In people with lower extremity peripheral artery disease (PAD) who do not have diabetes, does metformin improve walking ability compared with placebo? jamanetwork.com/journals/jam...

Do sociodemographics, APOE ε4 allele, lifestyle factors, and cardiovascular risk factors modify the effect of the Mediterranean–DASH Intervention for Neurodegenerative Delay (MIND) diet? alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Does consumption of caffeinated coffee have a beneficial, detrimental, or neutral effect on the risk of recurrent atrial fibrillation (AF) episodes? jamanetwork.com/journals/jam...

Blood Pressure After Changes in Light-to-Moderate Alcohol Consumption in Women and Men: Longitudinal Japanese Annual Checkup Analysis "Even at low levels, drinking was associated with higher BP, and cessation was associated with lower BP in both sexes." www.jacc.org/doi/10.1016/...

Selection of Ruthenium Polypyridyl Complex-Modified Aptamers for Photodynamic Therapy against Streptococcus Pneumonia pubs.acs.org/doi/10.1021/...

GLP-1 receptor agonists and cancer: current clinical evidence and translational opportunities for preclinical research Open Access www.jci.org/articles/vie... @lwellberg.bsky.social @jci.org

Cell populations in human breast cancers are molecularly and biologically distinct with age "how age affects cells in the breast tumor microenvironment or how they contribute to age-related pathology." www.nature.com/articles/s43...

Fischer-Tropsch synthesis can produce liquid fuels from nonpetroleum sources "Cofeeding 20 ppm bromomethane over an iron carbide catalyst decreased CO2 selectivity to <1% and increased olefin selectivity to ~85% among all carbon-containing products." www.science.org/doi/10.1126/...

Physical activity as a modifiable risk factor in preclinical Alzheimer’s disease "5,001–7,500 steps per day have a protective effect on tau accumulation and cognitive and functional decline in early AD." www.nature.com/articles/s41...

Noninvasive Assessment of Liver Fibrosis The prognosis of liver disease depends on the extent of fibrosis, which is usually staged with the use of liver biopsy. The limitations of biopsy have led to the development of noninvasive tests www.nejm.org/doi/full/10....

"Nature never uses DNA phosphates as catalysts, but we have shown that if designed properly, they can act like artificial enzymes." This method could make chem mfg more sustainable & eco-friendly, esp for producing complex, high-value mols used in pharma prods. www.nature.com/articles/s41...

Potential of new materials for absorbing 99.5% of light on solar towers "AZO-coated refractory nanoneedles as ultra-black wide-angle solar absorbers" www.sciencedirect.com/science/arti...

New antibody therapy reawakens immune system to fight pancreatic cancer "Study reveals how pancreatic tumors evade immunity using a sugar disguise, and how a new antibody restores immunity in mice" aacrjournals.org/cancerres/ar...

Rapid blood pressure fluctuations linked to early signs of brain degeneration in older adults www.eurekalert.org/news-release...

Joint adaptive immune mechanisms mediate cardiac injury after COVID-19 vaccination "Acute myopericarditis development after vaccination has repeatedly been reported; however, the pathogenesis of this complication remains elusive." www.ahajournals.org/doi/full/10....

Long-term prognosis of lean MASLD: evidence from three population-based prospective cohorts "Lean patients with MASLD have worse liver outcomes and greater risk of all-cause mortality, but similar risk of HCC and extrahepatic cancer, and lower CVD risk." gut.bmj.com/content/earl...

A review by Danielle Gallegos, PhD, addresses the dimensions and mechanisms of food and nutrition insecurity, as well as assessment, populations at highest risk, and health consequences across diverse contexts. www.nejm.org/doi/full/10....

Consciousness science: where are we, where are we going, and what if we get there? www.frontiersin.org/journals/sci...

Guidance for formulating good research questions www.sciencedirect.com/science/arti...

But as I downsized my office and changed my email signature to Emeritus Professor, I was unprepared for the reality of retirement. I found it difficult to adjust to no longer holding decision-making roles. www.science.org/content/arti...

Extraterrestrials illustrated A physicist and a cartoonist join forces with an accessible guide to thinking about life in the cosmos www.science.org/doi/10.1126/...

How collaboration with China can revitalize US automotive innovation "Strategic collaboration, not protectionist barriers, should be pursued" www.science.org/doi/10.1126/...

Farber et al. reviewed research on the connections between a material’s porosity and its use for energy-related technologies, including areas of commonality across length scales that can manifest as general models that may have broad relevance. www.science.org/doi/10.1126/...

Peroxisomal metabolism of branched fatty acids regulates energy homeostasis "This study identified a previously unrecognized role for peroxisomes in adipose tissue thermogenesis characterized by an mmBCFA synthesis and catabolism cycle." www.nature.com/articles/s41...

