So cool! I watched this 10x in a row.

Yes definitely! As a starting point, our lab had compiled a database of dynamics measurements for various TFs obtained through SMT, FRAP, FCS etc. (www.mir-lab.com/dynamics-dat...) and we want to continue to expand it.

1/🧵 Can transcription factor condensate formation be explained without phase separation? Our new preprint introduces SPARK, a simulation tool that reproduces condensate behavior (clustering, fusion, FRAP) from diffusion & binding kinetics alone. Movie: 60 sec FRAP sim www.biorxiv.org/content/10.6...

Thank you, we hope people use it to think about condensates in various systems! SPARK isn’t sequence-based but rather works by modulating kinetic parameters (diffusion coeff, binding probability, residence time etc.) which does affect properties like brightness and persistence of condensates (Fig 1)

The Bisson Lab at IU (bissonlab.com) is hiring makers/builders/engineers across all career stages to join our team in one of the most exciting and crazy projects I've set to work on. Candidates can email us: [email protected] More info in the thread [1/3]

Discussion Meeting of the VAAM special group "Microbial Cell Biology" October 5–7, 2026 | Marburg, Germany More information: mcb2026.eventbrite.com

I'm moving to Purdue University as a tenured professor this summer! Excited to hire postdocs there and get a lab up and running with @runxishen.bsky.social as co-lead. More details: www.linkedin.com/posts/anneca...

"Elsevier incurred costs of around £1.7 billion last year, which included investment to develop new technology and for improving services." Let that sink for a min. $1.7B expenses ($2.7B revenue and $1B profit) and they expect us to believe they're developing any sorts of technology.

We had covered the history of traction force microscopy (TFM) earlier: bsky.app/profile/epim... But what about applying TFM into more physiologically relevant systems, such as those in 3D? I am @barrasa-fano.bsky.social and I'll be your guide through this thread on #3DTractionForceMicroscopy.

HALOPHILES YESSSSSSSS

Can't miss this amazing study on the ribosome structure of the Haloferax archaeon 👏🏼👏🏼👏🏼!! Congrats to my good friend @diorgeps.bsky.social and all the other ppl involved!!

Another paper on a topic we never worked on before: a new ribosomal hibernation! Under the leadership of the super-postdoc Diorge, Davis Lab (ribo-cryoEM master), and @vikramalva.bsky.social (protein-evo whisperer), we identified AHA (not the song, but archaeal hibernation AMPKγ factor). (1/2)

Very cool work led by @diorgeps.bsky.social from the labs of @archaeon-alex.bsky.social & Joey Davis (MIT)! They solved the Haloferax volcanii ribosome and characterize AHA, a conserved archaeal hibernation factor. With several recent related preprints, it’s an exciting moment for the field!

Excited to share this new Preprint from our lab led by PhD Candidate Carl Stone (defending Tuesday). Here we present a framework for longitudinal rbTn-Seq and apply it to the Microbial extended growth curve to resolve the fitness seascape through growth, death, and long-term stationary phase!

The interplay between biomolecular assembly and phase separation. 🔗 buff.ly/lvTQhIM

🚨 Alarm!!! 🚨 AI/ML course for microscopy image analysis!!! 🧐 In 2026 at Janelia (@hhmijanelia.bsky.social), no tuition, housing and meals provided! Isn’t that borderline unbelievable?!? 20 students, ~14 TAs and lecturers 🗓️ June 4-18 2026 ✍️ Jan 15 2026 ✍️ 🔁 pls!! www.janelia.org/you-janelia/...

Another #notTHECover unfortunately. But this gorgeous, Tron-like vibe, drawn by the amazing @munafomarzia.bsky.social for our recent #ExM work with @gautamdey.bsky.social & @centriolelab.bsky.social will still be printed out in the lab. Read here: www.cell.com/cell/fulltex...

I am beyond excited to announce that the Bisson Lab has a new home!!! Starting January 2026, I will join the Biology Department at Indiana University Bloomington as Associate Professor with tenure. I am actively recruiting scientists across all levels. More in our website: bissonlab.com/join [1/4]

I am (months) late, but you HAVE TO read @huepfkiesel.bsky.social (there is an update version). How can ParM "turned MreB” in cyanos? shorturl.at/JXMjy This will become a classic. Such a clear example of homology =/= function. We need more studies to collect larger sample sizes to test it.

Episode 17 - perhaps my favorite yet. How do you write a forum.image.sc post that will get you the answers you need without revealing information you don't want to tell? @erinweisbart.bsky.social and I go through what the experts need to know to help you. Post your sci q's today on forum.image.sc !

I’ve been regularly volunteering at a food bank for about a year and please, if you want to help, consider donating cash. For $3, they can provide 15 meals and what they can do with the money you might spend on a few cans can be converted to vastly more in fresh fruit, vegetables, dairy, or meat.

"Electroboy" is my memoir about my battle with bipolar disorder and which is being made into a feature film with Timothee Chalamet. The book is out of print - I have h/c and p/b copies which I inscribe to you and ship overnight to you. The cost is $30 for a h/c and $20 for a p/c - send me a DM!

This is one of my fav bac cell div papers. It's remarkable how much we've learned about cytokinesis in the past decade, and how much we still don't know. This paper harmonizes many of the disagreements in the field, like what limits construction rates (1/4)

It bears repeating that nearly the entire US enterprise in science and technology has been irreversibly gutted. This is shocking. All this loss has occurred without any real benefit to the average US citizen. Except we now have the biggest, best funded secret police force perhaps ever. Yay for us!

