I like this. Since under RFK Jr, Covid shots are now for people with underlying conditions that put them at risk, Michigan’s chief medical executive Dr. Natasha Bagdasarian states that not having the most recent Covid shot constitutes such an underlying condition. www.michigan.gov/mdhhs/inside...

This is precisely the kind of government coercion that the First Amendment was designed to prevent — and media companies need to start standing up rather than capitulating to it.

Really exciting new paper from collaborator extraordinaire @neurobender.bsky.social on CRISPRa-mediated rescue of Scn2a loss-of-function. Happy to contribute a tiny bit to this behemoth of a story. Congrats, Kevin, Nadav, and everyone else!

Our new preprint is up! This is the main postdoc work of @wiesner-t.bsky.social focusing on exocytosis along the axon shaft and its regulation by the sub membrane actin-spectrin scaffold: www.biorxiv.org/content/10.1... Read the thread below for a summary of our findings 🧵1/11

🚨 Big news for the #SCN2A community 🚨 Landmark UCSF study shows CRISPR activation can restore SCN2A function — even later in development. A real step forward, and real hope, for families living with SCN2A-related disorders. www.prnewswire.com/news-release...

It is the job of the Democratic party to sell and defend the policies that most Democratic voters want, not to present a candidate slate that is palatable to moderate Republicans who might switch if they hate their own candidate enough.

A huge shoutout to all the dedicated grants management specialists at the NIH who are working around the clock to push grants out before the Sep 30 deadline. And also to the POs responding to frantic emails. Not an easy job under the best of circumstances and right now it's the pits. Thank you!

Things must be pretty dire with grant reviews at NIH. Got THREE! requests for me to sit on study section last week. Agreed to one (even though I'm working on a revision for that same time). Hoping that puts some good science karma in the grant-osphere.

For #mountainmonday a picture of the Rocky Mountains in Glacier National Park The Quakes were just starting to turn 9-10-2025 #scape #landscape #artyear #nationalparks

Reading today’s big NYT Magazine story made me physically sick It details how Trump & the men he put in charge of federal research—men like Jay Bhattacharya & RFK Jr—are dismantling cancer research Not just the US vaccine system—they’re crushing cancer R&D 🎁Link www.nytimes.com/2025/09/14/m...

Glad to see we’ve finally reached the “accurately observing the words used by a prominent fascist intellectual is the *real* fascism” stage of legacy media finger-wagging fascist accommodation. Great stuff!

No notes. 10/10.

🚨🚨🚨 Finally out!!, Our study describing the development and deployment of a bespoke CRISPR–Cas9 base editor for palliation of a severe monogenic vasculopathy by genome editing is published today in Nature Biomedical Engineering 🧵 to follow Here is a free link: rdcu.be/eFAEz

We have updated our preprint "A green lifetime biosensor for calcium that remains bright over its full dynamic range" with some new data - including this photo showing the difference in color for the Turquoise and Green lifetime probe. www.biorxiv.org/content/10.1...

AAAAAAAAAAAAAAAAAAAAAHHHHHHHHHHH

Here ye, here ye!!! #WCBR2026 #WinterConfrenceonBrainResearch will be extending the panel deadline one week for submission (new deadline 9/18/2025)! Official announcement coming soon so check your emails! please reskeet!

The NIMH Director job announcement and search is back on: hr.nih.gov/jobs/search/... The NIMH Director provides executive direction and scientific leadership for NIMH, overseeing a $2.3 billion budget and ~1600 employees, trainees, and contractors. Up for the challenge 😉? Apply!

<Crocodile Dundee voice> That's not a zucchini. THIS is a zucchini. #puremichigan

We’re delighted to have the one and only Paul Jenkins @pjenkinslab.bsky.social in the department today! We are all in for a treat…💥

Faculty opening in Cornell Chemistry at the Assistant Professor level in the area of chemical biology, broadly defined! academicjobsonline.org/ajo/jobs/30338 #chemjobs

Nice work, JNeuro!

In a time when many journals have gone off the deep end in terms of the review process, expectations for revisions, time to review, etc. I was very pleased with Neuropharmacology (EIC: ‪@jaredwyoung.bsky.social‬). Fast, reasonable, and fair reviews. Very quick turnaround. 100 out of 10, recommend.

Had a blast writing this insight article with @sydneytrask.bsky.social covering original research from the @michaeldrew.bsky.social lab on the stress-specific recruitment of a brain region that drives fear behaviors! doi.org/10.7554/eLif...

Congrats, Sandy! What a well-deserved honor!

On this day in 1934, Roberto Clemente was born in Barrio San Antón in Carolina, Puerto Rico. Perhaps the most important ballplayer in Latin American history, the quality of his play was only surpassed by the quality of his character. Here’s my painting of him during the 1972 season.

he landed

🟣Astrocytes extend a nurturing embrace around the retinal 🟢vasculature 💜💚 #fluorescencefriday

Geng, @kjverhey1.bsky.social et al find that KIF1C forms condensates where the exposed #kinesin motor domains entangle nearby #microtubules, causing them to bend & break in a process dependent on motor processivity, cluster properties, cytoplasmic viscosity, & MT anchors rupress.org/jcb/article/...

The data package HHS offered to defend Kennedy’s decision is not the work of U.S. government scientists… “The compilation originated as material for a book titled “TOXIC SHOT: Facing the Dangers of the COVID ‘Vaccines’,” an anthology of essays by prominent anti-vaxxers.” @jackiantonovich.bsky.social

Is this a special starvation plan?

To greet the morning #photography #NaturePhotography #landscape #stumpylake

New preprint + thread 🧵 #Psychedelics induce the formation of new synapses, but where do they connect? Our rabies tracing study reveals that #psilocybin shifts connectivity across specific cortical networks. www.biorxiv.org/content/10.1... 1/12

Wild case of ChatGPT almost killing a guy by telling him to substitute sodium bromine for table salt (sodium chloride) #medsky www.acpjournals.org/doi/10.7326/...

Patch clampers: we got an error 52 on our Leica vibracheck and the normal "blow on it like a nintendo in the 80s" fix didn't work. Nor did a cleaning of the LED and diode. LED does shine. Has anyone else had such an issue and managed to resurrect this very simple but stupidly expensive thing?

This thing goes to 11 (thousand feet). Hike to Sky Pond in Rocky Mountain National Park with collaborators @neurobender.bsky.social and Stephan Sanders!

More photos to come, but holy hell is Rocky Mountain National Park amazing. This was at sunrise on the way to Sky Pond. Magical.

Incredible thread painting embroidery!

This is one of the best ideas I've heard in ages.

Some journals are claiming that you need to pay big $$ for gold open access to comply with NIH's new public access policy. FYI that is total bs. You can comply by depositing the Accepted Manuscript into PubMed Central on the Date of Publication without embargo. Pass it on.

few outcomes, except for 99% of FDA-approved drugs, 174 recipients of 104 Nobel Prizes, training ~30K MDs and ~10K PhDs per year to enter the workforce, and a 34% reduction in age-adjusted cancer deaths since 1990 -- the largest decrease in history

Just an old-fashioned midwest thunderstorm. Yikes! Coming down in sheets.

What an ignorant jackass.

Not a bad day on the Huron today! The colors on that smallie were amazing. #4 olive wooly bugger with crystal flash was the winner. #puremichigan #flytying #flyfishing #largemouth #smallmouth

This is utter bullshit

The bluebirds are back! First clutch of the season. #bluebird

*Taps the sign again*

Lychee but a fresh black cherry right off the tree is pretty good too