In this month's ChemDev poster by Augustin "Gus" Péneau, we explore the process development behind a campaign to establish a manufacturing route for a topical pan-Trk inhibitor by Neil Stevenson with the BenevolentAI team! Key paper: doi.org/10.1021/acs....

Tune in today as Henrik Wilke joins us to share his work on the total synthesis of (±)-Dhilirolide U! Thanks to Alicia Wagner for hosting and editing! Link: youtu.be/-pBrDNQZ_hU @jacs.acspublications.org 2026, 148, 5916–5922. doi.org/10.1021/jacs...

Today Augustin "Gus" Péneau presents our ChemDev poster for May, featuring a convergent synthesis of GNE-6893 by the small molecule process team at Genentech! For more details check out the papers here: doi.org/10.1021/acs.... doi.org/10.1021/acsm... @acs.org

Tune in this week as Dr. Charis Amber @sarponggroup.bsky.social shares his work on the development of an "inside-out" strategy. for the synthesis of hispidospermidin! Link: youtu.be/Rtjb79JtvIE JACS Au 2026, 6, 600–606. doi.org/10.1021/jacs...

Tune in this week as Xieyang Zhang shares his work on catalytic stereospecific construction of aminocyclopropanes from the Morken group at Boston College! Link: youtu.be/UE-S8R3zd60 Key paper: @jacs.acspublications.org 2026, 148, 3944-3948. doi.org/10.1021/jacs...

This month's ChemDev poster by Augustin "Gus" Péneau is out now!! Check out how chemists from AbbVie scaled the synthesis of ABBV-105, a Bruton’s tyrosine kinase (BTK)-inhibitor! Key paper: Org. Process Res. Dev. 2024, 28, 8, 3229–3247 doi.org/10.1021/acs....

Join us this week on Synthesis Workshop as Stanislav Melnikov shares his work on the role of quantum tunneling in metal-ligand proton tautomerism! Link: youtu.be/4hnNuJDdI8Q Key paper: @jacs.acspublications.org 2026, 147, 50, 46324–46335. doi.org/10.1021/jacs...

Check out the first poster by Augustin "Gus" Péneau in our new monthly ChemDev virtual poster series, showing how syntheses evolve from Med Chem to Process Development. This poster highlights developments in the synthesis of the oral ERα degrader camizestrant!

Tune in this week on Synthesis Workshop as Bryan Parnitzke shares his work on Z-selective semihydrogenation reactions proceeding via multisite proton-coupled electron transfer!! Link: youtu.be/S2NS3sL6_g0 Key paper: ACS Catal. 2026, 16, 1, 203–210. doi.org/10.1021/acsc...

Join us this week on Synthesis Workshop as Dr. Lucia Anghileri shares her work on ligand design for light-driven nickel catalysis!! Link: youtu.be/-4ggoK4ACUk Key paper: J. Am. Chem. Soc. 2025, 147, 13169. doi.org/10.1021/jacs... Thanks to Dr. Alicia Wagner for hosting!

Tune in this week as Dr. Terrence-Thang Nguyen shares his work on asymmetric C-H functionalization and the synthesis of (-)-dragocin D!! Link: youtu.be/Gh1qxy7Z7K0 @jacs.acspublications.org 2025, 147, 31, 28098–28106. doi.org/10.1021/jacs... Thanks to Kathleen for hosting!

Another fantastic Chemical Science paper being highlighted by @synthesisworkshop.bsky.social! Check out the video and make sure to read the paper at pubs.rsc.org/en/content/a...!

Tune in this week as Joan Pereira shares his work on a bio-inspired total synthesis of daphnepapytone A!! Link: youtu.be/rhhpewmsRBc Big thanks to Reem for hosting and editing!

Tune in for our first Research Spotlight of 2026, where Dr. Ruocheng Sang shares his work on a radical approach to the boron-to-copper transmetalation problem!! Link: youtu.be/EVtEZwUSrbU @jacs.acspublications.org doi.org/10.1021/jacs...

Join us this week as Jordan Berreur shares his work on redox-powered autonomous directional C–C bond rotation under enzyme control, published this year in @nature.com!! Thanks to Xingfeng for hosting! Link: youtu.be/2InU6iFBYFQ Nature 2025, 644, 96–101. doi.org/10.1038/s415...

