Environmental stiffness regulates neuronal maturation via Piezo1-mediated transthyretin activity. My main postdoc paper is finally online! Thanks to all the co-authors, the entire Franze lab and the Káradóttir lab. @franzelab.bsky.social www.nature.com/articles/s41...

And just when you thought things were settling down, the enigmatic Asgard archaea have another surprise in store! Cell cycle/life cycle stage-specific internal compartments with almost no eukaryote-derived clues as to how they might function. Beautiful tomography and microscopy - congrats all 🤩

Under two weeks before my #play hits the stage @taratheatre.com ! Can't wait! Come see it if you're in London- it'll be great to have tons of people there. Book here: taratheatre.com/whats-on/i-d... A video of me wittering on about the play in the post below ⬇️ #theatre #newWriting #immigration

Nice preprint from Gerard Cantero @gercrcat.bsky.social! Loss of ClC-5 function causes Dent’s Disease type 1. In a renal proximal tubule epithelial cell line, ClC-5 mutations disrupt endolysosomal pH and the Golgi via TMEM9 and SEC22B, interesting pathophysiology. www.biorxiv.org/content/10.1...

Europe's MSCA postdoctoral fellowships are now attracting many researchers who would have gone to the US. So the payline has dropped below 10% (~1,600 fellowships to 17k applicants). Super tough situation. One more reason to double the next Horizon budget, as proposed by the EU Commission.

#MembraneTraffickers! Our next online seminar is this Thursday, Nov 6 at 5 PM CEST! We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease. Spread the word and join the discussion!

I have two open positions @ALMU @crg.eu: 1. Imaging Scientist (permanent position. Deadline 11th Nov.) recruitment.crg.eu/content/jobs... 2. Entry-Level Imaging Scientist (12 months fixed-term position. Deadline 18th Nov.) recruitment.crg.eu/content/jobs... Reposts appreciated.

The new Outlook app has achieved peak academic design: less functional, but somehow more confident.

Interested in intracellular organization and membrane trafficking? 🥞 Join us at @melisupf.bsky.social in Barcelona! We’re looking for postdocs to apply for a Juan de la Cierva fellowship (PhD between Jan’24–Dec ’25). If you’d like to work with us, get in touch! www.aei.gob.es/en/announcem...

Nice preprint from Mondira Kundu lab! Glucose starvation blocks SEC24C-dependent ER-to-Golgi export of some proteins like E-cadherin, reshaping the surface proteome - via AMPK-ULK1-Sec31A signalling. Controls cell migration and metastasis under nutrient stress. www.biorxiv.org/content/10.1...

🚨 #PhD Opportunities 🚨 🧵 How does plasma membrane structure underpin tissue development? Let’s find out! Opportunity to do a PhD with me, co-supervised by Darius Koester, at Warwick. Fully funded studentship by #MIBTP. 🔬✨🐟 More info: www.findaphd.com/phds/project... Interested? Reach out!

🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny. #ProtistsOnSky #SciComm #SciSky www.cell.com/cell/fulltex...

Should I be worried if I can't solve many of the 'are you human' puzzles on the internet?

Close-up of vesicular ER exit sites by volume electron imaging using FIB-SEM url: rupress.org/jcb/article-...

Had the pleasure of working with @mohannad-dardiry.bsky.social to rethink what it means to develop for life. Many thanks to @dev-journal.bsky.social! @embl.org #LifelongDevSI

Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis. www.nature.com/articles/s41...

📣 We are moving to Barcelona to join the amazing @crg.eu and explore how centrosomes & cilia work, evolve & respond to the environment. We are looking for PhD students www.crg.eu/en/content/t... Postdocs gimm.pt/jobs/postdoc... Other calls to open, also for an experienced lab manager. Get in touch!

Spread the word! There is a professor position opening at our University @upcite.bsky.social. There are several possible (great) labs to join, but if you are interested in DNA methylation and epigenetics in mammals, don't hesitate to contact me directly!

#JobOffer 💼 Postdoctoral Researcher (M/F) in Biophysics of Bacterial Infection 📆 January 1st, 2026 📍Institut Jacques Monod, Bonazzi Lab Apply before November 6th 🔗 emploi.cnrs.fr/Offres/CDD/U...

Calling all #Membrane enthusiasts! Our #MembraneTrafficking online seminar series is back for the 2025-26 season: 8 fantastic speakers from Nov'25 to Feb'26. The first talks are already next Thursday (Nov 6, 5pm CET) with @agatawitkowska.bsky.social and @abdourachidthiam.bsky.social !

📢 2 very exciting PhD opportunities, please share! We use a range of technologies+systems to study #collagen, #ECMatrix, and #fibrosis 👇 1) MRC CASE DTP - #3D #biomaterials, #immune cells alter, #drugscreens lnkd.in/e6eMqs8M 2) Bicentenary - #macrophages, #circadian, #omics. lnkd.in/ekZfJfsd

Our latest paper on a histone methyltransferase-independent function of PRC2 controlling small RNA dynamics during programmed DNA elimination in Paramecium is now published in #NAR. #RNAbiology #TEsky #smallRNAs #PRC2 #DNAelimination 1/5 academic.oup.com/nar/article-...

Attention membrane traffickers! I'm recruiting a post-doc to my lab in Dundee. We're dissecting the functions of intrinsically disordered domains of COPII coat proteins. We think they control timing of coat assembly and morphology of carriers. www.dundee.ac.uk/work-for-us/...

New preprint from Sean Munro @cellbiol-mrclmb.bsky.social! Golgi tether p115 directly binds Sec16A at ER exit sites. Mutations blocking this binding reduce secretion. A rich new mechanistic insight into physical coupling of ERES–ERGIC/Golgi. www.biorxiv.org/content/10.1...

