💥Systematic study of nitrogen heterocycles by Samuel Oger & Gwilherm Evano! Cu-photoredox catalysis + blue light drives exo-dig radical cyclizations of sulfonamides → azetidines, pyrrolidines, piperidines & azepanes💡 #copper #photoredox #alkynes 👉 buff.ly/eFcpFwQ

🚀 Countdown to SCNOW Virtual Summit, 6–7 Nov! 🌱♻️ Join top experts in sustainable & circular chemistry from #academia, #industry & #policy. Connect, exchange ideas & drive impact. 💻 Register NOW: cassyni.com/s/scnow-virt... #SCNOWVirtualSummit #SCNOWPosterSession #Sustainability

Advancing #phosphole chemistry! ✨ Our Account by Shibo Xu & Koji Hirano highlights regioselective C–H functionalization of benzophospholes via Pd-catalysis, photoredox, & photo-promoted #annulation 💡 #palladium 👉 buff.ly/lHhUqGs

Tackling the challenge of γ-lactams with chiral α-quaternary carbons! This #Synpacts article by Mengchun Ye & co-workers highlights asymmetric ring decoration & TM-catalyzed carbonylative cyclization, plus future directions🚀 #lactams #catalysis 👉 buff.ly/PGx50Dq

📢📜In this #Synpacts (@synlettjournal.bsky.social), we showcase how electrosynthesis enabled the design of innovative diastereo- and enantioselective alkene 1,2-difunctionalization reactions. These contributions have inspired a complementary “Sew & Cut” strategy www.thieme-connect.com/products/ejo...

First nickel-catalyzed reductive #CrossCoupling of aldehydes & alkenyl halides🚀 Takuya Kurahashi report a stereoconvergent route to allyl alcohols🌟 Enabled by silyl activation & polarity inversion, this strategy tackles a long-standing challenge in synthesis🧪 #nickel 👉 buff.ly/86v9fyB

Protecting-group-free #glycosylations are reshaping #glycoscience 🧪 From Ca²⁺-mediated regioselective reactions to #Mitsunobu + photoredox strategies, new methods enable direct, selective glycoside synthesis with high efficiency in our Account by Dey & Jayaraman⚡ 👉 buff.ly/lGbhN9i

#Alkene radical anions in the spotlight🧪 In this #Synpacts article, Polyzos & co-workers highlight advances in C(sp³)–C(sp³) bond formation via #photoredox & #electrosynthesis 🔋 Featuring electroreductive alkene–aldehyde coupling enabled by rapid alternating polarity⚡ 👉 buff.ly/uarxdeA

First MnO₂/I₂-catalyzed one-pot synthesis of benzo[d]imidazo[2,1-b]thiazoles!🚀 G. Anilkumar & co-workers achieve this via an #OrtolevaKing type reaction⚡This work showcases broad substrate scope, delivers good yields, and paves the way to fused #heterocycles 🧪 #manganese #iodine 👉 buff.ly/fh0Goya

Creative ligand design meets #GoldCatalysis 🌟 Antonio Echavarren & co-workers @iciq.org unveil novel chiral scaffolds 🧬to tackle #alkyne activation with a focus on 1,6-enyne cycloisomerization & #cycloaddition✨ #OpenAccess 👉 buff.ly/GMT9qrL

From classical methods to a dynamic kinetic strategy, Wang & co-workers showcase how #aziridines can be activated with precision✨Their radical–polar crossover (4+3) #cycloaddition unlocks diverse azepines & new paths for N-containing targets 🧪 #synpacts 👉 buff.ly/H5aiDLV

Iron-catalyzed & 1,2-cis selective #glycosylation for aminoglycoside synthesis⚡ Broad scope, reiterative use & scalable to multigrams! Mechanistic insights reveal a unique atom-transfer strategy in our #Synpacts by Hao Xu & co-workers #iron #catalysis 👉 buff.ly/woziH9i

