The human gut microbiota has rapidly changed during dietary urbanization. However, the human genome cannot change substantially over one generation, leaving it potentially ill-equipped to adapt to evolving microbial functions associated with rising non-communicable diseases (NCDs).

A modified prolactin-releasing peptide, NN501, with agonist properties at both GPR10 and neuropeptide FF receptor 2 (NPFFR2) causes significant weight loss without apparent side effects and with slower weight gain after cessation. www.cell.com/cell-metabol...

The quest to slow aging leads scientists into the powerhouse of cells www.washingtonpost.com/science/2025...

What to Know About the New Blood Pressure Guidelines "The guideline does note that reducing alcohol intake appears to have bigger BP reduction benefits for people who drink more, regardless of whether they have hypertension." jamanetwork.com/journals/jam...

Cardiometabolic parameter change by weight regain on tirzepatide withdrawal in adults with obesity jamanetwork.com/journals/jam...

Metformin Blunts Vascular Insulin Sensitivity After Exercise Training in Adults at Risk for Metabolic Syndrome academic.oup.com/jcem/advance...

Egg intake and cognitive function in healthy adults: A systematic review of the literature Moderate whole egg consumption may be associated with improvements in cognitive outcomes in healthy adults, including reduced dementia risk and better memory performance www.sciencedirect.com/science/arti...

Today, medical research builds up an understanding of the whole from molecular parts, but artificial intelligence can revive an approach building down from patient-level data to theory and understanding.

Fish Oil for Patients Receiving Hemodialysis — Red Herring or Great Catch? www.nejm.org/doi/full/10....

Yang et al. developed a self-adaptive fine-tuning method that dynamically adjusts the parameters of the models to minimize the loss function, which includes direct quantification of artifacts from live-cell imaging. doi.org/10.1016/j.xi... #deeplearning #microscopy #adaptiveimaging

This study shows that M31 UCXB-1 is a BH-WD system, with the shortest orbital period, the possibly strongest gravitational wave emission, and the most massive white dwarf among the known UCXBs. doi.org/10.1016/j.xi... #astrophysics #blackholes #GravitationalWaves #whitedwarfstars

Deng et al. analyzed an expanded genetic dataset comprising #systemiclupuserythematosus (SLE) with pulmonary arterial hypertension (PAH), SLE without PAH (SLE-nonPAH), and healthy control cohorts, identifying rare TRAF5 coding variants associated with SLE-PAH. doi.org/10.1016/j.xi... #genetics

Check out the latest issue of The Innovation Medicine!!! Volume 2, Issue 4 is now online! @innovationmedicine.bsky.social www.the-innovation.org/medicine/art... #medicine #biomedical #Cancer #immunotherapy #cadiovascular #type2diabetes #hypertension #ArtificialIntelligence #clinical #research

Follow @topscience.bsky.social for daily updates! 🥂💐 go.bsky.app/Rqtw6t4

Microplastic exposure linked to accelerated aging and impaired adipogenesis in fat cells "The multifaceted impact of microplastic exposure on adipose tissue: its role in inducing cellular senescence, amplifying inflammatory responses, and impairing differentiation capacity" doi.org/10.1038/s415...

The complete telomere-to-telomere sequence of a mouse genome. @science.org "This work allows for the characterization of ribosomal DNA, as well as previously uncharacterized genes, and will provide an important resource to researchers working in mouse genetics." www.science.org/doi/10.1126/...

A new way to create realistic 3D shapes using generative AI. #MIT Researchers propose a simple fix to an existing technique that could help artists, designers, and engineers create better 3D models. Read more news.mit.edu/2024/creatin... Paper: arxiv.org/pdf/2405.15891

Academic Journals and News (Updated Dec 3, 2024) go.bsky.app/hCfhqn

In case some mentors may want to read this. #Nature #PhD #scisky #student #mentor Source: www.researchgate.net/publication/...

How to write an excellent Review article @natrevbioeng.bsky.social #scisky #Science #REVIEW Open Access www.nature.com/articles/s44...

Seen this many times. But many academics will never understand this or will just pretend they don't understand this. They'd rather train PhD students to be machines.

This thread is about HUMAN IMMUNE SYSTEM Its primary function is to defend the body from pathogens, which are disease-causing organisms such as viruses and bacteria. Tissues, cells, and proteins in the immune system work together to achieve this function. @jama.com jamanetwork.com/journals/jam...

The Immune Response Source: Big Picture & Wellcome Trust HD: www.tes.com/teaching-res...

"Fecal microbial load is a major confounder in microbiome studies." Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations. #Cell @cellpress.bsky.social Open Access www.cell.com/cell/fulltex...

Here is a brief summary of academic journals and news account. Please help me add more accounts to this list! go.bsky.app/hCfhqn

A novel bisegmented coronavirus was found in the lesser panda. @biorxivpreprint.bsky.social Comprehensive viral surveillance in wildlife is essential for understanding and mitigating the risk of animal diseases and zoonotic spillover. Read more www.biorxiv.org/content/10.1...

"Sex is a critical modifier in demyelination during aging and with tau pathology, particularly in the presence of the APOE4 allele." This study used single-nuclei transcriptomics to dissect the contributions of sex chromosomes and gonads in demyelination and AD. www.science.org/doi/10.1126/...

Molecular basis of mRNA delivery to the bacterial ribosome. @science.org #scisky #biology #news #science "Visualized the early encounter between a transcribing RNA polymerase and a ribosome, which initiates translation on the nascent mRNA." Read more www.science.org/doi/10.1126/...

Disrupted endothelial function underlies the multiorgan complications of COVID-19. @science.org #scisky #medsky #news Open Access www.science.org/doi/10.1126/...

The struggle is “balancing their careers not just with motherhood, but with what comes before: relationships and planning for a family,” these postdocs write. www.science.org/content/arti...

“I think a lot of us get caught up in what we think we’re supposed to be good at, instead of focusing on what we’re naturally drawn to." #scisky #PhD #Academic #career Read more www.science.org/content/arti...