Awesome talk from @ox.ac.uk Prof. Alex Bullock @leidenscience.bsky.social today. Neat examples of #neomorphic gain-of-function mutations driving disease by acting as #molecularglues and using #FBDD to expand the #druggability of E3ligases with thesgc.bsky.social‬ an#EUbOPENEN @led3hub.bsky.social

The first Flash Talk at the 5th Virtual ChemBioTalks will be given by Jingzhi Fan. He will present on “Metabolomics-Inspired Biomaterials: Calcium Phosphate with Targeted Metabolic Enhancement for Bone Repair”. Register for free: web.cvent.com/event/60e9f3... #ChemBio #ChemSky #DrugDiscovery

Looking forward to a great @led3hub.bsky.social Lecture by Willem Velema on Thursday. Excited to learn, how his group is targeting RNA to develop novel #antibiotics. #ChemSky #ChemBio @leidenscience.bsky.social

Looking for a #PhD in #medicinal #chemistry and #chemical #proteomics focused on #drugdevelopment for #infectiousdiseases? We have a vacancy!! Come join our interdisciplinary team @leidenscience.bsky.social & and help develop new approaches to treat mycobacterial infections 😀 tinyurl.com/3srxfr55

Looking forward to hearing about the potential of machine learning for #Biology and #DrugDiscovery from an industry perspective. Register for the Virtual @chembiotalks.bsky.social to hear the perspective of Chris Dallago (@machine.learning.bio) from Nvidia. #ChemBio #Chemsky #ML #MachineLearning

Free registration is now open for the 5th Virtual ChemBioTalks on September 30th, 2025. We are looking forward to a full program including keynote lectures by Sarah O'Connor and @craigmcrews.bsky.social as well as five additional exciting lectures. (1/2) cvent.me/G1geWW #ChemBio #Chemsky

Very excited that Ed Tate will visit us for a @led3hub.bsky.social Lecture on May 22nd and talk about cutting-edge #ChemBio and #chemoproteomics research in the field of #DrugDiscovery. If you are interested, feel free to come by! #ChemSky

Great opportunity for #PhD #postdoc to showcase their #chemistry #chemicalprobe #proteomics #chembiol research at the next @chembiotalks.bsky.social Looking forward to keynotes from @craigmcrews.bsky.social and @oconnorlab.bsky.social and exciting #earlycareer Flashtalks!! #chemsky

Had a great time today discussing the power of #chemoproteomics to help develop #drugs with novel mechanisms of action today for @flgenomics.bsky.social webinar series. Great to see the #chemistry, #AI #proteomics, and #genomics communities coming together to drive change drug development!

If you are interested in lipids in bacteria, check out this awesome new review written by my talented student Alyssa Carter, super postdoc Emily Woods and me. #chembio www.sciencedirect.com/science/arti...

Exciting Day 3 RACI #MCCB2025 ! Starting with showstopping stories from GateBioscience's Pat Sharp on the development of Sec61 #inhibitors for Prion disease, & Prof. Avril Robertson from UQ on targeting NLRP3 #inflammasomes. Impressive preclinical efficacy fromin both stories!

Congrats to HHMI Investigator David R. Liu on receiving the 2025 Breakthrough Prize in Life Sciences! He is recognized for developing base editing & prime editing: 2 breakthrough gene-editing technologies that enable the correction or replacement of virtually any genetic mutation. hhmi.news/3RA6shj

Very excited that I will have the chance to work together with @mads-chem.bsky.social, @martola.bsky.social, Daan van der Es, Martijn Verdoes and Paul Geurink on this exciting event. (2/2)

Had an amazing time at #abpp2025 over the last couple of days. Incredible lineup of speakers showcasing why #ABPP and #proteomics have transformational for #drugdiscovery and #chembiol Already looking forward for #abpp2027 in @LeidenScience

We are very excited that three of our researchers, @mads-chem.bsky.social, @kimmb1.bsky.social and Sander van Kasteren, were successful in obtaining funding through the ZonMw open competition. Learn more about the three projects here: www.universiteitleiden.nl/en/news/2025...

Really enjoyed hosting @jpoverington.bsky.social from @drughunter.com today for @led3hub.bsky.social lecture @leidenscience.bsky.social Some great insights into how #genetics informs #drug target selection and how we can leverage #chemoinformatics to reduce attrition in #drugdevelopment.

Impressive talk by Georgia Andriopoulou from the group of @mads-chem.bsky.social of the @led3hub.bsky.social at #Lunteren. She talked about her research into new libraries of covalent compounds with tailored properties for #chemoproteomics identification of new therapeutic targets. #chemsky #chembio

On #WorldTBday @leidenscience.bsky.social "Dutch Perspective on Mycobacterial Infections" provided insights on #hostpathogen interactions #drugdevelopment & #immunology from global leaders. Unfortunatley, #MDR #infections continue to rise, urgently requiring new #drugs with new #targets

Huge congratulations to the first MSc #graduate from the Kavanagh lab (and future #PhD ) @leidenscience.bsky.social @led3hub.bsky.social Could not be more proud of Jakob and his hard work pushing forward the development of #chemicalprobes to modulate #immunology #chembio #STEMed

Excited to be joining an great line up of speakers at RACI #MCCB2025 in Darwin just a couple of weeks. Looking forward to exciting science with the #ozchem community #chembio #proteomics #drugdiscovery #NT bit.ly/3PNkUl6

Two amazing @led3hub.bsky.social Lectures are coming up: On March 17th, Jeff Kelly will talk about tackling neurodegenerative diseases. On March 27th, John Overington will talk about the power of data in Drug Discovery. Come by, if you are interested! www.universiteitleiden.nl/en/science/l...

