Sarpong Group
@sarponggroup.bsky.social
đ€ 900
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Student-run account for the Sarpong group at UC Berkeley
Excited to welcome first years Richard, David P., Nick, and David B. to the group!
about 1 month ago
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Congratulations to Taku and Pierre on the publication of their dahurelmusin synthesis! Thank you to Dr. Blane Zavesky, our collaborator from Corteva for going above and beyond!
doi.org/10.1021/acs....
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Total Synthesis of Dahurelmusin A and epi-Dahurelmusin A: Effect of a Single Stereocenter Change on Biological Activity
Reported herein is a total synthesis of the peptide-polyketide natural product dahurelmusin A along with its C10 epimer (epi-dahurelmusin A). The syntheses benefited from well-established aldol and macrocyclization technologies. Access to the natural product and its C10 epimer provided opportunities to test the importance of the C10 stereocenter in the biological activity of the natural product.
https://doi.org/10.1021/acs.orglett.5c03361
2 months ago
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Check out this highlight on our carbamorphone work!
www.acsh.org/news/2025/08...
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Carbamorphine: Could This Fascinating Molecule Become The Holy Grail of Pain Relief?
Since the beginning of time, humanity has searched for drugs that can relieve pain without sparking addiction or the other devastating problems tied to opioids. Itâs still very early, but a UC Berkele...
https://www.acsh.org/news/2025/08/13/carbamorphine-could-fascinating-molecule-become-holy-grail-pain-relief-49649
3 months ago
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reposted by
Sarpong Group
NSF Center for Computer Assisted Synthesis (C-CAS)
4 months ago
Congratulations to Dr. Richmond Sarpong (
@sarponggroup.bsky.social
) on being awarded the 2025 Inhoffen Medal. This award is considered to be "the most prestigious German award in the field of natural products chemistry."
chemistry.berkeley.edu/news/richmon...
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Richmond Sarpong has been awarded the Inhoffen Medal | College of Chemistry
https://chemistry.berkeley.edu/news/richmond-sarpong-has-been-awarded-inhoffen-medal
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reposted by
Sarpong Group
Keith Hornberger
3 months ago
This beautiful work from the
@sarponggroup.bsky.social
also got a nice write-up in
@cenmag.bsky.social
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Atom-swapped morphine may help create safer painkillers
By putting a carbon atom in place of a core oxygen, chemists constructed an opioid that blocks pain with less respiratory depression in mice
https://cen.acs.org/synthesis/medicinal-chemistry/Atom-swapped-morphine-help-create/103/web/2025/07
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reposted by
Sarpong Group
Keith Hornberger
3 months ago
Behold the double-edged sword of natural product medicinal chemistry! On the one hand, doing the SAR is such a pain that industry has largely given up. On the other, look what we havenât tapped into: a one-atom change to morphine, never before made in the 73 years since the first total synthesis!
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Total synthesis and biological activity of âcarbamorphineâ: O-to-CH2 replacement in the E-ring of the morphine core structure | PNAS
Morphine is a µ-opioid receptor (MOR) agonist and potent analgesic. However, it displays several side effects including respiratory depression and ...
https://www.pnas.org/doi/10.1073/pnas.2425438122
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Check out this Article in
@cenmag.bsky.social
. News on skeletal editing that discusses some of our group's work!
cen.acs.org/synthesis/Sk...
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Skeletal editing: How close are we to true cut-and-paste chemistry?
Reactions that alter organic scaffolds by a single atom are already proving useful, but time will tell if theyâll fundamentally change how molecules are made
https://cen.acs.org/synthesis/Skeletal-editing-cutpaste-chemistry/103/web/2025/07
4 months ago
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Congratulations to Jack and Safaa on their beautiful study toward the aphidicolin family of diterpenoids that just appeared in JOC!
pubs.acs.org/doi/full/10....
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Synthetic Studies toward the Aphidicolin Family of Diterpenoid Natural Products
Herein, we report an investigation of several synthetic strategies to access the aphidicolin family of natural products. Some unsuccessful approaches include strategies featuring DielsâAlder cycloaddi...
https://pubs.acs.org/doi/full/10.1021/acs.joc.5c01047
4 months ago
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Check out this article in
@dailycal.bsky.social
highlighting our recently published carbamorphine work!
www.dailycal.org/news/campus/...
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UC Berkeley researchers develop âcarbamorphine,â a safer painkiller
The molecule, coined âcarbamorphine,âwas built through total synthesis.
https://www.dailycal.org/news/campus/research-and-ideas/uc-berkeley-researchers-develop-carbamorphine-a-safer-painkiller/article_27a44e0b-a989-49bc-8e02-8979820ee410.html
4 months ago
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Congratulations to Team Carbamorphine, led by Sota, along with our collaborators from the Majumdar and McLaughlin groups on the publication of our work in PNAS!
www.pnas.org/doi/10.1073/...
