Look at this 🙂 #CryoEM Structural basis for CTCF-mediated chromatin organization by @lucas.farnunglab.com @voslab.org www.biorxiv.org/content/10.6...

Too much data, too little thinking. A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read. @Yale www.nature.com/articles/s41...

A new paper reports a “nucleotide code” that coordinates Lis1-dynein binding stoichiometry, which in turn governs Lis1’s ability to relieve dynein autoinhibition www.nature.com/articles/s41...

I’m excited to share my first-author paper, with co-first author @rongqinxiaoxiao.bsky.social, now out in @nature.com. We developed a live-cell single-particle tracking platform to see how TRiC & prefoldin engage proteins during co- and post-translational folding. 1/9 www.nature.com/articles/s41...

Nature research paper: PtdIns(3,5)P2 is an endogenous ligand of STING in innate immune signalling go.nature.com/4klvMp1

Our latest cotranslational folding story is now published @cp-molcell.bsky.social. Really cool (I think) new ideas about how exactly the ribosome directs folding and assembly to make sure complicated proteins mature efficiently in cells. www.cell.com/molecular-ce...

Have a look at our new structure of co translational folding in yeast. This is collaborative work initialized by the Rospert lab from the @uni-freiburg.de. Structural work has been done by the amazing @lgrundmann.bsky.social Stay tuned for the next ribosome paper from him, following very soon.

New preprint! Led by @sarahgersing.bsky.social we map how 7,500+ variants in glucokinase (GCK) affect binding to GKRP and disentangle this from stability. We now have activity, abundance, and interaction scores for 7,128 GCK variants - a resource for understanding phenotypes and glucose homeostasis.

With so many great reviews on LDs already out, do we need another? Sarah @cohenlaboratory.bsky.social and I were approached by @natrevmcb.nature.com to do a review on LD heterogeneity and inter-organelle contacts...topics in reviews, but not a focus. Fun project! www.nature.com/articles/s41...

"RNAPII clusters reflect local accumulations of transcriptionally engaged polymerases and do not form through higher-order mechanisms such as phase separation" 😬 www.biorxiv.org/content/10.1... by the @mirlab.bsky.social

Hey #portfolioday! I'm a bloke who used to investigate Genetics before turning into a full-time Artist. Now I do handmade installations, molecular graffiti, and digital design to convey the beauty of Science.

a Trp/Phospho/Ub trifecta linking metabolism and degradation - wow 🤩 big congrats to the whole team for this amazing, almost historic study.

Join us for the #Ubiquitin & Friends Symposium 2026, April 29-30, in Vienna! Fantastic guest speakers👇 & many slots for talks from abstracts, flash-talks & posters. Lots of opportunities to network. Register now to save your spot! ➡️ www.protein-degradation.org/symposium/ #ubfriends2026

Can we design mutations that bias proteins towards desired conformational states? Today in @science.org, we introduce Conformational Biasing (CB), a simple and scalable computational method that uses contrastive scoring by inverse folding models to identify conformation-biasing mutations.

We are thrilled to share our latest work uncovering the mechanistic basis of target-directed microRNA degradation (TDMD). This work was driven by @jakobfarnung.bsky.social and @elenaslo.bsky.social in a fantastic collaboration with Brenda Schulman's lab. tinyurl.com/E3TDMD (1/5)

This is really cool and important.

Writing is thinking - a short but memorable thread.

The Clavel Group is recruiting a new postdoc for two possible projects dealing with plant-virus interactions and selective autophagy! More (wordy) details below ⬇️🌱🦠

Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there?? #CellBiology #WTFology www.biorxiv.org/content/10.6...

New work describes our efforts to achieve CRISPR editing of the mitochondrial genome. www.biorxiv.org/lookup/conte...

Excited to share our work into ubiquitin E1-E2 specificity mechanisms. CryoEM visualising #ubiquitin transfer,biochemistry,evolution @labhofmann.bsky.social & tissue expression analyses @psarkies.bsky.social Big thanks to the team,reviewers & handling editor @dimitristypas.bsky.social rdcu.be/eTRdR

Für seinen Beitrag zum Verständnis der zellulären Kraftwerke (Mitochondrien) wurde Nikolaus Pfanner in die Accademia Nazionale dei Lincei, die nationale Akademie der Wissenschaften Italiens, aufgenommen. Zudem erhielt er die Walter Neupert-Medaille. ufr.link/auszeichnung-pfanner @cibss.bsky.social

The silence from the pro-LLPS crowd is deafening. As a (truly) unbiased observer, I for one am very curious to see the counterarguments, which surely must exist. The skeptics are having their day.

