Absolutely this. Holden is consistently thoughtful and measured, and precisely for those reasons his editorial here must be heeded.

There is a through line from "If we stop testing right now, we’d have very few cases" Trump, Allentown, June 2020 to the ongoing steps by a know-nothing administration to dismantle instruments of measurement, because data poses a threat to its grievance-driven political priorities.

This reminds me of the time, back in ~1993, that I showed my grad school advisor Yahoo! for the first time. Back then it was the only organized way you could find anything online. He asked me to look for a name. Didn't find it. He left. I continued to scour resources... It was a porn star. 🤯

Gosh the responses to this post are so depressing. Looks like a few low quality polls have determined who will govern CA. I thought polls were supposed to PREDICT who people would vote for, not TELL THEM who to vote for.

Update - 1 egg 😢

Of all the harm this administration has done to US science, today's proposed changes to the way federal grants are awarded and administered is the most damaging yet. The text of the federal register document is impenetrably tedious by design, so here's an excellent summary of what it says.

An unapologetically angry post about what’s being done to US science:

Scoop: NSF has been quietly blocking new funds and grants to four top universities: Duke, Harvard, Princeton, and Yale. Dozens of proposals from PIs at these universities—and their collaborators—have been stuck at the Office of Award Management awaiting finalization for months.

It is also unbelievably dumb even by Trump administration standards. We are telling the world that we don't want their best and brightest people, their inventors and entrepreneurs, to come here ever again. Trump has guaranteed the decline of this country for decades to come

"They leaked his tax returns, they tried to destroy him." If revealing your official tax returns -- something every single president and VP for forty years before Trump did voluntarily -- could possibly "destroy" you, that is the scandal.

Update! 2 eggs!!

It's me! And my kid. I didn't give him any advice, but he's doing what I did. Stay in school.

And another bsky.app/profile/jsro...

Hummingbird nest (and egg!) in our butterfly mobile. 😂 #birds #birdsky

Hummingbird nest (and egg!) in our butterfly mobile. 😂 #birds #birdsky

What episode of The Boys is this from?

Scoop: There has been a massive shakeup at the US National Institute of Allergy and Infectious Diseases (NIAID). Eight of the top ten officials have now been pushed out since President Donald Trump took office. In @nature.com www.nature.com/articles/d41...

NEW: A serious staffing shortage — of the Trump admin's own making — is delaying the agency's ability to send billions to universities around the country, leaving labs reeling in the meantime. “I thought we were at rock bottom”, a senior NIH official said. “We are below rock bottom now.”

RIP to the chemist who enabled the insane Barry Bonds/Mark McGwire era in baseball. #chemsky #chemchat www.nytimes.com/athletic/727...

How does this account have < 300 followers- c’mon people…

Super basic but key foundation to all this: TNBC is called this because the cancer is negative for a triple of markers (HR, HER2, and PR) that have associated treatments. So it makes total sense that if we use modern methods to find what the tumor is positive for, we can use those to treat it.

Just found pix I took of my grad school apartment. 🤣 Pre-digital and pre-much else!

Saw this in the neighborhood today. A perfect encapsulation of America in 2026.

Emotional unavailability? Maybe I'm old, but I wanna see a list ordering chemistry profs based on Emotional control. You know, like leaving handwritten notes saying "See me" on your desk first thing Saturday morning... #chemchat

YouTube has removed one of my videos because I reported that women can still access abortion pills. I shared *factual & medically accurate* information about women's health—yet the platform says I'm "facilitating the sale of illegal drugs"

One of the most severe & lasting wounds to the US will be the current administration's efforts to drive scientists away from America. I'm starting to think that a rational pitch for D politicians is "Make America Great Again." Again, like in the recent days when we welcomed the best-of-the-best.

This is infuriating. Nobody who has an interest in American "greatness" would drive our best scientists out of the country. Once again, only someone who wants to diminish America would support this.

🕯️🕯️

The Senate passed the Voting Rights Act renewal in 2006 by a vote of 98-0. The Supreme Court majority gutted it on the grounds that the Justices personally dislike the impact.

I can't imagine what would more effectively recruit US scientific talent to other countries around the world than destroying universities, eliminating research funding, and demonizing the very concept of expertise.

Just for kicks I asked Copilot to compare daraxonrasib and ERAS-0015 and HOLY COW it is beyond stupid and terrible. The structural comparison is AFTER I had to guide the ai away from its first completely wrong answer. Basically everything is wrong. But if you didn't know that at first... #chemchat

Just the first year of destruction of just one area of American science. Nobody voted for this.

Gosh who would have done that? Oh.

Nobody voted for this. Fewer grants ->fewer discoveries, fewer scientists, fewer treatments, more misery, less wealth The only people who want this are those who want America to fail.

Another long article about the variety of uses for GLP1s that doesn't even mention type 1 diabetes. I understand that most readers don't know that type 1 and type 2 are totally different conditions, but isn't educating people the point of such articles? Also @danieljdrucker.bsky.social ...

Can't argue with clinical trial results. But if this compound is acting selectively through GSK3-beta, I'll... be beyond surprised. pubs.acs.org/doi/10.1021/...

My kids have measles, I can't afford gas, and I'm going to be dead within 2 years now that the CDC cancelled funding for the mRNA treatment that might have save my life. But at least now we have Secretary of War who is a Pulp Fiction fan.

Future headline: TRUMP SACRIFICES MANY AMERICAN LIVES AND WASTES HUNDREDS OF BILLIONS OF DOLLARS TO RESURRECT OBAMA'S JCPOA.

I'm sad that, at least based on the Bluesky search box, this is the most recent RevMed post. Hello people!! Today's news is a bfd!! ir.revmed.com/news-release...

The “America First,” president wants to cut billions of dollars from American innovation and scientific research.   From NASA to NIH, no one would be spared.   We cannot let this budget pass. www.nature.com/articles/d41...

How did I get to be *this* old without knowing *this* ??

One year ago, Peter Navarro touted 90 trade deals in 90 days

Absolutely amazing. When I started grad school there, Scripps hadn't conferred a single PhD and wasn't accredited. My son is graduating college this year, which makes me positive: my folks must have thought I was insane.

I read this book! Or at least until the author casually mentioned that SARS-CoV2 was engineered in a lab in Wuhan, then leaked. I thought - I just can't trust that this author has their head on straight. 🤷

It's absolutely ridiculous that graduating from Yale with a 3.7+ GPA is equivalent to: the admissions committee liked your grades, scores, & extracurriculars from 3 yr of high school. And G-d forbid you had to take quantum mechanics... If so the AdCom must have made a mistake! 🤦

All we need is for someone to show these peptides elicit an immune response (any response) Then we start calling them Chinese vaccines Then RFKjr and the MAHA masses will turn tail and sue the peptide/Chinese vaccine manufacturers to bankruptcy

Proof that a scientist who actually remembers what lab was like during the "first one in lab picks the music" era... InPrep still has only 224 followers after publishing all these absolute bangers. (or maybe it's the youngs who haven't bothered with Bluesky 🤷)

Nobody voted for this

Penn should just rename itself after its most famous alum. After that, they'd surely get all the grants.