#Sulfur is shaping the future of #DrugDiscovery! Wonchul Lee & co-workers review cutting-edge total syntheses of sulfur-rich natural products (2020–2024), from #thioethers to #thiazoles 🧪 👉 buff.ly/CybW19K

Yanhua Zhang & co-workers showcase a green, efficient electrochemical method to turn aryl alkynes + CO₂ into acrylic & propionic acids! Using an Al/Pt/Ag–AgBr setup in TBAB/MeCN, yields reach 72% and product selectivity is tunable over time⚡️ #electrochemistry 👉 buff.ly/sNCqP8K

Explore the dynamic world of #spiropyrans & #merocyanines ! Discover how electron-donating and -withdrawing groups shape photochromic behavior using UV/Vis, NMR & DFT insights by Ralf Wolfgang Giernoth & co-workers📊 #photochromism 👉 buff.ly/65euLti

Transition metal-free #CrossCoupling 🚀 Alkyl fluorides + #Organolithiums react under mild heat with liquid-assisted stirring w/o expensive catalysts🔥 Tolerates 3° fluorides & diverse functional groups🧪 This breakthrough by Wolf & co-workers could reshape TM-free coupling chemistry 👉 buff.ly/tWFwGiw

From Si & Ge to Sn⚗️This review by Guillaume Lefèvre & co-workers explores #bis-alkenyl group XIV compounds – their formation from halide precursors, versatile functionalizations & roles in polymers, materials & fine chemicals🌟 👉 buff.ly/pqrRST0

Metal-free & radical💥A #xanthate -mediated cascade builds #spiroindolines via addition, spirocyclization & oxidation🌀 Broad scope (esters, nitriles, ketones, lactones) & up to 99% yield ⚗️Unlocking bioactive scaffolds by Luis D. Miranda & co-workers✨ 👉 buff.ly/2pAJOcC

Yongseok Kwon & co-workers review a decade of enantioselective C–C bond formation via redox-active esters + #photoredox & CPA catalysis💡 From Minisci α-amino radicals to Friedel–Crafts acylimines, dual activation is opening new stereochemical frontiers⚡ 👉 buff.ly/a1JV95z

Turning amides into amines & nitriles with light!💡Using Fe₂(CO)₉ under blue LED irradiation, Christophe Darcel & co-workers showcase a selective, mild #desulfurization via hydrosilylation, a sustainable twist on iron #catalysis 👉 buff.ly/UtXQrvR

Explore the #gold standard in #catalysis! Dive into our review by Long Li  & co-workers on gold-catalyzed asymmetric #alkyne transformations, from ligand engineering to central-to-axial conversions. Discover new paths in #chirality & sustainable synthesis✨ 👉 buff.ly/z0wMqw9

#Organosodium reagents are emerging as greener, more reactive alternatives to lithium🧪 Benzyl sodium shows divergent reactivity with #pyridines, unlocking access to #dihydropyridines 🔍 New mechanistic insights revealed by Eva Hevia & co-workers @evaheviagroup.bsky.social 👉 buff.ly/DThXVcG

🚀 Countdown to SCNOW Virtual Summit, 6–7 Nov! 🌱♻️ Join top experts in sustainable & circular chemistry from #academia, #industry & #policy. Connect, exchange ideas & drive impact. 💻 Register NOW: cassyni.com/s/scnow-virt... #SCNOWVirtualSummit #SCNOWPosterSession #Sustainability

🔎 Isocyanoalkenes, an underexplored class of #isocyanides , are unlocking new paths in heterocycle synthesis🌱From biosynthesis to reactivity (conjugate & radical additions), this review by Huan Tian & Fraser Fleming highlights their vast synthetic potential🧪 👉 buff.ly/tJWJ5Z4

Discover how chiral Pd complexes enable enantioselective #SuzukiMiyaura reactions with chain-walking🚀 A new path to pharmaceutically relevant, enantiomerically enriched targets by James Morken & co-workers✨ #organoboron #catalysis 👉 buff.ly/6YZ2sko

