Synthesis of Aryl Halides via a Safer Sandmeyer Reaction Protocol Submitting Authors: Tim Schulte, Felix Waldbach, Tobias Ritter Checking Authors: Kunj Kapur, Daniya Aynetdinova, and Nuno Maulide www.orgsyn.org/demo.aspx?pr...

Synthesis of N-Pyridinium Aziridines Submitting Authors: Samya Samanta, Hao Tan, Saikat Chatterjee, David C. Powers Checking Authors: Michael M. Gilbert and Nathan D. Ide www.orgsyn.org/demo.aspx?pr...

Simplified Preparation of the (1R,2S)-Berkessel salalen Ligand from cis-1,2-Diaminocyclohexane (cis-DACH) Submitting Authors: Christina Wartmann, Tobias M. Leuther, Hauke Engler, and Albrecht Berkessel Checking Authors: Mengfei Xu and Vy M. Dong www.orgsyn.org/demo.aspx?pr...

Amination of Aryl Boronic Acids Using O-(Diphenylphosphinyl)hydroxylamine (DPPH) Kasie H. Leung and Richard Y. Liu www.orgsyn.org/demo.aspx?pr...

Base-Promoted N-Heteroaryl C-H Oxidative Coupling With Alcohols for N-heteroaryl Ether Synthesis Samuel L. Graf 1 and Jeffrey S. Bandar www.orgsyn.org/demo.aspx?pr...

Iridium-Catalyzed Borylation of Silanes Christina A. Rivera, Benjamin A. Janda, and Neil K. Garg www.orgsyn.org/demo.aspx?pr...

Preparation of (S,S)-B2bg2, a Chiral Diboron Reagent Cliff Yang, Brooklyn Maddox, Anshu Yadav, Robert E. Maleczka Jr. www.orgsyn.org/demo.aspx?pr...

Preparation of Hexafluoroisopropyl Sulfamate (HFIPS) for the Sulfamoylation of Alcohols and Amines Mathew L. Piotrowski, Matthew Sguazzin, Jarrod W. Johnson, and Jakob Magolan www.orgsyn.org/demo.aspx?pr...

Enzymatic Saponification of Esters Containing β-Leaving Groups Benjamin A. Janda, Allison M. Clark, and Neil K. Garg www.orgsyn.org/demo.aspx?pr...

Umpolung Synthesis of α-Bromo Secondary Amides from Unactivated Hydroxamates Rui Wang, Hao Cao, and Wenbo H. Liu www.orgsyn.org/demo.aspx?pr...

Professor David Nagib of Ohio State presented the Organic Syntheses Lecture at the UC Irvine on November 3, 2025 on “Harnessing Radicals and Carbenes to Enable Unconventional Reactivity”.

Professo Yoonsu Park of KAIST presented the Organic Syntheses Lecture at the University of Hong Kong on November 5, 2025.

Palladium-Catalyzed Carbonylative Spirolactonization of Hydroxycyclopropanols  Cyrus C. Gudeman, Courtney M. Wiethorn, and Mingji Dai www.orgsyn.org/demo.aspx?pr...

Preparation of S-Trifluoromethyl Trifluoromethanesulfonothioate (TTST), a Highly Versatile and Atom-economical Trifluoromethylthiolating Agent Seyedesahar Miraghaee, Teruo Umemoto, and Gerald B. Hammond www.orgsyn.org/demo.aspx?pr...

Synthesis of 4,4-Dimethyl-1,6-Heptadiyne and Derivatives from Dimedone Amir Tavakoli, Nathaniel J. Selvaraj, and Gregory B. Dudley (www.uh.edu/nsm/chemistr...) www.orgsyn.org/demo.aspx?pr...

Professor Emeritus Tohru Fukuyama (University of Tokyo) presented the Organic Syntheses Lecture at Tohoku University on November 6th, 2025.