Skeletal editing meets #photochemistry 🌟 Swap, include, or remove atoms to build diverse molecular scaffolds 🧬 A comprehensive overview by Sudipta Raha Roy & co-workers of cutting-edge methods & future opportunities in #DrugDiscovery ✨ 👉 buff.ly/uSaPUu0

Discover the power of Boron in Organic Synthesis 🔬 at the upcoming Thieme #Cheminar! Join Profs. Varinder Aggarwal (🇬🇧), Andrei Yudin (🇨🇦), and Benjamin Stokes (🇺🇸) — chaired by Prof. Thierry Ollevier, brought to you by @synopenjournal.bsky.social 📅 October 16, 2025 ⏰ 3 PM (GMT+2) 👉 buff.ly/v41RiQI

Ethyl but-3-ynoate as a versatile C2 building block🧩 Enables asymmetric (4+2)-heterocycloadditions with Michael acceptors⚡ Chiral isochalcogenoureas deliver highly functionalized #dihydropyrans with excellent selectivity in the study by Waser & co-workers✨ #organocatalysis 👉 buff.ly/NlVUSKk

🔬 Check out the 2025 #NobelPrize in Chemistry! This year’s award goes to Susumu Kitagawa, Richard Robson, and Omar M. Yaghi for their pioneering work on metal–organic frameworks (#MOFs), highly porous materials that can capture CO₂, store gases, and even pull water from the air! 👉 buff.ly/Tj6ROAv

Vicinal tetrasubstituted carbons remain a tough synthetic challenge🔬 Sohtome & Sodeoka (RIKEN) unveil a catalytic aerobic #carbooxygenation strategy that balances uphill & downhill energy profiles, enabling efficient construction of these demanding motifs⚡ 👉 buff.ly/eBuOgso

#Cyclopentenones made simple🌟 Haberhauer & co-workers report a metal-free route via halogen-stabilized #carbanion + #thiolate cyclization🚀 Broad functional group tolerance & pharma relevance make this a powerful tool🔬 👉 buff.ly/WQhB4xs

Protecting-group-free #glycosylations are reshaping #glycoscience 🧪 From Ca²⁺-mediated regioselective reactions to #Mitsunobu + photoredox strategies, new methods enable direct, selective glycoside synthesis with high efficiency in our Account by Dey & Jayaraman⚡ 👉 buff.ly/HRUIAyu

#Benzimidazole breakthroughs in our Account by Sun & Pawar✨ Rh/Pd-catalyzed C–H activation + N–H DG enables diverse C–C, C–N, C–O & C–F bond formations using diazo, alkynes, maleimides & more🚀 #CHActivation 👉 buff.ly/T57Emm1

💡New photocatalytic route to deuterated #oxazoloisoindolinones ! Using D₂O as a cost-effective source, this method by Songjie Yu & co-workers delivers high deuterium incorporation⚡ #DrugDiscovery #deuterium 👉 buff.ly/RMCpnwZ

⚗️From silica & zeolites to MOFs, nanotubes & graphene – advanced templates are powering stable, efficient nanocatalysts⚡Driving sustainable organic transformations & industrial applications by Purohit, Rawat & Rawat🚀 #nanocatalysis 👉 buff.ly/VeKf9Hw

Josep Cornella & co-workers @cornellab.bsky.social unveil one-step heteroatom exchange🚀 A Ni(0)-catalyzed route converts #isoxazoles & #oxadiazoles into #pyrazoles & 1,2,4-triazoles🧪 A blueprint for rapid #azole scaffold exploration without de novo synthesis🌟 #nickel 👉 buff.ly/BabxqGG

Fuxing Yang & Lei Gong developed a dual-catalyst strategy combining photoinduced HAT + chiral #copper #catalysis ✨ Enables regiodivergent, enantioselective C(sp³)–H functionalization of N-aryl #glycines 🎯 👉 buff.ly/eXW6lVz

Dive into the fascinating world of eco-friendly photocyclization 🌱 Valerii Shirinian & co-workers report a novel, transition metal-free synthesis of oxa[5]helicenes, remarkably stable under UV & visible light💡 #photochemistry #photocyclization #helicenes 👉 buff.ly/2BLUMt4

