Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO

Exciting week in Frankfurt! Our CEOS energy filter and ASI Timepix3 are installed and we're looking forward to running the first tests :) #CryoEM #timepix #REELanalysis #4DSTEM @mpibp.bsky.social

Thrilled, and admittedly relieved, to see this major investment in Dutch #cryoEM become reality! 🇳🇱🔬 Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠 www.uu.nl/en/news/33-m...

Looking for an exciting #cryoEM postdoc position? 🤩 This one is highly recommended! 👇

Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️ Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...

Lauren Alexandrescu et al.: `Mix-it-up': accessible time-resolved cryo-EM on the millisecond timescale ##ElectronMicroscopy##CryoEM##TimeResolvedStudies... ##IUCrhttps://journals.iucr.org/paper?S2052252525008838

Have you registered to the next EMBO Practical Course on In-situ structural biology by Cryo-FIB and Cryo-ET? 🧊 Join us in Frankfurt for hands-on training on cryo-techniques and networking with experts! 🔗 Apply by Dec 8, 2025: meetings.embo.org/event/26-in-... 📍 Frankfurt | 📆 April 12–20, 2026

Mysteries of trafficking of the vRNP segmented genome and assembly of influenza A virus revealed by in situ cryo-ET! 🔗 rdcu.be/eMmct We are very excited that our paper is finally out! 🎉 Big congratulations to Moritz Wachsmuth-Melm and to everyone involved.

@mpibp.bsky.social’s handsome STEM scan of the day 🤩 Guess the crystal? Hint: S136

Are you interested in #StructuralBiology? Register for the Kroese-Duijsters Symposium 2025 organized by our LED3 colleagues @steffenbruenle.bsky.social and Sebastian Geibel. A great lineup of speakers including keynotes Ulrich Lorenz and Jörg Standfuss. www.universiteitleiden.nl/en/kroese-du...

Oh! Highly recommended, please consider applying! 👇🏻🤩

I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗 beta.ideas.lego.com/product-idea...

If I could ask all #cryoEM samples for one thing, it’d be to *please* behave like 1um TetraSpecks.

Only a few days left to apply for the great PhD Programme of @vbcscitraining.bsky.social 👇🏻

Correlative MS Imaging for cellular identification and analysis of in situ cryo-ET www.biorxiv.org/content/10.1101/2025.09.16.676641v1 #cryoem

❗️🤩👇🏻

Since it was published at peak holiday season, I'm taking the liberty to re-introduce our recent review article. We hope it will be a useful overview of RNA virus replication strategies, and how in situ cryo-EM have helped us understand them: www.sciencedirect.com/science/arti...

Ever wondered how to position organelles in bacteria? Wonder no more! Happy to have contributed to this fantastic story from @cellforganized.bsky.social' lab. The avenues this opens in the synthetic biology space are enormous! Movie: Carboxysomes positioned in E. coli! Preprint: shorturl.at/D6xVg

We welcome our new faculty member Ramachandra Bhaskara! His group uses simulations and modeling to study complex biological systems at the interface of biology, physics, and data science. #imprs #imprs_cbp @goetheuni.bsky.social

We followed with a day packed with CryoEM! We heard about the cryoEM from Werner Kühlbrandt, STEM-EELs from Bonnie Murphy and CryoET from Martin Beck.

A productive morning with Profs. Dötsch, García-Sáez and Helfrich! We learnt about transcription factors, cellular death and biosynthetic pathways. All before lunch time! #sciencemorning #gradschool @mpibp.bsky.social @goetheuni.bsky.social

At what number of hidden layers do shallow learning networks cross over to being deep learning? One? More? Depends?🤔

First webinar on the kit this Thu Sep 18th. You can still register in one of the links below.

Great session with Melanie McDowell today! She shared exciting insights into how proteins find their way into the ER. #imprs #imprs_cbp #phd #gradschool #biophysics

We're very excited to welcome the new generation of #IMPRS students during our Symposium on Cellular Biophysics 🧪 This morning, we heard spokespersons Volker Dötsch and Martin Beck, and coordinator Pamela Ornelas, introduce the doctoral program to the new students! #imprs_cbp #biophysics #gradschool

We had a great start of the #IMPRS Symposium on Cellular Biophysics to welcome our new students. Thank you for your fascinating talks Michaela Müller-McNicoll, Bernhard Hampölz and Christian Münch 👏 #imprs_cbp #phd #biophysics

Attending a mandatory radiation safety refresher course today (because where I am: no #cryoEM without certified radiation safety officer) and - right on cue - this came up 😶

We’re looking forward to the IMPRS-CBP Symposium on Cellular Biophysics at the @mpibp.bsky.social ! Join us on Sept 15–22 for a week+ of talks from our faculty as we welcome our new students! 🧑‍🎓Learn more here: imprs-cbp.mpg.de/symposium-on...

