🧪 New pyrazolo[1,5-a][1,3,5]triazines with promising anticancer activity! Lead compounds showed broad-spectrum growth inhibition, low cytotoxicity, and favorable predicted ADMET properties. 📖 Read the full paper: bit.ly/4eT1Zl1 #ChemSky #MedicinalChemistry #CancerResearch #DrugDiscovery

🏆 Congratulations to the winners of the #SynOpen Best Paper Award! 🎉 Limei Qian, Yi Jin & co-workers developed a mild, metal-free PIFA-mediated strategy to access valuable 2-hydroxy diarylureas. A scalable, efficient & more sustainable approach! Read the paper: bit.ly/3Su93gG #ChemSky #OpenAccess

🏆 Join the next Thieme Cheminar! Hear from the award-winning authors recognized by SYNTHESIS, SYNLETT, and SCNow. Chaired by Prof. Tanja Gulder, Assoc. Editor of @synlettjournal.bsky.social 📅 June 24, 2026 ⏰ 14:00 CEST 👉 Register here: bit.ly/3QtzzpM #Cheminar #ChemSky #OrganicChemistry

🧬 New paper on SIRT1 activators! This study reports new 1,5-benzodiazepine-based SIRT1 activators, combining organic synthesis, #molecular docking & biological evaluation. A lead compound demonstrated promising #antidiabetic activity in vivo. 🔗 Read now: bit.ly/4xkL1EK #ChemSky #MedicinalChemistry

🧪 Carbene or nitrene? This graphical review explores the diverse landscape of #carbene and #nitrene precursors, highlighting their synthesis, activation strategies, reactivity profiles & key synthetic applications. 🔗 Read here: bit.ly/4x2HBpT #ChemSky #OrganicChemistry #Synthesis

⚗️ From our #Catalysis Virtual Collection An aryl iodide-catalyzed oxidative strategy enables intramolecular C–N/C–O bond formation from diphenylpropanamides under mild, transition-metal-free conditions. 🔗 Read the full paper: bit.ly/3RX5qPP #ChemSky #OrganicChemistry

💡 From our #Catalysis Virtual Collection A metal-free iodide/peroxide strategy for direct C–H functionalization of quinoxalin-2(1H)-ones via cross-dehydrogenative coupling & arylation. Efficient access to valuable heterocycles! 🔗 Read here: bit.ly/4nvE66Z #ChemSky #OrganicChemistry

⚡ From our #Catalysis Virtual Collection An aerobic iron(III)-catalyzed direct thiolation of imidazo[1,2-a]pyridines enables regioselective access to C3-sulfenylated heterocycles under mild conditions. Efficient #synthesis with promising bioactive derivatives! 🔗 Read now: bit.ly/4eVcCpt #ChemSky

💡 From our #Catalysis Virtual Collection A visible-light-mediated photocatalytic oxidative cleavage of geminal diazides, using an organic dye as catalyst, enables efficient access to oxamates under mild, metal-free conditions. 🔗 Read here bit.ly/4utWTlC #ChemSky #OrganicChemistry #Photocatalysis

🚀 From our #Catalysis Virtual Collection An atom-economical, iodine-catalyzed oxidative route to olivetol, methyl olivetolate & protected derivatives from common precursors. A mild, efficient & scalable approach to valuable building blocks. 🔗 Read more: bit.ly/41ZwGzc #ChemSky #OrganicChemistry

🧪 1,1-Dibromoolefins: versatile building blocks in synthesis! Featuring two reactive C–Br bonds, they enable rapid access to heterocycles, functionalized olefins & alkynes from simple precursors. 📚 Explore the graphical review: bit.ly/4dU0yEk #ChemSky #OrganicChemistry #Synthesis

Discover boron chemistry in #catalysis in our next Thieme #Cheminar with our speakers Hirohisa Ohmiya (Japan), Elena Fernández (Spain), and James Morken (USA). Chaired by Martin Oestreich. 📅 Apr 14 | 🕑 14:00 CET 👉 Sign up now to save your spot: bit.ly/4t2czfA #ChemSky

🧪 Efficient Pd/C-catalyzed hydrogenation of diene carboxylates! A catalyst from Pd₂(dba)₃ on activated carbon (5% Pd) delivers high yields of fully saturated products, including challenging 5-membered rings. 🔗 Read more: bit.ly/4mbFnQk #ChemSky #Catalysis #OrganicChemistry

