It’s been an immense pleasure to present and discuss our work on genome organization and genomic imprinting with the Canadian community at the CEEHRC Epigenetics meeting #CanEpi25 in beautiful Banff. Immensely grateful to the trainee committee for their kind invitation

My lab is recruiting a post-doc ! please share ! emploi.cnrs.fr/Offres/CDD/U...

It is shocking how bad the @washingtonpost.com editorial page has become in the last year. The thrust of this article (so you don't have to read it) is "yeah, Trump is corrupt, but so were presidents in the 1880s" and I quote "In short, we need to get a grip." www.washingtonpost.com/opinions/202...

Vertebrate rna directed dna methylation!

1/ I’m very excited to share my postdoc work with @kseskv.bsky.social, in collaboration with @oligriffith.bsky.social. We explore embryonic DNA methylation reprogramming in the fat-tailed dunnart, an Australian marsupial 🦘🌏 www.biorxiv.org/content/10.1...

A preprint‼️that's bound to ruffle some 🪶 "Widespread DNA off-targeting confounds studies of RNA chromatin occupancy" led by our Micah Goldrich and Louis Delhaye from Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...

New paper from the lab: we’re using long-read sequencing to disentangle isoform complexity at allele-specific loci 🧬💡 Here, we combine the PacBio Iso-Seq workflow with the established WhatsHap phasing approach to assign long reads to the correct allele in polymorphic F1 mouse hybrids.

Are you an early-stage graduate student (2nd or 3rd year) or early-stage postdoc based in the US or Canada, working primarily in Drosophila? Would you like to help improve the experience of all trainees working in Drosophila research? If so, read on. (Please repost to reach a broad audience.)

Just out! Our work on active transport in epithelial tissues. Congrats to Huiqiong Wu, Greg Arkowitz and Ranjith Chilupuri in collaboration with C. Duclut and J. Prost! PNAS www.pnas.org/doi/10.1073/...

I am thinking of not replacing but assisting human review. Say, a human reviewer is assigned 10 preprints to screen. 9 of them are greenlighted by AI, so the human will only briefly glance at them. Only one preprint is flagged by AI, so the human will spend more time on this one preprint. Saves time

I feel like I'm going crazy. Is reviewing grants and papers time-consuming and painful, but a vitally important part of our job and the scientific enterprise? Or is it drudge work we're supposed to outsource to AI?

Switzerland is joining Horizon Europe! We are uniting two research powerhouses. For cutting-edge innovation that will boost our energy security, digital transformation, health and so much more. Today is a good day for science, and for our EU-Switzerland partnership.

📣 Paper alert! I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today! journals.biologists.com/dev/article/...

Want to join a happy bunch 🥳 to organise meetings, outreach activities and other initiatives about developmental biology in France? Apply and/or vote 🗳️!

Excited to share our new preprint on BioRxiv! A collaborative effort spanning many years and several labs to uncover what the germline chromosomes of Paramecium really look like. 🔗 www.biorxiv.org/content/10.1... 1/5

Bluetorial-Jim Watson I met Jim Watson a few times but did not know him well. However, I was greatly influenced by his book “The Double Helix”. He was a complicated human being with some very, very bad features, but some good contributions. What follows is my personal perspective. 1/41

Wondering if we can reform the publishing system without empowering the robot class

Agreed, this is really good (unpaywalled link if it can be useful to some: archive.is/lqSrX)

Yes and yet several European countries are embracing a far-right worldview that would burn these policies to the ground, so let’s be not be smug or complacent here - particularly as Mamdani‘s pro-immigration stance is radical by European standards.

Well, if @qedscience.bsky.social is good for at least one thing, it's for making excellent Bluesky discourse!

Our latest collaboration with the talented Susi @sbantele.bsky.social and Jiri Lukas is out now @science.org 🤩. We reveal the hidden price for DNA repair, with potential implications for genome function, gene therapy and ageing👇

Thrilled to start my Group Leader adventure with these and other great scientists!

As someone A) constantly amazed by the tech, B) allergic to the tech bro evangelism/promotion and C) worried where this will all go, I found this the best and most nuanced piece I have read about AI @newyorker.com www.newyorker.com/magazine/202...

