This is really cool and important.

Writing is thinking - a short but memorable thread.

The Clavel Group is recruiting a new postdoc for two possible projects dealing with plant-virus interactions and selective autophagy! More (wordy) details below ⬇️🌱🦠

Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there?? #CellBiology #WTFology www.biorxiv.org/content/10.6...

New work describes our efforts to achieve CRISPR editing of the mitochondrial genome. www.biorxiv.org/lookup/conte...

Excited to share our work into ubiquitin E1-E2 specificity mechanisms. CryoEM visualising #ubiquitin transfer,biochemistry,evolution @labhofmann.bsky.social & tissue expression analyses @psarkies.bsky.social Big thanks to the team,reviewers & handling editor @dimitristypas.bsky.social rdcu.be/eTRdR

Für seinen Beitrag zum Verständnis der zellulären Kraftwerke (Mitochondrien) wurde Nikolaus Pfanner in die Accademia Nazionale dei Lincei, die nationale Akademie der Wissenschaften Italiens, aufgenommen. Zudem erhielt er die Walter Neupert-Medaille. ufr.link/auszeichnung-pfanner @cibss.bsky.social

The silence from the pro-LLPS crowd is deafening. As a (truly) unbiased observer, I for one am very curious to see the counterarguments, which surely must exist. The skeptics are having their day.

This has now been published in print! Check it out: www.science.org/doi/10.1126/...

Join @uofglasgow.bsky.social for a funded 3.5 year PhD programme: www.gla.ac.uk/colleges/mvl... Also up for grabs is a project on antiviral PROTACs, supervised by us and the France lab (School of Chemistry) should ubiquitin and viruses appeal! Please get in touch with any questions.

🪱 Selfish genes are everywhere and drive some of biology’s biggest innovations (CRISPR, antibody recombination, epigenetics). Yet almost no one asks the obvious question: how does a selfish gene begin? Our new manuscript uncovers how selfishness can emerge directly from the host genome.

Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...

Inferring LLPS from macroscopic properties (roundness, “liquidity”) is unhelpful. Subcellular compartments likely arise from specific interactions among multivalent proteins—robust and insensitive to environment. These interactions can generate structures with some LLPS-like properties

great post on LLPS, flying elephants and phase behaviour beyond thermodynamics #PhaseFiction

The devil is in the details Atomically accurate de novo design of antibodies with RFdiffusion www.nature.com/articles/s41... success rates against each target range from 0% to 2% 😆 for SARS-CoV2 RBD target, 9000 designs screened, 5 SPR confirmed binders.

✨ Passionate about cell biology or biochemistry? Join the Martens Lab as a postdoc to uncover why autophagy stalls at disease-linked protein aggregates - and how to restart it 🧠 Apply here ➡️ tinyurl.com/24dcrcke

Join us for Journal Club tomorrow, November 12th, as Dr. Elias Adriaenssens presents his recently published article in Nature Cell Biology, titled “Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery.” We look forward to seeing you there!

Registration for THE chemical biology conference of 2026 is now open! EMBO ChemBio 2026 in Heidelberg DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social www.embl.org/about/info/c...

🤯This is wow! Molecular mechanism of mRNA export. by @juliusbrennecke.bsky.social @plaschkalab.bsky.social www.nature.com/articles/s41...

Very glad to see this work www.nature.com/articles/s41... by the @savitski-lab.bsky.social out @natsmb.nature.com High hopes that HT-PELSA will be a very useful tool to study protein-ligand interactions.

Postdoc position available in my lab in Jena (Germany. jobs.leibniz-fli.de/jobposting/6... If you're interested in protein biochemistry of amyloid proteins and chaperones, this job may be for you. B2 Level German is required as the candidate will be involved in teaching in German.

📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu

'In this manuscript, we show that tag fusions often change protein expression to a degree that is highly dependent on cell and tissue context. We characterise two underlying mechanisms, providing information that should help others to design more effective transgenic strategies'

On that note: hello world! My new lab on genetics of proteome remodeling is starting at the incredible MPI-CBG. We have big plans and open positions for PhD students and an RA. Apply now (!) at imprs.mpi-cbg.de and tinyurl.com/2vywj6f6 respectively.

Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...

The proteasome-substrate-shuttle protein UBQLN2 contains—like other quality control system proteins—a long region devoid of lysine (a lysine desert) Martin Grønbæk-Thygesen (from @rhp-lab.bsky.social) et al show that introducing K here causes ubiquitylation and degradation doi.org/10.1101/2025...

