Drug discovery is undergoing a paradigm shift—from static lock-and-key to systemic network modulation. This editorial unveils how multidisciplinary convergence reshapes cognition, technology, and ecosystem. doi.org/10.59717/j.x... #DrugDiscovery #ArtificialIntelligence

Hu et al. explore how integrating generative AI, like diffusion models, with rigorous physics-based validation prevents "structural hallucinations" and accelerates the translation of in silico peptide blueprints into viable clinical therapeutics. doi.org/10.59717/j.x... #DrugDiscovery #GenerativeAI

This review comprehensively examines the central role of PROTACs in regulating critical PCD mechanisms, including ferroptosis induction via GPX4 degradation, pyroptosis regulation through STING targeting... doi.org/10.1016/j.xi... #ProgrammedCellDeath #PrecisionMedicine

This commentary proposes a stratified sequential strategy that preserves Fecal Immunochemical Test based efficiency while using liquid biopsy only to rescue persistent non-responders. doi.org/10.59717/j.x... #OncologyResearch #liquidbiopsy #ColorectalCancer

Climate change harms health far beyond heat—through floods, droughts, wildfire smoke, infectious diseases, and strained health systems. doi.org/10.59717/j.x... #climatechange #PublicHealth

Cai and Tang report a 26-year-old male with aggressive T-LGLL and a near tetraploid karyotype. After failing #chemotherapy, he achieved complete remission with Tislelizumab and Pentostatin. No relapse at 6 months suggests a new role for #immunotherapy in aggressive T-LGLL. doi.org/10.59717/j.x...

@theinnovation.bsky.social #webinar: Sudden Cardiac Death: Warning Signs and Symptoms. Speaker: Xifu Wang, MD; Ke Wei, PhD Date & Time: Apr. 04, 2026 | 21:00-22:00 (Beijing Time) VooV meeting ID: 874-473-925 Join us this Saturday! #PublicHealth #suddencardiacdeath

In this paper, Luo and Li propose cross-section invariance and its intrinsic mechanisms for multifold high-degree #morphing, as well as their implementations. doi.org/10.1016/j.xi... #crosssectioninvariance #MechanicalIntelligence

The anti-inflammation effect of PAHSA is validated in this study and the LPS-neutralizing ability of PAHSA might be useful for the treatment of sepsis diseases in the clinic in the future. doi.org/10.59717/j.x... #LifeSciences #Pyroptosis #sepsis

The Innovation Insights is Coming! We are thrilled to announce the launch of The Innovation Insights, an international, peer-reviewed, open-access journal dedicated to publishing high quality research that provides deep #insights across multiple disciplines. www.the-innovation.org/the-innovati...

This guideline integrates frameworks from ELN for genetic risk stratification, NCCN for clinical protocols, Children’s Oncology Group for pediatric standards, and Chinese guidelines and consensus for regional adaptations. doi.org/10.59717/j.x... #medicine #guideline #acutemyeloidleukemia

This perspective aligns closely with the One Health concept, which underscores the imperative of coordinated actions across human, animal, and environmental sectors to foster their integrated and balanced development. doi.org/10.59717/j.x... #medicine #OneHealth #UrbanEcosystems

Global drug innovation is becoming increasingly multipolar. This decade-long analysis highlights the top 10 drug targets (2015–2024) and shows how emerging modalities reshape R&D priorities across immuno-oncology and metabolic diseases. doi.org/10.59717/j.x... #medicine #DrugDiscovery

Using multiple climate model simulations, Chen et al. demonstrate a significant intensification of the impact of SNTA SST on EASM and East Asian climate under greenhouse warming. doi.org/10.59717/j.x... #globalwarming #seasurfacetemperature

Chen et al. integrated process-based and machine learning approaches to reconstruct and project spatiotemporally consistent soil organic carbon time series at the centennial scale. doi.org/10.59717/j.x... #blacksoil #soilmanagement #foodsecurity

The Innovation Coffee | Global Science Journals: Past, Present, and Future. Speakers: Drs. Rongqi Na, Shuai Yan, Li Wang, Ke Chen 📅: Mar. 30, 2026 | 1:00 – 2:00 PM (UTC+8) 📍The Innovation Coffee, Beijing Institute of Technology VooV Meeting ID: 980-303-695 Attendance: In person or virtually!

