Pro-LLM academics bemoaning how long it takes to write and review papers are telling on themselves. Those tasks are supposed to take a long time because that's how you can be thoughtful, thorough, and rigorous. Filtering yourself is how you only communicate things you think are worth reading.

Publishers are already seeing unprecedented quantities of AI slop and unethical AI use by authors and reviewers, and it's terrifying that tools like this will open the floodgates further. Gen AI is a plague and I wish it a swift death.

Good start www.youtube.com/watch?v=VwcK...

BREAKING Greg Bovino has been removed as Border Patrol "commander at large" and will return to El Centro Calif, where he is expected to retire soon. A stunning turnaround after Pretti killing. Bovino's traveling blue city crackdown is over www.theatlantic.com/politics/202...

This is a wild story

The University of Chicago Department of Chemistry is currently seeking a Managing Director to Lead Department of Chemistry Operations. Follow the link for full job description, qualifications and benefits- tinyurl.com/3p3r8rn9

Today on @chemrxiv.org, we disclose a C-to-N replacement that actually works complex natural products - a pipe-dream when we started. The secret is to lean in to the triplet nitrene. Congrats Dong Il, and thanks to the whole team, including collaborators from Sanofi! chemrxiv.org/engage/chemr...

if you want a long read that involves udders, a hot air balloon, and some extremely dubious data on egg prices, the story I’ve been working on for the last few months where I tried to single-handedly take on every government function myself is now online! www.theatlantic.com/magazine/202...

Considering that IMAN (4) is also in this picture, the concentrated crossword power on display here is overwhelming. Blinding. Nuclear. ☢️

The National Weather Service used AI to create a forecast for Idaho. Low chances of wind for the nonexistent towns of Cocrerrireod, Orangeotild and Whata Bod www.washingtonpost.com/weather/2026...

I continue to be enraged by everything the secretary of health and human services is doing www.theatlantic.com/newsletters/...

is there some way I can quickly unlearn all of history so as to feel better about recent events

✂️ July: Adventures in atom swapping! cen.acs.org/synthesis/me... (see also this very successful feature cen.acs.org/synthesis/Sk...) 🧪 August: Beth Halford, Laura Howes, and I revamped C&EN's first disclosures coverage to put the molecules front and center cen.acs.org/pharmaceutic...

If you can't be bothered to actually write the peer review yourself why should the reviewee have to listen to it? Why write anything at all, ever? If you don't have enough time, fight for better working conditions instead of faking your work

Ok here it is - out of 44 FDA approvals this year, 31 are small molecules (70%), 26 of those are oral drugs (84%), 22 of them are chiral (71%). This is the largest number and percentage of chiral FDA approved molecules in a single year. Fitusiran is not a small molecule, bonus.

Just in time for the new year - we show that you can make either isomer of N-aryl pyrazole selectively from a single TDSO. We really believe in the power of these wacky heterocycles. chemrxiv.org/engage/chemr... Excellent work by superstar Alex Fanourakis, in collab with Osvaldo Gutierrez and J&J

I just taught my lecture course on mid-20th c US history, which starts with Harding and concludes with Nixon. For the first time, I had to pause and stress that those scandals were actually shocking at the time and, what’s more, that Americans actually demanded people be held accountable.

"Schools must adopt effective filters to block inappropriate or misleading content." What filters block misleading content from ChatGPT? Is there a "no disinfo" or "no faked citations" or "no hallucinations" filter? There is not. This is poisoned tech. You have to block the entire product.

Charlie Brown also invented the alkyne zipper reaction, look it up en.wikipedia.org/wiki/Alkyne_...

suspect a big reason why many academics and others who work in areas where getting facts RIGHT is key are disinterested in using LLMs for research: they’ve tried it, they keep noticing major errors in output, and they conclude that having to verify all that doesn’t actually save them time.

As a former process chemist, yes. You get such 3am calls such as “There’s yellow foam overflowing out of the vessel, what do we do?” Or “We accidentally charged the vermiculite packing into the vessel along with the hydride reagent, it’ll be okay right?”

makes me want to chew glass wapo.st/4aXfzn5

Nitrogen deletion made easier✏️ Novel N-(benzyloxy)-N-(pivaloyloxy)benzamides enable one-step #deamination & deaminative functionalization of amines🔬 Improved derivatives by Mark @levinchem.bsky.social show faster kinetics & higher yields, shedding light on stereoelectronic effects 👉 buff.ly/c0hBrru

Every morning while making coffee www.poetryfoundation.org/poetrymagazi...

Jonathan Chait on something I’ve noticed: that when you look for a defense on conservative media of many of the President’s actions… you find… nothing. www.theatlantic.com/ideas/2025/1...

God I wish it was only because of DOGE

Every ad now

Science as practiced in its best form is that if you disagree with it, you set up an experiment that would disprove it. If you can't do that, you shut your fucking mouth and learn something.

having the unmistakable urge to blog about the epstein documents by doing a taxonomy of creepy elite email writing styles DO NOT REPEAT THIS INSIGHT TO MY EDITORS

Re Abbvie #chemjobs

No idea if this is the case here, but a city council member in my suburb said that our many vacant downtown storefronts were due to a tax law that allows landlords to write off losses from vacant properties, so if they don't get the rent they want, they can make more money by letting it sit empty.

The NMR section is my favorite.

PSA for people with NIH grant periods starting January 1st (including most NIGMS MIRAs): your RPPR is due Saturday, but they haven’t sent out the usual automated reminders, presumably due to the shutdown

Opinion | Actually, don’t let them eat cake

Someday I will not have to write about Sarepta Therapeutics and their ineffective drugs that never should have been approved by the FDA in the first place. This is not that day.

Do an experiment? No darling I don’t think so

Mike Johnson: It’s True. I Am Tuning Out The News Cycle To Focus On Self-Care

Yeesh

Warning. ⚠️ If you are writing an NSF GRFP, new this year, you need official transcripts to apply. Beware. They will not review applications without official transcripts. ‼️

A device exploded inside the Goldenson Building in Harvard’s Longwood medical campus early Saturday morning, according to a message from the Harvard University Police Department to University affiliates. Matan H. Josephy and Laurel M. Shugart report. www.thecrimson.com/article/2025...

@ninaluong.bsky.social is really upping her costume game this year. And she can still work in it!

quite literally everything i hear about the economics of this feels insane, especially given the big issue of the tools not doing what boosters say they will do. so many details make me feel very not good!

So, if that's true, is there some kind of shot you could take, to help prevent autism?

Looking for some mad science journalism this Halloween? Look no further than 🩻Spooky, scary skeletal editing🩻 (and more chilling chemistry news from @cenmag.bsky.social) cen.acs.org/synthesis/Sk...

Professor Emeritus Axel D. Becke @dalhousieu.bsky.social has passed away at age 72.

For those who are wondering about grant proposal reviews in the USA

Yes, this is accurate.