#Morpholine amides take the spotlight🌟 Yohei Ogiwara reviews their unique reactivity & chemoselectivity in ketone, aldehyde & acylsilane synthesis🧪 Applications include natural product synthesis, Vilsmeier–Haack reactions & polymer recycling! #OpenAccess 👉 buff.ly/34Wm4nT

William Erb & co-workers show how #hexafluoroisopropanol (HFIP) promotes pseudo-benzylic substitutions, enabling access to bulky diphosphine ligands & phosphonates🧪 Key tools for metal complexes & #phosphine synthesis🌟 #ferrocene 👉 buff.ly/8QjPcGl

A fresh look at #gold & #platinum catalysis! ✨ Véronique Michelet @vmichelet06.bsky.social & co-workers review [2+2+2] Prins-type #cyclizations with alkynes/allenes, alkenes & carbonyls🔬 Covers intra/intermolecular strategies & enantioselective applications 🌟 👉 buff.ly/roTiTeW

Rapid access to 1,2- #diazepines from #pyridines via ylide formation under 370 nm light, as reported in the paper of Tomislav Rovis & coworkers🚀 Tuning the protecting group enables diverse substrates, offering a one-pot route to rare drug-like cores💊 👉 buff.ly/UXBkq9a

⚡Charge-enhanced H-bond & #Brønsted acid catalysis is redefining synthetic chemistry! Boosting rates & selectivity, these systems, like #amidinium & cationic phosphoric acids, bring enzyme-like efficiency, as highlighted in our review by Travis Dudding & co-workers🚀 👉 buff.ly/yidWGLw

Ni-catalyzed selective monodefluorinative alkylcarbonylation of α-CF₃ styrenes with alkylzinc pivalates under 1 atm CO gas by Jie Li & co-workers🚀 Mild conditions and broad substrate scope make this method highly versatile⚡ #monodefluorination #nickel #catalysis 👉 buff.ly/3EtnXgO

Exploring #enyne metathesis in green solvents, supercritical fluids & under microwave tech🌱 From cross- to ring-closing pathways, #ruthenium catalysts & tandem strategies, discover it all in this review by Mao, Melot @rmelot.bsky.social & Michelet @vmichelet06.bsky.social 🚀 👉 buff.ly/XNGUsN9

Harnessing sunlight for C–C bond formation☀️ Dimethyl-aniline–alkyl halide charge transfer complexes enable reactions with #malonates , #malononitriles & 2-cyano-esters 🔬✨ DFT unveils the mechanism in this study by Alex Szpilman @amszpilman.bsky.social & co-workers #photochemistry 👉 buff.ly/XNGUsN9

Join Thieme #Cheminar “Boron in Organic Synthesis”🔬 with our speakers Profs. Varinder Aggarwal (UK), Andrei Yudin (Canada) & Benjamin Stokes (USA), hosted by Prof. Thierry Ollevier and brought to you by @synopenjournal.bsky.social 📅October 16, 2025 ⏰3 PM (GMT+2) 👉 buff.ly/v41RiQI

From Ziegler’s legacy to today’s 🚀 #Organoaluminum chemistry is evolving: hydro-/ #carbometallation, terminal #alumination & C–H activation open new paths! Dive into the review by Piccardi & Micouin @lmicouin.bsky.social ✨ 👉 buff.ly/XNGUsN9

🔬 Check out the 2025 #NobelPrize in Chemistry! This year’s award goes to Susumu Kitagawa, Richard Robson, and Omar M. Yaghi for their pioneering work on metal–organic frameworks (#MOFs), highly porous materials that can capture CO₂, store gases, and even pull water from the air! 👉 buff.ly/Tj6ROAv

Versatile 1,2-oxazin-4-ones pave the way to enantiopure amino #polyols 🧩 Reissig, Zimmer & co-workers show syn/anti selectivity in #Grignard & #enolate additions, δ-lactone & bicyclic polyol formation, plus Pd & SmI₂ reductions⚡ 👉 buff.ly/uZan4s9

