Ciccone, Giuseppe, et al. "Epithelial Cell Mechanoresponse to Matrix Viscoelasticity and Confinement Within Micropatterned Viscoelastic Hydrogels." Advanced Science 2025 #EpithelialMechanics doi.org/10.1002/advs...

We know tissue mechanics matter in healing, but what happens at the chromatin level? Our new preprint shows that chromatin briefly “de-wets” from the lamina, then re-wets to kick off repair. Mechanics→chromatin→contraction→healing. Led by amazing PhD students Guillermo Bengoetxea & Lenka Backová 🙌

Shroff, N. P., Xu, P., Kim, S., Shelton, E. R., Gross, B. J., Liu, Y., ... & Klein, O. D. (2024). Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development. Nature cell biology, #EpithelialMechanics www.nature.com/articles/s41...

Ever wondered how to control stretch/compression in your epithelial system? Do you know why it’s important, which mechanotransduction mechanisms could be involved? I am @valeriaventurini.bsky.social and today I will guide you through this journey.

Ever wondered how to control stretch/compression in your epithelial system? Do you know why it’s important, which mechanotransduction mechanisms could be involved? I am @valeriaventurini.bsky.social and today I will guide you through this journey.

Di Meglio, I., Trushko, A., Guillamat, P., Blanch-Mercader, C., Abuhattum, S., & Roux, A. (2022). Pressure and curvature control of the cell cycle in epithelia growing under spherical confinement. Cell reports, #EpithelialMechanics doi.org/10.1016/j.ce...

Faure, L. M., Venturini, V., & Roca-Cusachs, P. (2025). Cell compression–relevance, mechanotransduction mechanisms and tools. Journal of Cell Science, #EpithelialMechanicsReview doi.org/10.1242/jcs....

Gudipaty, S. A., Lindblom, J., Loftus, P. D., Redd, M. J., Edes, K., Davey, C. F., ... & Rosenblatt, J. (2017). Mechanical stretch triggers rapid epithelial cell division through Piezo1. Nature, #EpithelialMechanics www.nature.com/articles/nat...

Conti, S., Venturini, V., Cañellas-Socias, A., ... & Trepat, X. (2024). Membrane to cortex attachment determines different mechanical phenotypes in LGR5+ and LGR5-colorectal cancer cells. Nature Communications, #EpithelialMechanics www.nature.com/articles/s41...

Mäntylä, E., & Ihalainen, T. O. (2021). Brick Strex: a robust device built of LEGO bricks for mechanical manipulation of cells. Scientific Reports, #EpithelialMechanics www.nature.com/articles/s41...

Eisenhoffer, G. T., Loftus, P. D., Yoshigi, M., Otsuna, H., Chien, C. B., Morcos, P. A., & Rosenblatt, J. (2012). Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia. Nature, www.nature.com/articles/nat... #EpithelialMechanics

How can we use cell shapes and geometry to study mechanics of tissues? I'm @juliaeckert.bsky.social, and with this thread, I would like to show you the secrets of cells and tissues. Let’s connect biology with a little bit of physics. Don't be scared and get inspired 😀. #EpithelialMechanics

How can we use cell shapes and geometry to study mechanics of tissues? I'm @juliaeckert.bsky.social, and with this thread, I would like to show you the secrets of cells and tissues. Let’s connect biology with a little bit of physics. Don't be scared and get inspired 😀. #EpithelialMechanics

Hoffmann, L. A., Carenza, L. N., Eckert, J., & Giomi, L. (2022). Theory of defect-mediated morphogenesis. Science advances, 8(15), eabk2712. #EpithelialMechanics buff.ly/wUYJE0s

Bi, D., Lopez, J., Schwarz, J., & Manning, M. L. (2015). A density-independent rigidity transition in biological tissues. Nature Phys 11, 1074–1079. (2015). #EpithelialMechanicsReview buff.ly/lJjDaK3

Roshal, D. S., Azzag, K., Le Goff, E., Rochal, S. B., & Baghdiguian, S. (2020). Crystal-like order and defects in metazoan epithelia with spherical geometry. Scientific reports, 10(1), 7652. #EpithelialMechanics buff.ly/B0dGm2o

Lemke, S. B., & Nelson, C. M. (2021). Dynamic changes in epithelial cell packing during tissue morphogenesis. Current biology : CB, 31(18), R1098–R1110. #EpithelialMechanicsReview buff.ly/kHXZkH3