Having a lot of fun at #EMBOMobileGenome 😃 Perfect timing for our paper from the lab of @toddmacfarlan.bsky.social to be out @natcomms.nature.com!! …and I’m currently on the job market looking for a new scientific home! www.nature.com/articles/s41...

And we have another open position, this time with a focus on Genome Biology! Join a great community in Vienna to bring your research to the next level!

Our latest paper has just been published in Cell! doi.org/10.1016/j.ce... We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.

Maybe Bluesky is real life!

Bluesky rn

one thing that other candidates need to learn from mamdani is how to deliver the most cold blooded attacks on an opponent with a smile on your face

The "oh and Dick Cheney died" is really the cherry on top 🇺🇸 🌊

Some hardcore mechanism, for the aficionados (from Peter Jones @vai.org and Ting-Hai Xu @slu-official.bsky.social labs) @natsmb.nature.com www.nature.com/articles/s41...

My team is recruiting a Study Engineer (IE) with experience in mammalian cell culture - ideally human iPSCs - to work on a project exploring the role of aneuploidy and centromere regulation in neuroblastoma initiation and progression. info and application here institut-curie.org/job/study-en....

Nature suggests you use their "Manuscript Adviser" bot to get advice before submitting I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:

ERC starter grant applications from US researchers nearly triple in 2025 compared to 2024 as Trump restricts funding. Good for "Choose Europe" initiatives, but dire for global and national science, given the limited volume of non-US funding available.

📢 Institut Jacques Monod Seminar 📅 November 14th 📍 Institut Jacques Monod Invited by @sandraduharcourt.bsky.social 's Lab, Cécile Courret will present the Institut Jacques Monod seminar « Rapid turnover of centromeric DNA reveals signatures of genetic conflict in Drosophila » ➡️ buff.ly/Wso6MPE

Paul Nurse describing the main job of a PI (From ‘The Thinking Game’, 2024)

We have progressed from data collection to data analysis.

Woah, did you know @akiyoshikitaoka.bsky.social was here, @wiringthebrain.bsky.social ? I think I discovered this account thanks to your retweets. Awesome follow!!!!

I've written a piece about great new article by @thibautbrunet.bsky.social, Chantal Combredet & Mylan Ansel. (www.cell.com/cell-reports... ) theconversation.com/how-the-firs...

I swear the French had a revolution for less than this... www.nytimes.com/2025/10/31/u...

'My situation was hardly unique — rampant A.I. cheating has been reported all over the country. But I felt a dread I struggled to express until a colleague articulated the problem in stark terms: “Our students are about to turn subcognitive,” she said.' www.nytimes.com/2025/10/29/o...

1/ 🚀 AEBP2 isn’t what we thought. You were told that AEBP2 promotes PRC2 activity on chromatin. We found the opposite: the most prevalent AEBP2 isoform inhibits PRC2 activity. 👉 surl.li/cgwqcq A thread 🧵

Archer is not so sure about this Halloween thing

“The bad review will come from your list of suggested reviewers”

I am delighted to share our latest work on memory gene circuits for plants. This work was led by the phenomenal PhD student @patrickgong.bsky.social A lot of debugging & highlights how even simple components in synthetic biology can have unexpected properties. www.biorxiv.org/content/10.1...

Very happy to see our paper published online natcomms.nature.com. Thank you to @wellcometrust.bsky.social for funding this work during my time with @robklose.bsky.social and David Booth! Thanks also to collaborators @garcialabms.bsky.social @alexdemendoza.bsky.social and the other authors!

Ever wondered how adult organs preserve epithelial barrier integrity while continuously exposed to mechanical stress? We tackled this question in our new preprint – led by our brilliant PhD student Vishnu Krishnakumar! (1/11) 🔗 www.biorxiv.org/content/10.1...

I am very excited to announce the opening of the submission site for the upcoming Conférences Jacques Monod on Developmental Biology, May 18-22, 2026 cjm.sb-roscoff.fr/en/conferenc... @lionlchristiaen.bsky.social and I have an exciting program of speakers and slots for selected short talks, etc.

Good to see this study from Ribes & co in print: PAX3/PAX7 transcription factors control neural tube patterning by simultaneously repressing ventral fates via H3K27me3 deposition at silencers & activating dorsal fates as pioneer factors at enhancers @ribes journals.plos.org/plosbiology/...