Patrick's paper is finally out, a label-free method to measure the composition of multicomponent biomolecular condensates!

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...

Excited to share our latest work out in @pnas.org! We show that the #SARSCoV2 nucleocapsid protein directly prevents DNA recognition of the immune sensor #cGAS by competing for DNA, which may delay early innate immune responses during infection. www.pnas.org/doi/epub/10.... #innateimmunity

We are very happy that XiaoYan's (Andy!) paper is out, congratulations to all authors @cellpress.bsky.social @xiaoyan52802927.bsky.social www.cell.com/cell/fulltex... Demixing of TDP-43 inside stress granules generates pathological aggregates linked to ALS/FTD @mpi-cbg.de @biotec-tud.bsky.social

The tricellular junction is a unique place where three or more cells contact. Here is our latest preprint showing the role of protein condensation in organizing molecular localization and function at tricellular junctions. www.biorxiv.org/content/10.1...

Some small molecules modulate protein condensation in cells, but how? Our latest work shows a possible mechanism of action of the small molecule lipoamide. This molecule prevents condensation of stress granules whose components are found as protein aggregates in ALS. www.nature.com/articles/s41...