Farhadifar, R., Röper, J. C., Aigouy, B., Eaton, S., & Jülicher, F. (2007). The influence of cell mechanics, cell-cell interactions, and proliferation on epithelial packing. Current biology : CB, 17(24), 2095–2104. #EpithelialMechanics buff.ly/7Drs38J

Maniou, E., Todros, S., Urciuolo, A., Moulding, D. A., Magnussen, M., Ampartzidis, I., Brandolino, L., ..., Galea, G. L., & Elvassore, N. (2024). Quantifying mechanical forces during vertebrate morphogenesis. Nature materials, 23(11), 1575–1581. #EpithelialMechanics buff.ly/iv3RjeP

Bubna-Litic, M., & Mayor, R. (2025). Beyond mechanosensing: How cells sense and shape their physical environment during development. Current opinion in cell biology, 94, 102514. #EpithelialMechanicsReview buff.ly/Ea2ZoFg

Stöberl, S., Flommersfeld, J., Kreft, M. M., Benoit, M., Broedersz, C. P., & Rädler, J. O. (2024). Nuclear deformation and dynamics of migrating cells in 3D confinement reveal adaptation of pulling and pushing forces. Science advances, 10(34), eadm9195. #EpithelialMechanics buff.ly/YjK7Gpq

Höllring, K., Nuić, L., Rogić, L., ..., Hubert, M., & Smith, A. S. (2024). Capturing the mechanosensitivity of cell proliferation in models of epithelium. Proceedings of the National Academy of Sciences of the United States of America, 121(45), e2308126121. #EpithelialMechanics buff.ly/cCmDwwk

Are different cell types like oil and water? Over a century ago, researchers found that dissociated sponges and embryonic tissues can self-assemble into functional structures. Join me, @benswedlund.bsky.social to explore the differential adhesion hypothesis & its applications in tissue engineering!

Different cell types are like oil and water - check out my @epimechfc.bsky.social thread on differential adhesion and its potential applications in tissue engineering!

Are different cell types like oil and water? Over a century ago, researchers found that dissociated sponges and embryonic tissues can self-assemble into functional structures. Join me, @benswedlund.bsky.social to explore the differential adhesion hypothesis & its applications in tissue engineering!

Fausto, C. C., Glykofrydis, F., Kumar, N., Schnell, J., Csipan, R. L., De Kuyper, F., ... & Lindström, N. O. (2024). Defining and controlling axial nephron patterning in human kidney organoids with synthetic Wnt-secreting organizers. bioRxiv #EpithelialMechanics doi.org/10.1101/2024...

Bao, M., Cornwall-Scoones, J., Sanchez-Vasquez, E., Cox, A. L., Chen, D. Y., De Jonghe, J., ... & Zernicka-Goetz, M. (2022). Stem cell-derived synthetic embryos self-assemble by exploiting cadherin codes and cortical tension. Nature Cell Biology #EpithelialMechanics www.nature.com/articles/s41...

Tsai, T. Y. C., Garner, R. M., & Megason, S. G. (2022). Adhesion-based self-organization in tissue patterning. Annual review of cell and developmental biology, #EpithelialMechanicsReview www.annualreviews.org/content/jour...

Toda, S., Blauch, L. R., Tang, S. K., Morsut, L., & Lim, W. A. (2018). Programming self-organizing multicellular structures with synthetic cell-cell signaling. Science, #EpithelialMechanics doi.org/10.1126/scie...

Stevens, A. J., Harris, A. R., Gerdts, J., Kim, K. H., Trentesaux, C., Ramirez, J. T., ... & Lim, W. A. (2023). Programming multicellular assembly with synthetic cell adhesion molecules. Nature, #EpithelialMechanics www.nature.com/articles/s41...

Tsai, T. Y. C., Sikora, M., Xia, P., Colak-Champollion, T., Knaut, H., Heisenberg, C. P., & Megason, S. G. (2020). An adhesion code ensures robust pattern formation during tissue morphogenesis. Science, #EpithelialMechanics doi.org/10.1126/scie...

Nose, A., Nagafuchi, A., & Takeichi, M. (1988). Expressed recombinant cadherins mediate cell sorting in model systems. Cell, #EpithelialMechanics doi.org/10.1016/0092...

Steinberg, M. S. (1963). Reconstruction of tissues by dissociated cells: some morphogenetic tissue movements and the sorting out of embryonic cells may have a common explanation. Science, #EpithelialMechanics www.science.org/doi/10.1126/...

