We've enrolled more than 700 participants (of 1,000 planned) in 3 weeks to a randomized trial for treatment of #LongCovid

Antibiotic use in early life impairs MAIT cell–mediated immunity in adulthood, say Gabrielle LeBlanc, Adam Sobel, Michael Constantinides (@mikerobe.bsky.social) and colleagues @scripps.edu: rupress.org/jem/article/... #InfectiousDisease #HostDefense #MucosalImmunology #LymphocyteBiology #Microbiome

Diagnosed with type 1 diabetes in childhood, Scripps Research scientist Josh Boyer uses his lived experience to improve diabetes education and explore new approaches to treatment. In our latest Q&A, he shares how he bridges patient care and research.

Celebrating another year of discoveries and the people behind them. Happy holidays from Scripps Research! 🎄🎉

A new @cp-cell.bsky.social study led by @ardemp.bskyverified.social and @rose-hill.bsky.social identifies a kidney mechanism that allows renin to adjust in real time, showing that PIEZO2 enables cells to sense physical forces and fine-tune renin release.

Electrically charged condensates are shown to induce localized changes in cell membrane voltage upon contact, according to a new Scripps Research study, revealing a previously unknown form of electrical transmission in cells with implications for bioelectric regulation.

A structure-guided nanoparticle designed by Professor Jiang Zhu published in @natcomms.nature.com stabilizes Ebola and Marburg surface proteins in their pre-fusion shape—prompting a strong antibody response in preclinical models and laying the foundation for a universal filovirus vaccine.

Congrats to Yuzhong Liu, PhD, who is named as a #PhF26 awardee of the @phrmafoundation.bsky.social Faculty Starter Grant in Drug Discovery, supporting her work in synthetic chemistry & biology to advance glycoside-based molecules for vaccine development. ow.ly/v5OP50XL48w

Excited to share research co-led by Gabby & Adam in @jem.org! Grateful to the NIH & @scripps.edu for support.

Research from Assoc. Prof. @mikerobe.bsky.social's lab identifies a probiotic-based solution to antibiotic-linked MAIT cell depletion. In preclinical models, pairing necessary antibiotics with a riboflavin-producing gut bacterium restored MAIT cell development during a key early-life window.

LeBlanc, Sobel, Constantinides et al. @scripps.edu show that antibiotic treatment in early life can deplete riboflavin-synthesizing commensals & impair #MAIT cell development, rendering adult animals more susceptible to bacterial #pneumonia. rupress.org/jem/article/... #Microbiome

Scripps Research professor Stuart Lipton has been inducted as a 2025 #NAIFellow into the National Academy of Inventors for pioneering work on the molecular drivers of brain disorders and for helping bring FDA-approved therapies for Alzheimer’s and Parkinson’s disease to patients.

The Yu lab reports a one-step method to stereoselectively attach fluorine to drug-like molecules using low-cost fluoride. The approach uses fluorine-18 for PET imaging to track bioactive compounds and accelerate drug discovery. More: ow.ly/kttg50XHyPg

Scripps Research prides itself on offering all students a tuition-free graduate education, and philanthropy-funded endowed fellowships give graduate students the freedom to pursue higher-impact science whose questions could transform science and medicine.

An enzyme-enabled route to synthesize saxitoxin—a nerve-blocking molecule—led by the Baran lab with Merck and the Roberto lab, bypasses marine sources and expands access to saxitoxin analogs for pain-therapy research, as shown in @nature.com. More at: ow.ly/b0Lq50XFXBs

Congrats to Scripps Research President & CEO Peter Schultz and EVP @erictopol.bsky.social for being named to the 2025 #SD500 list by the San Diego Business Journal, recognizing their leadership in advancing biomedical research, innovation and San Diego’s life sciences sector. More: ow.ly/iUqN50XFXsh

A @cp-cellreports.bsky.social study from @scripps.edu finds that SETX-deficient tumors can survive DNA breaks by activating a backup repair pathway called break-induced replication (BIR). Blocking key BIR factors prevents these cells from repairing DNA, revealing a synthetic-lethal vulnerability.

