Great @leidenscience.bsky.social Tuesday Talk by Ilze Bot of the @led3hub.bsky.social. She talked about her group's work into better understanding the involvement of #inflammation in the development of #atherosclerosis and its implications for therapy. www.sciencedirect.com/science/arti...

Interesting Tuesday Talk at @leidenscience.bsky.social by Ilze Bot of our LED3 hub. Under the title "Breaking the cycle of heart attacks", she talked about her research into, why heart attacks are still a big threat, even in patients receiving treatment. #ChemSky #ChemBio #DrugDiscovery

A pipeline for proteome-wide analysis of electrophile selectivity www.nature.com/artic... --- #proteomics #prot-paper

Do you want to help to gather data on the tenure- and career-track systems at Dutch Universities? Our friends at NextGenPhys@NL, the network of emerging physics researchers, are conducting a survey to explore how tenure- and career-track systems are structured.(1/4) docs.google.com/forms/d/e/1F...

Interesting talk by Petra de Jongh at the #Reedijk Symposium. She talked about the use of in situ/operando electron microscopy to better understand heterogeneous catalysts under conditions that are close to those used in industry-scale reactors. #ChemSky #Catalysis

Very happy that Storm van der Voort - PhD in the group of Hermen Overkleeft and in our group - was selected for a talk at the #Reedijk Symposium. He gave an excellent presentation on using direct-to-biology to efficiently make covalent libraries for antibacterial screening #ChemSky #ChemBio #ProudPI

Great talk by Jaco Geuchies at the #Reedijk Symposium of the Leiden Institute of Chemistry. He told us, how his group uses ultrafast spectroscopy to better understand the structure and properties of soft semiconductor materials such as metal-halide #perovskites. pubs.acs.org/doi/full/10.... #ChemSky

Insightful talk by Jeroen Codee at the #Reedijk Symposium. He talked about the importance of synthetic organic chemistry to make complex glycans to better understand #glycobiology. Very impressive, systematic work on glycosylation reactions. pubs.rsc.org/en/content/a... #ChemSky #ChemBio #Glycotime

Jeroen Codee speaks at the #Reedijk Symposium: "A new twist in the tale - stereoselective glycosylation reactions for bacterial glycan assembly". Exciting insights into the importance of advanced glycosylation chemistries to make complex glycosides to better understand (bacterial) biology.

Craig Crews also gave exciting insights into the power of RIPTACs that bring together a protein that is selectively expressed in tumors and a pan-essential protein. In this way, the pan-essential protein is only fully engaged in cancer cells leading to selective killing. www.cell.com/cell-chemica...

Inspiring #Havinga Medal lecture by @craigmcrews.bsky.social at the #Reedijk Symposium. Amazing to hear him talk about the full story of the development of induced proximity into a new paradigm of event-driven pharmacology for #DrugDiscovery. www.nature.com/articles/s41... #ChemSky #ChemBio #TPD

Huge congratulations to @craigmcrews.bsky.social on being awarded the #Havinga medal at the #Reedijk Symposium of the Leiden Institute of Chemistry for his groundbreaking work on induced proximity, including targeted protein degradation, as a new paradigm for #DrugDiscovery. #ChemSky #ChemBio #TPD

Great talk by @kimmb1.bsky.social of our @led3hub.bsky.social at the #Reedijk Symposium. She talked about the power of activity-based probes to study protein function on the example of live cell imaging of myeloperoxidase activity to study NETosis. www.nature.com/articles/s42... #ChemBio #ChemSky

Kim Bonger (@kimmb1.bsky.social) represents our @led3hub.bsky.social at the #Reedijk Symposium of the Leiden Institute of Chemistry with a great talk on "Chemical tools for profiling protein activity and cell targeting in (auto)immune disease". #ChemBio #ChemSky #DrugDiscovery #FluorescenceFriday

📢 New Award for #ECRs in #Biochemistry! Apply for our Meeting Award to get: ✅ 500 € grant for the #Biochemistry2026 conference ✅ 1 year of free division membership Apply now: en.gdch.de/network-s...#ECRs#Biochemistry!#Biochemistry2026hare with a #ECR who needs to see this! 👇 #Chemistry #ChemBio #AcademicTwitter #PhD

Profiling the proteome-wide selectivity of diverse electrophiles #nature #MassSpecRSS

I am thrilled to see the paper out now and grateful to all coauthors for their contributions to this work! Among a number of changes, we included additional probes as well as experiments in live bacterial cells. So be sure to check it out even if you are already familiar with the preprint!

