David Teis
@teislab.bsky.social
📤 437
📥 557
📝 17
organelles, proteostasis and lipids in the middle of the Alps
https://biochem.i-med.ac.at/
reposted by
David Teis
Bernd Bauer
8 days ago
Why do pathological protein aggregates persist in cells and how can we overcome this? In our new preprint, we show that Tau aggregates fail to initiate selective autophagy and that their autophagic degradation can be restored.
#Autophagy
#Tau
#Proteostasis
Out now 👇
www.biorxiv.org/content/10.6...
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https://www.biorxiv.org/content/10.64898/2026.02.12.705532v1
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reposted by
David Teis
João Diamantino
13 days ago
Very happy to share our new preprint on
#Golgi
#PQC
Very grateful to be working at the
@hellerschmiedlab.bsky.social
and with all the co-authors and colleagues. Special thanks to Sofia- without her, this story wouldn't have
#unfolded
as it did
@unidue-zmb.bsky.social
@imprs-lm.bsky.social
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happy to see this important work out - great paper from
@joaodiamantino.bsky.social
at
@hellerschmiedlab.bsky.social
lab identifying Golgi quality control and first EGAD components in human cells - excellent!
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16 days ago
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reposted by
David Teis
Schmidt Lab Innsbruck
16 days ago
Welcome, mammalian EGAD pathway :-)
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reposted by
David Teis
Ishier Raote
17 days ago
Postdoc job alert at Institut Jacques Monod in Paris! Interested in fundamental membrane trafficking? We seek a postdoc to study collagen secretion as a model for core principles of how cells and their environment build each other.
emploi.cnrs.fr/Offres/CDD/U...
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Portail Emploi CNRS - Offre d'emploi - Poste de chercheur postdoctoral en trafic membranaire fondamental et sécrétion du collagène (H/F)
Assurez-vous que votre profil candidat soit correctement renseigné avant de postuler
https://emploi.cnrs.fr/Offres/CDD/UMR7592-ISHRAO-006/Default.aspx
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reposted by
David Teis
Science Magazine
about 1 month ago
No bull: This Austrian cow has learned to use tools. Learn more:
https://scim.ag/3LYTXNd
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reposted by
David Teis
GeroldLab
about 1 month ago
Come join us for a newly funded
@horizoneu.bsky.social
@globalhealthedctp3.bsky.social
project on CHIKV vaccine responses in vulnerable populations in Africa. We seek a highly motivated and skilled
#postdoc
and
#projectmanager
. Please find details here:
virologie.i-med.ac.at/career/
#lovevirology
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Career | Institute of Virology Innsbruck - IVI
https://virologie.i-med.ac.at/career/
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reposted by
David Teis
Wilfling Lab
about 1 month ago
We are excited to share our new preprint which is now available to read on biorXiv:
doi.org/10.64898/202...
🎉🎉🎉
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reposted by
David Teis
bioRxivpreprint
2 months ago
Organelles harbour pH gradients
https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1
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reposted by
David Teis
Javier Espadas
3 months ago
New preprint from the lab!!🎉 We show that Asgard archaea ESCRT-III proteins can trigger membrane fission and reveal its molecular mechanism, offering clues to how these cells may have built internal compartments. But do these organisms even have these compartments?
www.biorxiv.org/content/10.1...
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Molecular basis for cellular compartmentalization by an ancient membrane fission mechanism
The emergence of cell compartmentalization depends on membrane fission to create the endomembrane compartments. In eukaryotes, membrane fission is commonly executed by ESCRT-III, a protein complex con...
https://www.biorxiv.org/content/10.1101/2025.11.28.690958v1
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reposted by
David Teis
James Olzmann
3 months ago
New preprint out! We show that PROTAC-induced ubiquitination can bypass canonical ERAD to degrade ER membrane proteins. Wonderful collaboration w/
@dannomura.bsky.social
and huge credit to grad student superstar Sydney Tomlinson!
www.biorxiv.org/content/10.1...
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Induced ubiquitination bypasses canonical ERAD to drive ER protein degradation
Heterobifunctional proteolysis-targeting chimeras (PROTACs) have emerged as a powerful strategy to degrade disease-relevant proteins, enabling targeting of previously "undruggable" proteins. Current d...
https://www.biorxiv.org/content/10.1101/2025.11.28.691080v1
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reposted by
David Teis
The EMBO Journal
3 months ago
Yeast cells utilize a TORC2 feedback loop for plasma membrane adaptation to mechanical stress, with increased sterol transport from plasma membrane to endoplasmic reticulum activating TORC2 signaling Robbie Loewith, Aurélien Roux
@rouxlab.bsky.social
and coworkers
www.embopress.org/doi/full/10....
