Thrilled to share our latest work--combining CATCH with whole-body HYBRiD imaging, leveraging click chemistry to visualize and identify drug-targeted cells across organ systems. Led by a brilliant team: former PhD student Ben Pang and former undergrad Verina Leung.

A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists! www.nature.com/articles/s41...

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

The @biophysicalsoc.bsky.social IDP Subgroup Postdoctoral Award honors outstanding Postdoctoral Fellows for research accomplishments with disordered proteins. APPLY by sending your nomination packet to [email protected] by Dec 15th! Info at: www.biophysics.org/awards-fundi...

Congratulations to Lucy Shapiro, 2025 #LaskerAward winner! – “for a 55-year career in biomedical science – honored for discovering how bacteria generate distinct daughter cells; and for exemplary leadership at the national level” #Lasker2025 #LaskerLaureate #devbio 🧪

Over the moon to see my postdoc advisor, Prof. Lucy Shapiro, receive a Lasker Award—a brilliant salute to her decades of trail-blazing science, visionary leadership, and transformative mentorship. Congratulations!

Join us this Thursday, June 12, at 1PM for the first of our three summer virtual masterclasses — where seasoned PIs share how they transformed foundational science into VC-backed startups. 🔬🌟 🎟️ For more info, contact [email protected].

🎉 Congratulations to Wolfgang Baumeister @maxplanck.de, awarded the 2025 #ShawPrize in Life Science & Medicine for pioneering work in cryo-ET! Learn more 👉 europa.eu/!JBXDBG #FrontierResearch #ERCSyG #CryoET #StructuralBiology #shawprize2025

Now published! Big congrats to first author @gginell.bsky.social We are actively working improving/updating various aspects of FINCHES; don't hesitate to reach out if you run into issues, have questions. www.science.org/doi/10.1126/...

In collaboration with the @lindorfflarsen.bsky.social group we release our map of degrons in >5,000 human cytosolic proteins with >99% coverage. A machine learning model trained on the data identifies missense variants forming degrons in exposed & disordered regions. Work led by @vvouts.bsky.social.

AlphaFold is amazing but gives you static structures 🧊 In a fantastic teamwork, @mcagiada.bsky.social and @emilthomasen.bsky.social developed AF2χ to generate conformational ensembles representing side-chain dynamics using AF2 💃 Code: github.com/KULL-Centre/... Colab: github.com/matteo-cagia...

Striking new study from @archaeon-alex.bsky.social's lab just out in @science.org on multicellular development induced by compression in Archaea: www.science.org/doi/10.1126/...

Announcing the joint @idpseminars.bsky.social / BPS IDP Subgroup Trainee Symposium Speakers! Join us on Mar 27, 12–2pm CST for 6 exciting talks focused on Intrinsically Disordered Proteins as part of #BophysicsWeek2025 with the @biophysicalsoc.bsky.social Sign up now using the QR code below!

This summer in beautiful Santa Barbara we will run a 3-day conference on “Biological Physics of Biomolecular Condensates: Bridging Theory and Experiment” June 16 to 18th. Register now: www.kitp.ucsb.edu/activities/b...

Big health breakthrough: a protein from tardigrades can now protect human cells from radiation. That’s going to lead to better cancer therapies.

New Preprint ‼️ Work led by the incredible @ananyac2000.bsky.social 💃🏽💃🏽 Mpipi-T is finally here!!! 🥳🥳 👇🏽👇🏽 www.biorxiv.org/content/10.1...

MBoC #CallForPapers: Special Issue on Biomolecular Condensates Submit to be considered by lead editors: Amy Gladfelter, University of North Carolina Jeffrey B. Woodruff, UT Southwestern Medical Center Huaiying Zhang, Carnegie Mellon University www.molbiolcell.org/biomolecular... #CellBiology

From MBoC AI: A transformative opportunity in cell biology, by Sandra Schmid, Chan Zuckerberg Biohub Network, et al. doi.org/10.1091/mbc.... #CellBiology

Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA. Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...

First senior-author paper is out today in the Journal of Microscopy! 🧪🔬 We present the first 3D printed microscope where both the optics & frame are entirely 3D printed - a low-cost, accessible, and reproducible tool for histological imaging! onlinelibrary.wiley.com/doi/full/10.1111/jmi.13398

In a new op-ed for the @sandiegouniontribune.com, Scripps Research President and CEO Pete Schultz discusses how proposed changes to federal science funding could have unintended consequences for biomedical research, innovation, and the broader life sciences ecosystem in San Diego.

Ever wondered how mammalian cells sense osmotic stress? There's gotta be a signaling pathway, right? We propose a *one-component system*: NFAT5, the transcription factor that executes the osmoprotective response, is also the stress sensor! www.science.org/doi/full/10....

