Which features of tissue flows are most robust and how do they emerge from #EpithelialMechanics? I’m @alex-plum.bsky.social (@mattiaserra.bsky.social group) and I’ll be sharing some papers on characterizing and controlling avian gastrulation flows.

Happy to share that this work is now published in @biophysj.bsky.social! doi.org/10.1016/j.bp...

(1/14) I’m happy and proud to introduce: SpinePy – a framework to detect the "spine" of gastruloids and measure biological and physical signals in a local dynamic 3D coordinate system. www.biorxiv.org/content/10.1...

Latest on Waddington Landscapes: Computational methods to fit dynamical landscapes directly to single cell data Applied to neural tube patterning shows morphogen-signalling landscapes can be linearly interpolated Connects interpretable landscape models with data www.biorxiv.org/content/10.1...

Hi bsky! Do embryonic tissues have backup plans🔀? Gastruloids (model of body elongation) can build an axis through different cellular mechanisms when on adherent substrates instead of free floating. A case of developmental plasticity! w/ A. Delahaye & ‪@bensteventon.bsky.social‬ shorturl.at/v01DO

What happens when you plate #gastruloids at different times on different subtstrates is that we learn about cells, pattern formation and gastrulation. Excellent experiments from G. Serrano and ‪@bensteventon.bsky.social‬ raising interesting questions www.biorxiv.org/content/10.1... #CellsRUs

🔔 Proud to share the preprint of my PhD work in the Petridou group @nicolettapetridou.bsky.social @embl.org ✨ “A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics” 🐟 🔁 📶 🔗 www.biorxiv.org/content/10.1... #devbio #biophysics 🧵⤵️

📣 New paper out! How do thousands of cells shape the emergent geometry of the avian embryo? We identify distinct, independently controllable mechanisms that contribute to embryo size and shape. @alex-plum.bsky.social @bensteventon.bsky.social @Guillermo Serrano Najera www.nature.com/articles/s41...

Our review on dynamical systems of fate and form in development!

@sreejithsanthosh.bsky.social developed a resource for analyzing motion on dynamic surfaces, including in morphogenesis! Tutorial and code: sreejithsanthosh.github.io/FTLEhub/FTLE...

Check out our new work! The code for performing coherent structure analysis, along with the documentation, is available at sreejithsanthosh.github.io/FTLEhub/. Please feel free to reach out if you are interested in using this analysis for kinematic data in your system!

Our latest "Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data" A rigorous mathematical foundation for Waddington's landscape to study cell fate decision making Applied to ventral neural tube development www.biorxiv.org/content/10.1...

Our paper on the E. coli Min system in vivo with @physicsoflifelmu.bsky.social & Judy Kim (UCSD) has been published in Nature Physics today. Tight integration of experiment and theory, and physiology and biophysics. Incredible perseverance of our young students. rdcu.be/ekIpO

Can using synthetic approaches to build biology help teach us the design principles of how embryos build themselves? 👷‍♀️🔧 If this is a question that interests you, come and share your thoughts at this Royal Society Workshop on Generative Biology www.royalsoc.ac.uk/science-even...

In developing embryos, cells move a lot! Plenty of that movement is random. Is random cell mixing a feature or bug for tissue patterning? Turns out, it’s both! Excited to share the 1st preprint from my postdoc w/ Sean Megason @seanemcgeary.bsky.social and Allon Klein. 1/20 doi.org/10.1101/2025...

Stoked to present our latest, superbly led by Chris et al & @torres-sanchez.bsky.social We tackled a fundamental problem – how tissues are patterned during development – found that geometry-constrained ECM fractures pattern the myocardium in the vertebrate heart 1/n www.biorxiv.org/content/10.1...

ICYMI: Commentary on "mechanism" in dev bio Ozpolat et al argue for diverse approaches to mechanism - from molecular to systems level journals.biologists.com/dev/article/...

Chuai et al 2023 nicely tie in large scale tissue deformations to local cell behaviors like intercalations and ingression.

📣Check out our work led by @alex-plum.bsky.social ! We developed a mathematical framework for morphogen patterning in dynamic tissues, revealing key insights into how morphogenesis mediates cell-cell communication, morphogen compartmentalization and fate coordination. biorxiv.org/content/10.1...

📣 Excited to receive the 💥 NSF CAREER 💥 Award. Our group is looking for PhD students and postdocs interested in the Nonlinear Dynamics and the Physics of Living Systems, with support from NSF, HFSP, and other sources. We’d appreciate your help in spreading the word! @ucsdphysci.bsky.social

Mindscape 302 | Chris Kempes on the Biophysics of Evolution. Even squishy organisms are subject to the fundamental laws of nature. #MindscapePodcast www.preposterousuniverse.com/podcast/2025...

Chuai, M., Serrano Nájera, G., Serra, M., Mahadevan, L., & Weijer, C. J. (2023). Reconstruction of distinct vertebrate gastrulation modes via modulation of key cell behaviors in the chick embryo. Science Advances, 9(1), eabn5429. https://doi.org/10.1126/sciadv.abn5429 #EpithelialMechanics

Nájera, G. S., & Weijer, C. J. (2023). The evolution of gastrulation morphologies. Development, 150(7), dev200885. https://doi.org/10.1242/dev.200885 #EpithelialMechanicsReview

🦦 Feed your intellectual curiosity & challenge your limits at SFI’s Undergraduate Complexity Research program. Pursue new research directions and walk away with an unforgettable, transformative experience. Apply by January 14: apply-sfi.smapply.org/prog/ucr2025/

A stimulating workshop on the subject of Waddington Landscapes in Lyon last week, prompted me to compose some thoughts on dynamical landscapes, gene regulatory networks, and single cell transcriptomics briscoelab.org/morphogenalia/

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