Tune in today as Dr. Benji Thoma returns for the second installment in our mini-course on prebiotic chemistry, this time focusing on prebiotic peptide synthesis!! Link: youtu.be/BDuyOmrTsqI Also check out the first installment on nucleic acid synthesis! youtu.be/Mi6ybPFtt7w

Curious to hear the story behind this paper? doi.org/10.1021/jacs... Tune in today on Synthesis Workshop to hear from Dr. Alessia Petti about this exciting advance: youtu.be/optSQ_YY5jE @jacs.acspublications.org

Join us today as Dr. Mikus Purins shares his work recently published in @science.org on bridging the pyridine-pyridazine synthesis gap using skeletal editing! Link: youtu.be/k2nOfYnNk6U Key paper: Science 2025, 389(6757), 295-298. www.science.org/doi/10.1126/... Thanks to Karim for hosting!!

🔬 You know a young innovator in #organicsynthesis? Great! Nominate them for the Thieme–IUPAC Prize 2026! 🎖️ €5,000 prize 📩 Deadline: Dec 12, 2025 📤 Send to: [email protected] More: thieme.de/en/thieme-ch... @synlettjournal.bsky.social @synthesisworkshop.bsky.social @orgsynth.bsky.social

Do make sure to check out this Synthesis Workshop video to discover how aluminyl anions can have enhanced reactivity which enables selective C-H activation! 🧪 #ChemSky

Is it possible to form a stereogenic carbon with four heteroatom substituents? Would it be configurationally stable? Tune in today to find out in a brand new episode with Olivier Viudes, hosted by Alicia Wagner! Link: youtu.be/-pyvGu56Suo @jacs.acspublications.org 2025, 147, 21121.

We have a brand new Research Spotlight episode, as well as a Problem Set and Solution set dropping today!! Tune in to learn about diastereoselective umpolung cyclization reactions with Dr. Giulia Iannelli! Link: youtu.be/uyKZgUbB5Fk Link to our problem sets: synthesis-workshop.com/problem-sets.

Tune in today for a brand new Research Spotlight episode with Charlotte O’Donnell, focusing on her recent total synthesis of aspidospermidine! Link: youtu.be/lzDv8cJRTyQ

Tune in today to hear Dr. Fabian Kallmeier explain how to enhance the nucleophilicity of aluminum anions, which he recently published in @chemicalscience.rsc.org, in a brand new Research Spotlight episode! Link: youtu.be/6XBF6Iqi3vE Key paper: doi.org/10.1039/D5SC...

Join us today to learn about controlled anionic polymerizations with Paige Jacky, focusing on her recently published work in Nature Chemistry!! Link: youtu.be/6XD7dBUByyQ Nat Chem. 2025, 17, 1076-1082. doi.org/10.1038/s415...

Join. us today as we kick off a brand new course, "Cheminformatics and Computational Chemistry", with an excellent introductory talk on cheminformatics by Dr. Fu Kit Sheong!! If you're interested in contributing to this course, reach out! Link: youtu.be/Hx8kVIsRlO4

Today after years of work and a tight collaboration between >40 chemists in academia and industry, we are thrilled to share the story of how our Advanced Organic Chemistry course and other courses were created in the Journal of Chemical Education! Link: doi.org/10.1021/acs....

The @synthesisworkshop.bsky.social channel covers a whole host of publications and cutting edge research in the area of organic chemistry. Highly recommended if you are in this area and would like to keep up to date with the field: www.youtube.com/@SynthesisWo...

Join us today to hear from Ann-Sophie Paschke and Stefanie Schiele from the @morandilab.bsky.social about their work on C-to-N atom swapping reactions!! Thanks to Karim for hosting and editing! Link: youtu.be/D513hX1gOTg @chemicalscience.rsc.org doi.org/10.1039/D5SC...

Join us this week on Synthesis Workshop as Immanuel Plangger shares his work on the development of a non-enzymatic methylcyclization reaction!! Thanks to Fabrizio Politano for hosting and editing! Link: youtu.be/fnFfw9T5DTM Key paper: Nat. Chem. 2025, 17, 904–910. doi.org/10.1038/s415...

Very excited to announce that our recent review has been featured on the cover of Synthesis!! If you haven't had a chance to check it out yet, here is a link to the review: doi.org/10.1055/a-26...

Join us this week as Jonathan Gruhin @alexanian-lab.bsky.social shares his work on the homologation of carboxylic acids! Thanks to Alicia Wagner for hosting and editing!! Link: youtu.be/hbrrRyy0zfU Key paper: J. Am. Chem. Soc. 2024, 146, 48, 32919–32924 doi.org/10.1021/jacs...