🎉🎉 Kudos to @bornanovak.bsky.social , Jeff, Ryan, and @alexholehouse.bsky.social —this breakthrough work paves the way for exciting new frontiers in disordered protein research! 🌟✨

Part 2 is starting soon! 🤩

Part I of BIV subgroup starts in an hour (8:30 am PT) Join us!

🚀 Join us at #BPS2025 tomorrow at 8:30 AM for a spectacular lineup of cutting-edge methods & biology in Biopolymers In Vivo! 🧪🔬 🧠 AI & IDP phase behavior | 🌱 Protein thermosensing | ❄️ Cryo-EM 🧬 GTPase activity | 🛠️ Engineered condensates | 🤖 Deep learning | 💧 Phase separation

Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5

🎉🧪New perspective paper! Single-point missense mutations are common in disordered regions but are often overlooked👀. We analyzed thousands of IDR point mutations associated with human congenital diseases to show that many can significantly change local IDR ensemble structure! shorturl.at/iIbLX

Who's going to #BPS2025? Please join us at the MGO Symposium @mgo-bps.bsky.social on Saturday 1:30 pm Room 511ABC Featuring experiments, simulations, and all the scales by @serenasanulli.bsky.social @melikel.bsky.social @maristizabal.bsky.social @janhuemar.bsky.social and more Please repost! 🚀✨

Announcing the Biophysics Week IDP Trainee Symposium on March 27 at 12pm CT hosted by @idpseminars.bsky.social & The BPS IDP Subgroup! Join via Zoom for talks by talented grad students & postdocs. Abstract submissions are open! See flyer for more details! #BiophysicsWeek @biophysicalsoc.bsky.social

Your Action Is Needed! Congress needs to hear from scientists. Call your representatives to oppose funding freezes and restrictions on research. Find contact info at govtrack.us and make your voice heard today! #SciencePolicy www.ascb.org/science-poli...

@lizneeley.bsky.social is publishing a weekly newsletter to track the ongoing attacks in science and higher ed. If you want to keep abreast without drowning in the news, I recommend it: buttondown.com/liminalcreat...

New review / perspective with @albertilab-tud.bsky.social on our thoughts on condensate speciality and recruitment, focusing on interplay between site specific and chemically specific interactions www.cell.com/molecular-ce...

The deadline to apply for the MBL Physiology course is fast approaching, January 27th! Consider applying to this amazing, life-changing research discovery experience in Woods Hole! www.mbl.edu/education/ad...

It's about time we have a conversation about the role of structured protein domains in form and function of bimolecular condensates. Proud of graduate student Nate Hess for taking the lead on synthesizing these ideas and identifying important gaps in the field!! www.sciencedirect.com/science/arti...

Are you interested in the role of protein condensation in plant biology? Come work with me at Syracuse University!

PhD opportunities (yes, plural!) We will launch a center of excellence “Plat-PATH” with @bjornppedersen.bsky.social this summer. We have an opening for some PhD students to work on plant hormone transporter mechanism. - Details and application link: tinyurl.com/44hf9zkd Please repost 💚

Two weeks left to apply for this year's Physiology Course! We are looking forward to another exciting summer 🔬🦑☀️

Congratulations, Alex, on this truly well-deserved honor! 🌟✨ It’s been an absolute privilege working together and witnessing your incredible creativity and dedication. The future is bright, and I’m thrilled to continue supporting you on this amazing journey. Onward and upward! 🚀👏🔥 #HannaGrayFellows

MBoC: An evolving champion of cell biology MBoC's new Editor-in-Chief discusses his thoughts on ASCB's scientific journal and its future. Read to learn more: www.molbiolcell.org/doi/10.1091/...

The scientist who is responsible for driving GLP-1 drugs for the treatment of obesity and testing them for prevention of Alzheimer's disease—Lotte Bjerre Knudsen— tells her story in a remarkable conversation. Full transcript, or video, all free, no ads. erictopol.substack.com/p/lotte-bjer...

1/Interested in biomolecular condensates? If yes, check 10.1073/pnas.2419610121 where we describe the in situ architecture of the PomXYZ co-condensate using cryo-correlative light and electron microscopy & in situ cryo-ET Wonderful coll/w Baumeister lab @madic.bsky.social‬ #teamtomo #cryoET #cryoEM

Is chromatin ordered or disordered? It all depends on the linker DNA length. Check our latest work with Mike Rosen and Sy Redding. We explore how changes in linker DNA length (as small as 1 bp) fine-tune chromatin structure, between order and disorder, and the properties of chromatin droplets

Excited to share our preprint, work by Anthony Gurunian, showing that #condensates can induce localized potentials in membranes + an analytical framework, with important biological implications, collaboration with @kerenlasker biorxiv.org/cgi/content/...

1/ 🚨We’re thrilled to share our latest study: "Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟 www.biorxiv.org/content/10.1... How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️