Discussion Addendum for: Nickel-Catalyzed Synthesis of Ketones from Alkyl Halides and Acid Chlorides: Preparation of Ethyl 4-Oxododecanoate Omar M. Beleh and Daniel J. Weix www.orgsyn.org/demo.aspx?pr...

Large-Scale Amino-Hydroxylation Using Tethered Nitreniums Shyam Sathyamoorthi (medchem.ku.edu/research/shy...) www.orgsyn.org/demo.aspx?pr...

Preparation of N-tert-Butylbenzenesulfinimidoyl Chloride Teruaki Mukaiyama, Yasuo Nakamura, and Jun-ichi Matsuo (yakugaku.w3.kanazawa-u.ac.jp/~gousei/) www.orgsyn.org/demo.aspx?pr...

Oxidative Nitrogen Atom Insertion into Cyclopentenones Bence B. Botlik and Bill Morandi (morandi.ethz.ch) www.orgsyn.org/demo.aspx?pr...

Summer 2026-2027 Research Grants for Faculty at Principally Undergraduate Institutions: Applications are due by November 1, 2025. For more information, visit orgsyn.org/puigrants.aspx

Professor Jeff Gustafson (Stony Brook University) (gustafsongroup.sdsu.edu/wordpress/) presented the Organic Syntheses Lecture at Notre Dame on September 24th, 2025.

Professor Vy Dong (UC Irvine) (sites.google.com/uci.edu/vydo...) and Dr. Jeff Kallemeyn (abbVie) presented the Organic Syntheses Lectures at Iowa State on September 12th 2025.

Synthesis of Abietatriene via Nitrogen Deletion Julia L. Driscoll, Carys E. Obertone, Liao Chen, and Mark D. Levin (levingroup.uchicago.edu) www.orgsyn.org/demo.aspx?pr...

Hydrosilylation of Propiolate Esters Allison M. Clark, Giulianna Miseo, and Neil K. Garg (garg.chem.ucla.edu) www.orgsyn.org/demo.aspx?pr...

Acid-Mediated Hydroaminomethylation of Unactivated Alkenes Uros Vezonik, Paolo Piacentini and Nuno Maulide (maulide.univie.ac.at) www.orgsyn.org/demo.aspx?pr...

Large-Scale Alkene Dimesyloxylation Shyam Sathyamoorthi (medchem.ku.edu/research/shy...) www.orgsyn.org/demo.aspx?pr...

Top Ten Organic Syntheses Articles (Volume 65 to present) accessed during 2024 (8) Jacobsen Mn Salen Epoxidation Catalyst Prepn. OS 1998, 75, 1 (9) Campagne Dipeptide Synthesis OS 2015, 92, 296 (10) Alberico Oxyma Peptide Synthesis OS 2013, 90, 306

Top Ten Organic Syntheses Articles (Volume 65 to present) accessed during 2024 (5) Tschaen NaOCl-TEMPO Oxidation OS 2005, 81, 195 (6) Ellman (S)-Nonafluorobutanesulfinamide Preparation OS 2005, 93, 319 (7) Danheiser Ynamide Synthesis OS 2007, 84, 88

Top Ten Organic Syntheses Articles (Volume 65 to present) accessed during 2024 (1) Kelly Carbazole Photoredox Catalyst OS 2019, 96, 455 (2) Taber Oxone Preparation OS 2013, 90, 350 (3) Miyaura Bis(pinacolato)diboron OS 2000, 77, 176 (4) Boeckman Dess Martin Reagent OS 2000, 77, 141

Synthesis of meta-Substituted Benzenes via Mo-Catalyzed Intermolecular Deoxygenative Coupling of Ynones and Allylic Amines Yi-Zhe Yu, Gang Fang, Hong-Yi Su, and Chun-Xiang Zhuo (zhuolab.xmu.edu.cn) www.orgsyn.org/demo.aspx?pr...