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bravo Maria 👍🥳
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3 months ago
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...explores an 'experiment of nature' to highlight the broad principles underlying the organisation and evolution of membrane homeostasis.... cool!
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4 months ago
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....explores an 'experiment of nature' to highlight the broad principles underlying the organisation and evolution of membrane homeostasis.... cool!
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4 months ago
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👏👏
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4 months ago
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reposted by
David Teis
Buzz Baum
4 months ago
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
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reposted by
David Teis
Tanmay Bharat
4 months ago
An Asgard archaeon with internal membrane compartments Brilliant study led by
@fmacleod.bsky.social
and Andriko von Kügelgen. Tight collaboration with
@buzzbaum.bsky.social
and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
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reposted by
David Teis
Max Perutz Labs Vienna
4 months ago
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️
tinyurl.com/brswbymu
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reposted by
David Teis
Elias Adriaenssens
4 months ago
Our latest review is now online! 👇
@martenslab.bsky.social
Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal
www.embopress.org/doi/full/10....
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Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
https://www.embopress.org/doi/full/10.1038/s44318-025-00615-w
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👏👏
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4 months ago
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reposted by
David Teis
Holthuis Lab
4 months ago
Proud to share a preprint of our paper on how bridge-like lipid transport protein VPS13C senses lysosomal membrane tension in anticipation of membrane lesions to initiate net ER-to-lysosome lipid transfer for efficient lysosomal repair
www.biorxiv.org/content/10.1...
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VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair
Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach,...
https://www.biorxiv.org/content/10.1101/2025.10.23.684214v1
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reposted by
David Teis
The EMBO Journal
4 months ago
How do cells curb nutrient uptake during quiescence & does it matter?
@teislab.bsky.social
& Co. show TXNIP-dependent endocytosis of amino acid transporter LAT1/SLC7A5 is essential to prevent cell death and human disease
#RefereedPreprint
c/o
@reviewcommons.org
www.embopress.org/doi/full/10....
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Quiescent cells stay alive by eating less. They downregulate amino acid transporters to match reduced demand. When this brake fails -> cell death & disease. More info in our new paper 👇
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4 months ago
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reposted by
David Teis
Johannes Zuber
5 months ago
Just out in
@science.org
: Together with the lab of
@wilhelmpalm.bsky.social
, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience.
www.science.org/doi/10.1126/...
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reposted by
David Teis
Lorenz Lab
5 months ago
Allosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators!
www.sciencedirect.com/science/arti...
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A Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity
Stringent control of ubiquitylation is a central requirement of signaling specificity in eukaryotes. Here, we discover a domain module integrating pro…
https://www.sciencedirect.com/science/article/pii/S1097276525007439
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🥳 MEGA NEWS: Michi Ebner has been awarded an ERC Starting Grant for his research on Lysosomal Lipid Logistics! PhD students and Postdocs: Join him at the Institute of Molecular Biochemistry (
biochem.i-med.ac.at/ebner
) at the Biocenter of the Medical University of Innsbruck! Just awesome science!
6 months ago
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rob! way to go🥳 congrats!
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6 months ago
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🥳 congrats hesso and team - targeting the folded protein response kills multiple myeloma
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8 months ago
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reposted by
David Teis
Hesso Farhan
8 months ago
Our new paper is out in Leukemia on Targeting proteostasis in multiple myeloma through inhibition of LTK. Thanks to Ludvig and Thea for this great collaborative work
rdcu.be/evyfX
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Targeting proteostasis in multiple myeloma through inhibition of LTK
Leukemia - Targeting proteostasis in multiple myeloma through inhibition of LTK
https://rdcu.be/evyfX
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excellent PhD opportunity if you are interested in studying the cell biology of CART cell and AML interaction!! apply now ! also we work in a nice location in the heart of the alps
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10 months ago
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reposted by
David Teis
Vanni Lab at UNIFR, Switzerland
10 months ago
Our lab is hiring 1 PhD and 1 Postdoc to study the mechanism of lipid transport using computational methods (Molecular Dynamics, AI). Fully funded by
@snsf-ch.bsky.social
for 4 years, with amazing collaborators and excellent life and working conditions. Apply by email. Please share and repost!
