Maybe it's just me, but in almost-2026, I can't be "optimistic" about another "new" review about amyloid/tau-based Alzheimer's therapies.

Nick Sirianni To Eagles Fans: ‘I Hate All Of You, Fuck You’ https://theonion.com/nick-sirianni-to-eagles-fans-i-hate-all-of-you-fuck-you/

The takedown of the US system of childhood vaccines which worked exceedingly well for decades for preventing diseases and major adverse outcomes

(please share) Immediate #postdoc job opening in the Millman lab at WashU Med (St. Louis, MO). Want to develop next-generation pancreatic islets for the study and treatment of diabetes? Email your CV to apply sites.wustl.edu/millmanlab/

I recommend the one-two punch of this story about how not-ready the trillions of dollars of ai market cap is to do anything useful for people with...

Does it happen irl anymore? Met my wife in lab. Grad student a year behind me met his wife in same lab. In the 90s, it seemed that was the most common way for scientists to meet partners. Are today's grad students not finding love in lab?

The thing you need to understand about the Right is that they are absolutely fine just plain burning down higher education if taking it over ideologically doesn’t work. They’re perfectly happy reducing it to ashes.

Yaghi, Kariko, Patapoutian ( @ardemp.bskyverified.social ), et al. should form an organization, American Nobel prize winners Born In Shithole Countries [ANBISC], and travel the country from now until Nov '26. They should should speak about what coming to America meant...

@warren.senate.gov publishes a report listing all the $$ that Congress gave to DOD to do DOD things that DOD instead spent on Stephen Miller's snatch and grab. As you look at these numbers, think how much cancer research could have been funded. www.warren.senate.gov/imo/media/do...

$140m. Think of how many cancer drug trials or free school lunches this could have paid for www.washingtonpost.com/immigration/...

Thanksgiving foliage

This is *losing* if that word means "giving away what your country spent the last 70 years striving, struggling, and spending for." If it were an emoji it would be a 🎀.

Movie I've watched? C'mon.

It's wild to read a paper in 2025 that reduces to practice an idea that was among the first I worked on as a grad student more than 30 years ago. I'm sad that the word "antibody" doesn't appear in the new paper, but I guess that's progress www.nature.com/articles/s41... www.pnas.org/doi/epdf/10....

For me, this is the highlight of the meeting. A basic rule of clinical trials was asked of the acting director for the FDA's Center for Drug Evaluation and Research, who is also an epidemiologist, and she got it completely wrong. That is about as good a summary of the situation as can be offered.

Don't look at this account's posts with your mouth full. 🤣🤣 #chemchat but sheesh, shouldn't there be a hashtag for stuff that just makes you smile? bsky.app/profile/inpr...

The rhetoric today is nearly indistinguishable from Know-Nothing rhetoric about the Irish, the Italians, and the Jews.

Good list at NYT, but missing one of my absolute favs, Patagonia Provisions sardines in coconut curry www.patagoniaprovisions.com/products/sar...

Some of it - yes, that's me. Some of it - c'mon, there's no way my #1 album in 2025 is from Dinosaur Jr.

Um, Apple Music?? Also, I listen to Apple Music every day and there's no way this list is correct.

Nobody voted for this

Fascinating drug discovery story here #chemchat #chemsky

Reminder: Your enzyme having that name DOES NOT mean that's all it does. Metabolic enzymes like PGDH have a bunch of substrates and the enzyme is usually named for the first and/or easiest to assay. Regardless, cool report on a cool drug target #chemsky #chemchat

It may not feel like it now, but this is a very dangerous time to be a criminal in the White House, and a great time to be a patriot. And the job of those patriots right now is to be as loud as possible to minimize the collateral damage. But make no mistake: there will be accountability. /fin

Risk, meet reward

TRUMP: If you’re trafficking drugs to the U.S. via the Caribbean I will kill you. ALSO TRUMP: If you’re doing time because you helped traffic 400 tons of cocaine to the U.S. via Honduras you get a “Full and Complete Pardon.” www.justice.gov/archives/opa...

The MAHA pitch was supposed to be that Americans don’t really need insurance, vaccines, or other “establishment” medical care — they just need better nutrition and less exposure to environmental toxins. And yet: www.nytimes.com/2025/11/26/h...

this should go without saying but if you were one of the lucky few we did get out of Afghanistan during the withdrawal and we got you out because you'd been working with us, deportation back is likely a death sentence.

Careful Rams. 21-0 in the first half against a team you should destroy is the most dangerous lead in the NFL.

And awesome. Why have I never thought of suspending my bathing suit before?

The guy who said nobody should listen to his medical advice is personally rewriting the Centers of Disease Control website. What kind of person does this? Someone you cannot trust.

Can’t believe the whole country has to suffer through the return of Dickensian childhood diseases because the worst, most ignorant attention-demanders decided other people’s expertise makes them feel bad

Weird and stupid

We've seen some remarkable outcomes in people with advanced, refractory cancers, including pancreatic, melanoma, and renal, with personalized neoantigen mRNA vaccines. But this work is now endangered. www.scientificamerican.com/article/pers...

People are so weird

Of course the White House is leaning into this. Because apparently they don't realize we exported more higher ed last year than natural gas & coal *combined*

Important new analysis identifying the scope of clinical trials disrupted because of NIH shenanigans. > 74 thousand trial participants affected jamanetwork.com/journals/jam... 1/4

As expected, Canada has lost its measles-free status because of the long-running outbreak there. With it goes the #measles elimination status of the entire zone of the Americas, the only division of the #WHO to ever have achieved measles elimination. www.statnews.com/2025/11/10/m...

Yeah, but my views on Argentina's leadership changed after listening to pca.st/episode/dc33...

I read Tbe Double Helix when I was in graduate school. The thing that most impacted me then and has stuck with me til now: they went on a ski trip (or some other vacation) when they were on the cusp of solving the structure. How!?!

And here's a YouTube link. www.youtube.com/watch?v=Oj0P...

Could this be true? Francis Crick, an academic for half a century, applied for only a SINGLE grant?! www.nature.com/articles/d41...

The plaintiffs have experienced violence for exercising their First Amendment rights under the constitution, Ellis says. Some have had that protected expression chilled by the violence from federal agents, Ellis says.

Thinking a lot about this thread tonight.

A poll from the journal Nature found that 75% of researchers in the U.S. are considering leaving the country. That includes a man who’s been dubbed the "Mozart of Math." (This PBS story on the scientific brain drain is heartbreaking & ominous for medicine, imo.) www.youtube.com/watch?v=yLvO...

🚨🚨 Today is the day 🚨🚨 Help us help the type 1 diabetic community Thanks

This is pathetic on two counts. First, the “Dear Leader” worship from Trump’s Cabinet is mind-boggling. Second, it’s dishonest — Trump’s been defunding science, driving talent overseas, and creating a brain drain.   Now, if there were a Nobel for idiocy, he’d be a finalist.

Halloween foliage