Excited to share emerging studies in the lab and learn from all the brilliant scientists at uw Madison!

Our paper is (finally) out in Cell today! CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis www.cell.com/cell/fulltex... Great collaborative effort - read more from first author @asamelson.bsky.social below:

Alex Pretti was a colleague at the VA. We hired him to recruit for our trial. He became an ICU nurse- I lover working with him. He was a good kind person who lived to help and these fuckers executed him. White. Hot. Rage.

NEW pub in @science.org 🥳 Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life? For over 15 years, #phylogenomic studies have been divided. We provide new evidence suggesting that... 🔗: www.science.org/doi/10.1126/...

When people celebrate the individual genius of folks in science, they should also mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)

Zara was one of the best people I've crossed paths with in this career, in this life. A fissure has opened with her departure, and I will miss her terribly.

Zara was an inspiration. We never met in person but became friends through Leading Edge. She zealously advocated for her ideals, but was also passionate about helping others realize why they should too. Her loss is gutting & the world is the worse for it. RIP, I'll do my best to continue the fight.

We are all better because of the energy, inspiration, brilliance, and tenacity that Zara was. A bright light, role model, advocate & snarky tweeter... everything I needed in a person when I was navigating dark times when we met in 2021. You will be missed deeply, Zara, but never forgotten ❤️

Zara was a great inspiration and mentor... Its really sad the excellent often leave us too soon... You will be missed Zara 💕

Zara will be missed. Such terrible news.

Zara Weinberg was a brilliant, loving, and beautiful woman. She inspired everyone who she interacted with, and always strived to make the world a better place for everyone. Tho the world is a little less bright today without her, her memory will always be a blessing. She was truly one of the best.

Truly one of the best. We worked on various initiatives/wrote a paper together, and had the best conference meet ups. She was a bold and tireless advocate for change. Last time we met, we had a great time trying new cuisine and imagining a future that’s so different for trainees than we experienced.

Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed. She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.

We are #hiring for a Tenure Track Assistant Professor position in the Department of Molecular&Cellular Physiology (med.stanford.edu/mcp.html) at @stanfordmedicine.bsky.social. Please apply or forward the opportunity to anybody who might be interested. facultypositions.stanford.edu/en-us/job/49...

Today I am so pleased to present our work on how chromatin remodelers affect mesoscale chromatin organization. www.science.org/doi/10.1126/...

I love writing spontaneous and unsolicited reviews. I would be thrilled folks did it to me too! I think it gets the heart of what we do science for - giving and getting feedback to get closer to the ‘truth’! Otherwise why post a preprint if you don’t want people to read and respond?

Check out MitoScribe in our new preprint led by Linhan Wang: www.biorxiv.org/content/10.1... It's an analog molecular recorder that uses neutral base edits to the mitochondrial genome to store information about historical signaling in a cell. Single cell resolution at scale (see next post)!

1st day of classes went well for this associate professor! I’ll ride this tenure/promotion wave for another week. I’m teaching a new chemical biology class this semester. Excited to bring computational chemistry topics & hands-on activities in the computer lab. Also still masking this semester!

Latest pre-print from our lab is out. Great work by @alexbendel.bsky.social and team. Full deep mutational scan of an entire human protein interaction domain family 2M quantitative measurement of protein-protein interaction -> deep learning model to predict PPI from sequence More details 👇

Congrats Kevin Allan, Jesse Zhan, @tymillerlab.bsky.social, @tesarlab.bsky.social, et al It was fun to do some super-resolution microscopy to help look into how a cell matures, all while sending a lot of spooky faces to Paul and Kevin since, unlike these Sox6 ko cells, I have yet to mature 😱😱😱😱😱

I am happy to finally share this preprint of my PhD project in @guillaumediss.bsky.social lab at the FMI in Basel. We used ddPCA to map the genetic architecture of the entire human bZIP interaction network. www.biorxiv.org/content/10.1... Thanks to all our co-authors for the great collaboration!

I got to share a bit about Indigenous values in chemistry on this pod! Thanks @nature for the feature and joining some an amazing list of ChangeMakers!

Assistant Professor position in Traditional Ecological Knowledge at Stanford University. Applications due Sept 30, 2025 facultypositions.stanford.edu/en-us/job/49...

ProDomino is a machine learning-based method that predicts domain insertion sites and helps guide the engineering of functional multi-domain proteins. www.nature.com/articles/s41...

Awesome work from @jingyour.bsky.social, @hjp.bsky.social and a lil bit us! New stats framework for mutational scanswhere we measure multiple phenotypes like expression & activity. Jingyou is able to pull out immediately patterns that took us otherwise weeks to months data digging. Amazing work!

So lucky to have the brilliant @jingyour.bsky.social joining the lab as a postdoc! It’s been inspiring collaborating the last couple years and I can’t wait to see the extraordinary things she’ll do :)

Super proud of my first student, @jingyour.bsky.social! Well done! Looking forward to the amazing work you will do in the future 🥲 bsky.app/profile/jing...

