Season’s greetings to all! May your experiments be reproducible, your reviewers constructive, and your controls unambiguous.

Interesting preprint from the Boyce lab! Sec23IP (protein linking COPII inner and outer coats) is regulated by O-GlcNAcylation. Site-specific modification of its disordered domain controls O-GlcNAcylation, Sec31A recruitment, COPII assembly, and ER exit site function. www.biorxiv.org/content/10.6...

Thanks @jcellsci.bsky.social for this opportunity to contribute to your centenary collection with our take on the state of the field - 10 years after its modern reincarnation 🧪🌍 W/ @alebenoit.bsky.social @eelcotromer.bsky.social @fritzlaylin.bsky.social journals.biologists.com/jcs/article/...

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

A very exciting preprint from @krishnanyamuna.bsky.social shows that pH within organelles is not uniform: stable sub-organellar pH gradients exist even at the ~100nm scale, implying limited proton mobility - redefining organelle identity and regulation. www.biorxiv.org/content/10.6...

@natcellbio.nature.com - Finally out! Skin cells mechanically protect their genome from UV by positioning melanin above nucleus. Keratin filaments & microtubules drive the process. Led by Silvia Benito-Martinez & @laurasalavessa.bsky.social @membramics-lab.bsky.social www.nature.com/articles/s41...

My excellent collaborator, Giulia Zanetti, is advertising for a post-doc to work on our shared MRC grant. Please consider applying to this great lab with a supportive mentor to do some exciting structural biology. www.ucl.ac.uk/work-at-ucl/...

TMEDs mediate versatile cargo transport in vesicle-dependent unconventional secretion url: rupress.org/jcb/article-...

Nice preprint from @derm-scientist.bsky.social! Ubiquitin system is key for tissue architecture in CYLD cutaneous syndrome (CCS) skin tumours. "Comparative ubiquitinomics of human skin reveals insulin receptor ubiquitination as a regulator of collagen secretion." www.biorxiv.org/content/10.6...

Come to be our colleague! Center of Paris, excellent facilities, research spanning the whole range of basic and biomedical life science topics, enthusiastic and collaborative colleagues, crème brûlée every Friday... What else could one want?

#membrane seminars are back this THURSDAY for a super session with @dr-downes.bsky.social from the @giuliazanetti.bsky.social lab and Xin Zhou from the Ikonen lab! @felixmendu.bsky.social @ishier.bsky.social

Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published: journals.biologists.com/jcs/article/... The result of a fantastic Iwasa-Drubin lab collaboration. @margotriggi.bsky.social @jiwasa.bsky.social movie.biologists.com/video/10.124...

Tissue stress measurements — our latest preprint is out: arxiv.org/abs/2512.00550 (publication coming soon!) Fantastic work by the three musketeers — @luanger.bsky.social, @andreasschoenit.bsky.social and @fanny-wodrascka.bsky.social — in collaboration with P. Marcq!

Useful insights from this nice, expert 'community comment' @natcomms.nature.com Biomolecular condensates aren’t just LLPS, or oil-and-water droplets. They span diverse material states and interactions. Nuanced, precise terms help capture this complex physics and move the field forward. rdcu.be/eSnXW

Well that settles it.

Delighted to have collaborated with the @dirktrauner.bsky.social lab on the development and characterisation of #photoswitchable #cholesterol derivatives, now out in @jacs.acspublications.org! (1/3) pubs.acs.org/doi/full/10....

Nice paper from @leventallab.bsky.social suggess lipid-driven domains organise cargo and trafficking machinery at ERES to sort and export transmembrane proteins. ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferring proteins for rapid ER export. rdcu.be/eR8jj

How do new centromeres evolve while staying compatible with the division machinery? Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore. 👉 doi.org/10.1038/s41586-025-09779-1

So proud to watch Jana turn a side quest into an entire research programme. Couldn’t imagine a more well-deserved outcome. 😍 The mighty yeast reveals what we believe are general principles of centromere evolution! Behind the curtain: communities.springernature.com/posts/counti... #MEvoSky 🧪🌎

Email from a predatory journal: "We were pleased to come across your publication ... We would like to cordially invite you to submit the SAME or a related manuscript to our journal." They want me to submit the same paper?

We are looking to hire a postdoc to work on the regulation of microtubule nucleation in neurons. See advert attached. Contact me by email for any extra info.

Nice paper from Kota @saitolab.bsky.social! Balanced phosphorylation of TANGO1 and Sec16A keep ER exit sites stable and functional. Do cells maintain this dynamically to keep secretory machinery primed and responsive to changing cargo loads or environmental signals? www.nature.com/articles/s41...

Congratulations to Celia Municio-Diaz in the lab for this new publication, showing that Cell Wall mechanosensors taken from distant yeast species can still function and detect forces in the foreign cell wall of fission yeast cells! @ijmonod.bsky.social @cnrsbiologie.bsky.social

Oh wow! An excellent engaged review of I Dream of Theresa May. I couldn't be happier! ⭐ ⭐ ⭐ ⭐ “A whip-smart piece of queer political satire.“ www.thestage.co.uk/reviews/i-dr... On until the 29th @taratheatre.com: taratheatre.com/whats-on/i-d... (Spoilers in the review- you have been warned)

A long-standing question in cell biology: why are Golgi cisternae flattened? A biophysical model from Jensen group (Manchester) suggests this architecture may directly influence glycosylation. Morphological determinants of glycosylation efficiency in Golgi cisternae www.biorxiv.org/content/10.1...

New Article: "A combined biochemical and computational approach provides evidence for membrane remodelling by the structural scaffold of the endocytic TPLATE complex" rdcu.be/eP4fX ... to generate a comprehensive structure of the multisubunit endocytic TPLATE complex.

