Excited that our study identifying TRIP12 - an essential E3 ligase mutated in a neurodevelopmental disease - as a critical component of the oxidative stress response is now online. Congratulations to Andrew, Devlon and Jenny! @ucberkeleyofficial.bsky.social www.sciencedirect.com/science/arti...

Tenure track position alert! Assistant Professor of Molecular Therapeutics in MCB @UCBerkeley. Apply and come be our colleague! 🎉 aprecruit.berkeley.edu/JPF05098

Excited about turning basic science into new therapeutic modalities? Want to work with brilliant and *friendly* colleagues? Hoping to be part of a public university that shapes California? Then come join us #MolecularTherapeutics, @ucberkeleyofficial.bsky.social !!! aprecruit.berkeley.edu/JPF05098

Thoughts from our own Tom Rapoport on the role of basic science in curing disease. magazine.hms.harvard.edu/articles/rev...

UC Berkeley isn’t just the No. 1 public research university in the nation — it’s a force for the public good. youtu.be/z0MokpvFauc?...

Congrats to MCB postdocs Aurora Alvarez-Buylla (Schepartz Lab), Grace Hibshman (Nogales Lab) and Heegwang Roh (Rapé Lab) for being selected as 2025 Jane Coffin Childs Fellows! 🎉👏 @jcchildsfund.bsky.social @nogaleslab.bsky.social @micharapelab.bsky.social www.jccfund.org/fellows/clas...

Many congratulations to Heegwang Roh for being selected as a Jane Coffin Childs postdoctoral fellow! Go Heegwang! www.jccfund.org/wp-content/u...

Thank you to Sara Osman for highlighting our recent SIFI work! www.nature.com/articles/s41...

Very excited about these unique opportunities - for advancing groundbreaking science and for our students to advance their careers - at @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social

Congratulations James! From basic discovery to drugging it in such a short time! Amazing work out of #MolecularTherapeutics @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social!!!

Congratulations to our grad students Rachael McMinimy and Chris Padovani, who yesterday received their degrees from @ucberkeleyofficial.bsky.social! Thank you for everything, and we will miss you!

Thank you to Michael Ward for presenting his amazing science addressing urgent problems in neurodegenerative disease at a joint #MolecularTherapeutics, @mti-ucb.bsky.social, and Neuroscience talk at @ucberkeleyofficial.bsky.social today! Great science helping patients is more important than ever!

Congratulations to #MolecularTherapeutics faculty and @mti-ucb.bsky.social member @olzmannlab.bsky.social for receiving the Beatriz Manz award for 'transformational teaching and community service'. Glad to have you as a friend and colleague @ucberkeleyofficial.bsky.social, James!

🌍 Meet Dr. Matt Welch, 2025 MTI Innovator Awardee! His lab is developing selective inhibitors of parasite-specific kinesins - a new and safer strategy to treat African sleeping sickness and related diseases. A leap forward in neglected tropical disease drug discovery. #MTI #GlobalHealth

Excited that our work revealing the structure and function of the monster stress response silencing factor, the E3 ligase SIFI, is now out! Congratulations to the most amazing team of Zhi Yang, Diane Haakonsen, Michael Heider and Sam Witus! www.nature.com/articles/s41...

🧠 Meet Dr. Ehud Isacoff, 2025 MTI Innovator Awardee! His lab is using FRET-based biosensors to find compounds that fine-tune glutamate receptors - unlocking new treatments for depression, including hard-to-treat cases. A new era of brain-targeted molecular therapeutics. #MTI #Neurobiology #FRET

Thank you to @brentstockwell.bsky.social of @columbiauniversity.bsky.social for visiting #MolecularTherapeutics at @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social and presenting a tour-de-force through the ferroptosis field!

Congratulations to #MolecularTherapeutics faculty and @mti-ucb.bsky.social member Markita Landry on winning a Guggenheim Fellowship! So cool to work with such amazing colleagues on a daily basis! news.berkeley.edu/2025/04/22/t...

Congratulations!

Wonderful talk by @rushika-perera.bsky.social of @ucsfhealth.bsky.social today in our @mti-ucb.bsky.social/#MolecularTherapeutics seminar series at @ucberkeleyofficial.bsky.social today, presenting cool data about organ-selective metastasis! Thank you!!!

New paper from @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social faculty member @robzonculab.bsky.social ! Congratulations!!!

Congratulations to Mangyu and Denis! @ucberkeleyofficial.bsky.social

Huge thank you to Leon Chen of The Column Group, who taught our #MolecularTherapeutics grad students the ins-and-outs of biotech today! 🙏

One of the best things about teaching (and doing research) at @ucberkeleyofficial.bsky.social is our environment. Huge thanks to Arnav Metha of The Column Group, who taught our #MolecularTherapeutics grad students the ins-and-outs of clinical trials!

Thank you to Spark NS for helping us turn the ubiquitin system against Parkinson's Disease! Kudos to @ucberkeleyofficial.bsky.social student Srividya Chandrasekhar and postdoc Josh Sheetz for their groundbreaking work! sparkns.org/programs/pro...