🚨 Last call for today’s #Cheminar! 👉 Secure your spot now: bit.ly/4uOWN95

Join the Thieme Chemistry Journals Awardees 2026 #Cheminar and explore cutting-edge research in #photocatalysis, #sustainable solvents, novel #heterocycles & more. 📅 Mar 30 🕔 4 PM CEST 👉 Register here: bit.ly/4uOWN95 #ChemSky #OrganicChemistry

Following their widely cited #NewTools article, Thomas S. Teets’s group has launched a searchable database for #photosensitizers buff.ly/VCPsybf Filter by photophysical & redox properties to quickly find the right catalyst⚡ Read here👉 buff.ly/HFSN9LS Updates and new entries welcome: [email protected]

⚡Electrophotocatalysis for C(sp²)–H functionalization! Graphical review by Jiusi Yang & Peng Qian on #photoelectrocatalytic C–H activation, merging light & electricity for selective functionalization of arenes, heteroarenes, #alkenes & imines 🔗 Read now: bit.ly/4799ul2 #ChemSky #Photochemistry

🧪 Copper #catalysts for alcohol #oxidation This graphical review highlights advances in Cu-catalyzed oxidation and dehydrogenation of alcohols (2015–present), including aerobic oxidation, acceptorless dehydrogenation, and homogeneous & heterogeneous systems! 🔗 Read now: bit.ly/3Pif6TL #ChemSky

⚡ Greener alcohol oxidations! Graphical review by @conchem.bsky.social & Prof. @klchemistry.bsky.social on non-transition-metal electrochemical #oxidation of alcohols. Featuring TEMPO and other mediator systems in #electrosynthesis. 🔗 Read more: bit.ly/4rRzoSr #OrganicChemistry #ChemSky

💡 Visible light unlocking #heterocycles! Eosin Y–catalyzed reductive cyclization of N/O-aryl bisenones affords functionalized pyrrolidines & THFs, exclusive trans #isomers & enantioenriched products! 🔗 Read the full paper: bit.ly/4tXrvwj #ChemSky #Photochemistry #OrganicChemistry

🚨 Last call to the Thieme #Cheminar! “Strain-Release Chemistry” with speakers Dr. Durga Hari (🇮🇳), Prof. Jérôme Waser (🇨🇭) @lcsolab.bsky.social & Prof. Peter Wipf (🇺🇸). Chaired by Akkattu T. Biju (Assoc. Editor of @synthesis1969.bsky.social) 📅 Feb 24, 2026 | ⏰ 11:00 AM(CET) 🔗 Register: bit.ly/4kGHtqm

📢 Join our next Thieme #Cheminar! 🧪 Strain-Release Chemistry 📅 Feb 24, 2026 | ⏰ 11:00 AM (CET) Discover how strained #molecules open new pathways for innovative transformations. Chaired by Akkattu T. Biju (Associate Editor of @synthesis1969.bsky.social) 🔗 Register here: bit.ly/4kGHtqm

🧪 New quinazoline-based #lidocaine analogue Scalable 7-step synthesis (10-g scale) delivers a promising next-generation local anesthetic with enhanced activity and improved pharmacokinetic profile! 🔗 Read the full paper: bit.ly/4rXt4Zw #ChemSky #MedicinalChemistry #DrugDiscovery

An efficient and mild dibromination of aromatics using Fe(NO₃)₃·9H₂O/FeBr₃ at room temperature. This protocol delivers good to excellent yields, avoids hazardous Br₂, and is scalable to gram scale. 🧪 🔗 Read here: bit.ly/4riD0gk #ChemSky #OrganicSynthesis #Halogenation #GreenChemistry

🌱 Polar organometallic reagents can thrive in #sustainable solvents! This graphical review highlights how organolithium, #Grignard, and related #reagents operate in water and deep eutectic solvents, redefining classical reactivity through #GreenChemistry. 🔗 Read now: bit.ly/4qVloXj #ChemSky

🧩 Sterically controlled, template-assisted macrocyclization enables hemisquaraine #rotaxanes with enhanced #fluorescence and stability. By combining #SupramolecularChemistry, photophysics, and DFT, this study reveals how steric effects control rotaxane formation. 🔗 Read here: bit.ly/3ZE8UaF

