Mosquitoes like Aedes aegypti spread viruses that cause major global diseases. We decided to have a closer look at a family of mosquito carbohydrate-binding proteins involved in infecting these vector species. We found some unexpected things 😁 Preprint out now 🦟🦟🦟 www.biorxiv.org/content/10.6...

Seeing mechanisms of disease Now online: “Seeing the mechanisms of disease with cryoEM” on Penn Medicine—how near-atomic views of molecules help us decode what goes wrong in illness. #cryoEM #SciComm www.pennmedicine.org/news/seeing-... @yiweichang.bsky.social @jrocereta.bsky.social

📢Paper alert📢 Now out in @bmc.springernature.com with open access: our very cool collaboration with @chlandalab.bsky.social on FIB-milling designs for cryoET rdcu.be/e2nXE Here you can see different designs for the stress relief cuts for dual-axis tomography. Read the paper for more details😀

🤔 ah, the German language and its compound words. This one’s messing even with native-speaker synapses 🤦🏻‍♀️

Thinking of applying to IMPRS-CBP? 👣 Here’s a quick look at our application process to guide you along the way. 🗓️ Deadline: March 11 Apply here 👉 imprs-cbp.mpg.de/call-for-app... #gradschool @mpibp.bsky.social @goetheuni.bsky.social @unimainz.bsky.social

Reminder with <2 weeks to deadline:

We are running the cryo-ET image processing workshop again this year! Come learn everything tomo: STA, segmentation, heterogeneity analysis from @baradlab.com @williamnwan.bsky.social and others! Apply!

I am super happy to share this paper in its final form. We used FIB milling to "dig in to" cell lines and mouse brains infected with tick-borne flaviviruses, followed by cryo-ET to study the virus replication. It's open access, so have a look! #virology #teamtomo www.nature.com/articles/s41...

10 years since I took this photo under a bridge in Tartu, Estonia. Still in keeping with the times, I’d say.

LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery. Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure. 🔗 doi.org/10.64898/202... #CryoET

Wondering if this is a very accurate (and creative) job title for what @atinygreencell.bsky.social is doing?

Exploring shaped focused ion beams for lamella preparation pubmed.ncbi.nlm.nih.gov/41529658/ #cryoem

🌟 PhD positions at IMPRS-CBP! Applications open from Jan 23 – Mar 11. Fully funded PhDs in cellular biophysics at @mpibp.bsky.social , @goetheuni.bsky.social l and @unimainz.bsky.social . 👉 imprs-cbp.mpg.de #phd #biophysics #imprs_cbp

We are excited to share our new preprint which is now available to read on biorXiv: doi.org/10.64898/202... 🎉🎉🎉

Feeling like Sir David Attenborough’s clumsy cousin today. Look what I found in the wild🦎🔍. For all those years I was convinced cryoEMs are too shy to do their colour change thing when someone’s watching.

The Vienna BioCenter Summer School 2026 call is open for talented undergrads, it's a great opportunity for students who are interested in graduate study in the life sciences. Sven Klumpe from the IMP/IMBA is recruiting! https://training.vbc.ac.at/summer-school/

We are celebrating 99 publications in 2025! 🎉 We would like to thank the members of our institute for your passion and expertise, your mutual support, and your perseverance! 💪 We look forward to making new discoveries in 2026! We wish everyone a joyful season and a successful start to the New Year!

What a girl wants for Christmas in 2025 vs what I got. I guess this one falls in the “tech/hobby items” category 🤷🏻‍♀️. Anyway, our Krios shines bright like a diamond again. ✨

The Vienna BioCenter Summer School 2026 call is now open for talented undergrads, it's a great for those interested in graduate study in the life sciences. Alejandro Burga from Institute of Molecular Biotechnology is recruiting! Please share https://training.vbc.ac.at/summer-school/

It’s out! Using cryo-ET in Dicty cells, we take a fresh in situ look at vaults. Surprisingly, we uncover vaults associated with ER and NE membranes, and find that many vaults enclose ribosomes in defined orientations, opening new avenues to their cellular function! www.biorxiv.org/lookup/conte...

Congratulations, Julia Mahamid! Julia Mahamid receives the @dfg.de Leibniz Prize for her work on structural cell biology! #LeibnizPreis

🤩if you are into #cryoEM, #cryoET and membrane trafficking, please consider applying. Highly recommended opportunity! 👇3 weeks left)

🥳 Our new paper on C2CD3 is out in @plosbiology.org With the labs of @cellarchlab.com , @chgenoud.bsky.social , and @stearnslab.bsky.social , we revealed the mammalian centriole Distal Ring architecture by combining #UExM and in situ #CryoET. Big congrats to @ebertiaux.bsky.social and all involved.

