Participants shared their work and ideas in our poster session at the @embo.org Practical Course on “In-situ structural biology by Cryo-FIB and Cryo-ET” at our institute! It was a great chance to connect, discuss, and get new perspectives on #cryoFIB and #cryoET. 🌍

We’ve kicked off our @embo.org Practical Course on #cryoFIB & #cryoET! Participants from around the world are joining us this week for hands-on training, from lamella milling to tomogram reconstruction 🔬

The cartwheel was first visualized ~70 years ago in the symbiont Trichonympha in the wood termite gut. We’ve discovered the cartwheel’s secret: a unique zigzag stacking of SAS-6 tetramers that facilitates the iconic 9-fold symmetry of cilia. #cellbiology #teamtomo #SAS6 #cartwheel

Unintentional staring contest with the FIB-SEM chamber (I won).

Little bit surprised to see most microscopy facilities now have dedicated image analysis support, but 1.0 FTE on average is nowhere near enough. And more than half don't charge for analysis services?!? 🤨 onlinelibrary.wiley.com/doi/10.1111/...

Using Cryogenic Electron Tomography (cryoET) to Determine Rubisco Polymerization Constants in α-Carboxysomes www.biorxiv.org/content/10.6...

New Title Alert: easymode- a collection of general pretrained networks for cellular cryoET. Learn more here: buff.ly/mLbcUbZ #SBGrid #SBGridSoftware

TIL what "unload sample from Compustage" of a cryo-EM actually looks like. Neat 🙂.

A consortium of group leaders from IMP, IMBA (Vienna BioCenter) and ISTA has been awarded an FWF Emerging Fields grant to study how germ cells safeguard and pass on genetic information across generations.

Cryo-EM question of the day: You want jam on it, too, do you? 🤦🏻‍♀️

The Trojan Horse is real, and it’s microscopic! 🐴🦠 Our paper is out today in @cellcellpress.bsky.social! We discovered that deltaviruses physically hide INSIDE helper viruses to sneak into new cells. And to prove it, we had to image them from every angle. 🧵👇 www.sciencedirect.com/science/arti...

Interested in protein mislocalisation and aggregation in neurodegenerative disease? 🧠 Check out the research of the Dormann Group (@dormannlab.bsky.social, @unimainz.bsky.social). 🗓 Application deadline: March 11 👉 imprs-cbp.mpg.de/call-for-applications #imprs_cbp #neurodegeneration #biophysics

We are on the home stretch! 🏁 Only 1.5 weeks left to #apply for our #gradschool! Don't miss this opportunity to get a #PhD position in the life sciences! 👉 imprs-cbp.mpg.de/call-for-app...

We’re still at the @biophysicalsoc.bsky.social #bps2026 Meeting in San Francisco! Come visit us at Booth 630 and take a #cellfie with us! 📸! Interested in a fully funded PhD through IMPRS-CBP? This is your chance to meet us, ask questions, and learn more about #PhDpositions in Germany. #biophysics

📷 (1) Kim Group, (3, 4) Shau Chung Shin / Max Planck Institute of Biophysics 🎶 Melek Özdemir / Max Planck Institute of Biophysics

Come visit our @mpibp.bsky.social booth at the @biophysicalsoc.bsky.social #bps2026 meeting in San Francisco! We’re looking forward to chat about our research, PhD opportunities, and international career paths! 🥳 We’d love to connect and take your #cellfie! 🦠 Find us in booth 630! #imprs #imprs_cbp

📷/🎥 (1) MrsKirk72 Pixabay, (2-4) Bernhard Hampölz / Max Planck Institute of Biophysics, (5) Shau Chung Shin / Max Planck Institute of Biophysics . 🎵 Melek Özdemir

Ribosomes in pairs: A survival strategy inside stressed cells. When nutrients drop or temperatures shift, cells switch to survival mode. New work by @erin-schuman.bsky.social & colleagues shows that inactive ribosomes pair up via a ribosomal RNA link @andschwarz.bsky.social @muellermara.bsky.social

Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA www.science.org/doi/10.1126/... co-first with: @andschwarz.bsky.social with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more 🧵 0/6 #MolBio 🧪

Why should you join our #gradschool? Check out our 10 #keyfeatures and find out how we support you during your #phdjourney! Apply by March 11! imprs-cbp.mpg.de/key-features

Into single-particle cryoEM and redox biology? Meet the Murphy Group in our First IMPRSsion video on YouTube. ( @bjmurphylab.bsky.social , @mpibp.bsky.social ) Watch it on our YouTube channel and apply to IMPRS-CBP: youtube.com/watch?v=aecFlDKjKzo #imprs_cbp #cryoEM #biophysics #phd

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...

❗️Highly recommended - please consider applying, 3 weeks to go👇🏻

Mosquitoes like Aedes aegypti spread viruses that cause major global diseases. We decided to have a closer look at a family of mosquito carbohydrate-binding proteins involved in infecting these vector species. We found some unexpected things 😁 Preprint out now 🦟🦟🦟 www.biorxiv.org/content/10.6...