This has now been published in print! Check it out: www.science.org/doi/10.1126/...

Join @uofglasgow.bsky.social for a funded 3.5 year PhD programme: www.gla.ac.uk/colleges/mvl... Also up for grabs is a project on antiviral PROTACs, supervised by us and the France lab (School of Chemistry) should ubiquitin and viruses appeal! Please get in touch with any questions.

🪱 Selfish genes are everywhere and drive some of biology’s biggest innovations (CRISPR, antibody recombination, epigenetics). Yet almost no one asks the obvious question: how does a selfish gene begin? Our new manuscript uncovers how selfishness can emerge directly from the host genome.

Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...

Inferring LLPS from macroscopic properties (roundness, “liquidity”) is unhelpful. Subcellular compartments likely arise from specific interactions among multivalent proteins—robust and insensitive to environment. These interactions can generate structures with some LLPS-like properties

great post on LLPS, flying elephants and phase behaviour beyond thermodynamics #PhaseFiction

The devil is in the details Atomically accurate de novo design of antibodies with RFdiffusion www.nature.com/articles/s41... success rates against each target range from 0% to 2% 😆 for SARS-CoV2 RBD target, 9000 designs screened, 5 SPR confirmed binders.

✨ Passionate about cell biology or biochemistry? Join the Martens Lab as a postdoc to uncover why autophagy stalls at disease-linked protein aggregates - and how to restart it 🧠 Apply here ➡️ tinyurl.com/24dcrcke

Join us for Journal Club tomorrow, November 12th, as Dr. Elias Adriaenssens presents his recently published article in Nature Cell Biology, titled “Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery.” We look forward to seeing you there!

Registration for THE chemical biology conference of 2026 is now open! EMBO ChemBio 2026 in Heidelberg DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social www.embl.org/about/info/c...

🤯This is wow! Molecular mechanism of mRNA export. by @juliusbrennecke.bsky.social @plaschkalab.bsky.social www.nature.com/articles/s41...

Very glad to see this work www.nature.com/articles/s41... by the @savitski-lab.bsky.social out @natsmb.nature.com High hopes that HT-PELSA will be a very useful tool to study protein-ligand interactions.

Postdoc position available in my lab in Jena (Germany. jobs.leibniz-fli.de/jobposting/6... If you're interested in protein biochemistry of amyloid proteins and chaperones, this job may be for you. B2 Level German is required as the candidate will be involved in teaching in German.

📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu

'In this manuscript, we show that tag fusions often change protein expression to a degree that is highly dependent on cell and tissue context. We characterise two underlying mechanisms, providing information that should help others to design more effective transgenic strategies'

On that note: hello world! My new lab on genetics of proteome remodeling is starting at the incredible MPI-CBG. We have big plans and open positions for PhD students and an RA. Apply now (!) at imprs.mpi-cbg.de and tinyurl.com/2vywj6f6 respectively.

Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...

The proteasome-substrate-shuttle protein UBQLN2 contains—like other quality control system proteins—a long region devoid of lysine (a lysine desert) Martin Grønbæk-Thygesen (from @rhp-lab.bsky.social) et al show that introducing K here causes ubiquitylation and degradation doi.org/10.1101/2025...

Science has lost a GIANT and the world has lost one of the kindest most inspiring people I had the pleasure of knowing. Just an extraordinary man whose curiosity was infectious and whose dry wit will always be memorable- RIP John www.cam.ac.uk/research/new...

Allosteric control of the bacterial ClpC/ClpP protease and its hijacking by antibacterial peptides Axel Mogk, Marta Carroni et al www.embopress.org/doi/full/10....

Allosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators! www.sciencedirect.com/science/arti...

Spectacular work. Absolutely spectacular. Go check out the paper. It truly is #lipidtime now

so well deserved

Dear scientific community, I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford. my.corehr.com/pls/uoxrecru... my.corehr.com/pls/uoxrecru...

The Vienna BioCenter PhD program in Molecular BioSciences will offer 20+ fully-funded positions in the Autumn Call which is now open. Please share. Further details: www.vbcphd.at