𝐂𝐨𝐦𝐩𝐚𝐧𝐲 𝐓𝐨𝐮𝐫: BiotechTV visited the new offices of @seaporttx.bsky.social today and was given a tour by Founder & CEO @daphnezohar.bsky.social

For @biotechtv.bsky.social's Biotech CEO Sisterhood series, our CEO @daphnezohar.bsky.social spoke to Sophie Kornowski on her journey leading Boston Pharmaceuticals to a $2B deal w/ GSK. Check this out for insights from both leaders on dealmaking, leadership strategies & mentorship: bit.ly/4m55kzG

Pleased to announce the first patient has been dosed in our Ph2b BUOY-1 study of GlyphAllo™ (SPT-300) in #MDD w/ or w/o anxious distress, an important milestone for Seaport’s pipeline that brings us closer to a potential new treatment for patients w/ MDD: bit.ly/3Uhn3YB

#BiotechHangout Eric Schmidt, Brad Loncar, Tim Opler, Tess Cameron on M&A: $MRK/$VRNA, $ABBV/Capstan, biotech takeouts, M&A wave, pharma’s $150B in LOE, plus Trump’s BBB/tariffs, $XBI & MFN, FDA’s CRL disclosures, $CAPR, $KALV, $PROK, obesity trends, $RARE/$MREO, $ABBV/Ichnos: bit.ly/3TuICVp

The Seaport crew kicked off summer with a fun gathering! Great opportunity to connect out of the office, strengthening our mission to develop life-changing medicines for #neuropsychiatric disorders. Looking forward to more moments together and progress towards transforming lives!

As #MentalHealthMonth closes, we welcomed a @namicommunicate.bsky.social patient representative to share his journey w/ mental health conditions. His story inspires our work at Seaport to help those struggling & develop new medicines for #depression & #anxiety. More: www.nami.org

#BiotechHangout: Chris Garabedian, Josh Schimmer, Nina Kjellson, Mike Yee, Tim Opler on market sentiment – where is the M&A?, FDA/CBER, wind downs vs reverse mergers, policy: #MAHA & COVID vaccine, $REGN/23andMe, data: $RCKT, psychedelics, $PRTA, $SPRO/$GSK, $GILD, $SMMT, #ASCO & more bit.ly/4dCFzDT

Two people were shot and killed outside a Jewish LGBTQ event in D.C.

This #MentalHealthMonth, we joined @namicommunicate.bsky.social's annual #NAMIWalks to combat stigma & promote mental health awareness. We stand with those affected by mental illness & are dedicated to developing new medicines for #depression & #anxiety. More about NAMI www.nami.org

#BiotechHangout: Sam Fazeli, John Maraganore, Nina Kjellson, Matt Gline on MFN: 30-day ultimatum, 180 days negotiation, reimportation, ex-US prices, DTC, Roche, $SNY, plus: budget reconciliation, IRA, $RXRX, Galapagos, $CTMX, $GSK buys Boston, $GSK/iTeos, $NVO CEO, RNA deals: bit.ly/3S3vhTh

Seems like Bluesky is losing momentum? Wouldn’t mind having one less place to check/post. Curious to hear from others

Important provisions added to reconciliation bills would be positive for bio if passed: ORPHAN Cures Act included, amend IRA PBM reforms delinking compensation from list price, increasing transparency & banning spread pricing in Medicaid Tax fix to allow for immediate deduction of R&D costs

Cantor has put out some really interesting notes lately. Dueling takes from Eric Schmidt & Josh Schimmer on short selling last week and then this week a thoughtful critique of issues that are ailing our industry. Link below: cantor2.bluematrix.com/sellside/Ema...

#BiotechHangout: Eric Schmidt, Sam Fazeli, Adam Feuerstein, Peter Kolchinsky on $XBI, market & macro trends, latest from FDA/Washington, Q1 earnings trends: tariffs, M&A & drug launches, data: $SMMT/Akeso & #AUA2025 & #AACR25 recap ($PFE, $JNJ, $BNTX, $CGON, China ADCs): twitter.com/i/spaces/1gq...

