ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions. www.nature.com/articles/s41...

🧬Ubiquitin Precursor: A Key to Healthy Aging? Scientists @cecad.bsky.social and @hhu.de have identified a new form of the protein Ubiquitin, responsible for proteostasis and healthy aging opening up potentially new perspectives for the treatment of cancer and age-related diseases. uni.koeln/BLXJA

Preprint alert! 🚨 We reveal molecular switches that enable the nucleolus to reorganise into a proteostasis hub - coordinating protein quality control with ribosome biogenesis and cross-talk with other stress-responsive organelles. A big tour de force by the team 💪 www.biorxiv.org/content/10.1...

The Sacca' lab investigates the behavior of molecular motors within engineered DNA origami nano-compartments to understanding of how nanoscale confinements influence biochemical processes and energy conversion. Interested? Then apply to @imprs-lm.bsky.social #IMPRS #PhDposition #Syntheticbiology

Are you eager to join an international community of scientists to tackle novel and exciting research projects in the areas of #biochemistry, #structuralbiology, #biophysics, #cellbiology, #chemicalbiology and #syntheticbiology? Apply NOW for a #fullyfunded #PhDpositions @IMPRS-LM.

If you would like to contribute to uncover the mechanisms by which proteolytic enzymes in the ubiquitin system operate and exploit these insights for novel therapeutic approaches, then apply to the Gersch lab @maltegersch.bsky.social #IMPRS-LM. #IMPRS #PhDposition #PhDprogram #ChemicalBiology

The 5th Virtual @chembiotalks.bsky.social on September 30th are one week away. We have an exciting program including our keynotes Sarah O'Connor (@oconnorlab.bsky.social) and @craigmcrews.bsky.social. Make sure to register for free: web.cvent.com/event/... #ChemSky #ChemBio

Excited to share our new paper! 🎉 The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona www.science.org/doi/10.1126/... Very thankful to @andrea-musacchio.bsky.social for his mentorship and support over the years.

The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona | Science Advances www.science.org/doi/10.1126/... Congratulations @vcmentowski.bsky.social for solving a remarkably challenging molecular puzzle

A few months ago, our review “The Molecular Toolbox for Linkage Type-Specific Analysis of Ubiquitin Signaling” 🧬🧰🛠️ came out in ChemBioChem. Time to give it a spotlight! chemistry-europe.onlinelibrary.wiley.com/doi/full/10....

Early-career researchers: want to run your own lab? 🌟Max Planck Research Groups offer 6+ years, up to €2.7M in funding, open-topic freedom, team support & tenure-track opportunities. Intrigued? 😃Apply by Oct 14, 2025! www.mpg.de/max-planck-r...

Springboard for an international scientific career! 🧬🧪🔭⚛️🧠🌱 Call for #MaxPlanckResearchGroups launched; applications are possible until October 14, 2025 www.mpg.de/max-planck-r... #ScienceCareer

🧬🧪 A research technician position - Protein Biochemistry (6 months) is available in my lab @gdsc-sussex.bsky.social investigating structure and function of fusion kinase complexes in Leukaemia. 📅 Deadline: 29th September 2025. 🙏 Please share with anyone who might be interested.

🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬 Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...

Just a few days until our annual hybrid TPD event! In-person registration is full, but you can still join us live on Zoom via our regular biweekly link. Register for the Zoom stream here: dfci.zoom.us/webinar/regi...

This week selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: ATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptation www.nature.com/articles/s42...

📅 Less than 2 weeks left to submit your abstract for our 6th Annual Symposium Webinar! 🎉Don’t miss this chance to share your work, hear the latest advances in autophagy research, and connect with a vibrant community! 🎉 The link for abstraction submission is below 👇 forms.office.com/r/wZbTvPePwR

Our new collection offers cell biologists practical, expert-driven guidance and best practices in the design, execution, and analysis of experiments, and the subsequent communication of their results to their peers. 👉 rupress.org/jcb/collecti... #Reproducibility

Exciting news📣: #ProteostasisUK is hiring a network manager to help drive an ambitious, #BBSRC funded initiative connecting and expanding #Proteostasis research across the UK. Position initially for 3 years. Deadline September 28th. More info: tinyurl.com/f83rp673 & proteostasisuk.co.uk Please RT

Happy to share our work on the structure and function of the unusual E3 ligase ZNFX1 @cp-cell.bsky.social. It uses a nucleic acid-activated transthiolation mechanism, ubiquitinating and clustering RNA to protect cells in an immune response. @clausenlab.bsky.social www.cell.com/cell/fulltex...

We're hiring! Join our team and help us further global bioinformatics knowledge. Part-time Events Officer: embl.wd103.myworkdayjobs.com/en-US/EMBL/d... Full-time Senior Scientific Project Officer: embl.wd103.myworkdayjobs.com/en-US/EMBL/d... Closing date 14 September 2025. #SciJob #EventProfs 🧬🥼🧪

A chaperone-proteasome-based fragmentation machinery is essential for aggrephagy www.nature.com/articles/s41...

Co-translational ribosome pairing enables native assembly of misfolding-prone subunits. www.nature.com/articles/s41...

