Happy #RNA day to all my fellow RNA lovers!

I am so incredibly excited to share our latest work, on the exploration of #RNA secondary structure ensembles and discovery of RNA regulatory structural switches in bacteria and human cells, just out in @natbiotech.nature.com: nature.com/articles/s41.... A short tread! (1/n)

The IncaRNAto lab is seeking a motivated #PhD candidate, interested in studying #RNA structural ensemble dynamics in living cells. Here's the link to the vacancy: www.rug.nl/about-ug/wor.... Please share!

#RNA Framework 2.9.3 is out! Lots of improvements! Check it out: github.com/dincarnato/R... & see the CHANGELOG (raw.githubusercontent.com/dincarnato/R...) for the details!

In a preprint published today, we are excited to report the secondary structure of the 1212 nt fission-yeast S. pombe telomerase RNA, TER1, and its roles in the physicofunctional organization of this massive, flexible enzymatic RNP complex. www.biorxiv.org/content/10.1...

NIH funding supporting the HMMER and Infernal software projects has been terminated. NIH states that our work, as well as all other federally funded research at Harvard, is of no benefit to the US.

Two 2-year postdoc positions available at @unigroningen.bsky.social with @incarnatolab.bsky.social Apply here: rug.nl/about-ug/wor... Info on the group: incarnatolab.com

#RNA rules

We present Rfam-based RNA structural alignments and other structure-based inputs for RNA 3D structure prediction by deep learning. www.biorxiv.org/content/10.1...

Inaugural post "All-at-one RNA folding with 3D motif prediction framed by evolutionary information" www.biorxiv.org/content/10.1... Introducing CaCoFold-R3D by @aakaran31.bsky.social and myself @rivaselenarivas.bsky.social

#RNA Framework 2.9.2 is out! Several fixes and improvements, particularly for mutlithreading. Check it out: buff.ly/4guLWsP & see the CHANGELOG (buff.ly/4gtJ67u) for the details!

Amazing new paper from @rivaselenarivas.bsky.social keeps improving #RNA covariation analysis, by adding RNA 3D motif prediction from alignment in R-scape!

The full #RNA conformational landscape of RNase P in solution: www.nature.com/articles/s41...

Hello Bluesky 🤠 Our very first post is about our recent paper in Nucleic Acids Research: so-called PUN motifs are repetitive elements enabling proteins to catalyze #RNA folding and RNA-dependent #condensate formation ( #LLPS). 15% of human proteins contain 3 or more PUN motifs. See bit.ly/4fZ3f54.

#RNA Framework 2.9.1 is out! Major NEW feature: RF can now use #R and #ggplot2 to generate several publication-ready plots.. Check it out: https://buff.ly/4guLWsP & see the CHANGELOG (https://buff.ly/4gtJ67u) for the details! Below a gallery of the various plots:

This is huge. Mis-splicing of a 24nt-long micro-exon in the CPEB4 #RNA binding protein leads to formation of irreversible aggregates, which normally would dissolve after depolarization, and consequent deregulation of genes associated with autism spectrum disorders www.nature.com/articles/s41...

#RNA Puzzles Round V www.nature.com/articles/s41...

🧬 Excited to share our new preprint! DMS chemical mapping, a key technique for studying RNA structure. Everyone assumes low DMS reactivity = Watson-Crick , high = non-WC. However, analyzing 7,500 RNA structures containing known 3D structures reveals it's not that simple. doi.org/10.1101/2024...

A language model-based deep learning approach for #RNA 3D structure prediction www.nature.com/articles/s41...

Fellow #RNA lovers, please repost 🙏: 2 ERC-funded Post-doc positions are available in our lab to investigate #RNA structural ensemble and their dynamics in living cells. Application link: t.co/pYJ3H3j705