Dendritic excitations primarily mediate back-propagation in CA1 pyramidal neurons during behavior https://www.biorxiv.org/content/10.64898/2026.01.03.696606v1

During Fiona Hill's testimony to Congress on Oct 14, 2019, she described how Trump and Putin discussed exchanging Ukraine for Venezuela. The quid pro quo was if Trump refuses to help Ukraine fight off a Russian invasion, Putin would not help Venezuela (a Russian ally) resist a US takeover.

Kidnapping the leader of a foreign state without any declaration of war and announcing it via social media is full-on rogue state stuff. From the world’s number one superpower.

Very cool paper and glad to see the ankyrin-G-GFP mouse getting used! Cre-dependent live labeling of the AIS allows in vivo, longitudinal tracking of AIS position changes in response to stimuli. Here it is being used to track changes in response to fear learning. Congrats, Jan, Maren, and team!

Proximity labeling users: check out this study by @zhixingchen2.bsky.social and Peng Zou, which establishes how much contact-dependence vs. diffusion is responsible for biotinylation — tl;dr TurboID has a much smaller effective radius! www.nature.com/articles/s41... 1/2

Fun in one of my favorite cities, Heidelberg! 🇩🇪

I hopped we would be well over this in 2025, but let me scream it one more time: "mRNAs LEVELS DO NOT CORRELATE WITH PROTEINS AMOUNTS, NOR THEIR PTMs AND CERTAINLY NOT THEIR SUB-CELLULAR FUNCTIONS/TURNOVER." So yeah, cells with similar RNA expression patterns can have different functions. Duh 🙄

Had a nice visit to the former stomping grounds of King Ludwig II at Neuschwanstein Castle today. 🇩🇪 #bavaria

Reflecting on autocrats that really like to build huge things while outside the former Nazi rally grounds is a bit too on the nose for today's times

Interesting preprint from the Boyce lab! Sec23IP (protein linking COPII inner and outer coats) is regulated by O-GlcNAcylation. Site-specific modification of its disordered domain controls O-GlcNAcylation, Sec31A recruitment, COPII assembly, and ER exit site function. www.biorxiv.org/content/10.6...

My lab in the NIH Intramural Program (Bethesda, MD) will be recruiting postdoctoral fellows over the next year with flexible start dates. We work on nanoscale cellular imaging of the plasma membrane and related organelles. Please reach out if you’re interested. www.training.nih.gov/jobs/pdp-053...

She let me know that they recently received guidance that, ONLY for the January EI deadline (1/27/2026) and the February ESI deadline (2/3/2026), PIs can submit MIRAs even if their previous application (R35, R01, R15, R21, and R37) is still considered under review.

On this day in 1934, Albert William Kaline was born in Baltimore, MD. In his 22 seasons as a player with Detroit, he hit 399 home runs, including two in a memorable 1968 World Series. Here’s my painting of him with the Tigers in June of 1954, his first full year with the club.

The name "Popular Science" doesn't mean we shift our coverage depending on public opinion. It means we cover relevant subjects that are rigorously researched, reliable, and grounded in reality. And trans lives are grounded in reality. We see y'all. No matter what. www.popsci.com/science/tran...

Excellent work, past me... That clears up everything.

Epic bullshit. 50% of researchers using AI for peer review. We're so cooked.

BREAKING: Mike Johnson orders second strike on surviving citizens clinging to the wreckage of this economy.

“Basic neuroscience hasn’t produced new drugs.” 💊 Not true - zuranolone (PPD), suzetrigine (pain), gepants (migraine), and more... were born out of a long arc of studies in the lab. I wrote a Perspective on why this matters. @thetransmitter.bsky.social www.thetransmitter.org/drug-develop...

Really interesting deficits in sensory coding in Scn2a heterozygous mice and rescue of these deficits with CRISPRa in adults. Implications for EEG-accessible biomarkers for Scn2a loss-of-function...

Dunno who needs to hear this, but before your start writing your reviewer comments, eat a cookie. Only you can prevent rude reviews.