Job alert 📣 Our faculty looks for a Junior Professor W1 with tt to W2 in Membrane Biology! We are looking for #ECRs working on membrane biogenesis,contact sites,composition & other aspects of membranes in 🌱 and other organisms! DM me if you need more details! jobs.ruhr-uni-bochum.de/jobposting/f...

If you are a #PhD candidate or #student in the fields of #Biochemistry or #ChemBio and would like to go to the #Biochemistry2026 conference in Würzburg, consider applying for the brand new @gdchbiochem.bsky.social Meeting #Award! en.gdch.de/network-stru... #ChemSky #ECR #EarlyCareerResearcher

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...

EMBO is #hiring a Policy Assistant for the EMBO Policy Programme – Apply now! www.embo.org/vacancy/poli... #JobOpening #JobSearch #CareerOpportunities 🧪

📆 Mark your calendars! The 2026 Keystone Symposium on Autophagy: Mechanisms to Therapy will take place February 2–5, 2026. 🔬 Check out the featured program and make note of key deadlines for registration and abstract submissions 👇

Cell biology enthusiasts: We look forward to the #DGZ meeting in Heidelberg in October to celebrate 50 years of @dgz.bsky.social! 4 keynote speakers, 12 DGZ workgroups showcasing the latest in their fields & DGZ awardees 2025 will present. Register by Sept 15. www.zellbiologie.de/dgz-internat...

"why [would] anyone intelligent enough to be a scientist choose to be one [given] the unfavorable risk-to-reward ratio "? One of the most intelligent people you could meet offers some answers: having ideas, watching them develop, and sharing them journals.biologists.com/jcs/article/...

📆✨Join us this November for the Women in Autophagy 6th Annual Symposium Webinar! Registration is free and abstract is due September 12th! 👇 Registration: forms.cloud.microsoft/pages/respon... Abstract submission: forms.cloud.microsoft/pages/respon...

Happy to share my first publication, where we present our discovery of multi-chaperone condensates that orchestrate protein folding in the endoplasmic reticulum! www.nature.com/articles/s41...

Exciting news for @ukproteostasis.bsky.social and for #proteostasis researchers across the UK! Funding from BBSRC will support the development of the UK Proteostasis network, including: - connecting & building the community to accelerate research - supporting ECRs www.babraham.ac.uk/news/2025/07...

In praise of the strangeness of scientific research, which these days I think could use a few good words said for it:

New online: Structure of the TXNL1-bound proteasome

Exciting opportunity for TT-Ass #Professorship in Quantitative Cell Biology @unibe.ch @izb-unibern.bsky.social! Applicants combining experimental and computational approaches/theory are particularly encouraged. Great colleagues, environment, infrastructure. What's not to like? tinyurl.com/42f3p863

Outstanding Faculty opportunity in the broad area of 'life sciences engineering' @EPFL School of Life Sciences, open to both junior and senior researchers. We may prefer metabolism-centric applications but remain open to outstanding applications across domains: www.epfl.ch/about/workin...

Unexpectedly, @jurgjn.bsky.social found that running Alphafold3 predictions for protein interactions can yield ipTM scores that are more predictive of true interactions when run in pools of proteins instead of pairwise predictions. Presumably, this reflects some sort of "competition effect".

Selective autophagy of organelles: the “disorder” is key. Intrinsically disordered regions of organellophagy receptors are interchangeable, required, and sufficient for organelle fragmentation and lysosomal delivery … and all about ORGATACs 😉 rdcu.be/ey8iL

Upcoming Event: "From Academia to Industry – Working at Novo Nordisk A/S" 📅 Date: August 21, 2025 🕟 Time: 4:30 p.m. 🎤 Speaker: Dr. Martin Peter 🔗 Register here: gbm-online.de/de/nachwuchs... Zoom link will be sent to registered participants. Please share with your postdoc colleagues!

Just 2 weeks left! The Vienna BioCenter PostDoc Program is still accepting applications. We have 16 fully-funded fellowships available for researchers in biology, chemistry, physics, bioinformatics, and more. Apply now: training.vbc.ac.at/post-docs/vi... #VBCPostDoc

Exciting new study by the @trentini-lab.bsky.social #ProteinHomeostasis #RQC #CFTR

Great work by our neighbours @hemmo-lab.bsky.social and their collaborators @crc1430.bsky.social @unidue-zmb.bsky.social

This programme is ideal for professional development (incl a budget for that) and comes with a competitive package - make sure to check it out

Less than two weeks left to apply! Postdoc positions in my lab to study 1. initiation of DNA replication. 2. chromatin replication/epigenetic inheritance. Great for biochemists, biophysicists & structural biologists. Deadline 3 August 2025. crick.wd3.myworkdayjobs.com/External/job...

Thoughts from our own Tom Rapoport on the role of basic science in curing disease. magazine.hms.harvard.edu/articles/rev...

Montes et al. @maliramanlab.bsky.social @tufts.edu find the p97 ATPase and its adaptor UBXD8 maintain #peroxisome abundance by suppressing #pexophagy. p97-UBXD8 degrade ubiquitylated peroxisomal proteins to bypass recognition by #autophagy receptors. rupress.org/jcb/article/... #Biochemistry