4 months ago
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reposted by
Sarpong Group
Mark Levin
5 months ago
A brief editorial with
@sarponggroup.bsky.social
and
@alisonwendlandt.bsky.social
where we try to answer an important question: What is Editing?
pubs.acs.org/doi/full/10....
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What is Editing?
You have not visited any articles yet, Please visit some articles to see contents here.
https://pubs.acs.org/doi/full/10.1021/acs.accounts.5c00268
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reposted by
Sarpong Group
NSF Center for Computer Assisted Synthesis (C-CAS)
5 months ago
Meet Sojung, a recent graduate of the
@sarponggroup.bsky.social
! Have a questions for Sojung? Let us know!
#NSF
#Chemistry
#C-CAS
#Meetascientist
#Chemsky
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Congratulations to Sojung, Charis, and Logan on the publication of their Accounts of Chemical Research paper on our group's skeletal editing work, which, at its core, is inspired by total synthesis!
pubs.acs.org/doi/epdf/10....
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Skeletal Editing Strategies Driven by Total Synthesis
ConspectusSingle-atom skeletal editing strategies that precisely modify the core frameworks of molecules have the potential to streamline and accelerate organic synthesis by enabling conceptually simp...
https://pubs.acs.org/doi/epdf/10.1021/acs.accounts.5c00174?ref=article_openPDF
6 months ago
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Check out this
@chemistryworld.com
highlight of Ryan and Moto's work!
www.chemistryworld.com/news/skeleta...
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Skeletal editing provides quick access to pharmaceutical âmatching pairsâ
Late-stage functional group switching in dibenzofurans will aid drug discovery chemistry
https://www.chemistryworld.com/news/skeletal-editing-provides-quick-access-to-pharmaceutical-matching-pairs/4021471.article
6 months ago
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reposted by
Sarpong Group
Sarah CP Williams
6 months ago
Chemists at
@ucberkeleyofficial.bsky.social
led by
@sarponggroup.bsky.social
figured out how to shuffle peripheral pieces of a molecule by twisting its interior structure, like rearranging a Rubik's cube. Their work, in
@science.org
, helps speed drug design.
chemistry.berkeley.edu/news/twist-c...
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Twist the core, change the function: chemists discover shortcut for drug design | College of Chemistry
https://chemistry.berkeley.edu/news/twist-core-change-function-chemists-discover-shortcut-drug-design
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Congratulations to Ryan and Moto on the publication of their 1,2-acyl transposition in 2,3-dihdyrobenzofurans in
@science.org
!
www.science.org/doi/10.1126/...
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1,2-Acyl transposition through photochemical skeletal rearrangement of 2,3-dihydrobenzofurans
Saturated heterocycles are commonly adorned with groups that influence their biological properties. Synthetic methods that transpose existing substituents on saturated heterocycles to multiple peripheral positions are therefore highly valuable. In this ...
https://www.science.org/doi/10.1126/science.adv9915
6 months ago
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reposted by
Sarpong Group
Jake Yeston
6 months ago
In
@science.org
this week, Ryan Steele and Motohiro Fujiu in
@sarponggroup.bsky.social
move an acyl group by transposing adjacent carbons rather than moving the oxygen đ chemsky đ§Ș
www.science.org/doi/10.1126/...
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1,2-Acyl transposition through photochemical skeletal rearrangement of 2,3-dihydrobenzofurans
Saturated heterocycles are commonly adorned with groups that influence their biological properties. Synthetic methods that transpose existing substituents on saturated heterocycles to multiple periphe...
https://www.science.org/doi/10.1126/science.adv9915
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Check out these articles highlighting Richmond's election to the National Academy of Sciences!
news.berkeley.edu/2025/05/02/n...
chemistry.berkeley.edu/news/richmon...
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National Academy of Sciences adds eight from UC Berkeley to its ranks - Berkeley News
The new members from Berkeley have spent decades researching gene editing, materials science, very young children, the depths of the universe and more.
https://news.berkeley.edu/2025/05/02/national-academy-of-sciences-adds-eight-from-uc-berkeley-to-its-ranks/
6 months ago
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Richmond has been elected into the US National Academy of Sciences!
www.nasonline.org/news/2025-na...
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National Academy of Sciences Elects Members and International Members - NAS
WASHINGTON â The National Academy of Sciences announced today the election of 120 members and 30 international members in recognition of their distinguished and continuing achievements in original res...
https://www.nasonline.org/news/2025-nas-election/
6 months ago
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Congratulations to
@gwynethpudner.bsky.social
, Selena and Eric on the publication of their approach to benzannulated seven-membered rings in
@synthesis1969.bsky.social
!
www.thieme-connect.com/products/ejo...
7 months ago
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Congrats to Nina for being awarded an NSF graduate research fellowship! đ We are so proud of you!