“It really gave me a lot of peace of mind that I could just focus on science without having to worry about where my next paycheck was coming from,” says Jose Colom-Lapetina, reflecting on how philanthropy shaped his experience at the Skaggs Graduate School. More: ow.ly/IqUK50Xyp1Y

From the genetic code underlying diseases to the chemical data driving drug discovery, scientists generate massive datasets. How do we organize this information to accelerate discovery? Scripps Research bioinformatician Andrew Su is tackling that question.

#ICYMI: @erictopol.bsky.social, Scripps Research EVP and founder of the Scripps Research Translational Institute, was listed among @usnews.com’s 2025 “Best Leaders”, recognized for his significant impact in business, education, health care and public service.

In a @nytimes.com feature on interoception, the body’s sixth internal sense, Scripps Research Nobel laureate @ardemp.bskyverified.social describes his lab’s work on Piezo proteins and a collaborative effort to build an atlas revealing how these internal signals shape emotions, decisions and health.

A single gift from Ellen Browning Scripps helped launch Scripps Research. Since then, 18 FDA-approved drugs have originated within our labs, improving the lives of people around the world. This #GivingTuesday, you can also be a part of that legacy. Visit scripps.edu/givingtuesday.

After immigrating to the U.S. from Lebanon, neuroscientist @ardemp.bskyverified.social found belonging in science—and did Nobel-winning work on the sense of touch: buff.ly/boCE6ZY

Great story by @carlzimmer.com in @nytimes.com that nicely conveys the excitement for the emerging field of interoception. @dulaclab.bsky.social and others are featured, including my tattoo 😳! Gift article link: www.nytimes.com/2025/11/25/s...

I have a story today about interoception--a kind of sixth sense that delivers information from within our bodies to our brains. nyti.ms/4rfTDtn

In his Front Row lecture, Benjamin Cravatt presented activity-based proteomics, an approach that tracks how small molecules interact with proteins in their natural environment. His lab is using it to uncover drug candidates for targets long considered “undruggable.” More: ow.ly/Osb550XvaTG

San Diego families connected with Scripps Researchers at the Fleet Science Center for our second annual Discovery Day! 🧪🥼 More than 60 grad students and postdocs led hands-on demos in chemistry, neuroscience, cancer research, vaccines, and more.

Founder and director of the Scripps Research Translational Institute, @erictopol.bsky.social, and Julia Moore Vogel, co–principal investigator of the Long COVID Treatment Trial, were featured in @wired.com, sharing insights on a nationwide study testing GLP-1s for long COVID.

Congratulations to Eric Topol, MD (@erictopol.bsky.social), Scripps Research EVP and founder of SRTI, who was listed among @usnews.com’s 2025 “Best Leaders”, recognized for his significant impact in business, education, health care and public service. More: ow.ly/cOTk50XuUvX

Scripps Research scientists Bryan Briney and Andrew Ward have received $1.1M from CHAVD for high-performance computing to accelerate HIV vaccine research, enabling tests of up to millions of candidates in the time it once took to study a few dozen. More: ow.ly/TLrm50XusmI

Modeyso™, the new FDA-approved treatment for a rare and aggressive pediatric brain cancer known as diffuse midline glioma, marks the 18th therapy that Scripps Research scientists have helped advance, thanks in part to two former members of the Janda lab.

The second annual Biotech Innovation Summit brought together leaders across science and industry to explore how strategic partnerships can transform early-stage research into real-world therapies. Revisit key moments shaping the future of biotech. 🔬🌟

New @science.org study from @ardemp.bskyverified.social’s lab, co-authored by @yunxiao-dr.bsky.social, shows how PIEZO proteins sense stretch and pressure in the uterus to help coordinate labor, while connexin 43 synchronizes muscle activity across cells.

Congratulations to eleven Scripps Research scientists named to the global list of #HighlyCited2025 Researchers by @clarivate.com, which recognizes individuals who exemplify research excellence and broad influence across fields including chemistry, microbiology, neuroscience and more.