Thrilled to share that I just successfully defended my PhD! Thanks to my committee, collaborators, and everyone who’d supported me throughout my seven years at UCLA. A special thank you to my PI Harold for his incredible mentorship! @hjp.bsky.social

🧪🖥️🧬 It's here!! Our second MPRA, which is totally different from the first. For starters, there's no human sequences anywhere! Instead there's marsupials, wolves, pandas and a lot of hard work from lab members past & present, chief amongst them @navya-shukla.bsky.social (looking for a postdoc btw)

Officially tenured. Thank you to all the mentors who guided me, and to the trainees who made this possible with your ideas, hard work, and scientific joy.

Very excited to have this work out by @jeromics.bsky.social ! Please check it out. I think my favorite story from the supplement is how impactful normalization can be in this context. bsky.app/profile/jero...

Check out Jerome's paper! As we push the boundaries of DMS, it is critical that we develop robust ways to score variant effects--and he is doing just that. Excited to put this to use in our upcoming GPCR-DMS endeavors :)

Check out @jeromics.bsky.social @hjp.bsky.socials recent facs based model for dms studies!!!

Congrats - amazing work show a beautiful landscape of opioid receptor conformations by EM

This is disappointing. To understand the significance of this area for Natives, listen to this Native American Calling episode with Natives in the area describing their relationship with this land. www.nativeamericacalling.com/tuesday-may-...

I’m super honored to be selected, and immensely grateful. Huge thanks, @hypothesisfund.bsky.social! We are looking forward to doing some fun science! bsky.app/profile/hypo...

Come and join us! We’re hiring a new Group Leader in Generative Biology at the @sangerinstitute.bsky.social Building AI models or the data to train them? Core funding of >$130M a year for a faculty of ~30. www.nature.com/naturecareer... acrobat.adobe.com/id/urn:aaid:... pls RT!

Not the wurst case science bluesky scenario: This post inspired me to look up a few other papers by the 'brilliant hoot' Fred Menger and led me to this absolute beauty! 🧪 Certainly NO ONE should feel pity for the mundane phospholipid and its inferiority complex as a "sausage casing" 🌭😂 #LipidLove

I’m no longer an assistant to the professor. It’s been a long journey to associate professor. I now join the 0.4% of tenured Native American/Alaska Native (AI/AN) faculty! In 2019, there were 50 tenure AI/AN in the sciences. This number still needs to increase! #NativesInSTEM

'(...) German research institute BioMed X is stepping in to offer a lifeline. The institute has opened a matchmaking program to align threatened NIH grants with potential new funders from the pharmaceutical industry.' www.fiercebiotech.com/research/ger...

This was the last @hhmi.org conference Lilly and Yuh-Nung Jan attended as investigators. They're becoming HHMI emeritus but still run a thriving NIH-funded lab. From cloning the first potassium ion channel (Shaker) to decoding neuronal development, the Jans have made a huge impact.

Wrapping up my time at the Full Circle of Native and Indigenous Scientists in Biology Symposium and I want to reflect on some thoughts mentioned today qbi.ucsf.edu/full-circle-... 1/5

Since then I have kept a running list of Native scientists I would like to meet. I have been fortunate enough to connect with many amazing Native and Indigenous biochemists and microbiologists but this symposium was by far the largest number of Native scientists I have ever been in a room with. 3/5

The #FullCircleSympisium is done and my heart is full. I want to thank ASSISTANT PROFESSOR @willowcoyote.bsky.social for organizing, along with his crew of students, administrators, and others who helped this run smoothly and even on time. I even called my dad after to tell him how awesome it was.

I am full of thanks to the Full Circle Symposium and @willowcoyote.bsky.social for creating a scientific space for futuristic and forward-thinking minds. It was a great way to reconnect. Also, thanks to @cheadlelab.bsky.social who snapped this picture:

I am at the Full Circle Symposium organized by @willowcoyote.bsky.social this week and I have so many thoughts. 🧵 #FullCircleSymposium qbi.ucsf.edu/full-circle-...

🌠 We're thrilled to announce our latest Hypothesis Fund awardees and their groundbreaking projects! From optimizing enzymes, to protein sequencing, and membrane 'functional hotspots', each of these projects holds the potential to be broadly transformative for science! 1/ 🧵

Looking forward to visiting UCSF this week for this symposium!

Just a little over a week out! The symposium is coming together wonderfully. Please join us either in person at UCSF or virtually in a webinar! Register here :) qbi.ucsf.edu/full-circle-...

Honored and grateful to receive the 2025 Bowes Biomedical Investigator Award - along with my friend, colleague and collaborator @annamolofskylab.bsky.social 😊🎉🎉🎉 www.ucsf.edu/news/2025/02...