A study by Scripps Research and @ucsandiego.bsky.social reports that subsets of hippocampal memory neurons occupy distinct high and low translation states. Published in @nature.com and co-led by @lippilab.bsky.social, the work maps protein production across ~20,000 single cells using Ribo-STAMP.

What a thrill to see this out! Our prospective, scalable, and target-centric solution for molecular glue discovery. More thoughts and details here: www.linkedin.com/posts/activi... Paper here: www.nature.com/articles/s41...

Calibr-Skaggs at Scripps Research and Kainomyx, Inc., today announced a new research collaboration, supported by the Gates Foundation, to pioneer novel malaria treatments that target parasite cytoskeletal pathways, with a focus on global access and affordability. More: ow.ly/z8wY50Yhi23

Assoc. Prof. @xinjin.bsky.social has been named a 2026 Sloan Research Fellow by the @sloanfoundation.bsky.social, recognized for pioneering in vivo Perturb-seq—a gene-editing approach combining CRISPR technology and single-cell RNA analysis to uncover how genetic variation shapes brain development.

Photographed Barry Sharpless at @scripps.edu. Two Nobels, for mastering chirality and inventing click chemistry. In his crowded office he spoke softly about life’s fragility and wonder. Still curious; still in awe. More: explorers.com/barry-sharpl... @nobelprize.org @nationalacademies.org #SciArt

"When I started doing chemistry, I did it the way I fished: for the excitement, the discovery, the adventure, for going after the most elusive catch imaginable in uncharted seas." - 2x @nobelprize.org winner, Barry Sharpless. @scripps.edu @nationalacademies.org @nasonline.org #SciArt

Congrats to Prof. Jeffery Kelly on being named to the @forbes.com Innovator 250 list! Recognized for co-founding FoldRx and advancing tafamidis—an FDA-approved drug for heart disease and neurodegeneration—his work helped lay the foundation for new therapeutic strategies.

Not all matters of the heart are metaphorical, including a damaged one ❤️‍🩹 Scripps Researchers are working with scientists at Calibr-Skaggs to advance regenerative approaches that could help injured heart tissue repair itself, moving beyond symptom management toward restoring function.

I photographed @erictopol.bsky.social at @scripps.edu. Calm, curious, grounded in evidence. No supplement hype. No product sponsorships. Just data. Diet, sleep, exercise, prevention. In a noisy longevity world, he’s a steady voice for real science. explorers.com/eric-topol/ @nationalacademies.org

'Fentanyl-Rewired: A 2-Azaspiro[3.3]heptane Core Preserves μ-Opioid Function' from ACS Medicinal Chemistry Letters is currently free to read as an #ACSEditorsChoice. 📖 Read the article: buff.ly/UgZCCza @scripps.edu

Chemists led by Scripps Research Professor Kim Janda report a core structural redesign of fentanyl that reduces respiratory depression while fully preserving its pain-relieving properties, as described in a study published in @acs.org and recognized in the #ACSEditorsChoice collection.

Congratulations to Scripps Research professor Darrell Irvine, who is featured in the 2026 TIME100 Health list. Irvine is recognized for his work in empowering the immune system to fight disease, including developing vaccines against HIV and cancer. More: ow.ly/orAY50YcZFx

Join @scripps.edu and Society for Science on February 18 for a conversation between Pete Schultz and @mayaajmera.bsky.social, moderated by Joe Palca. Register by Feb. 11. In person: https://ow.ly/CFBc50Y3V8F Virtual: https://ow.ly/tMAw50Y3V8E

Meet the speakers for next week’s fireside chat at Scripps Research 🎤 Peter Schultz, president and CEO of @scripps.edu, and Maya Ajmera, president and CEO of @society4science.bsky.social, join moderator Joe Palca (former @npr.org Science Correspondent) for a conversation on the future of science.

Join @scripps.edu and Society for Science on February 18 for a fireside chat on the future of STEM education, innovation and philanthropy, featuring Pete Schultz and @mayaajmera.bsky.social. Moderated by Joe Palca. In person: https://ow.ly/CFBc50Y3V8F Virtual: https://ow.ly/tMAw50Y3V8E

Scientists at Scripps Research and @mit.edu report a DNA-based vaccine scaffold that improves immune targeting of HIV by remaining immunologically “silent.” Published in @science.org, the DNA origami platform helps focus rare immune cells on vulnerable regions of the virus.