Together with colleagues at the Dept. of Microsystems Engineering, we are looking for a PhD student to develop methods for femtoliter-scale sample dispensing in cryoEM sample preparation. edu.nl/h436k If you like interdisciplinary research & fascinating physics at ultrasmall scales, please apply!

Optimal tilt-increment for cryo-ET https://www.biorxiv.org/content/10.1101/2025.08.20.671201v1

We’re hosting the @embo.org Practical Course on In-situ structural biology by CryoFIB and CryoET in April 2026! 🧬❄️ You can expect hands-on training, cutting-edge methods, and a chance to work alongside leading experts in structural biology. 🔗 Apply by Dec 8, 2025: meetings.embo.org/event/26-in-...

Deryck Mills is always missed dearly @mpibp.bsky.social, but some weeks his absence is more obvious than others. Just bought a new 30um aperture. Opened the bottom drawer of Deryck’s trolley days later - and found this 🤩

More great cryo-ET benchmarking work from my colleagues Maarten Tuijtel, Tomáš Majtner, Beata Turoňová, & @becklab.bsky.social: Systematic study of how tilt increment choice affects downstream TM & STA. Preprint has the optimally balanced tilt increment. #TeamTomo www.biorxiv.org/content/10.1...

My PhD paper is in press @cellpress.bsky.social and now online: www.sciencedirect.com/science/arti...! Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more! Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo

Science came to life at the Max Planck Institute of Biophysics during the 2025 Night of Science of @goetheuni.bsky.social! 🌙✨

🤩👇🏻three weeks to apply❗️

👏 Congrats to Schara Safarian on his nomination for the Paul Ehrlich & Ludwig Darmstaedter Early Career Award—Germany’s top honor for young life science researchers! 🎉 Hear his talk on Sept 15: 👉 goethe-university-frankfurt.de/150458316/Ea... #Biophysics #EarlyCareerAward #ScientificExcellence

Go check out the 2025 Bench to Art gallery. The theme is cryo-EM and/or membrane protein structures. They're all awesome!

Right. Technically, this does make sense in German. But who tf runs their marketing department.

🤩👇🏻❗️

A #FIBSEM #cryoET drama in 4 acts. Prelude: Aquilos shuttle rod does not reach cryo stage due to mechanical misalignment.

In their new study, Beata Turoňová and Tomáš Majtner trained 13 neural networks to automatically detect and remove those corrupted frames, speeding up processing and saving time for tomographers 🥳

New from my colleagues Markus Schreiber & Beata Turoňová: TANGO, an #opensource tool for more holistic spatial analysis of cryo-ET particles. It can clean or cluster particles, analyze lattices, and identify patterns. #TeamTomo www.biorxiv.org/content/10.1...

New paper from my colleague Soheil in the Mahamid and @jonasries.bsky.social groups looking at factors influencing laser devitrification on frozen #cryoem samples. With a far-red fluorophore, all-gold support grids will be especially good for correlative cryo-SMLM and EM! doi.org/10.1016/j.js...

Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...

I'm pleased to share our new review article on RNA virus replication and in situ cryo-EM! I personally had a Master's student in virology or biophysics in mind as a possible reader, and would be interested in feedback from that kind of crowd. www.sciencedirect.com/science/arti...

Love this excellent & comprehensive guide of current (& future) cryo-ET ways to yield new biological insights 🤩👍🏼. I just disagree with the term “solving biological problems”🤷🏻‍♀️. We’re trying to figure out how cell stuff works - the biology isn’t really a problem… it just is.

HIV-1 nuclear import is selective and depends on both capsid elasticity and nuclear pore adaptability pubmed.ncbi.nlm.nih.gov/40624219/ #cryoem

Gentle reminder for cryoEM ❄️🔬 folks with Autoloader systems out there: check every now and then that the cassette back plate is still screwed on tightly… 🤦🏻‍♀️