How is AI reshaping peer review? 🧠 At Synlett Journal, #PeerReviewWeek2025 is a chance to reflect on the opportunities AI offers, such as efficiency and support, while addressing questions of bias, transparency, and the role of human judgment. #AI #PeerReview #Thieme

We have just published a short overview article explaining the concepts copper catalysys with bifunctional ligands published recently. @synlettjournal.bsky.social. It's a short read, check it out here: www.thieme-connect.com/products/ejo... #CHEMnitz #copper #NHCs

Ni-catalyzed regioselective #hydroalkenylation of alkynes with #aziridines paves the way to valuable homoallylic amines✨ In this Letter by Ruben Martin & co-workers no stoichiometric organometallics required, just mild conditions and broad substrate scope🌿 #nickel 👉 buff.ly/AjXXA7D

In our #Synpacts by Qiqige Qiqige & Zhaobin Wang, #chromium #catalysis transforms gem-dihaloalkanes into chiral #cyclopropanes with high stereo-control & up to 3 contiguous stereocenters. 👉 buff.ly/m4MwnXW

#Thiosemicarbazones (TSCs) stand out for their structural diversity, bioactivity, & ion-sensing potential🧪 In our Account by Tahmeena Khan & co-workers, tweaking molecular weight, benzene rings, and functional groups can boost #ADME & bioactivity scores. 👉 buff.ly/tPHyu2Q

Discover a dual Ni/#organophotoredox catalytic system by Lei Shi & co-workers for stereoselective #allylation of aldehydes with vinyl cyclic carbonates💡 delivering 1,3-diols with tertiary stereocenters in high yield & dr (>20:1) at room temp! 🌟 #catalysis 👉 buff.ly/1eGcns5

How do you design #cyclooctynes that work in both #bioorthogonal and surface chemistry?🧠 Discover new functionalized cyclooctynes with high chemoselectivity, transannular compatibility & applications on Si(001) surfaces in our Account by Koert & co-workers🧪 Read more👉 buff.ly/b4S1znx

A protecting group-free, 4-step total synthesis of (±)-β-eudesmol in 25% yield by Pulukuri & co-workers!🚀 Highlights include a Cu-catalyzed Michael–aldol cascade and a one-step Fe(III)-mediated radical cyclization–oxidation to build the eudesmane core🧪 #TotalSynthesis 👉 buff.ly/c7upFCj

🌟From Cluster Hydrogen Atom Transfer Reactions🌟 Gong & co-workers report a decatungstate-mediated double #HAT for regioselective #hydroacylation of N-sulfonylimine esters 💡 Exclusive C–N bond formation gives diverse N-sulfonyl N-carbonyl amides #photocatalysis 👉 buff.ly/wSo72lo

🌟From Cluster Hydrogen Atom Transfer Reactions🌟 An #iron bromide/blue light system enables #cumene photooxidation to CHP via #HAT with bromine radicals💡Followed by Hock rearrangement, this offers a selective & mild route to #phenol production with broad scope 👉 buff.ly/us2Gb5u

🌟From Cluster Hydrogen Atom Transfer Reactions🌟 S. Hong & co-workers report phosphine-mediated 1,2-HAT of amidyl #radicals via FLP activation – no photocatalyst needed!💡This enables selective C4-alkylation of #pyridines with broad scope⚡ 👉 buff.ly/htGLoAw

🌟From Cluster Hydrogen Atom Transfer Reactions🌟 By merging palladium and tetrabutylammonium decatungstate as a HAT photocatalyst, Wang & co-workers achieved acyl C–H #alkenylation of aldehydes with alkenyl triflates, enabling multi-substituted cyclic alkenes💡 👉 buff.ly/qW9DGmA

🌟From Cluster Hydrogen Atom Transfer Reactions🌟 García Mancheño, Ohmatsu, Ooi & co-workers report a sustainable catalytic system for acceptorless #dehydrogenation. Hydrocarbons undergo smooth CAD using a zwitterionic acridinium amidate + cobaloxime🌱 #photocatalysis 👉 buff.ly/D3xFmv0