Collective cell motion has many forms, but rotation is the coolest of them all. I'm @onenimesa.bsky.social , and in this short🧵, I'll highlight some instances of global tissue rotation like this one from @BauschLab

Luciano, M., Tomba, C., Roux, A., & Gabriele, S. (2024). How multiscale curvature couples forces to cellular functions. Nature Reviews Physics, #EpithelialMechanicsReview www.nature.com/articles/s42...

Haigo, S. L., & Bilder, D. (2011). Global tissue revolutions in a morphogenetic movement controlling elongation. Science #EpithelialMechanics www.science.org/doi/10.1126/...

Tan, T. H., Amiri, A., Seijo-Barandiarán, I., Staddon, M. F., Materne, A., Tomas, S., ... & Jülicher, F. (2024). Emergent chirality in active solid rotation of pancreas spheres. PRX Life #EpithelialMechanics journals.aps.org/prxlife/abst...

Glentis, A., Blanch-Mercader, C., Balasubramaniam, L., Saw, T. B., d’Alessandro, J., Janel, S., ... & Ladoux, B. (2022). The emergence of spontaneous coordinated epithelial rotation on cylindrical curved surfaces. Science Advances, #EpithelialMechanics www.science.org/doi/10.1126/...

Lo Vecchio, S., Pertz, O., Szopos, M., Navoret, L., & Riveline, D. (2024). Spontaneous rotations in epithelia as an interplay between cell polarity and boundaries. Nature Physics, #EpithelialMechanics www.nature.com/articles/s41...

Brandstätter, T., Brückner, D. B., Han, Y. L., Alert, R., Guo, M., & Broedersz, C. P. (2023). Curvature induces active velocity waves in rotating spherical tissues. Nature Communications, www.nature.com/articles/s41... #EpithelialMechanics

Lu, L., Guyomar, T., Vagne, Q., Berthoz, R., Torres-Sánchez, A., Lieb, M., ... & Salbreux, G. (2024). Polarity-driven three-dimensional spontaneous rotation of a cell doublet. Nature Physics, www.nature.com/articles/s41... #EpithelialMechanics

Fernández, P. A., Buchmann, B., Goychuk, A., Engelbrecht, L. K., Raich, M. K., Scheel, C. H., ... & Bausch, A. R. (2021). Surface-tension-induced budding drives alveologenesis in human mammary gland organoids. Nature physics, www.nature.com/articles/s41... #EpithelialMechanics

Jain, S., Cachoux, V. M., Narayana, G. H., de Beco, S., D’alessandro, J., Cellerin, V., ... & Ladoux, B. (2020). The role of single-cell mechanical behaviour and polarity in driving collective cell migration. Nature physics www.nature.com/articles/s41... #EpithelialMechanics

Kozak, E. L., Miranda-Rodríguez, J. R., Borges, A., Dierkes, K., Mineo, A., Pinto-Teixeira, F., ... & López-Schier, H. (2023). Quantitative videomicroscopy reveals latent control of cell-pair rotations in vivo. Development, #EpithelialMechanics doi.org/10.1242/dev....

Hart, R. G., Kota, D., Li, F., Zhang, M., Ramallo, D., Price, A. J., ..., Liu, J., & Chandrasekar, I. (2024). Myosin II tension sensors visualize force generation within the actin cytoskeleton in living cells. Journal of cell science, 137(20), jcs262281. #EpithelialMechanics buff.ly/rb6Qzdj

Khandekar, A., & Ellis, S. J. (2024). An expanded view of cell competition. Development (Cambridge, England), 151(22), dev204212. #EpithelialMechanicsReview buff.ly/KhVqMNQ

Currin-Ross, D., Al-Izzi, S. C., Noordstra, I., Yap, A. S., & Morris, R. G. (2025). Advecting scaffolds: Controlling the remodeling of actomyosin with anillin. Phys. Rev. E, 111(2), 024403. #EpithelialMechanics buff.ly/KkMg1Vq

Wang, X., Cupo, C. M., Ostvar, S., Countryman, A. D., & Kasza, K. E. (2024). E-cadherin tunes tissue mechanical behavior before and during morphogenetic tissue flows. Current biology : CB, 34(15), 3367–3379.e5. #EpithelialMechanics buff.ly/1EbOcP4

Ever wondered how your body's tissues deal with recurring mechanical challenges? Check out our thread on cyclic loading via the epithelial mechanics fan club!

Synthetic materials accumulate damage with every mechanical challenge. Epithelial tissues are regularly loaded, yet healthy epithelia rarely rupture. Why? We are @epmech.bsky.social and @baldaufsci.bsky.social and in this thread we introduce you to cyclic loading. bsky.app/profile/epim...