Pre-fertilization-origin preservation of brown fat-mediated energy expenditure in humans Brown adipose tissue metabolic fate and susceptibility of metabolic diseases are preprogrammed by the epigenetic inheritance of cold exposure before the fertilization in humans www.nature.com/articles/s42...

How AI agents will change research: a scientist’s guide "Researchers are increasingly turning to artificial-intelligence tools that can handle complex, multi-step processes." www.nature.com/articles/d41...

Instead of focusing on things outside my control, I chose to shift my effort into expanding my knowledge, speaking up when I want, and asking for help when I need it without worrying I will be seen as inferior, incompetent, or troublesome. www.science.org/content/arti...

The ability to sense heat protects the body from burns and injury. But how the body actually feels temperature has remained an elusive mystery. "Molecular snapshots reveal how the body knows it’s too hot" www.nature.com/articles/s41...

New drug-eluting balloon may be as safe and effective as conventional metal stents for repeat percutaneous coronary interventions www.eurekalert.org/news-release...

Lilly's baricitinib delivered near-complete scalp hair regrowth at one year for adolescents with severe alopecia areata in Phase 3 BRAVE-AA-PEDS trial www.prnewswire.com/news-release...

Eliminating cockroach infestations could help improve indoor environmental health by greatly reducing allergens and endotoxins. www.jaci-global.org/article/S277...

Unsaturated fat alters clock phosphorylation to align rhythms to the season in mice "A diet high in fat enhanced the animals’ entrainment to a longer summerlike light cycle but decreased their rate of entrainment to a winter-like shorter light cycle." www.science.org/doi/10.1126/...

Melanocyte stem cells undergo cellular senescence-coupled differentiation (seno-differentiation) in response to DNA double-strand breaks, resulting in their selective depletion and hair greying, and effectively protecting against melanoma. www.nature.com/articles/s41...

How to develop good research questions "This Comment describes the iterative creative process for designing good research questions, and includes practical suggestions and ways to avoid common traps." www.nature.com/articles/s41...

As the U.S. confronts a historic healthcare workforce crisis, a new white paper released today calls on federal and state policymakers to modernize outdated laws, regulations, and payment systems in order to harness the full potential of AI in care delivery. westhealth.org/news/new-whi...

Microscopic DNA ‘flowers’ could deliver medicine exactly where it’s needed "The adaptability of flowers to environmental changes activates cascaded biocatalytic reactions and reveals gel-encrypted information." www.nature.com/articles/s41...

As an immigrant scientist in the U.S., travel bans and visa uncertainty are taking a toll www.science.org/content/arti...

On an Arctic archipelago, frozen soil may preserve a hidden history of viruses www.science.org/content/arti...

Delegation to artificial intelligence can increase dishonest behaviour www.nature.com/articles/s41...

Bad is Stronger than Good The greater power of bad events over good ones is found in everyday events, major life events (e.g., trauma), close relationship outcomes, social network patterns, interpersonal interactions, and learning processes. journals.sagepub.com/doi/10.1037/...

Life without sex: Large-scale study links sexlessness to physical, cognitive, and personality traits, socioecological factors, and DNA Open Access www.pnas.org/doi/10.1073/...

First-in-human study of high-dose gp96 in ALS: Safety and preliminary immunological effects www.the-innovation.org/article/doi/...

Environmental neurotoxicity revisited: Evaluating microplastics as a potential risk factor for autism spectrum disorder www.the-innovation.org/article/doi/...

This review examines ten distinct carbon sources and discuss their origins, bioconversion, and practical advantages and limitations, while also evaluating their technical feasibility and sustainability trade-offs. www.the-innovation.org/article/doi/...

Astaxanthin in metabolic control: From regulatory mechanisms to therapeutic prospects www.the-innovation.org/article/doi/...

Perfume scientists tweak cells into having ‘sense of smell’ A study could transform the lab study of olfaction—and may challenge a Nobel-winning hypothesis www.science.org/content/arti...

Dust devil migration patterns reveal strong near-surface winds across Mars Strong near-surface winds are abundant on Mars and play an important role in atmospheric dust sourcing, directly informing more accurate models of Mars’ atmosphere, weather, and climate. www.science.org/doi/10.1126/...

I will probably never be free of my stutter. If radiation can be used to cure cancer, why can’t my stutter make me better, too? www.science.org/content/arti...

People are thinking about what is not happening almost as often as they are thinking about what is. Doing so typically makes them unhappy. www.science.org/doi/10.1126/...

In-situ gas observation in thermal-driven degradation of LiFePO4 battery "Findings guide safer design of next-generation LiFePO4 battery packs" www.the-innovation.org/article/doi/...