🚀 Explore cutting-edge strategies for turning propargyl alcohols into #allenes ✨ A short review by Amgoune & co-workers (ICBMS) highlights how transition-metal #photoredox catalysisdrive these advances through oxidative addition & photoinduced C–O cleavage⚡ 👉 buff.ly/Sftvtf9

☀️Anthore-Dalion @lanthoredalion.bsky.social & co-workers report a Re(I) photocatalyst enabling ultra-fast (<5 min) #deoxygenation of N-heterocyclic & alkyl N-oxides💡Air-tolerant, scalable, and highly functional group-friendly⚡️ #rhenium #photocatalysis 👉 buff.ly/Wj7cEWT

🚀Acuña-Bolomey & Oestreich @silicon-martin.bsky.social reveal an enantioconvergent Ni-catalyzed C(sp³)–C(sp³) coupling, unlocking α-chiral #alkylgermanes🧪 Novel PyBox ligands tackle selectivity challenges & pave the way for next-gen #organogermanium chemistry✨ #nickel 👉 buff.ly/5sLCvWB

✨From Special Topic Romanian Chemists in Synthesis✨ One-step breakthrough⚡️A new catalytic system enables efficient synthesis of 5,5′-bi-triazole bis-macrocycles🧪Born from a serendipitous by-product➡️now optimized for selectivity & yield✨ #CuAAC #triazoles #macrocycles 👉 buff.ly/CqvtWHP

✨From Special Topic Romanian Chemists in Synthesis✨ 🚀π-Coordination is unlocking new ways for C–H & C–O activation! This review by Mutoh & Ilies highlights Pd–arene–Cr complexes and future transient strategies for sustainable synthesis🧪 #catalysis 👉 buff.ly/hkjGa8v

⚗️First-of-its-kind Co-catalyzed cross-coupling! Gosmini & co-workers report that benzyl sulfonium salts, readily made from alcohols, react with aryl bromides to give a wide variety of #diarylmethanes in good to excellent yields✨ #cobalt #catalysis 👉 buff.ly/kmBppFc

Why is #fluorine the ultimate game-changer in organic chemistry?💡In their latest review, Zhan-Yong Wang & co-workers cover a decade of #monofluorination breakthroughs – from radical routes to #Selectfluor magic – showing how chemists craft C–F bonds with precision. 👉 buff.ly/nEDKadM

💡Yadav & co-workers developed a divergent DABCO-catalyzed route to allyl #sulfones via α- and γ-substitution of Morita–Baylis–Hillman acetates with #sulfinates, delivering alkyl 2-(phenyl(tosyl)methyl)acrylate derivatives in high yields with excellent stereoselectivity 👉 buff.ly/0UFFoyf

💻 AI is changing research - and peer review is no exception. At Synthesis Journal, we mark #PeerReviewWeek2025 by reflecting on both the opportunities (efficiency, support, integrity) and the challenges (bias, transparency, safeguards) that AI brings to peer review. #AI #PeerReview #Thieme

Our review by Anju Nalikezhathu & Travis Williams explores hydrogen borrowing #catalysis, an atom-economical, cost-effective route where alcohols alkylate amines with only water as by-product💧Explore catalysts, pharma uses & green, low-PMI processes🔬 👉 buff.ly/IFhNlfh

In this work by Joyce Grimm & Nobel Laureate Benjamin List, the intramolecular #Prins reaction of O-prenylated #salicylaldehydes delivers 4-chromanols with outstanding efficiency & selectivity using a fluorinated iIDP #Brønsted acid catalyst⚗️ #organocatalysis 👉 buff.ly/ttXDIM9

Dive into the world of substituted alkynes🚀 From #diynes to #enynes, our review by Janine Cossy explores the latest in chemo- & stereoselective C–C bond formation via alkynyl #CrossCoupling, powered by affordable Mn, Fe, Co, Ni & Cu catalysts🔬 #catalysis 👉 buff.ly/YYAbvj5

Highlights from #OMCOS22 in Kyoto 🌸 Prof. Martin Oestreich gave a great talk titled ‘The Cation Shuttle‘ & handed the certificate for the ‘Lives in Chemistry’ project to Nobel Laureate Prof. Ryoji Noyori. Many thanks to Prof. Hideki Yorimitsu & Prof. Michinori Suginome for a fantastic event!