Asymmetric synthesis of 2-arylethylamines, key motifs in bioactive compounds and #MedicinalChemistry. This graphical review highlights 2025 advances in metal-free and metal-catalyzed methods, including #Organocatalysis, #Photocatalysis and #Biocatalysis. 🧪 🔗 Read here: bit.ly/3LORTHq #ChemSky

⚡ Turning alcohols into aldehydes with electricity. New open-access graphical review on electrochemical oxidations in @synopenjournal.bsky.social by @Conchem.bsky.social because chemists love schemes more than words 🤣 www.thieme-connect.com/products/ejo... #Electrosynthesis #Aldehydes #ChemSky

Discover how [2.2]paracyclophanes (PCPs) are functionalized using transition #metals and applied as planar #chiral ligands and catalysts. This graphical review offers a overview of C–H activation strategies and their impact on #stereoselective synthesis. 🔬📘 🔗 Read here: bit.ly/4qwWRb7 #ChemSky

An iodine-doped TiO₂ #photocatalyst shows efficient degradation of toxic dyes under UV and visible light, with enhanced activity and good reusability. A promising approach for sustainable #WaterTreatment. 🌱💧 🔗 Read the full article: bit.ly/4r2zgit #OpenAccess #ChemSky #SustainableChemistry

We’re live! Introducing Therapeutics NOW – Thieme’s new Gold Open Access journal driving breakthroughs in translational therapeutic research. ✅ Interdisciplinary by design ✅ Broad scope & impactful article formats ✅ Ultra-fast peer review via Select Crowd Review 🔗 www.thieme.com/en-us/thieme...

⚡🔬 Can #ElectricFields direct #ChemicalReactivity? This graphical review by Prof. Thomas Wirth & team (🇬🇧) shows how oriented external electric fields can control reaction pathways, enhance selectivity, and reduce energy input in #OrganicSynthesis. A must-read! 🔗 bit.ly/453gvCT #ChemSky #OpenAccess

✨ 2025 highlights ✨ 🥇 #1 Most Downloaded Paper of 2025 “Sodium Nitrite (NaNO₂): An Impressive and Efficient Nitrating/Nitrosating #Reagent in #OrganicSynthesis” Graphical review by Lamark, Barbosa & Jordão 🔗 Read now: bit.ly/4b9Di3x #ChemSky #Chemistry #OpenAccess

✨ 2025 highlights ✨ 📊 Top 5 most downloaded papers of 2025 ✅ #2 A convenient #synthesis of CHF₂O-containing #pyrrolidines and related compounds — Perspective building blocks for #DrugDiscovery by K. Levchenko et al. 🔗 Read here: bit.ly/498FiGQ #ChemSky #OrganicChemistry

✨ 2025 highlights ✨ 📊 Top 5 most downloaded papers of 2025 ✅ #3 “Synthesis, In Vitro and In Silico Molecular #Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to #Thalidomide as Potent #Antitubercular Agents” by S. Youssif & team 🔗 Read now: bit.ly/49cOqKG #ChemSky

✨ 2025 highlights ✨ 📊 We’re closing the year with the Top 5 most downloaded papers of 2025. ✅ #4 “Recent #Catalytic Applications of #Porphyrin and Phthalocyanine-Based Nanocomposites in #Organic Transformations” by P. Kumari & co-workers 🔗 Read now: bit.ly/48URmwu #ChemSky

✨️ 2025 highlights ✨️ 📊 Our final posts of the year highlight the Top 5 most downloaded papers of 2025. ✅ #5 “Development of a Novel Horner–Wadsworth–Emmons Reagent for the Facile Preparation of Mixed Phosphonoacetates" by Shigeki Sano & team. 🔗 Read it here: bit.ly/3YcSdT2 #ChemSky #Chemistry

✨ 2025 highlights ✨ A year of global connections and great #science for the Syn journals community: 10 events across 8 countries! 🇨🇭 🇰🇷 🇪🇸 🇬🇧 🇨🇳 🇯🇵 🇵🇹 🇮🇹 Thank you to everyone who made these meetings unforgettable! Special thanks to @rohitbhatia10.bsky.social 🇮🇳 for representing us at so many conferences!

