In the New and Notable "Plectin: The cytoskeletal cross-linker that shields the cell from mechanical damage," Farhan Chowdhury highlights the paper, "Plectin affects cell viscoelasticity at small and large deformations."

#OPENACCESS: Biomolecular condensates as cellular memory modules: Thermodynamic principles and plant stress adaptation. Sukhendu Maity and Panagiotis Nikolaou Moschou.

In the New and Notable "Glucose-driven mitochondrial transport adds a new dimension to mitochondrial heterogeneity," Abdul Haseeb Khan and Tatsuhisa Tsuboi highlight the paper "Mitochondrial position responds to glucose stimulation in a model of the pancreatic beta cell."

NMR and MD simulations-based study shows that the conformational preferences of an RNA internal loop are dictated by the base pairs flanking the loop.

#OPENACCESS: Strong yet flexible, how do cells manage both? Conboy et al. use single-cell compression measurements to show that the cross-linker protein plectin stiffens fibroblasts and organizes actin–vimentin networks to shield cells from mechanical damage.

Read about the cover art for the newly released issue of Biophysical Journal on the BPS Blog: www.biophysics.org/blog/the-whi...

Special issue call for papers: Viral Biophysics.

#OPENACCESS: Measuring brain elasticity is like squeezing a marshmallow vs. a gummy bear—how hard, how fast, and when you press changes the gray/white matter ratio. Timing & touch matter!

Special issue call for papers: Viral Biophysics.

#OPENACCESS: Cardiac action potential generation mechanisms via an intramembrane photoswitch. A simulation study. Ludovica Cestariolo, Chiara Florindi, Chiara Bertarelli, Antonio Zaza, Guglielmo Lanzani, Francesco Lodola, and Jose F. Rodriguez Matas. buff.ly/DGDX6Kr

A look into the mechanics of anesthesia: new study combining electrophysiology and calcium imaging reveals how propofol suppresses mechanosensation by inhibiting Piezo1 and Piezo2 channels.

#OPENACCESS: Touch without PIEZO2 is like ringing a doorbell with the wire cut—mechanical pokes still spark currents, but the signal’s mysterious! Sensory neurons keep surprising us.

#OPENACCESS: Movement of Piezo1 channel is heterogeneous in the plasma membrane, and it decreases by increased cholesterol and increases by cholesterol depletion shedding light on how cellular processes may influence channel mobility and activity.

How do mechanoreceptors shape muscle contraction? Fazyl et al. reveal that in C. elegans, the mechanosensitive channel PEZO-1 tunes muscle calcium dynamics, differentially regulating on swimming and crawling behaviors.

#OPENACCESS: Targeting Tmem63b and Piezo2 in C-fiber low-threshold mechanoreceptors: Limitation of Vglut3-IRES-Cre. Daniel J. Orlin Antonio Muñoz, Sage Berryman, Destinee Semidey, and Swetha E. Murthy.

In the New and Notable "Precision under pressure: The dawn of membrane tension clamping," Karan H. Muchhala and Arthur Beyder highlight the paper "A closed-loop system for millisecond readout and control of membrane tension."

PIEZO1 proteins aren’t strolling calmly—they’re more like city traffic! Some zip like scooters, others idle in jams. Single-particle tracking reveals a whole spectrum of motion. Biology = rush hour physics!

Special issue call for papers: Viral Biophysics.

Mun and Holt review 20+ years of research on the mechanics of hearing, highlighting key players in hair cell mechanotransduction, open challengers, and future directions.

Read about the cover art for the newly released issue of Biophysical Journal on the BPS Blog: www.biophysics.org/blog/muscles... @vidalgadealab.bsky.social @illinoisstateu.bsky.social

Now model the post-translational modifications on lysine in your protein molecules using ptmK, a computational toolkit that not only generates structural models of modifications but also evaluates the likelihood of a given lysine to be modified.

#OPENACCESS: Unmasking complex kinetics in viral entry by inferring hypoexponential models. Oyinkansola Adenekan and Peter M. Kasson.

Special issue call for papers: Viral Biophysics.

#OPENACCESS: Arash Karaei Shiraz et al., 2025, vesicles reshape themselves as internal active filaments push and pull—like tiny balloons being sculpted from the inside by energetic balloon animals.

#OPENACCESS: Ion-selective conformational stabilization of a disordered repeats-in-toxin protein domain. Alana P. Gudinas, Gatha M. Shambharkar, Marina P. Chang, Daniel Fernández, Tsutomu Matsui, and Danielle J. Mai.