How do NO₂ and O₃ work together to create a new pollution balance? This study reveals the dual-phase feedback mechanism under the inflection point of emission reduction and unlocks the key to the synergistic control of SOA and O₃. doi.org/10.59717/j.x... #airquality #PM25 #pollutioncontrol

Oxygenated julolidine-based Nile Red enables accurate mapping of various organelles and reveals the subtle differences in subcellular membrane heterogeneity. doi.org/10.1016/j.xi... #chemicalbiology #fluorescenceimaging

The emergence of the artificial intelligence virtual cell heralds a profound paradigm shift in oncology. This shift moves from traditional reductionist dissection of biological components to a generative, systems-level paradigm. doi.org/10.59717/j.x... #oncology #artificialintelligence #VirtualCell

Check out the latest issue in Energy Use!!! Volume 2, Issue 1 is now online! www.the-innovation.org/energy-use/a... #energyuse #EnergyStorage #EnergySystem #Battery #ThermalManagement #geothermal #powersystem #Sustainability

Xiao et al. introduce a WBIC system as a high-performance solution for fast high-resolution dental MRI. Combined with the deep learning method, the wireless braces-shaped electromagnetic metasurface array enabled fast high-resolution dental MRI in 68 seconds. doi.org/10.1016/j.xi... #dental #MRI

This study revisits battery degradation modeling from a visual perception perspective and proposes a new modeling paradigm for battery health prediction in real-world electric vehicles. doi.org/10.1016/j.xi... #lithiumionbatteries #electricvehicles #EnergyStorage

Wang et al. introduce a universal design principle for self-regulated all-optical devices, including diodes, transistors, and logic gates, leveraging photothermal-responsive soft actuators. doi.org/10.1016/j.xi... #engineering #materials #softactuator

Chen et al. developed behavioral paradigms to dissociate memory generalization from strengthening and found that negative experiences leading to memory overgeneralization, but not those enhancing memory strength alone, triggered stress-related behaviors in mice. doi.org/10.1016/j.xi... #depression

Yang et al. compiled 2222 radiocarbon measurements of soil organic matter from 408 soil profiles spanning all major biomes and coupled radiocarbon-based chronology with a chronosequence framework to reconstruct soil carbon accumulation since the early Holocene. doi.org/10.59717/j.x... #climatechange

@theinnovation.bsky.social #webinar: Accelerating #Materials Discovery through #ActiveLearning: Methods, Challenges and Opportunities. Speaker: Yi Du, PhD Date & Time: Mar. 28, 2026 | 21:00-22:00 (Beijing Time) VooV meeting ID: 113-554-467 Join us this Saturday! doi.org/10.59717/j.x...

The Innovation Physics Call for Youth Editor! The Innovation Physics aims to publish high-impact original research on topics spanning fundamental and applied physics. If you are interested in joining the youth editorial team, please send your CV to [email protected] #physics #youtheditor

Li et al. develop an integrated assessment framework that combines bottom-up economic costing, life cycle monetization, and scenario analysis to evaluate nine municipal solid waste treatment strategies across 352 Chinese cities. doi.org/10.1016/j.xi... #SustainableCity #WasteManagement

The Innovation Life Call for Youth Editor!!! There are 95 Editorial members from 18 countries, and their research interests cover all disciplines of life science. If you are interested in joining the youth editorial team, please send your CV to [email protected] #lifescience #youtheditor

What could open up opportunities and pave the way of the modern Moore’s Law IC development? The hot research has been discussed, and the materials-devices-architecture-algorithm framework has been proposed with the devices highlighted as the fundamental solution. doi.org/10.59717/j.x...

The Innovation #Materials Call for Youth Editor! The Innovation Materials as a sister journal of The Innovation, was launched in 2023 and has undergone rapid growth to become a rising star. If you are interested in joining the youth editorial team, please send your CV to [email protected]

The latest issue of @theinnovation.bsky.social features an article that reviews how novel pan-EGFR inhibitors can be designed to target all atypical EGFR mutations comprehensively. doi.org/10.1016/j.xi... #NSCLC #egfrinhibitor #drugdesign

Kong et al. created a completely novel research approach, aiming to solve interdisciplinary problems in geothermal energy research and engineering, enables users to obtain engineering-ready outputs and actionable solutions directly. doi.org/10.1016/j.xi... #geosciencesoftware #geophysics

