🚨 #REVIEW 🚨 Iacobucci & Mullighan discuss how advances in genomic, transcriptomic & epigenomic profiling of ALL have revealed molecular heterogeneity, lineage plasticity & mechanisms of treatment resistance in both B and T cell diseases. 👇 📖

#ResearchHighlight 🚨 A recent study identifies TEX264-dependent nucleophagy as an important mechanism that mediates the clearance of trapped PARP1, thereby limiting PARP1-induced toxicity and promoting resistance to PARP inhibitors. 👇

🚨 #REVIEW 🚨 Wang et al. describe how extracellular vesicles & particules contribute to the systemic effects of cancer. 👇 📖

🚨 #REVIEW 🚨 Grimm et al. describe the range of non-invasive diagnostic imaging approaches to monitor the various hallmarks of cancer and how their implementation is shaping clinical practice. 👇 📖

#ResearchHighlight A rcent study uncovers a role for microorganism-derived sulfur amino acid metabolism in enhancing immune responses against tumours, providing new insights into host–microbe interactions in cancer. 📖 👇

#Comment 🚨 @itaiyanai.bsky.social#Commentchallenges common assumptions about communicating research and reflects on how greater clarity, focus and audience awareness can help transform talks into more meaningful scientific exchanges. 📖 👇

Our JULY issue is now live!🌞 🏖️🍉 It features #REVIEWS on: - AI for integrating cancer multi-omics & clinical data - Targeting cancer dormancy - Context-dependent synthetic lethality - Microbiota in immune-related adverse events 📖 👇 http://dlvr.it/TTGZK8

🚨#REVIEW🚨 While tumour virology has focused on oncogenic viruses, some exposures can boost anti-tumour immunity. Wang et al. explore the protective roles of viruses in cancer & the implications for virome-guided cancer immunoprevention. 👇

#REVIEW 🚨 Here, Liu et al. describe tools for generating comprehensive 3D tumour atlases that could uncover novel biomarkers for risk stratification, early detection, preventive interventions, diagnosis and treatment. 👇

#ToolsoftheTrade 🚨 Bassel Ghaddar describes the development of PRISM, an efficient computational pipeline for microbial species detection and decontamination from genomic sequencing data, enabling the study of microbial associations with cancer. Check it out 👀 👇

The 2026 annual meeting of the American Association for Cancer Research (AACR) was held under the theme ‘Precision, Partnership, Purpose: Advancing Cancer Science to Save Lives Globally’. We summarized some key highlights from the meeting. 📖👇

Registration and abstract submissions are now open for Next Generation Cancer Therapeutics. This Nature Conference will bring together leading global researchers who are transforming the landscape of cancer therapies for discussions and networking. go.nature.com/4eHSlnc #STEMConference

Rare cancers remain underserved by precision oncology. In this #Comment, the authors propose that systematic, variant-level pharmacological mapping of approved kinase inhibitors can transform this gap into an opportunity for scalable drug repurposing. 📖 👇

In this #ToolsoftheTrade article, Guangqing Lu describes the development and use of cytokine cellular locating platforms (CyCLoPs), a technology that enables visualization and tracking of cytokine signalling in vivo. 📖 👇

#ResearchHIghlight 🚨 Hu et al. show extracellular vesicles (#EVs) from activated T cells enhance antigen presentation in tumour cells and dendritic cells, promoting immune-mediated tumour clearance 📖👇

#JournalClub🚨 Stephenson-Gussinye & Furlan-Magaril explore how 3D genome reorganization explains why only some variants drive gene expression changes in cancer 📖👇

In case you missed this #JournalClub🚨 Terrazas&Peón discuss a recurrent CTNNB1 mutation generating public #neoantigens recognized by engineered #TCRTcells, enabling potent antitumour responses across models 📖👇

#Research Highlight🚨 New research shows the heart's resistance to tumor formation is influenced by mechanical load. Cardiac contractions activate a mechano-epigenetic pathway that suppresses cancer cell proliferation in vivo and in engineered heart tissues. 📖👇 dlvr.it/TSlM5m

Our JUNE issue is now live! ☀️🍉 It features #REVIEWs on: - Balancing type I interferon signalling - Interplay between steatotic liver disease and liver cancer - KMT2C/KMT2D-COMPASS complex loss in cancer - #ExpertRecommendation on ovarian cancer 📖👇 http://dlvr.it/TSrBnm

#FreeAccess🚨 If you want to know more about #OvarianCancer, check out our #ExpertRecommendation on the progress in research and treatment of high-grade serous ovarian cancer. Completely free to access for 1 month from today! @Qmbci.bsky.social @qmul.bsky.social#FreeAccess📖👇

#JournalClub 🚨 Díaz-Muñoz discusses how IFC-305 restores mitochondrial structure and bioenergetics while reducing tumour burden in a rat model 📖👇

#Review 🚨 Emerging evidence links loss of the Y chromosome to cancer risk, progression and outcomes, highlighting its potential as a biomarker for prognosis and precision therapy. 📖👇

#Review 🚨 Lan Coffman&Co discuss the context-dependent role of mesenchymal stromal/stem cells (#MSCs) in supporting and restraining cancer growth and highlight how MSC biology can be exploited for cancer treatment. 📖👇

#Review 🚨 Cancer cells dynamically rewire immune checkpoint expression across multiple layers. Understanding these mechanisms could unlock new biomarkers and improve immunotherapy outcomes. 📖👇

#ToolsoftheTrade 🚨 A new epigenetic liquid-biopsy platform, cf-EpiTracing, captures histone modifications on cell-free chromatin from plasma, enabling unbiased cancer monitoring. 📖⬇️ http://dlvr.it/TSkzdL

#ResearchHighlight 🚨 Linking inflammation to cancer initiation, Nagaraja et al. show that colitis imprints a heritable epigenetic memory in colonic stem cells, enhancing AP1 programmes and accelerating tumour outgrowth after mutation. 📖⬇️

#REVIEW 🚨 How does #exercise reduce cancer risk? Zhuang et al. propose that physiological adaptation to aerobic activity reshapes adult stem cell behaviour, limiting transformation and tumour initiation 📖⬇️

#ResearchHighlight🚨 #Microplastics and nanoplastics are emerging as pervasive exposures. Li et al. quantify particle burden in human #brain tumours and healthy tissue, revealing composition and spatial distribution within the brain. 📖👇