Matthew Taliaferro
@jmtali.bsky.social
π€ 1361
π₯ 315
π 77
RNA biologist at University of Colorado Anschutz Medical Campus
http://www.taliaferrolab.com
Excited to share that this work is now published in its final form!
link.springer.com/article/10.1...
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11 days ago
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reposted by
Matthew Taliaferro
The EMBO Journal
11 days ago
A mechanism for controlling mRNA localization to neuronal projections: Daniel Dominguez, Matthew Taliaferro
@jmtali.bsky.social
and collaborators implicated ALS-linked TDP-43 as inhibitor of mRNA accumulation in neurites, possibly by promoting their decay
link.springer.com/article/10.1...
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TDP-43 directly inhibits mRNA accumulation in neurites through modulation of mRNA stability - The EMBO Journal
The subcellular localization of many mRNAs to neuronal projections allows neurons to efficiently and rapidly react to spatially restricted external cues. However, for most of these RNAs, the mechanism...
https://link.springer.com/article/10.1038/s44318-025-00653-4
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reposted by
Matthew Taliaferro
Lerit Lab
18 days ago
Join us in Porto for the forefront of RNA localization & local translation research! Registration is live!
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reposted by
Matthew Taliaferro
Simon Bullock
18 days ago
My favourite meeting! Highly recommend registering for this one...
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Announcing the 2026 edition of the EMBO workshop on RNA localization and local translation! This meeting will be held June 30 - July 4 near Porto, Portugal. Come for exciting updates in the field from both established investigators and trainees. See the link below for details!
18 days ago
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How does one review his paper if heβs infallible?
8 months ago
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reposted by
Matthew Taliaferro
Felipe del Valle Batalla
9 months ago
New
@prelights.bsky.social
post ! I'm happy to highlight
@jmtali.bsky.social
lab latest preprint
prelights.biologists.com/highlights/t...
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TDP-43 directly inhibits RNA accumulation in neurites through modulation of RNA stability - preLights
An intriguing twist! TDP-43 (linked to ALS) keeps RNAs out of neuronal projections by making them unstable preventing RNA buildup in neurites
https://prelights.biologists.com/highlights/tdp-43-directly-inhibits-rna-accumulation-in-neurites-through-modulation-of-rna-stability/
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We received notice that two F31s were terminated and submitted another F31 application two hours later. We keep on trucking, I guess.
9 months ago
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Two updates with this project! First, this work is now published here:
academic.oup.com/nar/article/...
Second, our software for identifying 8-oxoguanosine via RNAseq, PIGPEN, is now installable via bioconda:
anaconda.org/bioconda/pig...
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9 months ago
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Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.
10 months ago
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Save the date for the next edition of this wonderful meeting. We look forward to seeing you in Portugal!!
10 months ago
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From this we can conclude that I am: A. extremely arrogant about my own writing B. an idiot C. both
11 months ago
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Come be our colleague!
@cu-bmg.bsky.social
is running an open rank search for a structural biologist specializing in cryo-EM/ET. This is a great opportunity in a highly collegial and collaborative department. Apply here:
cu.taleo.net/careersectio...
11 months ago
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Start PCR. Ski. Purify PCR product.
@molbcu.bsky.social
12 months ago
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@triggerloop.bsky.social
ok seriously is a&m refusing to share the film or what is going on here
12 months ago
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@triggerloop.bsky.social
good for you. Got your win for the day. No need to worry about anything else.
about 1 year ago
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reposted by
Matthew Taliaferro
Heide Ford Lab
about 1 year ago
Interested in doing your postdoc with the Department of Pharmacology at @CUAnschutz? Join us for our Postdoctoral Education & Knowledge Summit with @cuanschutz_dpb and the Department of Biochemistry & Molecular Genetics! Applications close December 1st.
bit.ly/CU-PEAKS
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CU PEAKS
https://bit.ly/CU-PEAKS
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reposted by
Matthew Taliaferro
Danny IncaRNAto
about 1 year ago
Fellow
#RNA
lovers, please repost π: 2 ERC-funded Post-doc positions are available in our lab to investigate
#RNA
structural ensemble and their dynamics in living cells. Application link:
t.co/pYJ3H3j705
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https://www.rug.nl/about-ug/work-with-us/job-opportunities/?details=00347-02S000B06P
https://t.co/pYJ3H3j705
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Excited to share our latest work! In it, we develop a new method for studying RNA localization via proximity labeling: OINC-seq! In contrast to other proximity-based methods, labels deposited on RNAs are read directly by sequencing without the need for biotinylation.
biorxiv.org/cgi/content/...
about 1 year ago
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reposted by
Matthew Taliaferro
Stephen Floor
over 2 years ago
New preprint from my group! We used SHAPE-MaP to measure RNA structure of DDX3X-sensitive mRNAs, developed a colorimetric translation reporter for DDX3X activity, and identified amino acids in DDX3X that mediate interaction with the translation machinery:
www.biorxiv.org/content/10.1...
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Determinants of DDX3X sensitivity uncovered using a helicase activity in translation reporter
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
https://www.biorxiv.org/content/10.1101/2023.09.14.557805v1
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