7 months ago
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reposted by
Sarpong Group
NSF Center for Computer Assisted Synthesis (C-CAS)
7 months ago
Meet Suh, a graduate student in the
@sarponggroup.bsky.social
Check out our instagram @nsf_ccas to learn more about Suh.
#NSF
#Chemistry
#C-CAS
#Meetascientist
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Congrats to Logan & our collaborators Lucas (Sigman Group) & Reilly &
@charlesthechemist.bsky.social
(Merck) on the publication of our work on a cheminformatic analysis of core-atom transformations in pharmaceutically relevant heteroaromatics. Check it out in J. Med. Chem. now!
tinyurl.com/42re37pd
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Cheminformatic Analysis of Core-Atom Transformations in Pharmaceutically Relevant Heteroaromatics
Heteroaromatics are the basis for many pharmaceuticals. The ability to modify these structures through selective core-atom transformations, or âskeletal editsâ, can dramatically expand the landscape f...
https://doi.org/10.1021/acs.jmedchem.4c02839
8 months ago
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Congratulations to Team Macrocyclization (Lucas, Charis, Khalid and visiting scholars Philipp, Ismail (
@kokculer.bsky.social
), and Théo) and our collaborator Dr. Blane Zavesky from Corteva Agriscience on the publication of our work in JACS!
doi.org/10.1021/jacs...
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CâC Cleavage/Cross-Coupling Approach for the Modular Synthesis of Medium-to-Large Sized Rings: Total Synthesis of Resorcylic Acid Lactone Natural Products
The chemical synthesis of medium (8â11 membered) and large sized (â„12 membered) cyclic systems is often challenging. The introduction of transannular strain and loss of degrees of freedom in forming m...
https://doi.org/10.1021/jacs.5c00801
8 months ago
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Congrats to Logan, Sojung, Yusuke and collaborators from the Barner-Kowollik group, Gilead, and Merck on our indazole to benzimidazole conversion
onlinelibrary.wiley.com/doi/10.1002/...
coordinated with the Leonori group
onlinelibrary.wiley.com/doi/10.1002/...
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Phototransposition of Indazoles to Benzimidazoles: TautomerâDependent Reactivity, Wavelength Dependence, and Continuous Flow Studies
Herein, we report a detailed investigation of the photomediated transformation of indazoles to benzimidazoles through a nitrogen-carbon transposition. This phototransposition is known to occur in low....
https://onlinelibrary.wiley.com/doi/10.1002/anie.202423803
9 months ago
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Congratulations to Charis, Timothée, Giedre, Ryan, and visiting scholars Breanna and Julius as well as our collaborator Dr. Small on the publication of our work on the two-step isomerization of saturated cyclic amines, now on JACSAu!
pubs.acs.org/doi/10.1021/...
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Two-Step Constitutional Isomerization of Saturated Cyclic Amines Using Borane Catalysis
The prevalence of saturated azacycles within pharmaceuticals, natural products, and agrochemicals has prompted the development of many methods that modify their periphery. In contrast, technologies th...
https://pubs.acs.org/doi/10.1021/jacsau.4c01093
10 months ago
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Congratulations to Sojung, our collaborator from the Sigman group Jordan, our collaborators from Merck and former group members Justin and Yasuki on the publication of our work on understanding the enantioselectivity of our photomediated ring contraction in JACS!
doi.org/10.1021/jacs...
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Interrogation of Enantioselectivity in the Photomediated Ring Contractions of Saturated Heterocycles
We recently reported a chiral phosphoric acid (CPA) catalyzed enantioselective photomediated ring contraction of piperidines and other saturated heterocycles. By extruding a single heteroatom from a r...
https://doi.org/10.1021/jacs.4c13999
10 months ago
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reposted by
Sarpong Group
Mark Levin
12 months ago
Implicit in my highlight here was a hope someone would do the same thing for skeletal editing and well...
chemrxiv.org/engage/chemr...
Very useful analysis - should spur lots more development in skeletal editing!
@charlesthechemist.bsky.social
(Looks like Matt and Richmond aren't here yet?)
add a skeleton here at some point
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reposted by
Sarpong Group
André K. Isaacs
12 months ago
I had dinner with chemistry legends last night đ„°
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Congratulations to Brandon, Alessio, Taku, Dear, Sebastian, Sojung and our collaborators from the Paton group on the publication of our full account on calyciphylline A-type daphniphyllum alkaloids in JACS!
doi.org/10.1021/jacs...
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Molecular Complexity-Inspired Synthetic Strategies toward the Calyciphylline A-Type Daphniphyllum Alkaloids Himalensine A and Daphenylline
In this report, we detail two distinct synthetic approaches to calyciphylline A-type Daphniphyllum alkaloids himalensine A and daphenylline, which are inspired by our analysis of the structural comple...
https://doi.org/10.1021/jacs.4c11252
12 months ago
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