Seeing mechanisms of disease Now online: “Seeing the mechanisms of disease with cryoEM” on Penn Medicine—how near-atomic views of molecules help us decode what goes wrong in illness. #cryoEM #SciComm www.pennmedicine.org/news/seeing-... @yiweichang.bsky.social @jrocereta.bsky.social

📢Paper alert📢 Now out in @bmc.springernature.com with open access: our very cool collaboration with @chlandalab.bsky.social on FIB-milling designs for cryoET rdcu.be/e2nXE Here you can see different designs for the stress relief cuts for dual-axis tomography. Read the paper for more details😀

🤔 ah, the German language and its compound words. This one’s messing even with native-speaker synapses 🤦🏻‍♀️

Thinking of applying to IMPRS-CBP? 👣 Here’s a quick look at our application process to guide you along the way. 🗓️ Deadline: March 11 Apply here 👉 imprs-cbp.mpg.de/call-for-app... #gradschool @mpibp.bsky.social @goetheuni.bsky.social @unimainz.bsky.social

Reminder with <2 weeks to deadline:

We are running the cryo-ET image processing workshop again this year! Come learn everything tomo: STA, segmentation, heterogeneity analysis from @baradlab.com @williamnwan.bsky.social and others! Apply!

I am super happy to share this paper in its final form. We used FIB milling to "dig in to" cell lines and mouse brains infected with tick-borne flaviviruses, followed by cryo-ET to study the virus replication. It's open access, so have a look! #virology #teamtomo www.nature.com/articles/s41...

10 years since I took this photo under a bridge in Tartu, Estonia. Still in keeping with the times, I’d say.

LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery. Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure. 🔗 doi.org/10.64898/202... #CryoET

Wondering if this is a very accurate (and creative) job title for what @atinygreencell.bsky.social is doing?

Exploring shaped focused ion beams for lamella preparation pubmed.ncbi.nlm.nih.gov/41529658/ #cryoem

🌟 PhD positions at IMPRS-CBP! Applications open from Jan 23 – Mar 11. Fully funded PhDs in cellular biophysics at @mpibp.bsky.social , @goetheuni.bsky.social l and @unimainz.bsky.social . 👉 imprs-cbp.mpg.de #phd #biophysics #imprs_cbp

We are excited to share our new preprint which is now available to read on biorXiv: doi.org/10.64898/202... 🎉🎉🎉

Feeling like Sir David Attenborough’s clumsy cousin today. Look what I found in the wild🦎🔍. For all those years I was convinced cryoEMs are too shy to do their colour change thing when someone’s watching.

The Vienna BioCenter Summer School 2026 call is open for talented undergrads, it's a great opportunity for students who are interested in graduate study in the life sciences. Sven Klumpe from the IMP/IMBA is recruiting! https://training.vbc.ac.at/summer-school/

We are celebrating 99 publications in 2025! 🎉 We would like to thank the members of our institute for your passion and expertise, your mutual support, and your perseverance! 💪 We look forward to making new discoveries in 2026! We wish everyone a joyful season and a successful start to the New Year!

What a girl wants for Christmas in 2025 vs what I got. I guess this one falls in the “tech/hobby items” category 🤷🏻‍♀️. Anyway, our Krios shines bright like a diamond again. ✨

The Vienna BioCenter Summer School 2026 call is now open for talented undergrads, it's a great for those interested in graduate study in the life sciences. Alejandro Burga from Institute of Molecular Biotechnology is recruiting! Please share https://training.vbc.ac.at/summer-school/

It’s out! Using cryo-ET in Dicty cells, we take a fresh in situ look at vaults. Surprisingly, we uncover vaults associated with ER and NE membranes, and find that many vaults enclose ribosomes in defined orientations, opening new avenues to their cellular function! www.biorxiv.org/lookup/conte...

Congratulations, Julia Mahamid! Julia Mahamid receives the @dfg.de Leibniz Prize for her work on structural cell biology! #LeibnizPreis

🤩if you are into #cryoEM, #cryoET and membrane trafficking, please consider applying. Highly recommended opportunity! 👇3 weeks left)

🥳 Our new paper on C2CD3 is out in @plosbiology.org With the labs of @cellarchlab.com , @chgenoud.bsky.social , and @stearnslab.bsky.social , we revealed the mammalian centriole Distal Ring architecture by combining #UExM and in situ #CryoET. Big congrats to @ebertiaux.bsky.social and all involved.

Did you know we’re hosting the EMBO Practical Course on Cryo-FIB & Cryo-ET in April 2026? ❄️ We invite early career researchers and facility scientists to join us in Frankfurt and meet the leading experts in cryo-FIB/SEM and cryo-ET! 🔗 Apply by Dec 8: meetings.embo.org/event/26-in-...

If you'd like to celebrate the biology of viruses - or the fight against viral diseases - this winter, try out our free and updated #VirusSnowflake designs. Please share, and if you have any photos of Virus Snowflakes in your area it would be lovely to see them! cvr-engagement.co.uk/virus-snowfl...

The Vienna BioCenter Summer School 2026 call is open for talented undergrads, it's a great opportunity for students who are interested in graduate study in the life sciences. Nicolas Rivron from Institute of Molecular Biotechnology is recruiting! https://training.vbc.ac.at/summer-school/