Why do pathological protein aggregates persist in cells and how can we overcome this? In our new preprint, we show that Tau aggregates fail to initiate selective autophagy and that their autophagic degradation can be restored. #Autophagy #Tau #Proteostasis Out now 👇 www.biorxiv.org/content/10.6...

Very happy to share our new preprint on #Golgi #PQC Very grateful to be working at the @hellerschmiedlab.bsky.social and with all the co-authors and colleagues. Special thanks to Sofia- without her, this story wouldn't have #unfolded as it did @unidue-zmb.bsky.social @imprs-lm.bsky.social

happy to see this important work out - great paper from @joaodiamantino.bsky.social at @hellerschmiedlab.bsky.social lab identifying Golgi quality control and first EGAD components in human cells - excellent!

Welcome, mammalian EGAD pathway :-)

Postdoc job alert at Institut Jacques Monod in Paris! Interested in fundamental membrane trafficking? We seek a postdoc to study collagen secretion as a model for core principles of how cells and their environment build each other. emploi.cnrs.fr/Offres/CDD/U...

No bull: This Austrian cow has learned to use tools. Learn more: https://scim.ag/3LYTXNd

Come join us for a newly funded @horizoneu.bsky.social @globalhealthedctp3.bsky.social project on CHIKV vaccine responses in vulnerable populations in Africa. We seek a highly motivated and skilled #postdoc and #projectmanager. Please find details here: virologie.i-med.ac.at/career/ #lovevirology

We are excited to share our new preprint which is now available to read on biorXiv: doi.org/10.64898/202... 🎉🎉🎉

Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1

New preprint from the lab!!🎉 We show that Asgard archaea ESCRT-III proteins can trigger membrane fission and reveal its molecular mechanism, offering clues to how these cells may have built internal compartments. But do these organisms even have these compartments? www.biorxiv.org/content/10.1...

New preprint out! We show that PROTAC-induced ubiquitination can bypass canonical ERAD to degrade ER membrane proteins. Wonderful collaboration w/ @dannomura.bsky.social and huge credit to grad student superstar Sydney Tomlinson! www.biorxiv.org/content/10.1...

Yeast cells utilize a TORC2 feedback loop for plasma membrane adaptation to mechanical stress, with increased sterol transport from plasma membrane to endoplasmic reticulum activating TORC2 signaling Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers www.embopress.org/doi/full/10....

bravo Maria 👍🥳

...explores an 'experiment of nature' to highlight the broad principles underlying the organisation and evolution of membrane homeostasis.... cool!

....explores an 'experiment of nature' to highlight the broad principles underlying the organisation and evolution of membrane homeostasis.... cool!

👏👏

We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.

An Asgard archaeon with internal membrane compartments Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors! www.biorxiv.org/content/10.1...

📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu

Our latest review is now online! 👇 @martenslab.bsky.social Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal www.embopress.org/doi/full/10....

👏👏

Proud to share a preprint of our paper on how bridge-like lipid transport protein VPS13C senses lysosomal membrane tension in anticipation of membrane lesions to initiate net ER-to-lysosome lipid transfer for efficient lysosomal repair www.biorxiv.org/content/10.1...

How do cells curb nutrient uptake during quiescence & does it matter? @teislab.bsky.social & Co. show TXNIP-dependent endocytosis of amino acid transporter LAT1/SLC7A5 is essential to prevent cell death and human disease #RefereedPreprint c/o @reviewcommons.org www.embopress.org/doi/full/10....

Quiescent cells stay alive by eating less. They downregulate amino acid transporters to match reduced demand. When this brake fails -> cell death & disease. More info in our new paper 👇

Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...

Allosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators! www.sciencedirect.com/science/arti...

🥳 MEGA NEWS: Michi Ebner has been awarded an ERC Starting Grant for his research on Lysosomal Lipid Logistics! PhD students and Postdocs: Join him at the Institute of Molecular Biochemistry (biochem.i-med.ac.at/ebner) at the Biocenter of the Medical University of Innsbruck! Just awesome science!

rob! way to go🥳 congrats!

🥳 congrats hesso and team - targeting the folded protein response kills multiple myeloma

Our new paper is out in Leukemia on Targeting proteostasis in multiple myeloma through inhibition of LTK. Thanks to Ludvig and Thea for this great collaborative work rdcu.be/evyfX

excellent PhD opportunity if you are interested in studying the cell biology of CART cell and AML interaction!! apply now ! also we work in a nice location in the heart of the alps

Our lab is hiring 1 PhD and 1 Postdoc to study the mechanism of lipid transport using computational methods (Molecular Dynamics, AI). Fully funded by @snsf-ch.bsky.social for 4 years, with amazing collaborators and excellent life and working conditions. Apply by email. Please share and repost!

Bryce Brownfield's review on the structural biology of Golgi trafficking has been published! authors.elsevier.com/a/1kqrY3PA3s... Bryce is now a postdoc in the @buzbarstow.bsky.social lab, we miss him dearly!

thank you - it’s an important paper!!

Any1 is a phospholipid scramblase involved in #endosome biogenesis, say Jieqiong Gao, Christian Ungermann and colleagues (Osnabrück University): rupress.org/jcb/article/... #Membrane #lipid #Organelles #Biochemistry

Our work is finally published! We developed a robust in vitro platform to study a disease relevant membrane protease, notoriously difficult to isolate.This protease has linked to cancer & neurodegen,and our platform opens new doors for structural & drug discovery. sciencedirect.com/science/arti...

Excited to see work led by @autophazeke.bsky.social, @minghaochen.bsky.social, Thanh Nguyen, and Ainara Claveras out in @science.org today, the culmination of a 15-year project to understand structurally how the synthesis of the critical lipid of autophagy, PI3P, is regulated. tinyurl.com/ywvjh8u4

the disciples of ERES

I am looking for a #PhD working on this exciting project! In case you are interested in how #immunometabolism and #macrophages affect #adipose tissue function, check the link below and apply! www.immunometabolism.at/job-openings/

A unique postdoc position in academic drug discovery is open in the Hurley lab. We have a biochemistry-driven Parkinson’s disease drug discovery project funded and supported by SPARK-NS, which has an innovative model that turbocharges drug discovery in academic labs. (thread continues)

PhDs in biochemistry, structural biology, pharmacology, or similar, located in the US and with strong publication track records and a high motivation to solve Parkinson's, please send CV directly to me at [email protected]. Repost appreciated.

Excited to share our latest findings on how the phosphoinositide PI4P pool at the trans-Golgi network (TGN) is regulated through a SYS1-ARFRP1-ARL5-ARMH3-PI4KB pathway, in which ARMH3 (also known as C10orf76) acts as an ARL5 effector to activate PI4KB. rdcu.be/d1dZ2

How do quiescent cells stop to eat? TXNIP mediates LAT1/SLC7A5 endocytosis to curb amino acid uptake and to meet low metabolic needs of cells entering quiescence. Defects can result in metabolic disease. biorxiv.org/content/10.1... by @Jenny12119 with @Hesso_F_Sci @ThedieckLab

Welcome @teislab.bsky.social ;(