I am once again reminded that the loudest person in the room is not necessarily the smartest or most qualified

Reader, we would not like a dictator in the “land of the free and home of the brave”

Delighted to present our second paper of the year. This one explores the molecular mechanism of TTP, a key post-transcriptional regulator of AU-rich mRNAs. Work led and coordinated by @filippekovic.bsky.social, in collaboration with Perry Blackshear. www.nature.com/articles/s41...

I remember when OS updates were like "we will protect your computer from viruses and make it faster" and now they lead with

Paper 2 -- Translational co-regulation detected in mammalian cells www.nature.com/articles/s41... A deeper explanation of the human story, scientific conclusions, and Github/Zenodo links to use the pre-trained models: www.linkedin.com/feed/update/...

Very excited that our most significant work, a collaboration w/ Dr. Can Cenik at UT Austin on translational gene regulation, was finally published in Nature Biotechnology in a dual set of studies: Paper 1 -- an AI model trained to predict translation rates from mRNA sequences: rdcu.be/exN1l

Another example of spurious effects when you try to interpret RNA biology from DNA introduced into cells without confirming exactly what RNA processing is happening. Important and common confounder - great paper!

“With these considerations, we expect to fund through the 4th percentile.” There it is, in black and white, the destruction of cancer research in the US.

apropos of nothing, a strong rec for “The Tyranny of Merit”, in which Sandel notes a putative meritocracy “fosters a sense of entitlement among the successful while humiliating those who do not succeed, ultimately undermining the common good and social solidarity” bookshop.org/p/books/the-...

this is an example of the so-called meritocracy that’s threatened by introspection on who gets into college and why

great review on the myriad ways that genetic variation in mRNA untranslated regions can cause disease!

This July 4 I celebrate my country born by separation from a tyrannical king, with the principles that all people are created equal and that the government represents the will of the People, not a monarch. The unalienable rights of Life, Liberty, and the pursuit of Happiness. Let freedom ring!

absolutely love this new tour of the cosmos using the Skyviewer app built using new images off the Vera Rubin telescope - gorgeous and great explanations skyviewer.app/tours

whenever I need some sunshine I turn to cientotres 103.1 FM out of San José, Costa Rica radios-de-costa-rica.com/1031-fm

A federal judge on Monday declared the Trump administration’s move to cut hundreds of grants issued by the National Institutes of Health illegal, accusing the government of discrimination against minorities and L.G.B.T.Q. individuals. nyti.ms/4jSIjOG

the story today is of a profoundly low energy military parade being met with millions of americans in nationwide protests denouncing the dictatorial pretensions of the president

Traveling for a soccer tournament and there’s a rally of maybe 500 people here in South Lake Tahoe today, too. Solidarity. No kings, no tyrants 🇺🇸

Racism and xenophobia is already turning the US into a backwater to avoid

people will literally die because of this

"all the best" 💩🤡

I urge others to similarly support our patriots at NIH who use their training and talents to improve human health and position the US as the world’s leader in biomedical discovery, innovation and technology development 🙏

fully agree - the real question is: will Trump let the DOGEs out?

These are not just grants. This is thousands of people who devoted their lives and careers - taking pay cuts, working long hours, living with uncertainty - all for the chance to try to make people's lives a bit better for you and your loved ones. This breaks my heart.

local yay area man discusses choices, when to go (dumb), how to be sprinkled with game, and gouda + broccoli

if the US wants to be competitive on the world stage, investing in education, science, and technology is the way. one doesn’t simply discriminate your way to the top

prelim phase 1/2 trial results of the Moderna H5N1 vaccine program included no (none) dose-limiting toxicity and 97.8% (NINETY SEVEN POINT EIGHT PERCENT) of participants reaching protective antibody levels. defunding this program makes America sicker endpts.com/trump-axes-m...

Thinking of this @propublica.org reporting today about stillbirths of unvaccinated parents during the Delta wave, before CDC had explicitly recommended COVID vaccines for pregnant people and the damage the virus did to the placentas. www.propublica.org/article/covi...

today’s anti-vaccination, pro-disease decision by RFK in the Orwellian name of “making America healthy again” will lead to more moms dying and more unhealthy babies why anyone would choose to not protect moms and babies as best we can is beyond my comprehension

reminiscing over simpler times when controversy involved whether figures belong inline or at the end of paper drafts

This is exactly it. I’ve said the same thing in nearly the same words myself. The memory of this man and his very name should be a curse for future generations.

Eikon lays off ~15% of staff citing "external forces. For example, government funding cuts have constrained the budgets of academic institutions, necessitating that we pause development of our advanced instruments ... The market for these instruments has clearly evaporated."

must read thread on the Makary & Prasad NEJM screed (and corresponding FDA policy position) that will increase illness and death by limiting access to effective vaccines. this is the first action I’ve seen since Prasad’s joining CBER and it’s a bad portent

fire season should be fun this year, and by fun I mean really dangerous for people

metamodernism in fabric c/o Avavav & Adidas. mood fitting

The GOP campaign against RNA medicines is a modern-day witch-hunt, driven by a combination of political pandering, scientific ignorance and vindictiveness toward medical research. The potential of RNA medicine is enormous, and if we don’t develop it here in the US, other countries will.

ok hear me out: what if we transmitted covid back to bats and they can keep it

"Women are PIs on 58% of the canceled grants, although they are PIs on only 34% of all active NSF grants. Similarly, Blacks are PIs on 17% of the terminated grants, although they make only 4% of the total pool. Hispanic PIs and those with disabilities were twice as likely to lose a grant."

Racist and sexist roots in the cancellation of NSF grants under Trump: Grants with female PIs canceled 2x more than men Grants with Black PIs canceled 4x over White PIs Grants with Hispanic PIs canceled 2x over White PIs Grants with PIs with disabilities canceled 2x more than without

outrageous, harmful, contrary to the interest of the USA. boggles my mind on a daily basis that our Congress doesn’t stand up against this kind of regressive action

it’s a Faze-O kinda Friday 🍻 open.spotify.com/track/1SMve8...

Lux Capital & @wolfejosh.bsky.social are launching the Lux Science Helpline - a $100M commitment to support American scientists whose research is threatened by funding cuts, bureaucratic hurdles, and career roadblocks - that expands our Lux Labs program. www.luxcapital.com/news/our-hel...

bolded in a biotech SEQ 10-Q filing: "Changes in funding or disruptions at the FDA, the SEC and other government agencies, caused by reductions in staffing government shut downs could .. prevent new products and services from being developed or commercialized .. could negatively impact our business"

cant wait for the tariff bonus to my paychecks so I can pay all these tariff surcharges

if you like soccer at all (or if you just like amazing things) take some time out of your life and watch the full Barca vs Inter champions league semifinal from today (or at least highlights). both legs were amazing but this was one of the best soccer games I’ve ever seen. hats off to everyone

now that’s a funding cliff 📉💩

extreme whiplash from being so excited about science after the COVID vaccines saved millions of lives, likely including my own as an immunocompromised person and of my elderly family members, to the installation of anti-science, anti-vaccine, pro-dark-ages-suffering people in the FDA and government

take a deep breath with McCoy Tyner, Joe Henderson, Ron Carter, and Elvin Jones on this gem 💎 open.spotify.com/track/4qRJ7Z...

outstanding reporting and among other things it’s remarkable that the director of the NIH would take such an adversarial stance with a leading journal named Science. accidental literalism

based on my understanding of development, as chordates most congresspeople should have developed a backbone shortly after neural tube formation but perhaps US congress members are a new species

enacting this would be an unmitigated disaster for US science, health, innovation, economy, and leadership