Congratulations to former OS editor Brian M. Stoltz (www.stoltz.caltech.edu), recipient of the 2026 ACS Ernest Guenther Award in the Chemistry of Natural Products

Congratulations to OS editor Tehshik Yoon (yoon.chem.wisc.edu), recipient of the 2026 ACS David Evans Award for Advancement and Education of Organic Synthesis

Congratulations to OS editor Sophie Rousseaux (sites.chem.utoronto.ca/rousseaux/), recipient of a 2026 ACS Arthur C. Cope Scholar Award

Congratulations to OS editor Darren J. Dixon (dixon.chem.ox.ac.uk/darren.html), recipient of a 2026 ACS Arthur C. Cope Scholar Award

Organic Syntheses announces the election of Dr. Kevin M. Maloney, Executive Director and Head of Process Chemistry, Merck Research Laboratories, to the OS Board of Editors.

Synthesis of α-Aryl Ketones via the Nickel-Catalyzed Hydroacylation of Aryl Alkenes with Aroyl Fluorides Yoonho Lee, Yujin Jung, Seonhwa Choo, and Kwangmin Shin (www.kmshinlab.com) www.orgsyn.org/demo.aspx?pr...

The Sixth Organic Syntheses Inc Workshop for Young Investigators on Organic Synthesis and Natural Products Chemistry was held at the UC Santa Barbara Club on August 7 to 9

Preparation of tBu-MsFluind-Br Lucas Wagner and Josep Cornella (www.cornellab.com) www.orgsyn.org/demo.aspx?pr...

Ryan Gilmour (www.uni-muenster.de/Chemie.oc/gi...) of University of Münster presented the Org Syn Lecture at MIT on Thursday, April 17th, speaking on “Illuminating Stereoselective Catalysis”

Synthesis of 6-methoxy-2-methyl-2-(4-methylpent-3-en-1-yl)chroman-4-one via Kabbe Condensation Stephen A. Chamness, Emily F. Traficante, Trenton R. Vogel, and Corinna S. Schindler (www.schindlerresearchgroup.com) www.orgsyn.org/demo.aspx?pr...

Synthesis of gem-Difluoroalkenes through Ramberg-Bäcklund Reaction of Alkyltriflones Motoo Ohtsuka, Yasuyo Tahara-Tezuka, Yuuki Maekawa, Cathleen M. Crudden, and Masakazu Nambo (nagoya-uni-cruddengroup-en.labby.jp) www.orgsyn.org/demo.aspx?pr...

Organic Syntheses invites submission of articles incorporating video

Glass Cannula for Bulb-to-Bulb Cold Transfer Kaylin N. Flesch, Tyler J. Fulton, Nathan Hart, and Brian M. Stoltz (www.stoltz.caltech.edu) www.orgsyn.org/demo.aspx?pr...

Purification of Organic Compounds by Flash Column Chromatography Benjamin D. Senzer, Cholapat Varongchayakul, Rick L. Danheiser (danheiserlab.mit.edu), Brian Daniels and Vy M. Dong (sites.google.com/uci.edu/vydo...) www.orgsyn.org/demo.aspx?pr...

Organic Syntheses invites submission of OS Techniques articles. For guidance see orgsyn.org/Guidance_Tec...

Announcing a new category of Organic Syntheses article

Prof. Tianning Diao (NYU Chemistry) presented the Organic Syntheses Lecture at the University of Hong Kong on Thursday, June 12 2025, speaking on “Cross-Coupling and Late Stage Modification of Biomolecules” pchiu.chemistry.hku.hk/pc

Rapid Access to Enantiopure Protected (R)-Paraconyl Alcohol Haylie E. Hennigan, Namuunzul Otgontseren, and Elizabeth I. Parkinson www.orgsyn.org/demo.aspx?pr...

Efficient Preparation of Chiral Hydroxylamines via Nickel-Catalyzed Asymmetric Hydrogenation of Oximes Bowen Li, Jianzhong Chen, and Wanbin Zhang www.orgsyn.org/demo.aspx?pr...