Mouse pancreas epithelial cells with mutant RAS – have prominent nucleoli that sometimes arrange to make little smiley faces 📹 @zeinabrekad.bsky.social @oxfordbiochemistry.bsky.social. At the Dept's imaging facility Micron with @leicamicrosystems.bsky.social THUNDER ➡️ bpod.org.uk/archive/2025...

On the first day of the Christmas holidays, I got... a new preprint out! Challenging the reproducibility of our manual presynaptic actin nanostructure identification: www.biorxiv.org/content/10.6... (data from Bingham et al. @jcb.org 2023 doi.org/10.1083/jcb....) with @flevet.bsky.social

Telescope Types xkcd.com/3182/

- How many supplementary figures do you want? - 'yes'

Une honte 😮‍💨

That on its own could be a special 'academia 2.0' black mirror episode 😱

How are RNAs presented on the cell surface without any transmembrane domains? In our paper published at Molecular Cell @cp-molcell.bsky.social, we provide mechanistic insights into this pressing question. They form ternary complexes with RNA-binding proteins and heparan sulfate proteoglycans.

Flat cash for discovery research at UKRI ‘will increase competition’ Shakeup of spending at national research funder likely to be felt “pretty quickly”, experts say www.researchprofessionalnews.com/rr-news-uk-r...

Whooooooowww 🤩🤩🤩🤩🤩 Fantastic! #ChromatinSky

Shot in the dark, but has anyone tried transfecting EOL-1 cells (using lentiviruses, electroporation, or otherwise) and succeeded? We’re having some issues with these cells but it seems to be very vector-specific. Would appreciate any insight/reposts.

🔥🔥🔥🔥🔥🔥🔥🔬🔬🔬🔬🔬🔬👇🏻 #microscopy_sky

Oh where, oh where does my protein localize? Oh where, oh where can it be?🎵 Check out our Subcellular Localization Collection page, with fluorescent protein markers for organelles and cellular structures to help you find your way 🔬

We all need to be far more skeptical about the "promises" of AI in academia. This hands a terrifying amount of power to AI companies. And if we’re delegating all the critical thinking to AI (generate papers, summarize papers, review grants and papers, analyse data), this is the end of academia.

That's some very noble use of mass spectrometry! Viva extra virgin olive oil 🫒!!!!

Phoooooo that's ground breaking 🤯 I know quite few integrins afficionados that won't be thrilled by the news though haha 😅 What do you mean integrins aren't the master regulators of cell adhesion??? 🤪 Contrats 🎉!!!! #CellAdhesion_sky

OMG another RNA localization related paper published in one week 🥹🥹🥹🥹🥹 Could this be a sign? 🙃 Congrats 🎉 #RNAsky

Yup... 😔

Just so I'm clear on this, computer memory has tripled in price because a bunch of it that hasn't been produced yet has been ordered to populate GPUs that aren't installed in data centers that aren't built yet in order to service a demand that doesn't exist to make profits that don't happen.

I wrote a lil post on the amazing work that @ginareynolds.bsky.social does championing ggplot2 extension developers and teaching others to build their own! The post features the Scrollytelling Quarto extension and the group's cute #RStats hex 🐱: rworks.dev/posts/ggplot...

🌍 Imaging 4 All — 3rd Call Open! Fully funded mobility grants for low/middle-income country researchers to access imaging technologies for experiments and training. 🗓 Deadline: 28 Feb 2026 More info: globalbioimaging.org/i4a For questions: [email protected] #Imaging4All

#PhotoFiTT proposes a standard label-free and quantitative protocol, including #AIImageProcessing, to measure #phototoxicity derived cell stress 🧮 By systematically assessing deviations in cell behaviour, we can optimize #livecell experiments and stop blindly frying our cells💡🧫

God, I read this out of nowhere and was already imagining this being used on a stupid pamphlet for a 'rejuvenating' UV-face mask "Delay your mitosis-> delay your aging!" 😆😆😆😆😆 Jokes aside, this study is of public service for all live microscopists out there! #MicroscopyMonday

That's the biological equivalent of "you're job has been replaced with AI" #jobless methyltransferases 😆😆😆😆😆😆 Not to mention the whole 'enter cells' claim... 🙄🙄🙄🙄 Sometimes simplification should just be illegal.

Beautiful 😍 It's true that quite some literature is showing that many RNA can be localized to neurites, but what about quantity management over there ??? 😵‍💫🙃 Very cool !!! #RNAsky

Proteomic Ruler question: In Wiśniewski et al., MCP 2014, the histone→DNA proxy seems implicit. Is there any explicit reference stating that the Ruler uses only core histones (H2A/H2B/H3/H4) and excludes H1? #proteomics #massspec

Dear Bsky #imaging friends, what would you recommend to learn how to do cryo-EM? (from sample prep to analysis) What is/are 'THE' lab/ facility/ trainings/ conferences you recommend me to visit/attend? I am open to anything and Budget is not an issue. Bonus if they are #ribosome specialists. 🤓 🔬

Woow wooww, just wowwww! 🤯🤯🤯🤯🤯🤯 That is a very important reminder indeed! 👇🏻

The dark proteome: translation from noncanonical open reading frames 1⃣5'-UTR 2⃣3'-UTR small ORF/sORF 3⃣out-of-frame 4⃣In-frame overlapping ORF Translating micropeptide <100aa, proteins distinct from canonical ORFs, or isoforms #TrendsCellBio 2022 www.sciencedirect.com/science/arti...

The devastation I feel about this attack on science in particular is hard to cope with. It’s like watching my dad die all over again. I would do anything to spare someone a death via pancreatic cancer.

36 years ago today, 14 women, most of whom were studying engineering, were killed by an anti-feminist gun man at École Polytechnique in Montreal. I was a young graduate student studying physics at the time and I will never forget. #MontrealMassacre #NeverForget 🧪 👩‍🔬 ⚛️ 🎢 #AcademicSky 🇨🇦

Checkout @guijacquemet.bsky.social team amazing work ❤️

What do the pro-life supporters have to say on this one? Maybe they would be willing to help fund the medical bills.... Wait ....Nah....

This remains one of the most disturbing stories of the year. A 1st trimester fetus incubated in a dead woman's body against the will of her family until a very early term birth when the corpse could no longer sustain life. www.cbsnews.com/atlanta/news...

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Organising symposia is a whole lot less work and more fun when you've got an enthusiastic group of fellow organisers to help out. But #CBIAS2025 was my 6th and I think it's now time to step back a little. So from next year, @lankylaste.bsky.social will be taking the lead. Roll on #CBIAS2026!

A small bladder+ IBS... 🙄

Cause they can't do all that perfectly and in a world of apparent 'perfectness' the fear of not doing everything 100%+ intolerance to efforts has left many completely paralyzed (like toddlers in front of stairs) so instead of trying they just break down. They don't 'refuse', they just throw tantrums