Scripps Research Nobel Prize–winning neuroscientist @ardemp.bskyverified.social was featured on @scifri.bsky.social, where he reflected on the biology of touch, his early career path in science, and why he believes great scientists are practical dreamers who balance bold ideas with scientific rigor.

Using proximity labeling and a derivatized galectin-3, scientists in the lab of Professor Mia Huang mapped glycan–protein interactions that drive placental cell fusion, published in @pnas.org, offering new insight into placental development.

At the #JAWARDS2025, the San Diego Press Club (@sdpressclub.bsky.social) recognized Scripps Research’s Office of Marketing and Communications for excellence in science communication, with top honors in video production, magazine design and press release writing.

We’re just a few days away from Scripps Research Discovery Day at the Fleet Science Center! 🌟 This year’s event is shaping up to be even bigger, with 50+ graduate students and postdoctoral researchers leading interactive experiences in neuroscience, chemistry, immunology and more.

Just as we can distinguish between the sting of heat and the chill of cold, our immune system is finely tuned to detect a range of threats—from viruses and bacteria to allergens and injury—thanks to constant crosstalk between sensory neurons and immune cells.

Lights, camera, science! 🎬🔬🌟 Scripps Research Dean of Graduate and Postdoctoral Studies Keary Engle, PhD, and postgraduate students Jia Meng Pang and Paige Bensing joined KUSI News to share a sneak peek of Discovery Day at the Fleet Science Center!

The National Institutes of Health (NIH) has awarded a $6.9M grant to four Scripps Research scientists led by Bryan Briney, PhD, with Renan de Carvalho, PhD, Andrew Ward, PhD, and Darrell Irvine, PhD, to uncover how HIV vaccines can generate long-lasting immune protection. More: ow.ly/UcZC50Xmczc

The Society for Neuroscience (@sfn.org) has honored Professor Li Ye @liye-tsri.bsky.social with the Tianqiao and Chrissy Chen Young Investigator Award for pioneering techniques that set new standards for studying neural activity, advancing how researchers visualize brain function. ow.ly/cLWK50Xm8qK

🚀 Congrats to Associate Professor @xinjin.bsky.social, who has been named the 2026 Peter Gruss Young Investigator by @mpfneuro.bsky.social, recognized for pioneering high-throughput in vivo Perturb-seq and illuminating how mutations shape the brain development and circuit function! ow.ly/1XTQ50Xkwf4

We’re thrilled to announce that Dr. Xin Jin has been named the 2026 Peter Gruss Young Investigator. Her pioneering work developing high-throughput in vivo screening strategies is unraveling the genetic mechanisms of neurodevelopmental disorders. buff.ly/RI9emVa

Wishing you a Happy Halloween from all of us at Scripps Research! 👻 🎃 This year’s Spooky Social Hour brought costumes, candy, and scary good fun to campus. Our faculty and staff showed off their Halloween spirit with ghoulish, clever, and downright fa-BOO-lous looks!

Scripps Research Prof. Luc Teyton has received a $3.2M grant from the NIDDK to study how VAFs—rare pancreatic cells involved in antigen presentation—may contribute to type 1 diabetes. In collaboration with Asst. Prof. Joseph Jardine, the team will examine how inflammation disrupts immune tolerance.

From skin to gut, the body is constantly interpreting signals—deciding what’s dangerous and what can be ignored. Inside the lab of Assistant Professor Alejandra Mendoza, researchers show how neurons and immune cells coordinate defense across barrier tissues. 🧵⬇️

Join us for the 2025 Welch Conference on Chemical Research, “New Horizons in Drug Discovery,” Oct. 27-28 in-person or virtually. The event is completely free! Find more information here: welch1.org/conference/c...

Long before a medicine reaches a pharmacy, hospital, or clinic, it begins inside a lab like those at Scripps Research. Here, scientists spend years turning discoveries into new therapies, leading to more than 15 FDA-approved treatments that have helped people worldwide. More: ow.ly/qPXy50Xjc18

Ines Forrest, Ph.D., didn’t have a clear career path growing up. As part of a military family, her constant travels sparked a wide array of interests, including science. But it was the loss of her aunt to cancer in middle school that inspired her to dedicate her life to scientific research.