Did you know we’re hosting the EMBO Practical Course on Cryo-FIB & Cryo-ET in April 2026? ❄️ We invite early career researchers and facility scientists to join us in Frankfurt and meet the leading experts in cryo-FIB/SEM and cryo-ET! 🔗 Apply by Dec 8: meetings.embo.org/event/26-in-...

If you'd like to celebrate the biology of viruses - or the fight against viral diseases - this winter, try out our free and updated #VirusSnowflake designs. Please share, and if you have any photos of Virus Snowflakes in your area it would be lovely to see them! cvr-engagement.co.uk/virus-snowfl...

The Vienna BioCenter Summer School 2026 call is open for talented undergrads, it's a great opportunity for students who are interested in graduate study in the life sciences. Nicolas Rivron from Institute of Molecular Biotechnology is recruiting! https://training.vbc.ac.at/summer-school/

Airplanes and #cryoEM systems seem to have one thing in common: a tiny piece worth less than 1$ is broken and the whole thing goes down ⤵️. No sample loading, no cassette docking, no temperature control. Make your own guess which one's which 🤦‍♀️

Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO

Exciting week in Frankfurt! Our CEOS energy filter and ASI Timepix3 are installed and we're looking forward to running the first tests :) #CryoEM #timepix #REELanalysis #4DSTEM @mpibp.bsky.social

Thrilled, and admittedly relieved, to see this major investment in Dutch #cryoEM become reality! 🇳🇱🔬 Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠 www.uu.nl/en/news/33-m...

Looking for an exciting #cryoEM postdoc position? 🤩 This one is highly recommended! 👇

Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️ Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...

Lauren Alexandrescu et al.: `Mix-it-up': accessible time-resolved cryo-EM on the millisecond timescale ##ElectronMicroscopy##CryoEM##TimeResolvedStudies... ##IUCrhttps://journals.iucr.org/paper?S2052252525008838

Have you registered to the next EMBO Practical Course on In-situ structural biology by Cryo-FIB and Cryo-ET? 🧊 Join us in Frankfurt for hands-on training on cryo-techniques and networking with experts! 🔗 Apply by Dec 8, 2025: meetings.embo.org/event/26-in-... 📍 Frankfurt | 📆 April 12–20, 2026

Mysteries of trafficking of the vRNP segmented genome and assembly of influenza A virus revealed by in situ cryo-ET! 🔗 rdcu.be/eMmct We are very excited that our paper is finally out! 🎉 Big congratulations to Moritz Wachsmuth-Melm and to everyone involved.

@mpibp.bsky.social’s handsome STEM scan of the day 🤩 Guess the crystal? Hint: S136

Are you interested in #StructuralBiology? Register for the Kroese-Duijsters Symposium 2025 organized by our LED3 colleagues @steffenbruenle.bsky.social and Sebastian Geibel. A great lineup of speakers including keynotes Ulrich Lorenz and Jörg Standfuss. www.universiteitleiden.nl/en/kroese-du...

Oh! Highly recommended, please consider applying! 👇🏻🤩

I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗 beta.ideas.lego.com/product-idea...

If I could ask all #cryoEM samples for one thing, it’d be to *please* behave like 1um TetraSpecks.

Only a few days left to apply for the great PhD Programme of @vbcscitraining.bsky.social 👇🏻

Correlative MS Imaging for cellular identification and analysis of in situ cryo-ET www.biorxiv.org/content/10.1101/2025.09.16.676641v1 #cryoem

❗️🤩👇🏻

Since it was published at peak holiday season, I'm taking the liberty to re-introduce our recent review article. We hope it will be a useful overview of RNA virus replication strategies, and how in situ cryo-EM have helped us understand them: www.sciencedirect.com/science/arti...

Ever wondered how to position organelles in bacteria? Wonder no more! Happy to have contributed to this fantastic story from @cellforganized.bsky.social' lab. The avenues this opens in the synthetic biology space are enormous! Movie: Carboxysomes positioned in E. coli! Preprint: shorturl.at/D6xVg

We welcome our new faculty member Ramachandra Bhaskara! His group uses simulations and modeling to study complex biological systems at the interface of biology, physics, and data science. #imprs #imprs_cbp @goetheuni.bsky.social

We followed with a day packed with CryoEM! We heard about the cryoEM from Werner Kühlbrandt, STEM-EELs from Bonnie Murphy and CryoET from Martin Beck.

A productive morning with Profs. Dötsch, García-Sáez and Helfrich! We learnt about transcription factors, cellular death and biosynthetic pathways. All before lunch time! #sciencemorning #gradschool @mpibp.bsky.social @goetheuni.bsky.social

At what number of hidden layers do shallow learning networks cross over to being deep learning? One? More? Depends?🤔