Atproto craigslist when

This great piece resonates with my own sense of loss and mourning of my social and professional identity as a computer programmer as the community of software engineers embraces LLMs and continues to sink further into surveillance and behavioral manipulation-based technofascistic business models.

Wine moms are burning prospective concentration camps and flag dads are choking back tears at protests.

Well I've been programming for like 13 years at this point and I've finally gotten around to making phone apps

I'm writing a chat app with a unique use case, most of the front end and auth flow makes sense and now I'm looking into end-to-end message encryption and all I have to say is... @signal.org is a goddamn miracle

There are more Spanish speakers in the US than Spain. US has third most Latinos of any country after Brazil and Mexico. NFL is probably heavily hooked into customer centric marketing practices meaning... The NFL knows who has spent and will spend the most money on the NFL and acted accordingly.

下个周末在旧金山谁想跟我玩大老二吗？

Free Liam Conejo Ramos.

just saw 4 ice agents go up to a house and knock and within 1 minute there were 30 people out whistling and they left. we will not take our foot off the gas

I inhibit signs of intelligence

Does anyone know where I can get a COVID vaccine in the Bay Area? Spoken to two pharmacists now saying that they don't have any and that they're on hold in a warehouse somewhere but I need one now...

What it feels like to set up a GPU node for your home computing cluster

Got a 404 for all of a second when trying to look something up on Wikipedia and my heart stopped

Market Basket has a stronger fan base in New England than the Red Sox and it's not close

It's only been 6 weeks since we got a new pope from Chicago and it feels so long ago

I scored a fancy air fryer for 12 bucks at the thrift store what should I put in it?

I know almost two dozen languages and barely remember how to write a for loop in any of them

The only orange muppet to trust about science.

So many people my phone lost service and cars have completely given up crossing Market Street with some honking or even getting out of their cars in support.

People passing by me at ~20 people per second. This has been going at a similar rate for ~30 minutes and shows no signs of stopping.

There's so many people here that the cell phone towers nearby can't handle the traffic and my phone is struggling to post pictures.

I've never seen this many people at Dolores park

The war on science in the US is already having an effect on private sector research like AlphaFold. Bears repeating but the private sector builds on top of things created by academic research for the public good. This hurts everyone.

HMMER is the bedrock of genomic annotation globally, and now its funding is terminated for no reason. @cryptogenomicon.bsky.social is now on bsky:

HMMER is crucial to our modern understanding of protein biochemistry and has almost certainly generated at least a 10-fold return on investment for every dollar the US government has spent on funding it.

NIH funding supporting the HMMER and Infernal software projects has been terminated. NIH states that our work, as well as all other federally funded research at Harvard, is of no benefit to the US.

In my day people read the abstract when they wanted to pretend to be smart.

Chicago style pizza in the Vatican is now cannon.

Colossal bio guys have gone too far.

This is what happens when you try to make penguins fly. They're flightless for a reason.

This is such a crackpot idea but has anyone run for Congress on the explicit promise that they will insider trade and use the profits to set up a wealth fund for their district?

If you have a free tech or biotech event in the Bay Area that doesn't feature pizza, beer, and AI I will advertise tf out of it

I remember the first meetup I ever went to in the Bay Area had steak, mezcal, a DJ, and a dude who figured out how to run windows 98 in the browser via web assembly showing off for 150 nerds. We used to be a community, a proper community.

For almost a decade broke recent college grads in hubs like Boston and SF could eat for free and network almost every night as long as they didn't hit their pizza toxicity threshold.

 That's no longer the case and I wrote a little about what happened and why I want this back.

Reading papers again for the first time in a while and it feels so good

Don't think you can get away with just learning Worcester I've got a whole list of town names with spellings that are barely related to how they're pronounced.

My toxic trait is asking folk trying to do a Boston accent to read "Worcester" aloud.

I just made something that could be called BBQ curry risotto and I can't stop eating it

Hot pot but make it Italian

Could you electroporate cells with a defibrillator?

I'll cater. Anyone here like curry and rice?

Every time I see someone posting from my local #StandupForScience rally in SF I get giddy. We were all there! We care! We're not just profile picks on a microblogging app. WE HAVE MASS. This rocks and we should get more organized.

This machine kills fascists #standupforscience2025

I'm so food motivated

Dream life is to own a lab liquidation business how can we make this happen

Just give me a car with an electric motor, a crumple zone, and a stand to hold my MapQuest printouts.

Software is in too many things. Software was never meant to be in cars.