Allosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators! www.sciencedirect.com/science/arti...

🥳 MEGA NEWS: Michi Ebner has been awarded an ERC Starting Grant for his research on Lysosomal Lipid Logistics! PhD students and Postdocs: Join him at the Institute of Molecular Biochemistry (biochem.i-med.ac.at/ebner) at the Biocenter of the Medical University of Innsbruck! Just awesome science!

rob! way to go🥳 congrats!

🥳 congrats hesso and team - targeting the folded protein response kills multiple myeloma

Our new paper is out in Leukemia on Targeting proteostasis in multiple myeloma through inhibition of LTK. Thanks to Ludvig and Thea for this great collaborative work rdcu.be/evyfX

excellent PhD opportunity if you are interested in studying the cell biology of CART cell and AML interaction!! apply now ! also we work in a nice location in the heart of the alps

Our lab is hiring 1 PhD and 1 Postdoc to study the mechanism of lipid transport using computational methods (Molecular Dynamics, AI). Fully funded by @snsf-ch.bsky.social for 4 years, with amazing collaborators and excellent life and working conditions. Apply by email. Please share and repost!

Bryce Brownfield's review on the structural biology of Golgi trafficking has been published! authors.elsevier.com/a/1kqrY3PA3s... Bryce is now a postdoc in the @buzbarstow.bsky.social lab, we miss him dearly!

thank you - it’s an important paper!!

Any1 is a phospholipid scramblase involved in #endosome biogenesis, say Jieqiong Gao, Christian Ungermann and colleagues (Osnabrück University): rupress.org/jcb/article/... #Membrane #lipid #Organelles #Biochemistry

Our work is finally published! We developed a robust in vitro platform to study a disease relevant membrane protease, notoriously difficult to isolate.This protease has linked to cancer & neurodegen,and our platform opens new doors for structural & drug discovery. sciencedirect.com/science/arti...

Excited to see work led by @autophazeke.bsky.social, @minghaochen.bsky.social, Thanh Nguyen, and Ainara Claveras out in @science.org today, the culmination of a 15-year project to understand structurally how the synthesis of the critical lipid of autophagy, PI3P, is regulated. tinyurl.com/ywvjh8u4

the disciples of ERES

I am looking for a #PhD working on this exciting project! In case you are interested in how #immunometabolism and #macrophages affect #adipose tissue function, check the link below and apply! www.immunometabolism.at/job-openings/

A unique postdoc position in academic drug discovery is open in the Hurley lab. We have a biochemistry-driven Parkinson’s disease drug discovery project funded and supported by SPARK-NS, which has an innovative model that turbocharges drug discovery in academic labs. (thread continues)

PhDs in biochemistry, structural biology, pharmacology, or similar, located in the US and with strong publication track records and a high motivation to solve Parkinson's, please send CV directly to me at [email protected]. Repost appreciated.

Excited to share our latest findings on how the phosphoinositide PI4P pool at the trans-Golgi network (TGN) is regulated through a SYS1-ARFRP1-ARL5-ARMH3-PI4KB pathway, in which ARMH3 (also known as C10orf76) acts as an ARL5 effector to activate PI4KB. rdcu.be/d1dZ2

How do quiescent cells stop to eat? TXNIP mediates LAT1/SLC7A5 endocytosis to curb amino acid uptake and to meet low metabolic needs of cells entering quiescence. Defects can result in metabolic disease. biorxiv.org/content/10.1... by @Jenny12119 with @Hesso_F_Sci @ThedieckLab

Welcome @teislab.bsky.social ;(