We finally made it over here ! And excited to share our new paper on mechanical forces regulating stem cell plasticity in colorectal cancer, involving force transduction via mechanosensitive calcium channels! www.cell.com/cell-reports...

Beussman, K. M., Mollica, M. Y., Leonard, A., Miles, J., Hocter, J., ..., Thomas, W. E., & Sniadecki, N. J. (2023). Black dots: High-yield traction force microscopy reveals structural factors contributing to platelet forces. Acta biomaterialia, 163, 302–311. #EpithelialMechanics buff.ly/cByoHep

Surface mechanics and compressive stress impact mammalian follicle development ->Nature | More from Lil Dr Glen EcoChat at BigEarthData.ai

Check out the awesome new website of my favourite club!

Vinculin is a simple adapter protein right? Wrong! That’s been the prevailing view for the 46 years since it was discovered. Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains. www.science.org/doi/10.1126/...

Jaydeep Mandal, Hartmut L\"owen, Prabal K. Maiti: Phase behaviour and defect structure of soft rods on a sphere https://arxiv.org/abs/2510.27201 https://arxiv.org/pdf/2510.27201 https://arxiv.org/html/2510.27201

Integrating theory with experiments to better understand gastrulation flows 🤩 Check out this fascinating #EpithelialMechanics thread by @alex-plum.bsky.social 👇

Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩 We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species ➡️ www.biorxiv.org/content/10.1...

Cell-cell junction proteins like ZO-1 not only play a critical role in the mechanical interaction between cells, but also participate in the biochemical signalling to coordinate the cell sheet. Check out this review on collective cell migration here to learn more: doi.org/10.1016/j.cd...

Mechanical forces can affect the way tissue grows. Ideally, we want to characterize them without interfering with the processes we are studying. Is there a way to achieve this? I am @borgesaugust.bsky.social Welcome to my stress inference tutorial! #EpithelialMechanics

New paper out now! 🎉 We tackle the challenge of quantifying novel contraction waves observed in the extra-embryonic membranes of the red flour beetle, Tribolium castaneum. Open Access: doi.org/10.1186/s128... #Bioinformatics #Tribolium #DevelopmentalBiology #ImageAnalysis

📢 New preprint ! Please check if you are interested in the comparison between 2d and 3d nematic theories 🤔 I show that the 2d description can lead to artefacts on curved surfaces, and I propose a thin film description of nematic shells with full 3d orientation ! This was a funny summer project 😊

Exciting News! 🥳 Our Epithelial Mechanics Fan Club website is now live! 🎉 👉 epithelialmechanics.github.io Discover our #EpithelialMechanics threads and get to know our amazing delegates behind them. Would you like to share your story? Please DM us!

Now out in @biophysj.bsky.social with open access and for the special issue dedicated to Erich Sackmann: our model for mechanochemical signal propagation in cell layers. Led by Dennis Wörthmüller from @institutcurie.bsky.social and implemented with discontinuous Galerkin FEM. doi.org/10.1016/j.bp...

Nematic cell alignment directs calcium waves https://www.biorxiv.org/content/10.1101/2025.10.20.683494v1

How do cells adapt their volumes when they proliferate and form a multicellular mass in 3D? If you have wondered about this or work with 3D in-vitro systems, then you will be happy to read our paper now on bioRxiv! www.biorxiv.org/content/10.1... See the thread 🧵 below for more information.

Our ForSys method to infer the mechanical state of a tissue in space and time is published now in @cp-iscience.bsky.social ! www.cell.com/iscience/ful... (1/10)

1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social : "Self-organization of tumor heterogeneity and plasticity" biorxiv.org/content/10.1... Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated? A thread👇

Non-canonical cytokinesis driven by mechanical uncoupling via nematic flows and adhesion-based invagination www.biorxiv.org/content/10.1...

Borges, A., & Chara, O. (2024). Peeking into the future: inferring mechanics in dynamical tissues. Biochemical Society transactions, 52(6), 2579–2592. #EpithelialMechanicsReview buff.ly/sntsjqb

Synthetic mechanotransduction

Very nice paper on shear flows and nematic ordering in endothelial cells. www.nature.com/articles/s41... #activematter #Mechanobiology

So: can a cell hold hands with itself…and do we care? YES and YES! Read on to learn WHY, HOW, and what this has to do with…PARIS (and tree-hugging)? Swansong of Dr. Anamika; Hannah Kim on drums; and fantastic undergrads (Margaret/Lauren) ! 1/n advanced.onlinelibrary.wiley.com/doi/10.1002/...

1/ 🐣⚒️ To study mechanics, we need to apply prescribed forces - how can we do that in living tissues? I am @eigenp.bsky.social and in this thread I'll highlight our new approach for applying tension on epithelial tissues in vivo!

