Tags, reporters, luciferase — oh my! To celebrate the expansion of the Promega Plasmid Collection, we’re spotlighting some of our most popular blogs on the technologies researchers rely on every day — tools you can access through Addgene.

I wrote down some of my thoughts down on the current race to build virtual cell models. Overall, excited and wary about the work ahead. Also, it's my first post to Substack; getting more excited about it as a replacement for X and Blue Sky. srikosuri.substack.com/p/the-elusiv...

Lux Capital & @wolfejosh.bsky.social are launching the Lux Science Helpline - a $100M commitment to support American scientists whose research is threatened by funding cuts, bureaucratic hurdles, and career roadblocks - that expands our Lux Labs program. www.luxcapital.com/news/our-hel...

An update: After the diagnosis change to AML/myeloid sarcoma, we got a lot of great input. We’ve decided to go to St Jude’s to enroll in a clinical trial. We left for Memphis yesterday. We’ll be staying here for the next several months. Anxious but ready for the path ahead.

Quick update: Thanks so much for the outpouring of support and help. We learned a lot in the last week and the tumor is actually a myeloid sarcoma likely derived from early AML, with the hope of possible targeted therapies as well (KMT2Ar).

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

Serenity now

This is part of my effort of rewriting all materials for my UT Austin dataviz class in Quarto. It's going very well. Most importantly, I now have live exercises integrated into the site, thanks to Quarto live. Check it out here: wilkelab.org/SDS366/

Check out our work, where we discover how receptor GPCR senses pH! We solved a longstanding question by developing foundational GPCR DMS tech dev + structural bio! Led by brilliant PhD student @matthewkhoward.bsky.social and Nick Hoppe w/ @amanglik.bsky.social! www.cell.com/cell/fulltex...

Today's holiday ☕ reading is this 2024 paper on PARIS, a bacterial defense system shaped like a literal propeller that responds to viral infection by hitting the cellular self-destruct button - cleaving an essential tRNA. www.nature.com/articles/s41...

Really beautiful paper by @kjarmache.bsky.social revealing read-write mechanisms of histone ubiquitylation by Polycomb complexes - through an intricate interplay of ubiquitin binding and ubiquitin transfer. Congratulations to all authors! www.nature.com/articles/s41...

Out now - National Academies consensus report on Understanding and Addressing Misinformation About Science 🧪 It was a privilege to serve as one of the 15 committee members from a wide range of scientific disciplines who put this report together. Quick 🧵1/ www.nationalacademies.org/our-work/und...

In new study, we measure how all mutations to rabies G affect cell entry & antibody neutralization Sheds light on constraints on type III fusion proteins, suggests ways to stabilize G vaccine antigens, and quantifies antibody robustness to rabies variation www.biorxiv.org/content/10.1...

What do GWAS and rare variant burden tests discover, and why? Do these studies find the most IMPORTANT genes? If not, how DO they rank genes? Here we present a surprising result: these studies actually test for SPECIFICITY! A 🧵on what this means... (🧪🧬) www.biorxiv.org/content/10.1...

The responses to this are why change is not really going to happen within the universities themselves. I’m excited that AI has the possibility to break the cost curves to broad access to education. Lots of work to do, and thanks to those putting in that work to build a brighter future.

I'm thrilled to announce a new preprint describing collaborative work with Ajay Jain and Ann Cleves Jain, "Deep-Learning Based Docking Methods: Fair Comparisons to Conventional Docking Workflows". arxiv.org/abs/2412.02889

"Wuhan lab samples hold no close relatives to virus behind COVID" That should settle it, right? The problem, of course, it won't because we're dealing with conspiracy theories and not scientific inquiry - no amount of additional data will change un-evidenced beliefs. www.nature.com/articles/d41...

Is there a way to do starter pack for people to block? Would love to just block folks en masse that are cheering on the execution of a company CEO b/c they hate capitalism or whatever. It's insufferable.

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..

Have been thinking about Brian Thompson and his family all day. This one hits home. You kiss your kids goodbye and get on a plane, eat dinner with colleagues prepare your presentation and walk toward the conference hotel. A scenario we all have lived dozens of times. The family must be devastated 😞

First post on bsky to highlight our latest work on smell receptors (www.nature.com/articles/s41...). Odorant receptors are notoriously challenging to work with - we used a classic strategy from protein engineering to get a peek into how these receptors recognize such a diversity of smells.