Small-molecule #alcohols go beyond solvents⚡️A new review by Dayun Huang & co-workers explores their role as green, versatile reactants in organic #electrochemical synthesis, covering etherification, esterification & alkylation 🍃 Read more👉 buff.ly/KVuWmCm

H. Gong & co-workers report a Ni-catalyzed cross-#hydrodimerization of enamides & unactivated alkenes, delivering α-branched amines/secondary amides via C(sp³)–C(sp³) bond formation with high regio- & enantioselectivity🌟 #catalysis #BiOx 👉 buff.ly/G2P3onl

Once overlooked, the Cargill-type rearrangement is making a comeback. Strain-driven [1,2]-shifts are unlocking new paths in #SkeletalEditing - a focused review by Bo Xu & co-workers explores its mechanism⚙️, scope, and strategic potential in #TotalSynthesis 👉 buff.ly/XvYGfsW

✨From Special Topic Romanian Chemists in Synthesis✨ Andruh, Nica & co-workers report a [2+3] hexaimine cage from #azulene units with symmetric π-stacking, visible absorption & #fluorescence. Reduction to a hexaamine cage alters stability & redox properties💡 👉 buff.ly/Zfm6t4m

✨From Special Topic Romanian Chemists in Synthesis✨ Explore redox-switchable #polymerization! See how #counteranion choice tunes rates and monomer selectivity for diblock copolymer design in the letter by Diaconescu & co-workers⚡ #electrochemistry 👉 buff.ly/f0XFpv2

🚨Special Issue Alert! Discover our latest research in SYNLETT celebrating the achievements of Romanian Chemists in #synthesis 🇷🇴 Innovative chemistry from talented researchers!🔬 🔜 This week we’ll spotlight all papers from this special topic. Stay tuned! Read it here👉 buff.ly/hQNM3Sz

Very excited to announce that our recent review has been featured on the cover of Synthesis!! If you haven't had a chance to check it out yet, here is a link to the review: doi.org/10.1055/a-26...

✨Bürgenstock Special Section 2023✨ Electrochemical α-functionalization of #ketones by Vantourout, Echeverria, Gnaim & co-workers⚡#Umpolung reactivity enables C–C, C–Cl, and [3+2] #cyclizations in an undivided cell, air/water tolerant! #electrosynthesis 👉 buff.ly/XyaDJ73

✨Bürgenstock Special Section 2023✨ Catalyst-free #photochemistry by Line Næsborg & co-workers!🌱 Protonation of (E)-anethole in HFIP leads to a photoactive EDA complex that drives radical chain cyclizations under green light #irradiation 💡 👉 buff.ly/hykT1ri

✨Bürgenstock Special Section 2023✨ #Electrochemical insights⚡ Alicia Casitas @aliciacasitas.bsky.social & co-workers report reduction potentials for 50 iodine(III) reagents, including cyclic alkynyl, vinyl, aryl, CN, CF₃, and iodonium salts, measured by CV 👉 buff.ly/XXB8mEn

✨Bürgenstock Special Section 2023✨ First enantioselective #TotalSynthesis of lucidumone in 13 steps🍄! Aurélien de la Torre @auredelatorre.bsky.social & co-workers use a retro-[4+2]/#DielsAlder cascade to access this COX-2 selective #meroterpenoid 👉 buff.ly/O6SQ8Os

✨Bürgenstock Special Section 2023✨ Christopher Teskey & co-workers highlight how simple ligand #photodissociation in #cobalt #catalysis enables light-controlled reactivity switches🔦, offering access to distinct outcomes. #photochemistry 👉 buff.ly/JpLDLih