✍️ The Raote Lab ( @ishier.bsky.social ) contributed to the publication of a new article 📖 @natrevmcb.nature.com 📃 Towards a unified framework for the function of endoplasmic reticulum exit sites 🔗 www.nature.com/articles/s41...

Latest from ours: www.cell.com/cell-reports... This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵

Our latest preprint! Into morphogenesis, Yap, ECM, signaling, vertex models, feedbacks/robustness? There is something here for everyone. We discovered a positive feedback loop that extends inner ear canals, and a built-in mechanism that shuts it down when morphogenesis is done. tinyurl.com/464wsjhd

Check out this new Roadmap, a fantastic team effort by a consortium of ER researchers. Glad we could provide the space for this synthesis, which came out of discussions at a fruitful meeting, see below:

We are highlighting Cathy Jackson, @biologyopen.bsky.social Deputy Editor and an Editorial Advisory Board member at @jcellsci.bsky.social, as an extraordinary biologist this week. #100biologists @ijmonod.bsky.social

LMB PhD studentship available in the Baum lab to use informatics to infer cell structure from genomic data in collaboration with the brilliant Tom Williams. If you write to me and I don’t reply - try again - the spam filter is hungry…

It was a great pleasure to work on this paper. What started as a small meeting in January this year resulted in this beautiful piece of work.

ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions. www.nature.com/articles/s41...

TODAY! Mini-symposium with the #MembraneTrafficking webinar series. Join us for exciting cell biology from @nickader.bsky.social, @maiblab.bsky.social and Mónica Quiñones-Frías. Keynote lecture from Gillian Griffiths @griffithslab.bsky.social Don't miss it! focalplane.biologists.com/2025/09/16/f...

Really glad to show our recent work using recombinant phosphoinositide probes to investigate membrane identity changes during endosomal trafficking. Should be a great mini symposium to highlight the power of fluorescent microscopy techniques for cell biology!

Just stumbled upon a German tongue-twister song by Bodo Wartke… about the sexiest cell organelle. Yes, endoplasmic reticulum - your moment has come. youtube.com/shorts/EP5pd...

🧵 I've been meaning to write a #Skytorial on our recently posted prepring in which we show evidence that the Golgi 🥞 is a mechanoresponsive organelle. Extracellular mechanical forces also tune Golgi export capacity! 👉 www.biorxiv.org/content/10.1...

This is already This Thursday (25th September)! Join us at the @focalplane.bsky.social features #MembraneTrafficking for lots of amazing microscopy and interesting membrane biology! @franbottanelli.bsky.social @ishier.bsky.social @biologists.bsky.social

My new smartwatch keeps nagging me to destress or to exercise. Honestly, the stress is the watch telling me not to stress. But I’ve cracked the code: the only time it says I'm relaxed is when I'm in the lab: discussing data, writing a review and reading a preprint. Science is my wellness app.

How do resident Golgi proteins recycle during cisternal maturation? Nice preprint from Adam Krahn in the Glick lab shows different classes of intra-Golgi vesicles in yeast: two COPI-dependent (early and mid) and one late clathrin/AP-1/Ent5 pathway. www.biorxiv.org/content/10.1...

Next Thursday Sept 25 (4-6pm CET) we have our first #FocalPlaneFeatures together with our #membranetrafficking community! Thanks to all who submitted such exciting abstracts. The final program is out, featuring a keynote by Gillian Griffiths. Register here: focalplane.biologists.com/2025/09/16/f...

Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...

My office card reader is out of battery, so I can’t get in. I'm calling this a desk reject.

New short paper from our lab @currentbiology.bsky.social, in which we discover of a new mode of cell motility for choanoflagellates: flagellar gliding. www.cell.com/current-biol... - A 🧵

Interesting preprint from Ginny Farias! Axons locally synthesize transmembrane proteins that traffic via axonal ERES, bypassing the Golgi, using HDLBP and NRZ tether-SEC22B. This unconventional secretion is crucial for axon growth and bouton assembly. www.biorxiv.org/content/10.1...

Another interesting preprint on the mechanobiology of Golgi export! Matrix stiffness boosts secretion via a Src-FAK-AMPK-GBF1 pathway, controlling Golgi cargo sorting and preventing lysosomal degradation, linking mechanics to trafficking. www.biorxiv.org/content/10.1...

Exciting preprint on organelle mechanoadaptation from Stephanie Miserey and Felix Campelo @felixmendu.bsky.social! Extracellular forces modulate Golgi secretory output by tuning carrier biogenesis via microtubule acetylation, DAG, and PKD. Golgi is a mechanoregulator! www.biorxiv.org/content/10.1...

Final year PhD students, I know you’re desperately trying to finish experiments/revisions/submissions/write a thesis & just survive - but please spare a few minutes to apply to your dream postdoc labs. It easily takes A YEAR from first contact, even if everything goes to plan on both sides.

Gutted to hear of Prof PP Divakaran’s passing. Friend, mentor, drinking companion; a trove of insights on physics, ancient math, politics, architecture. He loved food, wine and conversation; each talk full of curiosity and humour. Endlessly generous with mind and company. He will be deeply missed.

Last call for applications for ECRs to speak at our #FocalPlaneFeatures symposium co-hosted with the #MembraneTrafficking webinar series organised by @franbottanelli.bsky.social @felixmendu.bsky.social & @ishier.bsky.social. Apply by 24 August focalplane.biologists.com/2025/07/14/f...

Want to acquire #ExM images like this and help us understand the true extent of cytoskeletal diversity across the tree of life? This position might be for you! embl.wd103.myworkdayjobs.com/en-US/EMBL/j... With @dudinlab.bsky.social @embl.org @biology-unige.bsky.social @moorefound.bsky.social