Amazing story from #MolecularTherapeutics faculty @robzonculab.bsky.social with lead author @aakritijain.bsky.social describing membrane protein degradation in the lysosome. Congratulations!! www.science.org/doi/10.1126/...

If you are immigrant into the US and work in the biomedical sciences (like me) and are still young (not like me), please apply for the Vilcek prizes for Creative Promise founded by an inspiring immigrant couple, Marica and Jan Vilcek. vilcek.org/prizes/vilce...

Thank you to Christina Woo for presenting such a data-packed, standing-room only seminar in Molecular Therapeutics @ucberkeleyofficial.bsky.social this week! Awesome work!!!

Congratulations to Xavier Darzacq, central Molecular Therapeutics faculty member at @ucberkeleyofficial.bsky.social and co-founder of CxT Discovery and Eikon Tx, for his well-deserved promotion to Full Professor! We are so glad to count you among our colleagues! mcb.berkeley.edu/news-and-eve...

Excited to be at a University, where grad student recruits can hear a first-hand account of CRISPR - from discovery to early clinical trials! #MolecularTherapeutics @jenniferdoudna.bsky.social @ucberkeleyofficial.bsky.social

It was great to see you again, @alessiociulli.bsky.social

Really inspiring visit and talk from @alessiociulli.bsky.social of the Center for Targeted Protein Degradation at the University of Dundee in our #MolecularTherapeutics series at UC Berkeley.! It is amazing what you have built in Dundee, Alessio!

Many thanks to Dan Erlanson, Chief Innovation Officer at Frontier Medicines and the mind behind the blog Practical Fragments for giving an exciting standing room-only fireside chat at Molecular Therapeutics at @ucberkeleyofficial.bsky.social today! Thank you Dan!!

Exciting work from #MolecularTherapeutics @ucberkeleyofficial.bsky.social faculty Jim Hurley! Congratulations!!!

Very excited to highlight @jcornlab's beautiful work on the E3 ligase SCF-FBXO31, which recognizes chemically damaged proteins. Mutations in FBXO31 cause disease by substrate-rewiring, really cool. Congratulations to all authors! rdcu.be/d7WGc

Many thanks to Sylvie Callegari @wehi-research.bsky.social for her beautiful spotlight describing our recent discovery of localized, and ROS-regulated, protein degradation at mitochondrial import gates! www.sciencedirect.com/science/arti...

Scientific Director, Cal-Cryo. We are looking for an outstanding microscopist to run our cryo-EM facility (two Krioses and an Arctica), increase training, engagement, and collaboration on campus, expand our user base, and join our community of cutting edge cryo-EM researchers. tinyurl.com/ykasna3p

This paper is a stark reminder for why it is so important that we innovate drug discovery against neurodegenerative diseases now. www.nature.com/articles/s41...

Thank you to Eric Gomez for introducing TCG labs Soleil to Molecular Therapeutics faculty at @ucberkeleyofficial.bsky.social today!

I am excited to report the preprint of my postdoc work in the @olzmannlab.bsky.social! We have discovered the first lipid droplet quality control pathway with broad implications for lipid physiology and diseases associated with LD accumulation and oxidative stress! #lipidtime shorturl.at/2HqFd

Excited to share our new preprint! Exceptional work by @mikelangelipid.bsky.social identifies the first #LipidDroplet lipid quality control pathway! LD-localized FSP1 safeguards neutral lipids from peroxidation and prevents #ferroptosis. 🤩https://www.biorxiv.org/content/10.1101/2025.01.06.631537v1

Congratulations to all new Hannah Grey fellows of @hhmi.bsky.social ! www.hhmi.org/news/hhmi-na...

Congratulations to #MolecularTherapeutics and MTI faculty member Jennifer Doudna on having received the National Medal of Technology and Innovation by President Biden!!! @ucberkeleyofficial.bsky.social www.whitehouse.gov/briefing-roo...

As the sun is setting one last time in 2024 behind the Golden Gate, all the best for 2025! To a year full of friendship, health, fun and great science!

Fundamental research led to the discovery of #Remicade, the first biologic drug that has saved millions of people from suffering. The Vilceks have channeled their fortunes into supporting #immigrants. Please check out various opps on the website!

Thank you to Shigeo Murata and Kazu Iwai for writing this heartfelt obituary for Keiji Tanaka, who played such important roles in the early characterization of the proteasome and building the vibrant protein degradation community in Japan. www.cell.com/cell/fulltex...

Inspiring (and often devastating) article in @nytimes.com underscoring the human toll of neurodegeneration and why we need to work together to connect basic to translational science to find effective cures. www.nytimes.com/2024/12/22/h...

Really beautiful paper by @kjarmache.bsky.social revealing read-write mechanisms of histone ubiquitylation by Polycomb complexes - through an intricate interplay of ubiquitin binding and ubiquitin transfer. Congratulations to all authors! www.nature.com/articles/s41...

Huge thank you to @a16z.bsky.social for partnering with Molecular Therapeutics and MTI at @ucberkeleyofficial.bsky.social last night for the Faculty Founders' Reception. It was really great bringing together partners in drug discovery!

Wonderful upcoming ubiquitin meeting in 2025, close to home in Franconia ;-) www.ubiquitin-wuerzburg-2025.de