What music should we play to our cells? This was the start of an amazing journey from @ivaskalab.bsky.social at @turkubioscience.bsky.social with Jasmin Kaivola and collaborators @sarawickstrom.bsky.social and others to explore larynx cancer mechanosensitivity! www.nature.com/articles/s41...

Incredibly bright 🌈

Delighted to share our latest preprint "Filopodia-mediated trans-endocytosis" www.biorxiv.org/content/10.6... Work driven by many people including Hanna, Marcela, Sujan, Marie-Catherine, Anna and Monika. Fantastic collaboration with Johanna Englund, Emilia Peuhu, and Eija Jokitalo

A TRPV4-dependent calcium signaling axis regulates lamellipodial actin architecture to promote cell migration: Current Biology www.cell.com/current-biol...

My personal obituary for Richard Hynes now live on the Manchester Cell-Matrix Centre website. www.manchester-matrix.org/news/profess...

Last night @museeorsay.bsky.social we saw fluorescence images of cells or protein filaments seemingly grow along the internal structures of the ceiling of the main hallway. It was mesmerising I loved it Science is Art! More of this please! Congratulations @manuelthery.bsky.social very cool 🤩🤓

🚨 We are hiring TWO postdocs to join the Cell Migration Lab (cellmig.org) 🇫🇮 as part of the new Centre of Excellence in Immune–Endothelial Interfaces (IMMENs). Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬 Details in thread 🧵👇 #ScienceSky #Postdoc #AcademicJobs Please RT🫶

Check out our new Talin Infographic! The poster summarises why we think there is a binary code in animals. Great artwork made by Josh Hawley @golgigraphics.bsky.social

Excited to share our new preprint! and the surprising finding that the second integrin-binding site (IBS2) does not bind integrin. IBS2 can be better explained as talin-talin interactions mediated via a cryptic talin-binding site in R11. We also show a new role for vinculin as a mechano-chaperone

Excited to share our new preprint! and the surprising finding that the second integrin-binding site (IBS2) does not bind integrin. IBS2 can be better explained as talin-talin interactions mediated via a cryptic talin-binding site in R11. We also show a new role for vinculin as a mechano-chaperone

Coming 2027...

Delighted to share the latest paper from the lab "Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers" Amazing work driven by @follainga.bsky.social with contributions from many. link.springer.com/article/10.1...

New paper out! We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution. Huge congrats to Aurélie Favarin, Rayan Said, & all authors! In Science Advances: www.science.org/doi/10.1126/... #actin #myosin #mechanobiology

I will be recruiting two postdocs early next year. - One image analyst - one biologist interested in working on lymphatics! Reach out if you are interested 👍

Latest from the lab "Filopodome proteomics identifies CCT8 as a MYO10 interactor critical for filopodia functions " www.biorxiv.org/content/10.6... Work driven by @anagracanin.bsky.social A great collaboration with @ivaskalab.bsky.social and @bengoult.bsky.social

🎉

This title has "very lethal" energy

Congratulations, @samstehbens.bsky.social & Co !!! 🥳🥳🥳👏👏👏 www.nature.com/articles/s41...

spicy! genesdev.cshlp.org/content/33/2...

🧵

Optogenetic control of mechanotransduction based on light-induced homodimerization of talin url: journals.biologists.com/jcs/article-...

🧠 Fully funded 4-year PhD studentship 🧠 Please repost BBSRC NWD project with @parikki.bsky.social and @iamabyron.bsky.social Come join us to look at how mechanical and oxidative stress signalling pathways converge on the synaptic scaffold protein talin. www.findaphd.com/phds/project...

Vinculin is a simple adapter protein right? Wrong! That’s been the prevailing view for the 46 years since it was discovered. Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains. www.science.org/doi/10.1126/...

Another great opportunity for a PhD linking hypoxia to cell matrix mechanobiology!

Thanks to inattentive travel booking I have given myself a cheeky 6hr stopover in Munich. 🤦

Vinculin is a simple adapter protein right? Wrong! That’s been the prevailing view for the 46 years since it was discovered. Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains. www.science.org/doi/10.1126/...