Great work Stephan! Of course we are happy that TMS-EBX is the reagent labelling most cysteines among all investigated! Great also to finally quantify the alkynylation to addition ratio for alkyl-EBX reagents.

I was very happy to host Nicolas Winssinger today for a well-attended @led3hub.bsky.social Lecture. He gave us exciting insights into the power of nucleic acid assemblies. Very exciting data on a highly selective thrombin inhibitor that can be switched off on demand. www.nature.com/articles/s41...

Wow! Looks like Christmas morning for the machine learning folks!

How selective is your favourite electrophile? 🤔 🧪 🧫 🎯 Check out this thorough study from the @stephanhacker2.bsky.social lab, now published in Nature Chemistry! Many congrats to everyone. We are thrilled to have contributed a little! Many congrats to @klanglab.bsky.social alumni Kristina and Marko!

Check out this chemoproteomics tour de force from @stephanhacker2.bsky.social and colleagues — want to know which electrophiles label which amino acid residues proteome-wide? Finally, a comprehensive comparative study with a ton of insights on old and new warheads and optimized workflows. Bravo!

This project started 5 years ago. It led us to add isotope-labeling support to #FragPipe/#IonQuant. Since then, the tools have grown so much and are now widely used in #Chemoproteomics. Huge thanks to everyone, and special thanks to @stephanhacker2.bsky.social and @pzanon.bsky.social

How can the selectivity of covalent inhibitors be studied at diverse amino acids? In their Nature Chemistry paper the group of @stephanhacker2.bsky.social of our LED3hub developed an unbiased workflow to study electrophile reactivity and selectivity proteome-wide.(1/2) www.nature.com/articles/s41...

Our new Nature Chemistry paper is also accompanied by an insightful News and Views article by @jeyunjo.bsky.social and @mbogyo.bsky.social. Check it out here: www.nature.com/articles/s41... Thank you very much for the kind comments on our work!

How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid? Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7) www.nature.com/articles/s41...

We are looking forward to the LED3 Lecture of Nicolas Winssinger on Thursday October 30th: "Programing responsive assemblies from PNA-encoded and folded peptides" If you are interested, make sure to come by! www.universiteitleiden.nl/en/science/l... #ChemBio #Chemistry #DrugDiscovery

I am very happy that the General Assembly of @apnet.bsky.social elected me as president. I am very much looking forward to working with everyone in the new board and closely with all of our members! Join us by registering and make your voice heard: www.ap-net.nl/register

We had an amazing and well-attended in-person event yesterday in Utrecht! We set up APNet for the future and followed an inspiring workshop on strategic leadership by Maria Sovago from Stralia. (1/10) #Academia #AssistantProfessor

Very excited to be in Utrecht for the @apnet.bsky.social general assembly and our first in-person workshop on strategic career development. Very much looking forward to meeting everyone!

Join us in building a strong #Network of Assistant Professors in the #Netherlands! - Networking opportunities with peers - Workshops and events tailored to nurture your career - Advocacy on key issues affecting Assistant Professors Register: lnkd.in/eTTxQ28t #Academia #AssistantProfessor

What will future last resort #antibiotics look like? How can we make them safer to use? In their project PRADA, the group of Nathaniel Martin is setting out to answer these questions. Check out the linked video to learn more. www.linkedin.com/posts/biotec... #ChemSky #DrugDiscovery #Antibiotics

We are looking forward to the LED3 Lecture of Nicolas Winssinger on Thursday October 30th: "Programing responsive assemblies from PNA-encoded and folded peptides" If you are interested, make sure to come by! www.universiteitleiden.nl/en/science/l... #ChemBio #ChemSky #DrugDiscovery

Thank you Stephan for supporting us through the scientific committee and for being an absolutely amazing session chair this morning!!!