The final report from the COVID Sub Committee is released and it is as expected given that the origin "has been contorted by politics, while scientific discourse has been abandoned in pursuit of a preferred, coordinated narrative", as I stated in my written testimony. BUT, there's a bombshell.. 🧵👇

Three BioML starter packs now! Pack 1: go.bsky.app/2VWBcCd Pack 2: go.bsky.app/Bw84Hmc Pack 3: go.bsky.app/NAKYUok DM if you want to be included (or nominate people who should be!)

New blogpost: The ABCs of Alphafold 3, Boltz and Chai-1 blog.booleanbiotech.com/alphafold3-b...

💡💥Here’s a modest proposal I’ve been pondering for a while on how to change the PEER REVIEW process and start more community-driven SCIENCE FUNDING. Lots of feedback/discussion welcomed! Other variants of the idea might exist already—not claiming originality. (a long 🧵) (1/9)

Anyone’s dm’s still broken? I keep on getting an error called “bad token method”. DMs haven’t worked from the start for me. I’ve tried reinstalling the app and logging off and then back in. Anyone have any fixes?

Heterozygous mutations in leptin receptor gene (LEPR) do not cause obesity. The finding goes against the rationale for a recent clinical trial that test setmelanotide for obesity treatment in heterozygous carriers of LEPR variants. Delplanque et al. AJHG www.sciencedirect.com/science/arti...

Your periodic reminder: read the 8th Day of Creation "The basic principles of the genetic code & the molecular biology of prokaryotes were established in the years between (1953 & 1973) as documented in extraordinary detail in 1979 by Horace Freeland Judson in the “Eighth Day of Creation”

We are hiring! We are looking for a Project Scientist to be in charge of the day-to-day operation of our tumor organoid pipeline. Come join our team of rare cancer aficionados looking to leverage organoids for functional precision medicine. Apply by November 24th! recruit.apo.ucla.edu/JPF09960

Cool history! New Innovator was amazing for my career. It allowed me to focus on my research right off the bat. Getting it all at once was awesome too because I could use it instead of my startup (and reclaim some overhead). FYI: I posted my app here many years ago: www.kosurilab.org/blog/new-inv...

🚨Out in Science!🚨 Conspiracy beliefs famously resist correction, ya? WRONG: We show brief convos w GPT4 reduce conspiracy beliefs by ~20%! -Lasts over 2mo -Works on entrenched beliefs -Tailored AI response rebuts specific evidence offered by believers www.science.org/doi/10.1126/...

Octant Thanksgiving!

Had the privilege of being at the Atlas Venture retreat to see Bruce Booth give his “Year in Review 2024” talk and they managed to get it up online the next day. Well worth the watch (as always). We need to find a way to get Bruce over here to Bluesky #biotech. youtu.be/szwRUERnoOM?...

www.nature.com/articles/d41...

A thread on NIH Reorganization and the Scientific Management Review Board (SMRB) Disclosure: I was involved with the SMRB since its inception and have very strong feelings about how it was used, misused, and abandoned. My passion on these issues will undoubtably show through. 1/n

Made a biotech founders starter pack, DM me to be added! go.bsky.app/LWm8uPE

It’s not an AI drug discovery company, but at the same time it is. Yes, it’s Schrödinger www.statnews.com/2024/11/20/s...

Made this one a week ago and could update it to include more go.bsky.app/TbKxUEk

Started creating a synthetic biology starter pack. Still missing many so reply here if I forgot you or someone else. go.bsky.app/SjfpxTK #synbio

Two new non-prescription continuous glucose monitors have just been approved by the FDA for use by the general population, no longer limiting their use primarily to diabetics. www.cnet.com/health/medic...

We're here now!

Here's my starter pack go.bsky.app/36QCKD2

I’m creating a drug development starter pack, reach out to join or suggest additions: go.bsky.app/B2pzQm2

Are there a lot of biotech folks on here? Is there a starter pack yet? Should I start one?

Baker lab not slowing down post Nobel. Here they are getting at engineering signaling dynamics using protein design. Super cool frontier and love this direction. www.biorxiv.org/content/10.1...

One of the more visceral things in being surrounded by the tech industry after academia is 20-30 yo are given vastly more responsibility & power, which leads to a diff culture. It maybe even a little too much on the other side (like >40yo are assumed to be out of touch). H/t @pracheeac.bsky.social

How transformer #AI models are transforming www.wsj.com/tech/ai/a-po... by @mims.bsky.social

It’s really nice to be on this TL without all the ads, bots and meme peddlers.That said, I wonder how long it takes before it gets there. One question is how does Bluesky plan to monetize?