyfy.jobs/job/pktg6ivj...

Great to see this out. A story that spanned continents, cities and budget codes… www.nature.com/articles/s41... Big thanks to all the teams involved! @clausenlab.bsky.social @e3chembio.bsky.social

Haven’t shared this in a while. But the #ubiquitin and #ubl Starter Pack now includes 116 profiles to follow if you’re interested in the field: signalling, structure and biochemistry, biology, mechanisms, proteostasis, TPD, chemical biology… Check out the list and let me know if you are missing.

Happy to see our review out in ChemBioChem @chemistryeurope.bsky.social in which we describe the tools and strategies for deciphering linkage type-specific #ubiquitin signalling: doi.org/10.1002/cbic.... Thanks to Julian for spearheading this, and to Camilla and Dominik for important contributions.

Happy to see our review out in ChemBioChem @chemistryeurope.bsky.social in which we describe the tools and strategies for deciphering linkage type-specific #ubiquitin signalling: doi.org/10.1002/cbic.... Thanks to Julian for spearheading this, and to Camilla and Dominik for important contributions.

Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes. rdcu.be/edRwF

Lungfish xkcd.com/3064

Nysgerrighedsdrevet, uafhængig forskning er en samfundssøjle - i disse tider er det mere tydeligt end nogensinde. Og EU har en særlig vigtig rolle.

Ny kronik fra DUA i Dagbladet Information på baggrund af de verserende rygter om at ville indføre større politisk styring og strategisk prioritering af midlerne i ERC.

European Research Council må ikke blive udvandet ifm forhandlingerne om EU’s forskningsbudget. ERC skal forblive en uafhængig enhed, der investerer i nysgerrighedsdreven forskning - for det er grundlaget for de nye indsigter, der driver vores samfund fremad. www.information.dk/debat/2025/0...

What determines if a preprint from @biorxivpreprint.bsky.social is also indexed in PubMed? It appears some are, but others aren’t. Our recent preprint for some reason isn’t. Does one have to opt into that? Or how does it work?

Autophagy UK & Proteostasis UK joint meeting -June 3-5. Exploring the lifecycle of cellular components from synthesis to degradation. Going to be a great meeting and we look forward to welcoming you to Dundee! Exciting lineup of speakers and opportunities for ECRs Register here: tinyurl.com/mr3p49f9

Cells are filled with toxic stuff that damages healthy proteins. Is that garbage just left to rot on the curb? No way! Ubiquitin ligases have evolved to recognize chemical damage and clean it up! www.nature.com/articles/s41...

American science and medicine has been thrown into chaos and uncertainty over the past week. Here are some stories to get up to speed. 1/12

🌱 We're hiring! Join our new ⭐Center of Excellence⭐, Plant-PATH, as Center Administrator and help us drive basic research in plant molecular biology🌱. www.au.dk/om/stillinge... #Science #dkforsk #dkscience #dkvid #JobOpening #Research

We made it to 100! 📢💯 The #ubiquitin and #ubl Starter Pack now includes 100 profiles to follow if you’re interested in any aspect of the field: signalling, structure and biochemistry, biology, mechanisms, proteostasis, TPD, chemical biology… Check out the list and let me know if you are missing.

We made it to 100! 📢💯 The #ubiquitin and #ubl Starter Pack now includes 100 profiles to follow if you’re interested in any aspect of the field: signalling, structure and biochemistry, biology, mechanisms, proteostasis, TPD, chemical biology… Check out the list and let me know if you are missing.

I will say that AI has truly exposed what forms of writing we do is make-work vs. content with real meaning in it. I find that I still do all my paper writing by hand (with AI as more of an assistant) because it has (I hope) high "thought density". Other forms of writing… less so.

Sure, writing is thinking and all that high-minded stuff, but when you're eyes are bleeding right before the deadline because you have to write a Project Summary that, uhhh, summarizes your project for the nth time…

Despite all the bugs, they are still the future 🧑‍🎓

Despite all the bugs, they are still the future 🧑‍🎓

By my reckoning, yesterday marked the 50th anniversary of ubiquitin's discovery! 🎈🎉🎁🥂 www.pnas.org/doi/10.1073/...

Yesterday, we had the first breakfast seminar of the year in the Section for Medical Biotechnology. Always great to catch up with colleagues. This time with news from Chiara Francavilla's group about receptor kinases signalling and cell signalling architecture.

Happy New Year! Let’s start with an updated starter pack. Now with 94 profiles to follow if you are interested in anything #ubiquitin or #Ubl: signalling, structure and biochemistry, biology, mechanisms, proteostasis, TPD, chemical biology, etc. Let me know if you or anyone else is missing.

Happy New Year! Let’s start with an updated starter pack. Now with 94 profiles to follow if you are interested in anything #ubiquitin or #Ubl: signalling, structure and biochemistry, biology, mechanisms, proteostasis, TPD, chemical biology, etc. Let me know if you or anyone else is missing.

Exactly the same in Denmark, unfortunately. Three years for a PhD, during which students at Danish universities also have to both teach and take 6 months worth or coursework, is simply too short in most cases.

New week, updated starter pack. Now with 87 profiles to follow if you are interested in anything #ubiquitin or #Ubl: signalling, structure and biochemistry, biology, mechanisms, proteostasis, TPD, chemical biology, etc. Let me know if you or anyone else is missing.

100% agreed with this. I cut out acronyms from drafts constantly, but reading the full name of a gene is horrible. It makes sentences unreadable and more often than not gives incorrect information. Looking at you, tumour necrosis factor alpha and macrophage inflammatory protein 3 beta.

My peer review of peer review: 1. "Community standards" typically devolve rapidly into stock critiques. 2. I don't think it's a "dialog" when one participant has a gun to the other's head. 3. The cost of wasted time due to silly revision experiments is very high and not a good use of research $$.