Congrats to my friends in the Boettiger lab for this really beautiful live imaging work. A big leap forward in understanding the dynamic side of genome organization. www.science.org/doi/10.1126/...

My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...

Fantastic recognition for seminal work in the phase séparation field. And guess what? Work from the Gohrlich lab focuses on my favourite compartment: The nuclear pore complexes! I told you they are fascinating!

I am happy, excited and very humbled to have obtained an ERC starting grant to study the interplay betweeen nuclear pores and chromatin organization! Keep posted for job advertisements and pretty microscopy pictures ;-)

It is with infinite sadness that we learned of the passing of Clarisse Orniacki. She joined @vdoye.bsky.social lab and defended her thesis in December 2022 and pursued her career with a postdoc in‬ @tedfon.bsky.social at McGill University in Montreal . Tribute 🔗 www.ijm.fr/tribute-to-c...

The nuclear lamina strengthens the nucleus and organizes the genome. So what happens when you acutely degrade it in living cells? Not what we thought! (1/n) www.molbiolcell.org/doi/10.1091/...

Very excited to share the first preprint of the lab! We show that the nuclear pore protein TPR forms biomolecular condensates which keep heterochromatin away from the nuclear pore complexes and maintains global chromatin organization. Check it out, share it, tell us what you think!!

DNA methylation and inflammation, what else?

Academia??? Please!!!

Kotb, N. M., Ulukaya, G., Chavan, A., Nguyen, S. C., Proskauer, L., Joyce, E., Hasson, D., Jagannathan, M., Rangan, P. (2023). Genome organization regulates nuclear pore complex formation and promotes differentiation during #Drosophila oogenesis. bioRxiv, www.biorxiv.org/content/10.1...

🚨 New publication! What cellular structure is as intricate as the arms of an octopus? 🐙 The nuclear pore basket - a filamentous structure on the NPC. Edvinas Stankunas and Alwin Köhler reveal the basket's structure and docking mechanisms in Nature Cell Biology ➡️ tinyurl.com/yc69dhx3

Nucleoporin Nup153 docks the splicing machinery to the nuclear pore for efficient mRNA processing https://www.biorxiv.org/content/10.1101/2024.09.30.615666v1

Did you know that nuclear pore complexes can show up outside the ☢️ ✉️? This study by Jenny Sachweh and her colleagues uncovers that the surrounding cellular milieu determines NPC composition via the nuclear transport system. #teamtomo #NPC #cryoET ❄️🔬

Ever wondered if nuclear pore architecture and function changes during germ cell differentiation? In human spermatogenesis it does, and radically!! Check out our first lab preprint @AliaCSantos et al! www.biorxiv.org/content/10.1...

'Here, we report that (S)-ACE-OH, a metabolite of the antipsychotic drug acepromazine, acts as a molecular glue to induce an interaction between the E3 ubiquitin ligase TRIM21 & the nucleoporin NUP98, leading to the degradation of nuclear pore proteins & disruption of nucleocytoplasmic trafficking'

www.cell.com/cell/fulltex... The chromosome folding problem and how cells solve it Great review by @jobdekker.bsky.social & Leonid Mirny

Here is the link to video of introduction course @cdf1530 on biological information. A historical perspective on evolution of representations of the genome, highlighting contributions of von Neumann, Jacob&Monod, Waddington, Alberch etc. Video (french)+pdf (english): tinyurl.com/y4k44cd4

Fantastic opportunity, highly recommend!