New research explores a promising, low-toxicity transplant strategy for diabetes. Learn more: https://www.jci.org/articles/view/201105#SEC7 And to view diabetic specific models, visit: https://www.mmrrc.org/catalog/StrainCatalogSearchForm.php?search_query=DOID:9352

When global competitors are accelerating their investments in biomedical research, America cannot afford to fall behind...https://www.fiercebiotech.com/research/despite-delays-nih-grants-generated-250-return-366b-investment-2025-report?utm_medium=email&utm_source=nl&utm_campaign=LS-NL-FierceP

Advances in organ and computer models are raising the prospect that some animal experiments could be eliminated. But there are still huge hurdles to overcome. Read More Here: https://postly.click/5vU

The research landscape is approaching a turning point. Proposed cuts would weaken science—especially physiology—that drives medical breakthroughs. This overview sets the stage for a deeper look at what’s at stake and why this full report matters: https://www.physio

Scientists, with initial mouse models findings, expand results in organoids to confirm nerve-repair treatment can trigger healing in human spinal tissue. Source: https://www.sciencealert.com/scientists-grew-mini-human-spinal-cords-then-made-them-repair-after-injury

🫱A new polymer delivery system may allow insulin to be absorbed through the skin and control blood sugar without injections, at least in animal studies! Source: https://www.nature.com/articles/s41586-025-09729-x

In vivo & in silico: Compounds linked to traditional medicine reduced anxiety-, depression-, and pain-related behaviors in mice. Computer modeling suggested key compounds and targets, while mouse studies showed how those predictions played out biologically: https://doi.org/10.100

Turning Back Immune System Aging: A new method instructs liver to pump out specific proteins, effectively hitting the "reset" button on an aging immune system to restore youthful defense capabilities. Source: www.livescience.com/health/immun...

📖 To celebrate the holidays, we've taken some of our strains to compose a seasonal story. Written version is below. Or spoken version here: youtu.be/xl-pHB0Y5bc . For the full "cast" see this link: postly.click/s61

National Security Commission on Emerging Biotechnology warns U.S. science is getting outpaced: https://www.fiercebiotech.com/biotech/us-commission-recommends-federal-research-revamp-avoid-losing-global-biotech-edge?utm_medium=email&utm_source=nl&utm_campaign=LS-NL-FierceBiotechResearch&oly_enc

Scientists found that HSL not only breaks down fat but also works inside the nucleus of to keep adipose tissue healthy, explaining why people lacking HSL lose fat instead of becoming obese. https://scitechdaily.com/obesity-discovery-

The research landscape is approaching a turning point. Proposed cuts would weaken science—especially physiology—that drives medical breakthroughs. This overview sets the stage for a deeper look at what’s at stake and why this full report matters: https://www.physio

The FDA has approved Kygevvi (doxecitine + doxribtimine) as the first-ever treatment for Thymidine Kinase 2 Deficiency (TK2d), offering hope to patients with this devastating mitochondrial disease. https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-1st-

Scientists have made major progress in understanding and treating thymidine kinase 2 deficiency (TK2d), a rare genetic disorder that weakens muscles by disrupting mitochondrial DNA maintenance. https://postly.click/ABY

James D. Watson, part of the team that uncovered the double-helix structure of DNA in 1953 with Francis Crick, Rosalind Franklin and Maurice Wilkins, has died at 97. His work marked a notable moment in biology. https://www.yahoo.com/news/articles/james-watson-co-discoverer-double-1957www.yahoo.com/n

As oocytes grow, H2A.Z shifts from marking active genes to spreading across broader, silent DNA regions, working hand-in-hand with another modification to support healthy meiosis and prepare the egg’s epigenetic blueprint for early embryonic life. .nature.com/articles/s41594-025-01573-xMore Info:

IMPC Strategic Conference ‘Insights from the Past, Shaping the Future’ Program and key information 👉 https://www.mousephenotype.org/news/2025-virtual-impc-conference-registration-and-agenda/ Free Registration 👉https://tinyurl.com/yz7znkde

🎉 Big congrats to Dr. Eric Green for receiving the American Society of Human Genetics Leadership Award — a standing ovation for visionary leadership in genomics! Read About it here: https://www.genengnews.com/topics/omics/eric-green-receives-ashg-leadership-award-to-standing-ovation/

"Animal models provide insights that alternative approaches can’t. A heated debate about which method is better is distracting researchers from doing good science." https://EcKc5wILd4%3D

MMRRC is in Boston at ASHG for the next 3 days - booth 1327! For more info: https://meetings.ashg.org/event/ASHG25/program/schedule

What Baby KJ’s CRISPR Breakthrough Really Tells Us. Reflections on the balance between hope and realism — new therapies are exciting, but they’re not universal cures yet. Read More: https://www.statnews.com/2025/10/09/crispr-cure-baby-kj-rare-diseases-personalized-gene-editing-drugs/?_hsmi=38470699

Congratulations to Drs. Brunkow, Ramsdell, & Sakaguchi! For More information: https://postly.click/ECH

“...the first step out of the maze for young men begins by reasserting to them the virtue of hard work — an often grueling but indispensable part of finding the right answers in science.” Read the essay with our gift article here: www.nytimes.com/2025/10/03/o...

