Edward Fon
@tedfon.bsky.social
📤 98
đź“Ą 88
đź“ť 11
Scientific Director, Montreal Neurological Institute-Hospital, Professor, McGill University
Emma MacDougall’s paper is now published. Congratulations!
rdcu.be/e8P0Z
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LRRK2 kinase mediates increased GCase activity in microglia in response to IFNÎł-induced proinflammatory stimulation
npj Parkinson's Disease - LRRK2 kinase mediates increased GCase activity in microglia in response to IFNÎł-induced proinflammatory stimulation
https://rdcu.be/e8P0Z
15 days ago
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Have a look at our new preprint on alpha-Synuclein acetylation.
www.biorxiv.org/content/10.1...
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N-terminal acetylation reduces α-synuclein pathology in models of Parkinson’s disease
The α-synuclein protein, encoded by SNCA gene, is a major constituent of pathological intracellular inclusions such as Lewy bodies found in the brains of patients with Parkinson’s disease and other sy...
https://www.biorxiv.org/content/10.1101/2025.11.21.689703v1
3 months ago
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We are looking for talented international PhD students and postdoctoral researchers -
www.mcgill.ca/edwardfonlab/
3 months ago
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Emma MacDougall’s paper showing the interaction between the two PD genes, LRRK2 and GBA1, in human iPSC microglia is now online
can01.safelinks.protection.outlook.com?url=https%3A...
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LRRK2 Kinase Mediates Increased GCase Activity in Microglia in Response to Proinflammatory Stimuli
Variants in the LRRK2 and GBA1 genes are among the most common risk factors associated with Parkinson's disease (PD). Both patients carrying PD-associated variants in GBA1, encoding lysosomal enzyme g...
https://can01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.biorxiv.org%2Fcgi%2Fcontent%2Fshort%2F2025.10.10.681687v1&data=05%7C02%7Cted.fon%40mcgill.ca%7C3967a295d7ef448cc63308de09c3b274%7Ccd31967152e74a68afa9fcf8f89f09ea%7C0%7C0%7C638958933336302029%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=swokoqVEFVunhPgcmen1qgCq8EietLVfgOatufmZK1I%3D&reserved=0
6 months ago
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Zaid Al-Azzawi’s paper showing the importance of the alpha-Synuclein purification method on the consistency of the Seed Amplification Assay (SAA) is now online.
www.biorxiv.org/cgi/content/...
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α-Synuclein purification significantly impacts seed amplification assay performance and consistency
α-Synuclein seed amplification assays are a promising diagnostic tool for synucleinopathies such as Parkinson disease and multiple system atrophy. Standardized conditions are required to ensure a high...
https://www.biorxiv.org/cgi/content/short/2025.05.08.652548v1
11 months ago
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Ghislaine Deyab’s paper showing that midbrain organoids from patients with Parkinson’s disease exhibit hallmarks of network activity abnormalities seen in vivo is now out on biorxiv.
www.biorxiv.org/cgi/content/...
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Midbrain organoids with an SNCA gene triplication display dopamine-dependent alterations in network activity
Human midbrain organoids (hMOs) show promise as a patient-derived model for the study of Parkinson's disease (PD). Yet, much remains unknown about how accurately hMOs recapitulate key features of PD i...
https://www.biorxiv.org/cgi/content/short/2025.04.23.650231v1
11 months ago
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Just got around to closing my X account!
about 1 year ago
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reposted by
Edward Fon
McGill University
over 1 year ago
The Quebec government has awarded $1.6M to three McGill researchers to support projects advancing genomics, imaging, and manufacturing. These initiatives will foster collaborations and deliver significant benefits to Quebec and beyond. ➡️
mcgill.ca/x/wr8
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reposted by
Edward Fon
The New York Times
over 1 year ago
A number of colleges, including Harvard, USC and Cornell, are advising their international students to return to campus before President-elect Donald Trump is inaugurated on Jan. 20.
nyti.ms/41qkzft
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reposted by
Edward Fon
Sylvain Baillet
over 1 year ago
Mood in Montreal today.
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reposted by
Edward Fon
McGill University
over 1 year ago
Lab-grown brain cells help uncover new targets for Parkinson’s treatments. 🧠Researchers at The Neuro have uncovered a new link between the immune system and the development of the disease. ➡️
mcgill.ca/x/wDZ
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reposted by
Edward Fon
Le Neuro (Institut-Hôpital neurologique de Montréal)
over 1 year ago
Le Gouvernement du Québec, par l’intermédiaire du CQDM, octroya une subvention de 1,5 million pour la plateforme YCharOS. Ce projet dirigé par les neuroscientifiques
@peter-mcpherson.bsky.social
et Carl Laflamme, valide des réactifs d’anticorps pour les protéines humaines.
https://buff.ly/3OjmpXD
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Financement de 1,5 million de dollars pour un projet de science ouverte
La plateforme de caractérisation des anticorps YCharOS s’attaque à la « crise de la reproductibilité » dans la recherche Le gouvernement du Québec par l’intermédiaire du CQDM vient d’octroyer une…
https://buff.ly/3OjmpXD
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Our new paper on Cathepsin B in Parkinson’s just published
rdcu.be/d1sJ2
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The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons
https://rdcu.be/d1sJ2
over 1 year ago
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