Collective cell motion has many forms, but rotation is the coolest of them all. I'm @onenimesa.bsky.social , and in this short🧵, I'll highlight some instances of global tissue rotation like this one from @BauschLab

Trump doesn't seem to see that some people are still immune to his threats. Jack White criticized Trump's Oval Office decor. The White House then called White a "washed-up, has-been loser... masquerading as a real artist." And White, undeterred, posted an absolutely blistering takedown in response.

We all need both government and each other to survive in society. Let's contribite to support those who need.

🎨 © René Magritte

🍀🔬 CSLD5-mediated cell wall remodelling regulates tissue mechanics and shoot meristem growth @natcomms.nature.com www.nature.com/articles/s41... Movies: Cell division orientation in wild-type (attached) and csld5 (comment) shoot apical meristem.

New preprint up now! Interested in the evolution of halophily within DPANN archaea we decided to investigate the sister phylum to the Nanohaloarchaeota, GTDB phylum EX4484-52, for which we propose the name Caliditerrarchaeota www.biorxiv.org/content/10.1...

Check out this awesome study from my phenomenally talented colleague @accorsi-alice.bsky.social ! Apple snails can regrow their eyes! How do they do this? 👀 Read below ⬇️ to find out more! #regeneration

I'm tired of people "liking" my #Epstein and #Trump posts. The point, folks, is to "repost" them. Spread the word about these two disgusting #pedophiles and #rapists

With my memoir, "Electroboy: A Memoir of Mania," a chronicle of my battle with bipolar disorder about to be made into a feature film, I'm sharing this interview with Stephen Fry the English actor, comedian, writer, director, narrator, and broadcaster. Enjoy! www.youtube.com/watch?v=JUpt...

Great opportunity! The Uni Vienna has launched a call (APART) for 4-funding for outstanding postdocs from a US institution. The host lab has to nominate by 1 August a candidate for further selection. Anyone interested in our work please contact me by email with CV/motivation letter. Hurry up!

Are you developing with TrackMate? If yes let's get in touch: I plan to make API breaking changes in the future version (v8, soonish) that will break existing detector and segmentation algorithms integration. Details on the forum: forum.image.sc/t/upcoming-b...

Excited to share our new paper in @cellreports.bsky.social that reshapes our understanding of chromosome organization's deep evolutionary roots! Our work dives into the origins of the machinery that structures our very genomes. 🔗: doi.org/10.1016/j.ce... #Genomics #Evolution #CellBiology #LECA

Alright fellas. Come one come all, #amateurbiology poster presentation at #asmicrobe on our first set of methylation screening results on Halococcus. Come ask about an exciting new finding I couldn't put on the poster! #archaeasky EEB 1147 🧪🧫🦠

FINALLY out in #Science Advances! 🎉 3 years of hard work, a fantastic team — and I’m proud to be first and co-corresponding author! It's about Plexin signaling driving collective cell migration & organ sculpting. Check out the videos 😀 www.science.org/doi/10.1126/... #DevBio #CellBio #Microscopy

Special kudos to 1rst authors @serenaflori.bsky.social @fmikus.bsky.social @eliottflaum.bsky.social, @embl.org EMCF facilities, @yschwab.bsky.social, @embltrec.bsky.social for the TREC samples & of course unique ExM gourous, collaborators and friends @dudinlab.bsky.social & @gautamdey.bsky.social

Excited to share the lab's 1rst preprint! Rapid high-res immunofluorescence is now possible in cultured & environmental diatoms thanks to 4-fold expansion microscopy. A step-change for comparative cell biology in one of the most important phytoplankton groups on the planet 🥳 tinyurl.com/m9s5su7s 1/2

The best post-COVID meeting I've attended. Each talk was a "wait, what?" moment. It is beautiful to see how technology and the expansion of different subfields have pushed prokaryotic cell biology from a model organism-focused enterprise to one that is question- and discovery-driven.

First post on Bluesky! Our paper on previously uncultured Group-TE Glissomonad protists has been published. Video teaser below. #protists #ProtistsOnSky journals.asm.org/doi/10.1128/...

XKCD’s take on archaea

Reposting as I hear about a German Pubmed-like initiative: let's build on Europe PMC which is already great

What it has become a classic review published every ~5y, Polschroder (UPenn) and Schulze (RIT) summarize the Mol-Cell Bio technical advances for Haloferax volcanii , the "E. coli" of the archaeal models. Proud of our community progress given the genome was published only 15y ago! asm.social/2qE

🧵 Excited to share our latest preprint! www.biorxiv.org/content/10.1... We developed a method to generate high-affinity binders against membrane proteins in their native-like environment! 🧪 #MembraneProteins #Nanobodies

Preprint: IntAct-U-ExM enables robust, isoform-specific expansion microscopy of actin networks in yeast and mammalian cells. A cool study led by @anubhavdhar.bsky.social in collaboration with Sudarshan and Deepak Nair. www.biorxiv.org/content/10.1...

Today is the inaugural Duke Climate and Fungi symposium. Arturo Casadevall is the first keynote speaker. “Whenever the earth does poorly, the fungi do well” mgm.duke.edu/about-mgm/se...

AN IMMENSE WORLD: YOUNG READERS EDITION is out today! 🥳 I’m really grateful to AnnMarie Anderson for adapting it, Rebecca Mills for illustrating, Tom Russell for shepherding, and Rose Eveleth for reading the audiobook. (And it’s dedicated to Typo.) bookshop.org/p/books/an-i...

We don’t protect science by automating it. We protect it by funding the people who dedicate their lives to it. #AI #ScienceMatters