💊🌟 Meet a next-generation approach to cancer treatment. Switchable CAR-T is a programmable immunotherapy designed to give scientists greater control over how—and when—the immune system targets cancer. The technology is now being tested in a Phase 1 trial for metastatic breast cancer.

Asst. Prof. Yuzhong Liu studies how glycosylated molecules shape immune responses and drug behavior. Her lab produces QS-21, an FDA-approved vaccine adjuvant, and other complex natural products in baker’s yeast—reducing reliance on a decades-long, tree-based process.

Join @scripps.edu and Society for Science on February 18 for a fireside chat on the future of STEM education, innovation and philanthropy, featuring Pete Schultz and @mayaajmera.bsky.social. Moderated by Joe Palca. In person: ow.ly/CFBc50Y3V8F Virtual: ow.ly/tMAw50Y3V8E

Scripps Research scientist Prof. Jeffery Kelly received an unexpected visit from a patient whose life was dramatically improved by tafamidis—a revolutionary drug for treating neurodegenerative and heart diseases, developed by Kelly himself. #NationalPatientRecognitionWeek

At Calibr-Skaggs, @scripps.edu’s drug discovery division, scientists use the open-access ReFRAME drug library to take a second look at approved medicines or molecules with extensive human safety data, exploring how they might work against diseases often overlooked, like neglected tropical diseases.

Congrats to Scripps Research Professor Benjamin Cravatt on being elected as a Fellow of the AACR Academy. 🎉

The AACR is pleased to announce the Fellows of the AACR Academy Class of 2026. The Academy honors distinguished scientists whose contributions have propelled significant advances in cancer research and treatment. Learn more: buff.ly/ZZ268R4 #AACRFellows

Congratulations to Scripps Research chemist Benjamin Cravatt on receiving the 2026 NAS Award in Chemical Sciences from the National Academy of Sciences (@nasonline.org) for providing foundational insights into enzyme function and dysregulation in disease!

A brief look at where Scripps alumni are now, and the work they are doing across academia, biotech and public service.

Graduate student Abigail Reeves from Mia Huang’s lab shows us what a syncytiotrophoblast looks like on Maternal Health Awareness Day. 🔬💗 Her work in @pnas.org mapped glycan–protein interactions linked to placental cell fusion, offering new insight into placental development.

Congratulations to #NASmember Benjamin F. Cravatt of @scripps.edu, winner of the 2026 NAS Award in Chemical Sciences for providing foundational insights into enzyme function and dysregulation in disease! Learn more about his discoveries: www.nasonline.org/award/nas-aw... #NASaward #chemistry

For @mikerobe.bsky.social, science is more than a search for answers—it’s a chance to guide others along the way. In a Q&A with Scripps Research Magazine, he shares how he mentors young scientists and studies innate immune cells that protect barrier tissues like skin and gut.

From faculty recognition to major institute milestones, 2025 marked major scientific progress for Scripps Research that reflects the strength and reach of our research community. Explore the top moments from 2025: ow.ly/zsZV50XTEay

Surface morphometrics reveals local #membrane thickness variation in organellar subcompartments. New study from Michaela Medina, Ya-Ting Chang, Danielle A. Grotjahn @nanigrotjahn.bsky.social and colleagues @scripps.edu: rupress.org/jcb/article/... #Biophysics #StructuralBiology #Organelles #CryoET

Reported in #JCellBiol, a method developed in the lab of Associate Professor Danielle Grotjahn (@nanigrotjahn.bsky.social) measures membrane thickness directly inside intact cells and identifies ATP synthase clusters in curved, unusually thick membrane regions.