Happy to share our new protocol in @cp-starprotocols.bsky.social: CATCH—Covalent Anchoring of Tethered Ligands to Chemogenetic Handles! This method enables precise, long-lasting, and pharmacologically specific inhibition of brain receptors in vivo. 👉 www.sciencedirect.com/science/arti...

Check out our @ascbiology.bsky.social #CellBio2025 Minisymposium on ER Homeostasis. With THIS speaker lineup, this event will be as dynamic, transformative and productive as the ER itself! So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)

Environmental stiffness regulates neuronal maturation via Piezo1-mediated transthyretin activity. My main postdoc paper is finally online! Thanks to all the co-authors, the entire Franze lab and the Káradóttir lab. @franzelab.bsky.social www.nature.com/articles/s41...

And just when you thought things were settling down, the enigmatic Asgard archaea have another surprise in store! Cell cycle/life cycle stage-specific internal compartments with almost no eukaryote-derived clues as to how they might function. Beautiful tomography and microscopy - congrats all 🤩

Under two weeks before my #play hits the stage @taratheatre.com ! Can't wait! Come see it if you're in London- it'll be great to have tons of people there. Book here: taratheatre.com/whats-on/i-d... A video of me wittering on about the play in the post below ⬇️ #theatre #newWriting #immigration

Nice preprint from Gerard Cantero @gercrcat.bsky.social! Loss of ClC-5 function causes Dent’s Disease type 1. In a renal proximal tubule epithelial cell line, ClC-5 mutations disrupt endolysosomal pH and the Golgi via TMEM9 and SEC22B, interesting pathophysiology. www.biorxiv.org/content/10.1...

Europe's MSCA postdoctoral fellowships are now attracting many researchers who would have gone to the US. So the payline has dropped below 10% (~1,600 fellowships to 17k applicants). Super tough situation. One more reason to double the next Horizon budget, as proposed by the EU Commission.

#MembraneTraffickers! Our next online seminar is this Thursday, Nov 6 at 5 PM CEST! We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease. Spread the word and join the discussion!

I have two open positions @ALMU @crg.eu: 1. Imaging Scientist (permanent position. Deadline 11th Nov.) recruitment.crg.eu/content/jobs... 2. Entry-Level Imaging Scientist (12 months fixed-term position. Deadline 18th Nov.) recruitment.crg.eu/content/jobs... Reposts appreciated.

The new Outlook app has achieved peak academic design: less functional, but somehow more confident.

Interested in intracellular organization and membrane trafficking? 🥞 Join us at @melisupf.bsky.social in Barcelona! We’re looking for postdocs to apply for a Juan de la Cierva fellowship (PhD between Jan’24–Dec ’25). If you’d like to work with us, get in touch! www.aei.gob.es/en/announcem...

Nice preprint from Mondira Kundu lab! Glucose starvation blocks SEC24C-dependent ER-to-Golgi export of some proteins like E-cadherin, reshaping the surface proteome - via AMPK-ULK1-Sec31A signalling. Controls cell migration and metastasis under nutrient stress. www.biorxiv.org/content/10.1...

🚨 #PhD Opportunities 🚨 🧵 How does plasma membrane structure underpin tissue development? Let’s find out! Opportunity to do a PhD with me, co-supervised by Darius Koester, at Warwick. Fully funded studentship by #MIBTP. 🔬✨🐟 More info: www.findaphd.com/phds/project... Interested? Reach out!

🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny. #ProtistsOnSky #SciComm #SciSky www.cell.com/cell/fulltex...

Should I be worried if I can't solve many of the 'are you human' puzzles on the internet?

Close-up of vesicular ER exit sites by volume electron imaging using FIB-SEM url: rupress.org/jcb/article-...

Had the pleasure of working with @mohannad-dardiry.bsky.social to rethink what it means to develop for life. Many thanks to @dev-journal.bsky.social! @embl.org #LifelongDevSI

Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis. www.nature.com/articles/s41...

📣 We are moving to Barcelona to join the amazing @crg.eu and explore how centrosomes & cilia work, evolve & respond to the environment. We are looking for PhD students www.crg.eu/en/content/t... Postdocs gimm.pt/jobs/postdoc... Other calls to open, also for an experienced lab manager. Get in touch!

Spread the word! There is a professor position opening at our University @upcite.bsky.social. There are several possible (great) labs to join, but if you are interested in DNA methylation and epigenetics in mammals, don't hesitate to contact me directly!

#JobOffer 💼 Postdoctoral Researcher (M/F) in Biophysics of Bacterial Infection 📆 January 1st, 2026 📍Institut Jacques Monod, Bonazzi Lab Apply before November 6th 🔗 emploi.cnrs.fr/Offres/CDD/U...

Calling all #Membrane enthusiasts! Our #MembraneTrafficking online seminar series is back for the 2025-26 season: 8 fantastic speakers from Nov'25 to Feb'26. The first talks are already next Thursday (Nov 6, 5pm CET) with @agatawitkowska.bsky.social and @abdourachidthiam.bsky.social !

📢 2 very exciting PhD opportunities, please share! We use a range of technologies+systems to study #collagen, #ECMatrix, and #fibrosis 👇 1) MRC CASE DTP - #3D #biomaterials, #immune cells alter, #drugscreens lnkd.in/e6eMqs8M 2) Bicentenary - #macrophages, #circadian, #omics. lnkd.in/ekZfJfsd

Our latest paper on a histone methyltransferase-independent function of PRC2 controlling small RNA dynamics during programmed DNA elimination in Paramecium is now published in #NAR. #RNAbiology #TEsky #smallRNAs #PRC2 #DNAelimination 1/5 academic.oup.com/nar/article-...