🎄 2025 highlights! 🎄 The SynOpen Best Paper Award 2024 to Ben Stokes & co-workers (Santa Clara University, 🇺🇸) for their publication "Pd-Catalyzed Transfer Hydrogenation of Alkenes Using Tetrahydroxydiboron as the Sole Hydrogen Donor" 👀 Revisit the paper: bit.ly/3MSJsuR #Throwback #ChemSky

🎄 As 2025 comes to a close, we at @thieme-gruppe.bsky.social look back at our #Cheminar series! From Chemical Synthesis & #Catalysts to Medicinal #Chemistry, plus special sessions and Best Paper Awardees. Thanks to all chairs, speakers, and attendees. 👀 More Cheminars in 2026. Stay tuned!

📢 Last call for our Thieme #Cheminar! Dive into the world of Small #Molecules in Medicinal Chemistry. Session with Profs. Arlene G. Corrêa (🇧🇷) & Kelvin Billingsley (🇺🇸), chaired by Debabrata Maiti (🇮🇳). 📅 Dec 10, 2025 ⏰ 5 PM (CET) 🔗 Register now: bit.ly/4aDJWie #ChemSky

📢 Cheminar Alert! Our next Thieme #Cheminar is coming up: “Small Molecules in #MedicinalChemistry” 📅 Dec 10, 5:00 PM (CET) Featuring Prof. Arlene Corrêa and Prof. Kelvin Billingsley, with Prof. Debabrata Maiti (EiC of @synlettjournal.bsky.social) chairing. 🔗 Register now: bit.ly/4aDJWie #ChemSky

🧬 New #anticancer candidates from functionalized oxazoles! M. V. Kachaeva & team report 5-S-substituted 1,3-oxazolylphosphonates and 1,3-oxazole-4-carbonitriles, with several compounds showing high potency against multiple #cancer cell lines! 📄 Read here: bit.ly/4pmeAl4 #ChemSky #MedChem #Synthesis

🔬 Prof. Ying Xia and colleagues highlight recent advances in the #synthesis of axially #chiral cycloalkanes, covering key strategies such as asymmetric allylic substitution, #alkene insertion, #carbene cross-coupling, [2+2] #cycloadditions, and #deracemization. 🔗 Read now: bit.ly/4pCRhTy #ChemSky

Potential new type of #herbicides! 🌱 In this paper, J. Frackenpohl & team report the design, #synthesis, and #biological evaluation of substituted azetidinyl carboxamides, developed through scaffold hopping and #bioisosteric strategies. 🔗 Read the full article: bit.ly/4iplJyn #ChemSky #SAR

Prof. Michael P. Doyle & L. De Angelis (UTSA) highlight how 1,2,3-triazine 1-oxides provide a powerful platform for constructing diverse #heterocycles. From nucleophilic substitution & #deoxygenation to Diels–Alder #reactions and more! 🔗 Read the graphical review: bit.ly/48qm7Jg #ChemSky #Synthesis

✨ New Graphical Review! A. V. Dobrydnev presents overview of synthetic strategies for building endocyclic sulfoximines. They possess unique #physicochemical and structural features, including #chirality and thermal stability. 🔗 Read more: bit.ly/482WRr7 #ChemSky #OrganicChemistry #Heterocycles

⚡ In this review, J. Yang & team highlight recent advances in metal-enabled #electrophotocatalysis, integrating photo-, electro-, and metal-catalyzed processes to develop #sustainable routes for C–H activation, #decarboxylation, and cross-coupling under mild conditions. 🔗 Read now: bit.ly/43vqgZH

M. V. Kachaeva & team designed and synthesized novel oxazolo[4,5-d]pyrimidine derivatives showing strong activity against glioblastoma and lung #cancer cell lines. 🔍 #MachineLearning, #QSAR modeling, and #docking revealed carbonic anhydrase XII as a potential target. 👉 Read more: bit.ly/47NQt75

🚀 Countdown to SCNOW Virtual Summit, 6–7 Nov! 🌱♻️ Join top experts in sustainable & circular chemistry from #academia, #industry & #policy. Connect, exchange ideas & drive impact. 💻 Register NOW: cassyni.com/s/scnow-virt... #SCNOWVirtualSummit #SCNOWPosterSession #Sustainability