#Depression & #anxiety are among the most common & disabling #mentalhealth conditions. This #MentalHealthAwarenessMonth we're spotlighting our commitment to developing better medicines & reducing the stigma for those dealing w/these conditions. Learn more: www.seaporttx.com

“When Secretary Kennedy offers a suggestion to me, he always adds, “You decide for yourself.” So, yes, there is independence.” New interview with Marty Makary sheds more light on re-org (no plans), PDUFA dates, morale and his independence from RFK insidemedicine.substack.com/p/exclusive-...

#BiotechHangout: Daphne Zohar, Josh Schimmer, Tim Opler, John Maraganore, Paul Matteis on macroenvironment, $XBI, $SWTX $MRCG takeout rumors, policy: (FDA, tariffs), data: ($BMY, $QURE, #AUA25: $JNJ/$CGON), Trump vs. Harvard, buyside & short-selling, CEO survival tips: x.com/biotechch/st...

We're at #SOBP2025 to present new preclinical data on SPT-320, a novel oral prodrug of agomelatine. SPT-320 increased lymphatic transport >50% compared to <1% agomelatine alone & increased plasma exposure >10-fold. SPT-320 progressing into clinic for #GAD. bit.ly/4ixtOzs

Makary interview: “Why does it take 10 years to bring a drug to market in US? People are dying. Our # 1 goal is delivering cures, meaningful treatments, healthier food” 1 randomized controlled trial & then intense post marketing surveillance (link for full text): www.linkedin.com/posts/daphne...

Insider close to administration: Elon’s DOGE work almost done. Lutnick & Navarro losing influence & Bessent gaining. Most interesting: “If Secretary of HHS makes it through the year I’ll be shocked.” Oz important. Last night’s EO opportunity “pill penalty.” Sounds like they’re coming after CVS/PBMs

Congrats @daphnezohar.bsky.social, named to @statnews.com #STATUSList, "the ultimate list of leaders in health, medicine, & science," for founding Seaport & raising $325M. “That’s big & her influence on the biotech field extends beyond that” & cofounding Karuna & PureTech bit.ly/4coOF6B

Here’s a letter that a group of biotech CEOs/investors have addressed to Sen Cassidy, Chair of Senate HELP committee which describes issues biotech companies are experiencing wrt @US_FDA cuts & offers specific and actionable solutions. Please sign & share nopatientleftbehind.org/preserving-the…

Seaport aims to develop better treatments for depression & anxiety. This commitment comes from our exceptional team, all rowing in the same direction to deliver new drugs to make the lives of patients better. What inspires us daily? Hear from our team!

Should be helpful for US biotech. National Security Commission on Emerging Biotechnology Urges Swift Action to Protect U.S. National Security $XBI $BBC biotech.senate.gov

It’s been a year!!

The Office of the U.S. Trade Rep. (USTR) has confirmed that pharmaceuticals are exempt from BOTH the 10% base rate tariff plus additional reciprocal tariffs. Small ray of hope for biotech (for now).

This is quite concerning. Too much experience being lost. Exclusive | Top Vaccine Official Out at FDA - WSJ www.wsj.com/politics/top...

#BiotechHangout: Chris Garabedian, Tim Opler, Bruce Booth & Sam Fazeli on investor mood, PIPEs, startup contraction, policy updates: (FDA, NIH, CDC, HHS) data: ($CGON, $SLNO), #ELCC2025: ($JNJ, $AZN, $BNTX), $NVO’s obesity deals, aging report, $LYRA wind-down & more: twitter.com/i/spaces/1MY...

Yesterday our Co-founder & CEO, @daphnezohar.bsky.social, spoke at @massbio.bsky.social's #StateofPossible25 participating in a panel with the Biotech CEO Sisterhood, discussing their journeys as business leaders, challenges faced and mutual support through their networks.

There’s been a lot of discussion about wall crossed PIPEs. I asked one of the banks to pull the numbers (shared with their permission without attribution). The first group below are WC PIPEs & registered directs/PMUOs where data announced post/with deal

#BiotechHangout: Sam Fazeli, Eric Schmidt, Brian Skorney with Matthew Gline on data: $IMVT/$ROIV, $INCY, $RNA/$DYN, $SRPT, #MDA conference, $ALNY, deals: $AZN, $SNY/Dren Bio, $GILD/$GSK & potential HIV fund cuts, $CRGX updates, $STRO/ELEV layoffs & more biotech zombies? x.com/i/spaces/1kv...