How to develop good research questions www.nature.com/articles/s41...

Harmonic fields and the mechanical response of a cellular monolayer to ablation arxiv.org/abs/2510.05193

So excited to announce lab alumni Dr. Helen Mengze He and Liana Boraas work at @yalecvrc.bsky.social in collaboration with the Kaelyn Sumigray lab @yaleschoolofmed.bsky.social is published today in @natcomms.nature.com and highlighted in Yale News! medicine.yale.edu/news-article...

How are tissue folds stabilized during animal organ development? Our latest preprint helps to answer this question, using the fruit fly wing disc as a model doi.org/10.1101/2025.... @poldresden.bsky.social @mpipks.bsky.social @dfg.de @janafuhrmann.bsky.social @vicioms.bsky.social @mbisg.bsky.social

Cell tracking with accurate error prediction ->Nature | More from Lil' Dr Glen at BigEarthData.ai

Charras, G. and Yap, A. S. (2018). Tensile forces and mechanotransduction at cell–cell junctions. Current Biology, #EpithelialMechanicsReview www.cell.com/current-biol...

Happy to share the last version of our story @currentbiology.bsky.social on the role of interfacial tension in mechanical cell competition led by @leovalon.bsky.social and Alexis Matamoro Vidal www.sciencedirect.com/science/arti...

New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains 1/ doi.org/10.1101/2025...

Ever wondered how adult organs preserve epithelial barrier integrity while continuously exposed to mechanical stress? We tackled this question in our new preprint – led by our brilliant PhD student Vishnu Krishnakumar! (1/11) 🔗 www.biorxiv.org/content/10.1...

Mechanobiology across timescales A Review by Bo Cheng, Moxiao Li, Min Lin, Hui Guo & Feng Xu ⚛️🧪 www.nature.com/articles/s42...

John Clarke, Michel Devoret and John Martinis have been awarded the 2025 Nobel Prize in Physics for demonstrating quantum physics on the macroscopic scale go.nature.com/3WnEUhE

Garcia Lab did it again! Such a fantastic read if you are interested in FAs mechanics and biology. Congratulations to @garcialabgt.bsky.social

🚨 New preprint out! “Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM” with Tithi Mandal and @rouxlab.bsky.social We benchmark and describe step-by-step Flipper-TR FLIM measurements across different set-ups and and strategies. www.biorxiv.org/content/10.1...

How do dynamic forces influence symmetry-breaking in embryonic development? Hi, I’m @dr-rajendra-s-negi.bsky.social & in this thread, I’d like to introduce some aspects of the interdisciplinary research on tissue dynamics.

My entry for today’s #FluorescenceFriday: a pupal #Drosophila testis with muscles expressing 🔵 lifeact & 🔴 RFP-nls Honored & grateful to receive an honorable mention at @healthcare.nikon.com Nikon Small World 🌍🔬✨ 🔗 www.nikonsmallworld.com/galleries/20... #NikonSmallWorld #Microscopy #ScienceArt

Mechanical constraints disrupt gastruloid polarisation without changing gene expression - uncouples morphogenesis & patterning Gregor & co use tunable hydrogels to show cell motility, not gene expression, drives axis formation in gastruloids journals.biologists.com/dev/article/...

Lea Happel, Griseldis Oberschelp, Anneli Richter, Gwenda Roselene Rode, Valeriia Grudtsyna, Amin Doostmohammadi, Axel Voigt: A spectrum of p-atic symmetries and defects in confluent epithelia https://arxiv.org/abs/2510.02160 https://arxiv.org/pdf/2510.02160 https://arxiv.org/html/2510.02160

Excited to participate in the Scientific Art Contest at #CellMech2025.

@epimechfc.bsky.social discussion with @dedenonmathieu.bsky.social at #CellMech2025 :)

See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...

🚨New academic year calls for a new lineup of speakers. ✍️Sign up to our mailing list to hear these wonderful array of speakers this term. Please reshare among your networks 📩 lists.cam.ac.uk/sympa/subscr...

🤩👍🏼💪🏼 Meet #TopoSPAM - a high-performance simulation platform for biological morphogenesis with a friendly Python interface. @tudresden.bsky.social @csbdresden.bsky.social @mpi-cbg.de. Solve both continuous and discrete active mechanics! Released today: arxiv.org/abs/2509.24905

Xie, Modak, Usman, Tan, Coca, De Jesus, Wang, Thirumalai, Li, Irianto: Rotational migration in human pancreatic ductal organoids depends on actin and myosin activity https://arxiv.org/abs/2509.25680 https://arxiv.org/pdf/2509.25680 https://arxiv.org/html/2509.25680

Identification of optimal fluorophores for use in the Drosophila embryo by Timothy E Saunders and team: www.biorxiv.org/content/10.1...