There is no rock bottom. So vile.

ERA Commons having a totally normal one...

the snow has fallen such that it looks like a little child, standing on a pile of snow, watching the snow fall

New lab photo just dropped. This is the kind of stuff I am subjected to. 🤣 #justoneoftheladies #flowinglocks #sororitysquat

It's this Thursday! Register below 👇🏻

If I wanted to see what that dipshit Elon Musk was saying, I would have stayed on X. I wish people would stop posting his idiotic, racist drivel.

*This* is what the people of Pompeii, and Herculaneum, and many other hapless souls saw—this is what a pyroclastic density current looks coming RIGHT at you. Filmed from a CCTV camera during the Mount Semeru eruption on Java, Indonesia on 4 December 2022. Video credit: PT United Tractors Tbk

Always nice to see my friends from the FamilieSCN2A Foundation (@scn2a.bsky.social)! Catching up at the 2025 @amepilepsysoc.bsky.social annual meeting.

The hepatitis B vaccine had been recommended for all newborns since 1991. From 1990-2019, acute hepatitis B infections reported among children and teens fell 99 percent. www.nytimes.com/2025/09/16/w...

Just got done reviewing applications for the Eagles Autism Foundation. Might be the closest I get to one of these, as a Detroit Lions fan.

The recent seiche on Lake Erie, driven by strong NE winds, resulted in a remarkable tilting of lake levels. This particular seiche resulted in a lake-level difference of about 8-10 ft. Here is a plot of lake levels in Buffalo and Toledo (at either end of Lake Erie). #LakeErie #seiche

i think if you want to have those disgusting LED headlights on your car, you should have to do a test where they blast you point blank with your own headlights and then you have 15 seconds to successfully complete some sort of vision-based task, and if you can't do it they push your car off a cliff

UNC's Center for Molecular Medicine has up to three open-rank positions for faculty conducting research with relevance to gene therapy, including: novel iPSC and animal models of disease and basic cell biology. Join us in beautiful Chapel Hill! Deadline 1/31/26: unc.peopleadmin.com/postings/309...

NEW: An analysis finds that NIH funding cuts have disrupted at least 383 clinical trials, affecting over 74,000 participants that were enrolled in studies that were testing treatments for conditions including cancer, heart disease and brain disease.

This is a real flight school, teaching people to fly planes!!! Like????

Every. Accusation. Is. An. Admission.

After 10 years, I am stepping down as chair of our department and we have an active search going on! Utah is a phenomenal place to live and work and it's been the honor of a lifetime chairing the department founded by Lou Goodman. #MedSky #Neuroskyence Repost! jobs.chronicle.com/job/37914733...

New preprint 🥳! We made photoclickable HaloTag ligands to precisely control protein labeling on living cells. With it, we can do some cool multicolor stuff. Huge congrats to Franzi and all co-authors! Check it out 👇 www.biorxiv.org/content/10.1...

The Germans have a word, Backpfeifengesicht, which roughly translates to "a face in need of a fist". Just going to leave that bit of knowledge there.

The Republican president is a pedophile who has doubled my healthcare costs and let scores of violent criminals out of jail. But a Democratic mayor-elect wants to make busses free in a city I don't live in. I have never felt more politically homeless.

Fantastic to see these initiatives popping up around Ireland. Oysters are such amazing creatures! www.rte.ie/news/dublin/...

Apparently not

Biological Chemistry's position is still taking applications. UM is a great place to be a PI, I'd love to see a new membrane biology or lipids expert join our community. This is open for new and established investigators.

BREAKING: SANDWICH GUY ACQUITTED. NOT GUILTY!

The q.e.d feedback that you get when you run your paper via @biorxivpreprint.bsky.social is not posted there, it's private and for your eyes only. In the future we want to create a report that you'll be able to attach to your preprint like a cover letter (it's all opt in of course)

This is my son’s soccer teammate. This is heartbreaking to watch, no kid should go through this. I know his parents, they are good people. No family should endure this. The cruelty and evil actions of the trump administration and ICE are tearing families and communities apart.