🌟From Cluster Hydrogen Atom Transfer Reactions🌟 Kokotos & co-workers present a green, metal-free approach🌱 for selective C–H activation: #hydroacylation of alkenes using NBI #photocatalysis under blue LEDs💡 #organocatalysis Read more👉 buff.ly/c5NKx3e

🌟From Cluster Hydrogen Atom Transfer Reactions🌟 Explore how #cumyloxyl radicals unlock new insights into C–H bond reactivity. A kinetic, product & DFT study by Liu, Houk, Bietti & co-workers reveals how 1,3-diaxial #StrainRelease shapes HAT selectivity in #cyclohexanes 🧪 👉 buff.ly/psJGxcr

🚨 Special Issue Alert❗ Explore the latest #HAT Reactions research in SYNLETT! Cutting-edge radical chemistry and innovative transformations await⚡ 🔜 Next weeks we’ll spotlight all letters from this cluster. Stay tuned! Read it here👉 buff.ly/KfAghrR

A simple, scalable method by Jurk & van Gemmeren @vangemmerenlab.bsky.social to convert secondary sulfonamides into sulfonyl fluorides using affordable #DAST ⚗️, yielding excellent results! These sulfonyl fluorides readily couple with amines to create diverse libraries. #SuFEx 👉 buff.ly/hjkyEap

Breaking benzene’s rules: Rare-earth #metallacycles drive the first aromatic ring-opening #metathesis via [2+2] cycloaddition/cycloreversion!🧪 A bold new strategy for C–C activation & skeletal editing by Liu & Zhang✨ Read more👉 buff.ly/uhapncE

✨Our August Thieme #Cheminar dedicated to prof. Carreira was a big success with 406 attendees at peak!✨ Thanks to everyone who joined the discussions, our speakers for the excellent presentations👏, and our EiC @marklautens.bsky.social for chairing the session! Watch later👉 buff.ly/K2XxagR

#Tuberculosis drug resistance fuels urgent need for new treatments💊 Kumar, Debnath & Roy highlight thiazole-based compounds showing potent activity against MDR/XDR strains. Novel syntheses, molecular docking, and nanotech delivery boost their potential! 👉 buff.ly/4v7Ael6

Unlocking complex spirocyclic oroidin #alkaloids like palau’amine🔬 Carl Lovely & co-workers report a novel Diels–Alder sequence with tandem #TBAF desilylation, oxidation & rearrangement to create a versatile intermediate for #TotalSynthesis. #cycloaddition 👉 buff.ly/mi6k9Sl

Reminder!⏰ The Thieme #Cheminar dedicated to Prof. Erick Carreira is tomorrow, August 14th! Join the conversation with our fantastic speakers at 3 PM (GMT+2). 👉 buff.ly/aKtx0Fx

Explore the power of #fluorine in pharma & agrochemicals!🌟 The trifluoromethyl CF₃ & trifluoromethylthio SCF₃ groups boost activity with unique electronegativity & lipophilicity. New breakthroughs in #AsymmetricSynthesis of C(sp³)–SCF₃ compounds by Kojima & Hirano are on the rise! 👉 buff.ly/dkDglBZ

New Research! 🚀 Discover efficient catalytic C–C bond formations using earth-abundant iron-phosphine complexes! Kakiuchi & Kochi's work explores C–H bond cleavage in aromatic ketones🌱 Dive into their findings on four key transformations. #catalysis #iron 👉 buff.ly/YsZJUb7

Our speakers Profs. T. Ritter (🇩🇪), S. Lin @songlin1.bsky.social (🇺🇸) & S. Reisman @reiswoman.bsky.social (🇺🇸) present their latest results in a Thieme #Cheminar dedicated to Prof. Erick Carrera🌟 Chaired by Prof. M. Lautens @marklautens.bsky.social 📅August 14, 2025 ⏰3 PM (GMT+2) 👉 buff.ly/aKtx0Fx