Want to apply for an EMBO Postdoctoral #Fellowship? 🧪 Here are tips from the EMBO Fellowship Committee: www.youtube.com/watch?v=xY7c... #LifeSciences #grant #funding

What's the role of stress granules in translation? Here we provide a clue: we characterized the distribution of ribosomal complexes within SGs and reproduced this landscape with a phase-field model, pointing to a new regulatory mechanism. #TEAMTOMO www.science.org/doi/10.1126/...

🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/

Happy to share latest work from the lab. Led by talented first author @awmartinelli.bsky.social. Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux | Science Advances www.science.org/doi/10.1126/... Congratulations to all the team.

#RNAsky 💜💜💜💜💜💜💜

On my way back from a truly brilliant yeast meeting! With more than 500 participants, so much cool science and loads of fruitful discussions, this week was remarkable! #yeast2025

I am in Paris this week for #yeast2025!

Delighted to share our latest work on ABHD11 as a novel deglutarylating enzyme, and its role in T cell metabolism @natchembio.nature.com rdcu.be/ewiYZ. Many congratulations to co-first authors Guine Grice, Eleanor Minogue and @hudsonwilco.bsky.social! Great team effort with Randall Johnson's lab.

Our new preprint: how photoprotection is spatially coordinated with energy metabolism. Photosystem I is major source of radicals. We report EM structure of PSI in complex with superoxide dismutase SOD: direct link between energy conversion & oxidative stress defence www.biorxiv.org/content/10.1...

🎉Excited to share our latest paper, published in Nature Communications!🎉 "Enhancing autophagy by redox regulation extends lifespan in Drosophila" #redox #metabolism #ageing #Drosophila @natcomms.nature.com @mrc-lms.bsky.social doi.org/10.1038/s414...

New tools! GreenPy and ApplePy are fluorescent biosensors for pyruvate with huge responses (20–40x in vitro) and a range of affinities (10s of μM to mM). These should be game changers for imaging of metabolism! Great work by Shosei Imai @sikmys.bsky.social and team 👏. www.biorxiv.org/content/10.1...

How do cells switch on the actin assembly at endocytic sites? How can this on-switch evolve? Check out our new preprint! www.biorxiv.org/content/10.1...

1/27 We have a new paper out! Turns out that snowflake yeast have been hiding a secret from us - they've evolved a (very!) crude circulatory system. Not with blood vessels or a heart, but through spontaneous fluid flows powered by their metabolism. 🧪🔬 www.science.org/doi/full/10....

Are you looking for a postdoc? I will be looking for 2-4 people after the summer to join the lab !! Do not hesitate to reach out and disseminate !!

Congratulations to Dr Aphrodite Vasilaki and Dr Paraskevi Kritsiligkou @parikki.bsky.social who won the Leopold Flohé Redox Pioneer Young Investigator Award and Catherine Pasquier Award respectively at the 2025 Society for Free Radical Research International meeting ▶️ bit.ly/4ebZ9XN

Spent the day listening to some amazing talks from first and second year PhD students in our Biochemistry, Cell and Systems Biology Department! I loved how confident and knowledgeable our students are! Can’t wait for my students to give their talks next year 🥹

Had a great time at the SFRR-I meeting! I listened to some exciting new science, spent time with my friends that live far away and met my fellow @sfrre-ecr.bsky.social in person!❤️ We successfully organised networking events and a sunrise seminar and it is clear we are building a great community 🎉

Outstanding talk by @parikki.bsky.social , recipient of the CATHERINE PASQUIER AWARD LECTURE at SFFR-I Biennial Meeting in Galway @uniofgalway.bsky.social. Are ROS generated in nanodomains / condensates in cells? Want to know more, please read her paper lnkd.in/dq_6Rnaw @sfrre-ecr.bsky.social

Liverpool's @parikki.bsky.social giving the Catherine Pasquier Award lecture at the SFRRI Biennial Meeting in Galway. Fantastic talk 👏🏻 @liverpooluni.bsky.social @livuni-ismib.bsky.social @livunihls.bsky.social

www.nature.com/articles/s41... From Denis Hnisz lab

Attending the Careers beyond Gender session this morning! Hozumi Motohashi is an inspiration to us all! ❤️

In Galway for the SFRR-I meeting!With >400 delegates, this week is gonna be epic! If you are an ECR, don’t miss out on the activities the @sfrre-ecr.bsky.social committee is organising! Today join us at 18:30 for a fun meet the professor session and at 19:30 for our annual ECR networking event!

🧫 Rise and shine—it’s the Yeastosaurus!

The Montpellier Institute of Molecular Genetics is recruiting group leaders (open rank). IGMM studies fundamental mechanisms underlying cellular processes and their links to human pathologies. Montpellier 🇨🇵 is an absolutely wonderful place to live. Deadline 31st October. jobrxiv.org/job/montpell...