Solution-oriented

The project is now live on FindaPhD and open for applications. Deadline December 4th

New episode on the CDKL5 in Color podcast and it's a science one! Let us know what you think! open.spotify.com/episode/5Lkx...

This was good fun to do, and I really enjoyed getting to chat about our CDKL5 research for a non-scientist audience with Marissa and Amanda. Thanks for having me.

*Fully funded 4-year PhD studentship available* This MRC DiMeN DTP funded project will look at the direct interactions between talin and the hypoxic response machinery to define the protective mechanisms at play in cells that protect against oxygen depletion www.findaphd.com/phds/project...

Off to Boston tomorrow to present our work on talin in epilepsy at the CDKL5 Forum. I will talk about our preprint reporting new interactions of CDKL5, with talin and PDZ-domain containing proteins which together identify CDKL5 as a mechanically regulated enzyme. www.biorxiv.org/content/10.1...

Great time in Paris at the Valorant Champions with Oliver.

First day back at @liverpooluni.bsky.social after my 4 week trip, and got off to a bad start as broke my best espresso cup. 😭

This was an excellent meeting.

So excited to see the first part of my thesis work with @harmitmalik.bsky.social and @melodygcampbell.bsky.social in print! www.science.org/doi/10.1126/... We have a bit of evolution and a whole lotta structure to figure out how new protein domains work

Venkatesh B, et al. (@tanentzapflab.bsky.social lab) Inside-out integrin activation is essential for early mammalian development. Mol Biol Cell. 2025 Sep 3;:mbcE25030106. [Epub ahead of print]. PMID: 40901728

Excellent science, inspiring discussions … and scientists in the sea! Special thanks to Andreja, @bengoult.bsky.social, Vasso, Nina, Marina and Marija for organising such a great meeting! 🐬 🐬

🎉It's finally out! Mechanosensitive biochemical imprinting of the talin interaction with DLC1 regulates RhoA activity and cardiomyocyte remodeling | Science Advances www.science.org/doi/10.1126/... - Amazing work Emilie, Ioannis and all co-authors and collaborators!

Really happy to have contributed to this great story as part of our BHF special project grant.

Excited to share our new preprint in @biorxiv-neursci.bsky.social "Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains" Instead of a 🧵 the paper is summarised in this video. www.biorxiv.org/content/10.1...

Sea was quite moody tonight

Almost all previous studies on CDKL5 have used a C-terminal tagging strategy (presumably to position the tag away from the kinase domain), but here we show that such modification of the C-term is disasterous as it abolishes CDKL5 synaptic localisation and function. www.biorxiv.org/content/10.1...

ADHERE 2 conference is next week! Great line up of speakers and fun acitivities planned, this is going to be amazing! Hope to see you all in Zadar, Croatia. ☀️ event.fourwaves.com/adhere2/pages

Excited to share our new preprint in @biorxiv-neursci.bsky.social "Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains" Instead of a 🧵 the paper is summarised in this video. www.biorxiv.org/content/10.1...

In the week I was out of office, this cheeky opportunist dropped a root into a nearby plants pot. 🌱

Congratulations to @stefanosala89.bsky.social , with help from @shreya-c.bsky.social al‬ on the optogenetic experiments, for the awesome story! Read the full preprint here: www.biorxiv.org/content/10.1... and thanks for listening!

This is amazing, art work based on The MeshCODE Theory. www.davinci-project.com/collection/a... Thanks Nash Cruz and Mireya Vazquez-Prada

Our study on the mechanosensitive behavior of cell adhesion, showing the existence of a force-transmission mechanism that behaves very differently from the well-known 'load-and-fail' mechanism, was published in Nature Physics: www.nature.com/articles/s41...

ISMIB seminar Thursday 17th July 1pm Physiology Seminar Room Speaker: Prof Haguy Wolfenson Title: Understanding and modulating cell fate decisions mediated by cell-ECM interactions Host @bengoult.bsky.social