I had an amazing time at the 25th anniversary symposium of ChemBioChem and ChemPhysChem #ChemBioPhys2025. We had two days of exciting science and important interactions. Thank you to the organizers from @chemistryeurope.bsky.social and especially to @rubenragg.bsky.social. #ChemSky #ChemBio

@rubenragg.bsky.social and Meghan Lucas close a great #ChemBioPhys2025 symposium and present the poster prizes. Congratulations to the winners. Very curious to see, what the next 25 years of ChemBioChem and ChemPhysChem of @chemistryeurope.bsky.social will bring. #ChemSky #ChemBio

#ChemBioPhys2025 comes to a close with an exciting lecture by @klanglab.bsky.social. Genetic code expansion to site-specifically study PTMs in cells. Great insights into hijacking an ABC transporter to increase uptake for many exciting amino acids. www.nature.com/articles/s41... #ChemSky #ChemBio

Interesting talk by Claus Seidel at #ChemBioPhys2025. He talked about the use of Förster resonance energy transfer (FRET) to understand the dynamics and function of transient states in single enzyme molecules. www.nature.com/articles/s41...

Interesting talk by Jan Götze at #ChemBioPhys2025. He gave exciting insights into his group's research into the importance of Förster resonance energy transfer (FRET) in the photosynthetic complexes. pubs.acs.org/doi/10.1021/...

Interesting talk by Anahita Khammari at #ChemBioPhys2025. She talked about her research into investigating the interaction of the deubiquitinase USP48 with its inhibitor ML364 and its analogs using docking approaches. onlinelibrary.wiley.com/doi/full/10.... #ChemSky #ChemBio #DrugDiscovery

Exciting lecture by Stefan Raunser (@raunser-lab.bsky.social) at #ChemBioPhys2025. He talked about his group's amazing science to better understand actin filament disassembly to better understand muscle function. (1/2) www.cell.com/cell/fulltex... #ChemBio #ChemSky #cryoEM #muscles

After the lunch break, #ChemBioPhys2025 continues with an excellent lecture by Sandrine Lévêque-Fort (@slfort.bsky.social). She talked about exciting single-molecule microscopy technologies using modulated illumination with great 3D resolution. www.nature.com/articles/s41...

It was a huge pleasure to host the morning session of #ChemBioPhys2025. A huge thank you to the speakers @gassergroup.bsky.social, Harald Schwalbe, @ezgikaraca.bsky.social, Stephen Kent, Joseph Braymer, Hsuan-Ai Chen, @borisvauzeilles.bsky.social and @romanrenger.bsky.social. I learned a lot!

In the final lecture of the morning session at #ChemBioPhys2025, @romanrenger.bsky.social from Exciting Instruments talked about, how they add dynamics to structural biology using smFRET and FCCS. academic.oup.com/nar/article/... #ChemSky #ChemBio #DrugDiscovery

Exciting lecture by @borisvauzeilles.bsky.social at #ChemBioPhys2025. He gave exciting insights into his group's work of using synthetic #OrganicChemistry to develop new tools to study #biology. (1/4)

Interesting talk by Hsuan-Ai Chen at #ChemBioPhys2025. She talked about the work in the Claudia Höbartner lab (@chlab.bsky.social) on the development of nucleic acid-alkylating ribozymes. (1/2) www.nature.com/articles/s41... #ChemSky #ChemBio #RNA #Ribozyme

Interesting talk by Joseph Braymer at #ChemBioPhys2025. He talked about the huge importance of FeS clusters for biology and how he studies their biogenesis using EPR and Mössbauer spectroscopy. www.sciencedirect.com/science/arti... www.biorxiv.org/content/10.1...

A truly inspiring talk by Stephen B. H. Kent at #ChemBioPhys2025. He talked about his group's many contributions to protein synthesis and crystallization. (1/5) #ChemBio #ChemSky #StructuralBiology

Interesting talk by @ezgikaraca.bsky.social at #ChemBioPhys2025. She talked about the use of AI for predictions of protein structures with a lot of exciting insights into the CASP competition and into the prediction of protein-protein interactions. www.biorxiv.org/content/10.1...