Some good research "food for thought... " https://www.nature.com/articles/d41586-025-02920-0?utm_source=Live+Audience&utm_campaign=b2c87a0562-nature-briefing-daily-20250916&utm_medium=email&utm_term=0_-33f35e09ea-49915704

🌟 We’re proud to support the Rare Diseases Are Not Rare! Challenge—working together for faster treatments. With over 10,000 rare diseases, collaboration is key to speeding discovery and care. Learn more: https://www.challenge.gov/?challenge=rare-diseases-are-not-rare-2025-challenge

We're taking efforts to improve the information of new strains at the MMRRC, with our new Strain Quality Control. To view an example of one, visit this strain: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=75745#gene_info_Strain_Quality_Control

"To be clear, there is no replacement yet for animal research in biomedical science...it remains to be seen how faithfully these [stem cell] reprogrammed cells and organoids mimic various complex biological processes.

Mice treated with a copper drug repaired faulty brain proteins, reversing Parkinson’s symptoms and offering new hope. Source: https://www.goodnewsnetwork.org/scientists-reverse-parkinsons-symptoms-in-mice-we-were-astonished-by-the-success/

What happens when lifesaving research quietly disappears? A look at critical NIH-funded projects lost to sudden budget cuts: projects.propublica.org/nih-cuts-res...

Imagine a future where the smell of menthol could alleviate some of the worst symptoms of Alzheimer’s disease. Read More: https://theconversation.com/when-mice-with-alzheimers-inhaled-menthol-their-cognitive-abilities-improved-230330

Scientists used gene-edited mice to test a custom therapy for a deadly infant liver disease—then saved a real child! (P.S., A MMRRC Center Director is an author on this paper!) Source: www.nejm.org/doi/full/10....

Food for thought - "There’s no mystery to innovation and economic growth; the US must nurture its scientists or find out the hard way.

Something different: 3D-printing inside a living mouse’s bladder using sound waves! No cuts. Just ultrasound. Curious? Find out in Science: www.science.org/doi/10.1126/...

Scientists can now guide how cells self-organize using internal forces. Imagine using this to grow tissues in mice faster to test new therapies. Source: journals.aps.org/prl/abstract/10.1103/PhysRevLett.134.148301

Mouse studies reveal gut viruses help antibiotics — without them, bacteria resist treatment. 🐭🦠Source: cell.com/cell-host-microbe/abstract/S1931-3128(25)00135-0

​Sweden launches PROMISE, a national initiative to integrate large-scale multi-omics data with healthcare and research. By bridging fragmented datasets and improving data access, Sweden aims to unlock the full potential of precision medicine.

In an era where chronic illnesses are on the rise and research funding faces unprecedented challenges, the role of the MMRRC has never been more critical.

A new webinar is coming regarding how ambient temperature affects metabolic rate, concepts of a thermoneutral zone vs thermoneutral points, and much more! physiology.org/detail/event/2025/05/06/default-calendar/understanding-body-temperature-and-energy-homeostasis-in-mice?SSO=Y&_zs=qQHNW&_zl=2imS4

Sharing a message from the new NIH director regarding direction and aims. We hope to look at these goals to support researchers worldwide with the efforts we're known for and our desire to propel research forward.

Biotech worries as FDA's Peter Marks retires—key voice in gene therapy, vaccines, and biologics regulation. Source: www.genengnews.com/topics/drug-...

We want to thank Dr. Green for the 15 years of service he's provided to both our country and to research endeavors worldwide. fiercebiotech.com/biotech/director-nihs-national-human-genome-research-institute-steps-down

Memory formation REVEALED! NIH study shows brain's flexibility at the cellular level. Source: bit.ly/4iGwk6T

Scientists Discover Mysterious New Brain Cells That Could Change How We Treat Alzheimer’s scitechdaily.com/scientists-discover-mysterious-new-brain-cells-that-could-change-how-we-treat-alzheimers

FYI - Judge issues preliminary injunction blocking Trump cuts to NIH research overhead payments. Source:

#REVIEW 🚨 Genomic mutations can lead to modified functional proteins, impacting protein–protein interactions (PPIs) & cellular functions. Fu, Mo & Ivanov explore the mechanisms, monitoring technologies & therapeutic implications of this. https://bit.ly/3Chl0...

Welcome to the Bluesky account for Stand Up for Science 2025! Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide! #scienceforall #sciencenotsilence

Dr. Francis Collins' leadership at NIH advanced science and improved lives. We appreciate his impact and wish him the best! For more information: www.genengnews.com/topics/omics...

We have deposited the following mice (all B6/J backcrossed) to @mmrrc.bsky.social Adgrf5-EGFP-CT-IRES-CRE GPR123- EGFP-CT-IRES-CRE GPR124- EGFP-CT-IRES-CRE GPR125- EGFP-CT-IRES-CRE Gpr133-EGFP-CT-IRES-CRE GPR156-IRES-Cre GPR156-mGL-IRES-Cre GPR75-IRES-Cre

Happy Rare Disease Day! Thank you for all you do to contribute to the efforts to advance science in Rare Diseases. Learn more at www.rarediseaseday.us