Join us in Leiden on March 17th for the @led3hub.bsky.social Lecture of Jeffery W. Kelly of @scripps.edu.

Happy #IWD2025 ! Special shout out to all those #STEMwomen today (including my mum!) keep being amazing #mentorsmatter #DEI #standupforscience

Whom would you like to hear at our next event? The planning for the 5th Virtual ChemBioTalks is starting. We are excited for talks by @oconnorlab.bsky.social, @craigmcrews.bsky.social and Kelly Chibale. Let us know in reply to this post, whom you would additionally like to hear!

Anyone looking to brush up on #ochem should check out this awesome #free resource from @synthesisworkshop.bsky.social Lecture notes, videos, problem sets & more ! #StemEd #chemnerd #medchem #synthesis Also check out their #podcast (The SW Pod) and #youtube lectures! youtu.be/Yn7o9z_93WY?...

Malaria is one of the most devastating diseases especially on the African continent. In his keynote lecture at the #LED3LUCID Symposium, Kelly Chibale talked about his group's amazing contributions to finding new drugs to fight malaria. (1/4)

Fantastic start to the #LED3LUCID symposium today with @mvdstelt.bsky.social from @led3hub.bsky.social sharing their discovery of #stereoselctive DNA gyrase inhibitor #antibiotics A collaborative #drugdiscovery program leveraging #medchem #chembiol #microbiology www.nature.com/articles/s41...

We have PhD scholarships @sydneyuni.bsky.social School of Chemistry available to work on a range of drug discovery and chemical biology projects in my lab, applications close Feb 21 Please let any potentially interested candidates know! www.sydney.edu.au/scholarships...

Topping off #EFMCISCB25 we had an exciting talk on #molecularglue #TPD from @monterosatx.bsky.social Nice to see how rapidly the rational discovery and of #smallmolecule degraders is developing and the insight these platforms are providing into #biology @euromedchem.bsky.social

Lovely talk on #fragment based #covalent strategy to drug Leishmania #bromodomain at #EFMCISCB25 this morning from Claudine Greenwood @glaxosmithkline.bsky.social . Great to see this strategy being used for neglected #infectiousdisease

An amazing KL by Akane Kawamura (@kawamuragroup.bsky.social) opened the session on “Chemical Biology of Chromatin and the Epitranscriptome” at #EFMCISCB25, chaired by Paola Arimondo. Akane thrilled the audience with her work on 2OG Oxygenases in Epigenetic Regulation. @euromedchem.bsky.social

Up next at #EFMCISCB25 @kjohnsson.bsky.social sharing #fluorescent tools for cell imaging and @mvdstelt.bsky.social from @unileiden.bsky.social showcasing #chembiol and #proteomics to understand #lipid signaling in the diseased brain.

First up on day 2 of @euromedchem.bsky.social #EFMCISCB25 is Ben Davis from @ox.ac.uk talking about awesome #chemistry to edit #proteins eg. chemical #mutagenesis, such as Cys>Dha>Xxx transitions #chembiol #chemsky

The 2nd talk at #EFMCISCB was from @berndwollscheid.bsky.social from @ethzurich.bsky.social who shared his labs work on #cellsurface capture technology using #chemoproteomics. insight into cell type-specific proteins, monitoring ligand-receptor affinity, spatial distribution of complexes! #chembiol

Fantastic kickoff to @euromedchem.bsky.social #EFMCISCB 2025 Peng Chen from Peking University sharing the diverse applications of #bioorthogonal de-caging reactions to #chembiol and #drugdiscovery

Can't wait for 4 days of #chembiol #medchem #chemicalprobes #drugdiscovery and #chemoproteomics @RACInational #MCCB2025 Great line of #science and catching up with old friends in #NT bit.ly/3PNkUl6

Last chance to register for #ABPP2025 ! Don't miss an incredible line up of talks on #proteomics #chemicalprobes #drugdiscovery #immunology #cancer plus an #earlycareer research. 30th March - 2nd April in London. Registration www.eventcreate.com/e/abpp2025/

Great to also see him highlight two of the most recent studies of his group: A highly potent monoacylglycerol lipase inhibitor: www.nature.com/articles/s41... A platform to study target engagement of kinases in cells: www.biorxiv.org/content/10.1... #chemsky #ChemBio

Very happy to present our latest work by Tijn van der Velden and co-workers. Cytochrome bd from Mycobacterium tuberculosis has been studied for a while, but nobody was able to show catalytic activity of the purified enzyme: Find out why here in our JBC paper: www.sciencedirect.com/science/arti...