Yesterday I had the pleasure to examine a PhD thesis! It was a great experience, because the student was awesome and I learned so much from the external examiner on how to go about it! Can’t wait for the next one! 😂

Had a fantastic day being at the University of Manchester today, giving a talk at the Protein and RNA fate seminar series! Very thankful for the invite and the opportunity to share some super new, super cool data from my lab!

Some small molecules modulate protein condensation in cells, but how? Our latest work shows a possible mechanism of action of the small molecule lipoamide. This molecule prevents condensation of stress granules whose components are found as protein aggregates in ALS. www.nature.com/articles/s41...

💫NEW: Wei et al. report that MBD2 forms condensates through #PhaseSeparation in diverse cancers where it assembles the NuRD complex. MBD2 condensates are redox-sensitive and mediate transcriptional repression in #cancer cells. 👉https://rdcu.be/elKdU go.nature.com/4iW4nrd

Convergent evolution of "smelling like rotting meat" is mediated by a 3 amino-acid chance in a conserved enzymes, just out @science.org 🔽 www.science.org/doi/10.1126/...

New structural insights into SBPase from #Chlamydomonas reinhardtii. This study reveals how #redox state influences the enzyme’s oligomeric form and offers clues to its regulation in the Calvin cycle. buff.ly/qfy40Ii

Proud present our latest work led by Blessy Paul, now in Developmental Cell @cellpress.bsky.social. Here, we characterize an ER-localized antioxidant enzyme in humans and Drosophila that acts as a lipid quality control factor to suppress ER lipid oxidation. www.cell.com/developmenta...

Join us tomorrow online! Amal is such a passionate speaker and determined scientist!

Join us in Engelberg, Switzerland, for an exciting #EMBO workshop on #mitochondria in the nervous system #EMBOmitoNervousSys! Great speaker line up and opportunities for short talks from early career scientists. Submit your abstract until May 30st! @jcourchet.bsky.social @tatjanakleele.bsky.social

Can metabolism regulate more than bioenergetics during human development? Our new study says YES! We show that metabolism influences cell fate choice in human naïve pluripotent stem cells, histone acetylation, and trophectoderm maturation. rb.gy/spqr9j @natcellbio.nature.com

Booking for the @ukbspr.bsky.social post-conference single-cell proteomics workshop is now open! Numbers are capped at 20 participants, so please register early to avoid disappointment. payments.liv.ac.uk/conferences-... If the system tells you it is at capacity, please drop me an email.

Had a wonderful time in London! Many thanks to Olena, Jörg and Giovanni for such lovely, inclusive meeting (sponsored by SFRR-E)! I mostly enjoyed being a poster judge, was great to see so much cool redox science coming up and meet all the ambitious young researchers!

Registration deadline for the EMBO Thiol meeting is 18 May 2025! Don’t miss it! meetings.emboss.org/event/25-thi...

Just back from a truly amazing Redox Week in Sendai, Japan and already heading into London for the UK redox network meeting! I can’t wait for tomorrow! Also, I should say, I really love my job ❤️🙂

this paper is really spectacular, it was presented at the ASCB last year. Our beloved ESCRTs play a significant role in here, what is not to like? www.biorxiv.org/content/10.1...

To the top of the "to-read" list. Looks like a heroic amount of work from the Hahn lab (large-scale ChEC-seq compendium!) www.nature.com/articles/s41...

I am in Japan for Redox Week 2025! 🇯🇵🌸 I am extremely grateful for the invitation to talk about my work and excited to be reunited with friends, colleagues and collaborators! I can’t wait to hear about all the super cool new discoveries in the field! 🎉 www.redoxweek2025.jp

📢 Exciting Webinar Alert! Join us tomorrow, April 1st, at 15:00 CET for an unmissable webinar on chaperones in redox biology, hosted by @sfrre-ecr.bsky.social! We’re thrilled to welcome two fantastic speakers: @ulrichlab.bsky.social and @rsutandy.bsky.social. See you there!

I am delighted to be in London next month for the UK Redox Network! If you would like to join us, there is still time to register forms.office.com/e/8Zt9Kq2dag! I am very thankful for the opportunity to talk about my work (two years in a row)! Hopefully I wont be broken this time, just jet lagged...

I am having a fantastic morning at the EuroAgeNet meeting! It’s great to see so many familiar faces and hear about exciting new discoveries on such a wonderful sunny day at the top floor of the Spine! 🥰

Glad to see this paper on the role of #mitochondria in #ageing from Alberto Sanz lab finally out, cool story that was in development for a long time. As always a pleasure to collaborate! www.embopress.org/doi/full/10....