Today our Co-founder & CEO @daphnezohar.bsky.social will present at Stifel 2025 Virtual CNS Forum. She will be joined by Co-Founder & Board Chair Steve Paul, M.D., & Co-Founder & CSO, Michael Chen, Ph.D., for the Q&A session. Tune in at 2pm EDT: wsw.com/webcast/stif...

A dark read from a biotech investor. Some important themes here about prioritizing shareholders substack.com/inbox/post/1...

BIO's John Crowley emphasizes the behind-the-scenes work happening with policymakers in Washington. “Believe me, I get all the uncertainty, the chaos and trying to manage through all of that. Our job is to make sure that we advocate strongly and fiercely for positive change at the FDA.”

Nice balanced piece in the @WSJ on the tremendous promise and also the challenges in neuropsychiatry www.wsj.com/tech/biotech...

Today we welcomed Bob Hombach to our Board of Directors as the Chair of the Audit Committee. His 3 decades of experience includes CFO Baxter ($BAX) & Baxalta ($BXLT) plus Board positions at FORTUNE 500 companies like BioMarin ($BMRN) & Henry Schein ($HSIC). bit.ly/4iDs08j

#BiotechHangout: Daphne Zohar, Eric Schmidt, Tess Cameron, Brian Skorney, Yaron Werber on market/investor blues, #TDCowen Conf, deals ($JAZZ + $CMRX, $ABBV + $GUBRA,Merck KgaA + $SWTX), data ($PLRX, $BHVN, $BMY), RFK Jr's #measles response, Senate hearings,$PFE Cavazzoni appt: x.com/i/spaces/1rm...

Docs who receive $ from industry are experts in their field, involved w/ multiple companies/studies & have a broad perspective on the field. Can’t think of any respectable oncologist pushing treatments because of consulting fees. People have all kinds of conflicts eg seeking power/fame/subscriptions

RFK editorial this evening: MMR vaccine is crucial to avoiding potentially deadly disease www.foxnews.com/opinion/robe...

This new podcast by Melanie Whittington interviewing @franksdavid.bsky.social provides a nice discussion about the use of models for investors and health economists. Well worth the listen. leerink.com/podcast/mana... @tuftscevr.bsky.social

Mike Myers as Elon Musk (power plays and alarming statements followed by “just kidding” and “glitches”). Includes satire on yesterday’s Zelensky meeting & references healthcare/vaccines: “The Department of Undoing Child Healthcare…” @saturdaynightlive.bsky.social

Latest Stifel report reflects on gloomy biotech sentiment but notes a few positives: 1- fund redemption time is behind us (!) 2- M&A $28B so far this year makes it a strong start 3- biopharma sector has outperformed the S&P 500 for more than 50 years and biotech is up more than 20x in last 30 years

"The terrorists didn't shoot them, they murdered them with their hands." This sentence, and the horrifying images it evokes, will be burned into my brain forever. Such inconceivable cruelty.

#BiotechHangout today: Brad Loncar, Eric Schmidt, Tess Cameron, Luba Greenwood, Tim Opler, Adam Feuerstein discuss zombie biotechs, company news: $BIIB/$STOK, $SLDB, $SWTX, $BLUE, $SEPN, $FGEN, $BBIO, Formycon $HIMS, + deals, pharma priorities, market mood, 13f filings & fund returns: bit.ly/41qM0VY

Major depressive disorder studies have a high failure rate w/ one issue being high placebo response. Our team analyzed 27 industry-sponsored Phase 2-4, placebo-controlled MDD trials from past 10 yrs to look at factors associated with higher placebo response

There’s never an excuse to hold a baby hostage. Glad we can at least agree on that.

FDA EMPLOYEES REVIEWING MUSK’S NEURALINK BRAIN IMPLANT WERE REMOVED IN DOGE FIRINGS (via firstsquawk) & Here’s what Musk’s Grok has to say about his potential conflicts: x.com/i/grok/share...

The inaugural director of ARPA-H is among federal health agency employees who were fired this week for no reason. Below is Renee Wegrzyn's Linked In post: www.linkedin.com/posts/renee-... #medsky #biosky