This consensus systematically establishes a biomarker-driven decision framework for first-line precision therapy in advanced #gastriccancer, proposing a prioritized treatment stratification framework based on MSI-H/dMMR, HER2, PD-L1, and Claudin18.2 status. doi.org/10.1016/j.xi... #cancertreatment

Yuan et al. provide a comprehensive synthesis of current advances in particulate matter associated lung carcinogenesis, from population-level risk patterns to molecular pathogenesis and translational strategies. doi.org/10.1016/j.xi... #lungcancerresearch #airpollution #particulatematter

Luo et al. outline the technological roadmaps essential to unlock the optimized potential of all elements in biomass waste, ensuring that every element finds its rightful place to achieve enhanced circularity. doi.org/10.1016/j.xi... #bioeconomy #sustainablity

Zhang et al. highlight how complex triggers and conditioning factors, cascading and compound hazards, sparse field observations, uneven EWS performance, and persistent social and governance constraints collectively limit the predictability of GLOFs. doi.org/10.1016/j.xi... #flood #glacial

@theinnovation.bsky.social #webinar: Impact of global warming and groundwater abstraction on #waterbalance, #salinity and lake ecosystems in arid and semi-arid regions. Speaker: Erik Jeppesen, DSc Date & Time: Mar. 21, 2026 | 21:00-22:00 (UTC+8) VooV meeting ID: 168-520-223 Join us this Saturday!

The Innovation Energy (TIE) Call for Youth Editor!!! TIE is a sister journal of The Innovation. TIE publishes innovative, rigorous and cutting-edge progress in #energy science. If you are interested in joining the youth editorial team, please send your CV to [email protected] #youtheditor

This study demonstrates that large wind farms can significantly influence local land surface temperature, producing opposite effects during the day and night, and ultimately reducing the diurnal temperature range. doi.org/10.59717/j.x... #windfarm #CleanEnergy #microclimate

Novel SAXS/WAXS/XRF cross-scale combined technique surmounts the limitations of traditional single-characterization methods, real-time tracks the dynamic multi-scale structural evolution of electrocatalysts in MEA electrolyzers. doi.org/10.59717/j.x... #chemistry #sustainability

The emerging organic permeable base phototransistor, which integrates high-gain photodetection with long-term information storage, is promising for overcoming conventional limitations and enabling low-power, ultrasensitive devices with integrated sensing and memory doi.org/10.59717/j.x... #materials

By symbolic regression with experimental data, Han and Jin developed a general theory for diffusion coefficients that can be applied to a wide range of organic compounds at varying temperatures. doi.org/10.59717/j.x... #symbolicregression #diffusioncoefficient

The Innovation Geoscience has been indexed in Google Scholar, Scopus, CAS, DOAJ, OARL and we are actively pursuing indexing by other major scientific databases... If you are interested in joining the youth editorial team, please send your CV to [email protected]. #geoscience #youtheditor

Zircon U isotope compositions reveal a shift in magma oxygen fugacity, constrain the onset of the plate tectonic regime, and open a new window into understanding continental crust evolution. doi.org/10.59717/j.x... #zircon #geology #platetectonics

Heatwaves followed by heavy rain within a week are rising. Liang et al. define Compound heatwave–pluvial events, map global increases and hotspots (1980–2021), and quantify future inequalities in population and GDP exposure under warming. doi.org/10.59717/j.x... #heatwaves #ClimateInequality

This study proposes a thermal management system using cooling tubes to actively regulate the temperature of the track slab. doi.org/10.59717/ipj... #thermalmamagement #HighSpeedRailway #SustainableTransportation

Deng et al. propose cell editing—a technology inspired by endosymbiosis—for implementing complex functions into a host chassis that are currently difficult or impossible to achieve. doi.org/10.59717/j.x... #LifeSciences #syntheticbiology #cellediting #biotechnology

@theinnovation.bsky.social #webinar: "One Health" Strategies and Technological Innovations for Addressing Microbial Challenges. Speakers: Shunbo Li, PhD Date & Time: Mar. 14, 2026 | 21:00-22:00 (Beijing Time) VooV meeting ID: 562-275-493 Join us this Saturday! #OneHealth #Microbiota

The evidence synthesized in this review compellingly argues that late-onset Alzheimer's disease is not a distinct disease separate from aging, but rather a manifestation of maladaptive aging in the brain. doi.org/10.59717/j.x... #AlzheimersDisease #aging #epigenetics