#OPENACCESS: Disease-related miRNA mutations are associated with mature miRNA secondary structure changes. Javor K. Novev and Sebastian E. Ahnert.

#OPENACCESS: Using high-fidelity computational modeling, Mohan et al illustrate how tumor and angiogenic vasculature affect red blood cell transport and capillary hemodynamics. Read more to discover the biophysical differences between healthy, angiogenic, and tumor microcirculation.

#OPENACCESS: Mapping intracellular dynamics across the whole cell with spatial statistics. Yohei Okabe, Takumi Saito, Outa Nakashima, Daiki Matsunaga, and Shinji Deguchi.

In Xiaoyu Yu et al. cells navigate curved surfaces like hikers on twisty trails—sometimes wandering freely, sometimes marching with purpose depending on the slope.

#OPENACCESS: Near-cognate tRNAs enhance tRNA rejection and prime the ribosome for rapid subsequent tRNA testing. Clark Fritsch, Arpan Bhattacharya, Martin Y. Ng, Hong Li, Philip C. Nelson, Barry S. Cooperman, and Yale E. Goldman.

Special issue call for papers: Viral Biophysics.

In the New and Notable "tRNA selection in eukaryotes: A new twist in a familiar tale," Moumita Dey and Alexey Petrov highlight the paper "Near-Cognate tRNAs Enhance tRNA Rejection and Prime the Ribosome for Rapid Subsequent tRNA Testing."

Too fluid, too rigid, no patterning. Garner et al. identify tissue fluidity—how freely cells move within a tissue—as a critical regulator of adhesion-based cell sorting. Read their study to learn how tissues can tune their fluidity to enable patterning.

#OPENACCESS: The influence of proline on surface interactions in aqueous solutions. Kieran J. Agg, James E. Hallett, and Susan Perkin.

#OPENACCESS: Helical sensors of membrane saturation: Changes in orientation and curvature preference. Sushmita Pal, Peter Pajtinka, Matti Javanainen, and Robert Vácha.

Read about the cover art for the newly released issue of Biophysical Journal on the BPS Blog: www.biophysics.org/blog/dynamic...

Special issue call for papers: Viral Biophysics.

#OPENACCESS: Multi-scale simulations of MUT-16 scaffold protein phase separation and client recognition. Kumar Gaurav, Virginia Busetto, Diego Javier Páez-Moscoso, Arya Changiarath, Sonya M. Hanson, Sebastian Falk, René F. Ketting, and Lukas S. Stelzl.

#OPENACCESS: Chromatin unfolding via loops can drive clustered transposon insertion. Roshan Prizak, Aaron Gadzekpo, and Lennart Hilbert.

New study by Arjun Valiya Parambathu et al. (2025) uncovers why concentrated mAbs get so gooey—it’s like a crowded dance floor where every antibody keeps bumping, sticking, and slowing the groove. High viscosity = molecular traffic jam!

#OPENACCESS: Transformer graph variational autoencoder for generative molecular design. Trieu Nguyen and Aleksandra Karolak.

The authors present a simulation toolbox designed to project membrane and biopolymer properties to a two-dimensional plane. The dimension reduction helps to characterize the patterns of lipid-lipid and lipid-biopolymer surfaces.

#OPENACCESS: A single molecular switch controls the clock – New study using Markovian state models maps the conformational landscape of CK1, revealing how kinase shape tunes substrate specificity and circadian timing.

Special issue call for papers: Modeling Biology at Multiple Scales: From Macromolecules to Cells, Dedicated to Jie Liang.

New study by Deng Li et al. (2025) shows how SP-D grabs glycans using a slick new computational workflow—like watching a molecular claw machine finally reveal its strategy. Precision, pattern-spotting, and plenty of biophysical flair!

A brand-new MD algorithm tailored to sample the protein intermediate states, termed as ‘discard-and-restart’, enhancing the design of ligands targeting dynamic protein states.

Special issue call for papers: Martin Karplus: In Memoriam.

#OPENACCESS: Structural and functional characterization of the Pro64Ser leptin mutant: Implications for congenital leptin deficiency. Bao Quoc Ngo, Outi Lampela, and André H. Juffer.

Many ligands, many sites. Orr et al. combine experiments and simulations to show how drugs and excipients bind multiple sites on human serum albumin, with important implications for improved therapeutic formulations.

Read about the cover art for the newly released issue of Biophysical Journal on the BPS Blog: www.biophysics.org/blog/harness...