Aashish Manglik
@amanglik.bsky.social
π€ 489
π₯ 225
π 9
@UCSF Associate Professor | G protein coupled receptor aficionado
reposted by
Aashish Manglik
KQED Forum
9 months ago
FRI at 10AM:
@latimes.com
journalist Maxwell Williams and UCSF pharmaceutical chemistry professor
@amanglik.bsky.social
join to talk about the unique scents that surround us in the Golden State. βWhat smell says California to you? Sequoia trees? Ojai tangerines? Ocean spray?
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What's that smell? Readers share the scents that remind them of L.A.
From wafting tar pits and smells of the beach to native plants and a chocolate factory, our readers smelled Los Angeles and told us about it.
https://buff.ly/ANFRlts
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reposted by
Aashish Manglik
Jimmie Ye
10 months ago
1/n: 2nd preprint this week:
www.biorxiv.org/content/10.1...
. We functionalized a G(13)PCR P2RY8 that keeps germinal center (GC) B cells confined. Taylor LaFlam performed saturation mutagenesis, Aashish Manglik's lab solved the structure, and collaboration with Cyster lab validated variant effects.
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Phenotypic pleiotropy of missense variants in human B cell-confinement receptor P2RY8
Missense variants can have pleiotropic effects on protein function and predicting these effects can be difficult. We performed near-saturation deep mutational scanning of P2RY8, a G-protein-coupled re...
https://www.biorxiv.org/content/10.1101/2025.02.28.640567v1
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reposted by
Aashish Manglik
Bryan Roth
10 months ago
We have deposited the following mice (all B6/J backcrossed) to
@mmrrc.bsky.social
Adgrf5-EGFP-CT-IRES-CRE GPR123- EGFP-CT-IRES-CRE GPR124- EGFP-CT-IRES-CRE GPR125- EGFP-CT-IRES-CRE Gpr133-EGFP-CT-IRES-CRE GPR156-IRES-Cre GPR156-mGL-IRES-Cre GPR75-IRES-Cre
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Please check out our recent work led by brilliant student
@matthewkhoward.bsky.social
jointly mentored with
@willowcoyote.bsky.social
. Willow and I are recruiting joint postdocs - contact us!
add a skeleton here at some point
12 months ago
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reposted by
Aashish Manglik
Willow Coyote-Maestas
12 months ago
Tune in for
@matthewkhoward.bsky.social
to give a talk tomorrow! Brilliant student from my and
@amanglik.bsky.social
βs lab working on transformational DMS approaches for gpcrs. Also right on the heels of his first paper from our labs!!!
add a skeleton here at some point
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First post on bsky to highlight our latest work on smell receptors (
www.nature.com/articles/s41...
). Odorant receptors are notoriously challenging to work with - we used a classic strategy from protein engineering to get a peek into how these receptors recognize such a diversity of smells.
about 1 year ago
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