Join @society4science.bsky.social and @scripps.edu for a fireside chat on the future of science—exploring STEM education, discovery, and philanthropy through a shared Scripps family legacy. 🗓️ Feb 18, 4pm. Reserve your seat now! 💻 Virtual: ow.ly/STNi50XXplR 📍 In-person: ow.ly/v8Y050XXplS

We're pleased to announce that 45 Scripps Research scientists have been named to the #HighlyRankedScholars list by ScholarGPS, placing them among the top 0.05% of scholars worldwide based on research productivity, impact, and quality across all fields. ow.ly/TcLS50XVNJp

Prof. Benjamin Cravatt has been named the inaugural recipient of the Chi-Huey Wong Chemical Biology Award by the Chemical Society of Taiwan for pioneering ABPP, an approach to studying protein function in living systems that has advanced drug discovery. More: ow.ly/fKVw50XVU4H

In his #FrontRow lecture, Prof. Howard Hang explained how DNA sequencing revealed the scale of the human microbiome, and how his lab studies the microbial enzymes and metabolites that modulate immune signaling, influencing infection outcomes and responses to cancer immunotherapy. ow.ly/f2M850XSCEI

In 2025, our labs continued to generate breakthrough discoveries across chemistry, biology, infectious disease, immunology, cancer, neuroscience and beyond. This snapshot highlights the year’s progress and the impact our community continues to make. More: ow.ly/zsZV50XTEay

Scripps Research scientists published a new #mSystems article describing the @niaidnews.bsky.social Discovery Portal, a metadata-driven platform that enables discovery of infectious and immune-mediated disease datasets. More: ow.ly/iGwC50XSA8G #BiomedicalData #InfectiousDisease

Assoc. Prof. @nanigrotjahn.bsky.social was recognized in the #JCellBiol's The Year in Cell Biology: 2025 for her team’s paper, “Cytoplasmic ribosomes on mitochondria alter the local membrane environment for protein import,” which reveals the molecular architecture of protein import machinery.

New work from LeBlanc, Sobel, Constantinides (@mikerobe.bsky.social) et al. @scripps.edu demonstrates that transient depletion of riboflavin-synthesizing commensals in early life can adversely affect responses to subsequent infections. rupress.org/jem/article/... #MucosalImmunology #Microbiome #MAIT

Alcohol dependence disrupts signaling balance in a stress-processing brain region, according to new findings from the Fardon lab published in #FrontPharmacol. Blocking either pathway reduces relapse-like behavior, while inhibiting both cancels the effect.

A new technique developed by @liye-tsri.bsky.social’s lab and published in @cp-cell.bsky.social maps where covalent drugs bind cell by cell across the body, with the potential to guide safer drug development.

We've enrolled more than 700 participants (of 1,000 planned) in 3 weeks to a randomized trial for treatment of #LongCovid

Antibiotic use in early life impairs MAIT cell–mediated immunity in adulthood, say Gabrielle LeBlanc, Adam Sobel, Michael Constantinides (@mikerobe.bsky.social) and colleagues @scripps.edu: rupress.org/jem/article/... #InfectiousDisease #HostDefense #MucosalImmunology #LymphocyteBiology #Microbiome

Diagnosed with type 1 diabetes in childhood, Scripps Research scientist Josh Boyer uses his lived experience to improve diabetes education and explore new approaches to treatment. In our latest Q&A, he shares how he bridges patient care and research.

Celebrating another year of discoveries and the people behind them. Happy holidays from Scripps Research! 🎄🎉

A new @cp-cell.bsky.social study led by @ardemp.bskyverified.social and @rose-hill.bsky.social identifies a kidney mechanism that allows renin to adjust in real time, showing that PIEZO2 enables cells to sense physical forces and fine-tune renin release.

Electrically charged condensates are shown to induce localized changes in cell membrane voltage upon contact, according to a new Scripps Research study, revealing a previously unknown form of electrical transmission in cells with implications for bioelectric regulation.

A structure-guided nanoparticle designed by Professor Jiang Zhu published in @natcomms.nature.com stabilizes Ebola and Marburg surface proteins in their pre-fusion shape—prompting a strong antibody response in preclinical models and laying the foundation for a universal filovirus vaccine.

Congrats to Yuzhong Liu, PhD, who is named as a #PhF26 awardee of the @phrmafoundation.bsky.social Faculty Starter Grant in Drug Discovery, supporting her work in synthetic chemistry & biology to advance glycoside-based molecules for vaccine development. ow.ly/v5OP50XL48w

Excited to share research co-led by Gabby & Adam in @jem.org! Grateful to the NIH & @scripps.edu for support.