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reposted by
David Teis
Fromme Lab
11 months ago
Bryce Brownfield's review on the structural biology of Golgi trafficking has been published!
authors.elsevier.com/a/1kqrY3PA3s...
Bryce is now a postdoc in the
@buzbarstow.bsky.social
lab, we miss him dearly!
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https://authors.elsevier.com/a/1kqrY3PA3scelm
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thank you - it’s an important paper!!
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11 months ago
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reposted by
David Teis
Journal of Cell Biology
12 months ago
Any1 is a phospholipid scramblase involved in
#endosome
biogenesis, say Jieqiong Gao, Christian Ungermann and colleagues (Osnabrück University):
rupress.org/jcb/article/...
#Membrane
#lipid
#Organelles
#Biochemistry
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reposted by
David Teis
Sonya Neal
about 1 year ago
Our work is finally published! We developed a robust in vitro platform to study a disease relevant membrane protease, notoriously difficult to isolate.This protease has linked to cancer & neurodegen,and our platform opens new doors for structural & drug discovery.
sciencedirect.com/science/arti...
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An in vitro platform for the enzymatic characterization of the rhomboid protease RHBDL4
Rhomboid proteases are ubiquitous intramembrane serine proteases that can cleave transmembrane substrates within lipid bilayers. They exhibit many and…
https://sciencedirect.com/science/article/pii/S0021925825001231?via%3Dihub
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reposted by
David Teis
Jim Hurley
about 1 year ago
Excited to see work led by
@autophazeke.bsky.social
,
@minghaochen.bsky.social
, Thanh Nguyen, and Ainara Claveras out in
@science.org
today, the culmination of a 15-year project to understand structurally how the synthesis of the critical lipid of autophagy, PI3P, is regulated.
tinyurl.com/ywvjh8u4
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the disciples of ERES
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about 1 year ago
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reposted by
David Teis
Martina Schweiger
about 1 year ago
I am looking for a
#PhD
working on this exciting project! In case you are interested in how
#immunometabolism
and
#macrophages
affect
#adipose
tissue function, check the link below and apply!
www.immunometabolism.at/job-openings/
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CALL for doctoral and postdoctoral researchers to join the special research program “Immunometabolism”
Three Austrian Universities located in Vienna and Graz combine forces to explore the immunometabolic interaction of macrophages with tissues. We are looking for 6 PhD and 6 postdoctoral researchers jo...
https://www.immunometabolism.at/job-openings/
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reposted by
David Teis
Jim Hurley
about 1 year ago
A unique postdoc position in academic drug discovery is open in the Hurley lab. We have a biochemistry-driven Parkinson’s disease drug discovery project funded and supported by SPARK-NS, which has an innovative model that turbocharges drug discovery in academic labs. (thread continues)
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reposted by
David Teis
Jim Hurley
about 1 year ago
PhDs in biochemistry, structural biology, pharmacology, or similar, located in the US and with strong publication track records and a high motivation to solve Parkinson's, please send CV directly to me at
[email protected]
. Repost appreciated.
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reposted by
David Teis
Juan S. Bonifacino
about 1 year ago
Excited to share our latest findings on how the phosphoinositide PI4P pool at the trans-Golgi network (TGN) is regulated through a SYS1-ARFRP1-ARL5-ARMH3-PI4KB pathway, in which ARMH3 (also known as C10orf76) acts as an ARL5 effector to activate PI4KB.
rdcu.be/d1dZ2
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How do quiescent cells stop to eat? TXNIP mediates LAT1/SLC7A5 endocytosis to curb amino acid uptake and to meet low metabolic needs of cells entering quiescence. Defects can result in metabolic disease.
biorxiv.org/content/10.1...
by @Jenny12119 with @Hesso_F_Sci @ThedieckLab
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TXNIP mediates LAT1/SLC7A5 endocytosis to reduce amino acid uptake in cells entering quiescence
Entry and exit from quiescence require changes in cellular nutrient acquisition. How quiescent cells reduce nutrient uptake was unclear. Here, we demonstrate that cells entering quiescence select plas...
https://biorxiv.org/content/10.1101/2024.10.29.620655v1
over 1 year ago
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David Teis
Snezhka Oliferenko
over 2 years ago
Welcome
@teislab.bsky.social
;(
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