Science has lost a GIANT and the world has lost one of the kindest most inspiring people I had the pleasure of knowing. Just an extraordinary man whose curiosity was infectious and whose dry wit will always be memorable- RIP John www.cam.ac.uk/research/new...

Allosteric control of the bacterial ClpC/ClpP protease and its hijacking by antibacterial peptides Axel Mogk, Marta Carroni et al www.embopress.org/doi/full/10....

Allosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators! www.sciencedirect.com/science/arti...

Spectacular work. Absolutely spectacular. Go check out the paper. It truly is #lipidtime now

so well deserved

Dear scientific community, I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford. my.corehr.com/pls/uoxrecru... my.corehr.com/pls/uoxrecru...

The Vienna BioCenter PhD program in Molecular BioSciences will offer 20+ fully-funded positions in the Autumn Call which is now open. Please share. Further details: www.vbcphd.at

Our Wadjet-II paper by @roisnehamelinf.bsky.social is out in polished form: www.cell.com/structure/fu... With a great preview by @kevincorbett.bsky.social & @amardeeep.bsky.social highlighting the potential of Wadjets: Wadjet—Keeping a watchful eye on circular DNA. www.cell.com/structure/fu...

WARM congratulations to: Tom DENDOOVEN, @martinpacesa.bsky.social, @mschuhmacher.bsky.social , @lfmilles.bsky.social, @preinerin.bsky.social,Markus Hopfler, @charleneboumendil.bsky.social, Gergo Gogl, @shifralansky.bsky.social, @alexanderbelyy.bsky.social,Erik Benson, @dbojar.bsky.social! 🤩 #ERCStG

Job opportunity: come join the excellent and friendly #ProteostasisUK community!

I’ve already highlighted this landmark #lipidtime paper by @nadlerlab.bsky.social & colleagues, but ICYMI, do read André’s thread — this study is a huge leap forward in understanding the logic of intracellular lipid flux & is a phenomenal example of #chembio probes 🤝 quantitative imaging 🤝 modeling!

Happy to share our work on the structure and function of the unusual E3 ligase ZNFX1 @cp-cell.bsky.social. It uses a nucleic acid-activated transthiolation mechanism, ubiquitinating and clustering RNA to protect cells in an immune response. @clausenlab.bsky.social www.cell.com/cell/fulltex...

Want to know how lipidation of some nascent chains takes place by NMT2-- Check our latest work on how NAC couples Protein Synthesis with Nascent Polypeptide Myristoylation on the Ribosome out today @embojournal.org‬: www.embopress.org/doi/full/10....

Co-translational ribosome pairing enables native assembly of misfolding-prone subunits. www.nature.com/articles/s41...

The beautiful, ever-expanding universe of viral proteins targeting nucleotide immune signals! Paper by @reneechang.bsky.social in @cp-molcell.bsky.social on a nucleotide sponge www.cell.com/molecular-ce... and preprint by @doudna-lab.bsky.social on viral nucleases www.biorxiv.org/content/10.1...

big one! a decade in the making. nadler & team develop tools to track lipid transport in living cells at single-species resolution. turns out non-vesicular, asymmetry-driven transport is the main architect of organelle identity. feels like the dawn of a golden era for lipid biology. rdcu.be/eBGJv

My PhD paper is in press @cellpress.bsky.social and now online: www.sciencedirect.com/science/arti...! Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more! Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before. www.biorxiv.org/content/10.1...

Fantastic work by the group of @matteoall.bsky.social : a SUN5:Nesprin3 complex at the head:tail junction of sperm cells. 🤯 #teamtomo www.biorxiv.org/content/10.1...

🎉Congratulations to our PhD student Moritz Helmut Wallnöfer from the Clausen lab on receiving a fellowship from the Boehringer Ingelheim Fonds (BIF)! The fellowship will support his research on how human cells detect and fight off intracellular pathogens: www.imp.ac.at/news/article...

🚨 Out now! Autophagy keeps cells healthy - and when it goes wrong, diseases like Parkinson’s can emerge. @elias-adriaenssens.bsky.social (Martens lab) in @natureportfolio.nature.com Cell Biology challenge the conventional hierarchy of autophagy factors ➡️ tinyurl.com/y33nrtn2

@aithyra.bsky.social Opening Symposium "AI for Life Science" with Nobel Laureate Frances Arnold as keynote speaker in addition to an outstanding line up of speakers on a variety of topics across biological scales and data modalities. Registration is now open at cemm.at/aithyra-symp...