Dive into chiral #DrugDevelopment 💊 This review by Álvarez-Calero & Horwitz @synthesisworkshop.bsky.social highlights efficient, scalable #API synthesis for new drug substances. Discover how asymmetric synthesis drives #pharma innovation via diverse case studies 🧬 👉 buff.ly/ganycgH

Join us today as Michael Zott and Daniel Zuschlag share their work with Prof. Dirk Trauner on the synthesis of isosteroidal alkaloids!! youtu.be/Be-vVFLuGzE Key reference: J. Am. Chem. Soc. 2025, 147, 3010-3016. doi.org/10.1021/jacs...

Today Ömer Taşpınar joins us to share his work from the Clayden group on asymmetric intramolecular arylation reactions in a virtual research poster!! Check out the full paper, published under a month ago in Angewandte Chemie here: doi.org/10.1002/anie...

This is just one example of the problems you'll find in our latest problem set on covalent and noncovalent organocatalysis!! Check out the full set at synthesis-workshop.com in the Problem Sets or Courses section (see the Asymmetric Organocatalysis course).

Check out the latest installment in our Asymmetric Organocatalysis course!! Link: youtu.be/pwtS9YWxldI Once you're done, head over to synthesis-workshop.com and check out the corresponding problem and solution set! You can find it either in the Problem Sets or Courses section.

Join us this week as Rahul Giri shares his work on dual-functional group transfer reagents for the dihalogenation of hydrocarbons!! Thanks to Andy for hosting! Link: youtu.be/eL7dFssUHcA

Join us this week to hear from Dr. Feba Pulikkottil about her recently published work on eFluorination!! Link: youtu.be/U6V6rYhMu1A Key paper: Org. Lett. 2024, 26, 29, 6103–6108 doi.org/10.1021/acs....

Join us today on Synthesis Workshop as Prahallad Meher shares his work on site-selective alkylation and acylation reactions on glycines and peptides!! Thanks to Matteo Balletti for hosting! Link: youtu.be/D7GsRePvxSs Key paper: ACS Catal. 2024, 14, 18896-18906. doi.org/10.1021/acsc...

Join us today as Nicolò Tampellini shares his recently published work on asymmetric cyclization reactions!! Link: youtu.be/9e4Hxt5FjH4 J. Am. Chem. Soc. 2025, 147, 4624-4630. doi.org/10.1021/jacs...

Also check out our new problem and solution set on synthetic electrochemistry, created by Dr. Peter Bellotti! Available for download for free on our project homepage in the Courses or Problem Set section (www.synthesis-workshop.com)!

Tune in for an ⚡⚡⚡ELECTRIFYING⚡⚡⚡ talk! Today we release our introductory mini-course on synthetic electrochemistry, led by Dr. Max Palkowitz and hosted by Alicia Wagner!! Link: youtu.be/pBW4xHF2bBw

Welcome to the team!!!

Join us this week to hear from Enric Adillon about his work on a carborane-derived proton-coupled electron-transfer reagent!! Thanks to Matteo Balletti for hosting! Link: youtu.be/PDAUl-I8e3g Key reference: J. Am. Chem. Soc. 2024, 146, 30204-30211. doi.org/10.1021/jacs...

Did you like our Advanced Organic Chemistry course Good news! You can now download all the PDFs on our project homepage: synthesis-workshop.com#downloads Haven't seen the course yet? Check it out! www.youtube.com/playlist?lis...

Tune in to see an incredible recent total synthesis, explained by Hiroshige Ogawa!! Thanks to Kathleen for hosting! Link: youtu.be/qVz9znlbeFg @angewandtechemie.bsky.social Int. Ed. 2024, e202414295. doi.org/10.1002/anie...

Tune in this week as we're joined by Zhihang Li, who shares his recently published work on sulfoxylate-mediated aldehyde-olefin coupling! Thanks to Aidan Looby for hosting and editing! Link: youtu.be/0r_svfWvQYM Key paper: J. Am. Chem. Soc. 2024, 146, 26616–26621. doi.org/10.1021/jacs...

Check out our latest Research Spotlight with Liam Franov on electroinduced alkene-aldehyde couplings! Link: youtu.be/_gDvUnRoWag Key paper: J. Am. Chem. Soc. 2024, 146, 29450-29461. doi.org/10.1021/jacs...

Curious about photoredox chemistry but don't know where to start? Start here! In this amazing introduction to photoredox catalysis, Dr. Tracy Liu takes us through the core concepts of the field! youtu.be/JnUI0QoloVc