Antibiotic use in early life impairs MAIT cell–mediated immunity in adulthood, say Gabrielle LeBlanc, Adam Sobel, Michael Constantinides (@mikerobe.bsky.social) and colleagues @scripps.edu: rupress.org/jem/article/... #InfectiousDisease #HostDefense #MucosalImmunology #LymphocyteBiology #Microbiome

Research from Assoc. Prof. @mikerobe.bsky.social's lab identifies a probiotic-based solution to antibiotic-linked MAIT cell depletion. In preclinical models, pairing necessary antibiotics with a riboflavin-producing gut bacterium restored MAIT cell development during a key early-life window.

Excited to share research co-led by Gabby & Adam in @jem.org! Grateful to the NIH & @scripps.edu for support.

Thankful for this talented group!

Nice to catch up with fellow @belkaidlab.bsky.social alum @michelenamorado.bsky.social in sunny San Diego!

Mini golf to celebrate my promotion to associate professor. Grateful to the past & present trainees that made this possible!

Our work co-led by @scripps.edu students Dominic & Jonathan shows that microbial tropism determines how metabolites are presented to #MAIT cells!

Congrats to @scripps.edu PhD candidate Dom Haas, who was offered a Canada Graduate Scholarship, the highest doctoral award from NSERC! 🗡️🍾🥂