@mgflast.bsky.social showing us how to do cellular structural biology on easymode thanks to his collection of pretrained nets 😎 Particularly cool: he demonstrates custom tomo picking workflows e.g. yTuRC at the minus end of MTs, restricting picks to specific cellular compartments Check it out!

First international VISION symposium on Integrated Structural Virology 📅 8 – 9 September 2026 📍 @cssbhamburg.bsky.social , Hamburg, Germany 📝 Registration Open| Deadline: 19 July 2026 🔗

PhD: defended ✅🎉 My work used in situ cryo-ET #teamtomo to investigate cellular machines from ribosome translation and HIV capsid at the nuclear pore to membrane association of vault, and the molecular architecture of heterochromatin. Huge thanks to @becklab.bsky.social. What a wonderful ride!

If it fits, it sits, #cryoEM version. Rear door of Krios at @mpibp.bsky.social has a cat flap now🚪

Komm’ am 12. Juni auf die Night of Science✨! Erlebe, wie aus Stickstoff leckeres Eis🍦wird und welche Aufgaben verschiedene Proteine in unserem Körper übernehmen! Erfahre in Vorträgen und bei einer Elektronenmikroskopie-Tour 🔬 mehr über unsere Forschung! Infos: 👉 www.biophys.mpg.de/de/night-of-...

Sub-cellular chemical mapping using correlated cryogenic electron and mass spectrometry imaging online @natmethods.nature.com, led by Hannah Ochner, collaboration with @catfranco.bsky.social and @kiranrpatil.bsky.social labs doi.org/10.1038/s415...

If you love phages and CryoEM, the deadline to apply for a PhD studentship in my lab is 8th June!

GBM Lunch on May 20, 2026 (12.30 pm) Speaker: @dodonova-sveta.bsky.social (EMBL Heidelberg) Title: "Insights into nsights into Chromatin Architecture in Archaea by Cryo-EM and Cryo-ET" Chair: Janosch Hennig (University of Bayreuth) Organizer: GBM Study Group "Structural Biology" #GBMLunch

Banksy's rat with suitcase resurfaced after 16 years at a research center near Tokyo? 🙃

Join a rising star and very friendly colleague! #PhDposition

www.biorxiv.org/content/10.1... In situ cryo-ET defines the ultrastructure of ER exit sites in human cells

If you’re looking for a dream combo postdoc position that includes #cryoET plus #virology plus a scientifically and geographically very appealing lab: please consider applying 👇🏻🤩

That’s a wrap on the @embo.org Practical Course on “In-situ structural biology by #cryoFIB and #cryoET” @mpibp.bsky.social! Our students tutored 18 participants for an intensive, hands-on course covering the full workflow! It was an incredible week of learning, collaboration, and shared expertise! 🤩

Preprint 🧵! I’m really excited to introduce BIGSMALL, an interleaved multi-magnification cryo-ET scheme bridging molecular and cellular scales in a single acquisition! BIGSMALL = 𝐁road 𝐈nformation 𝐆athering 𝐒trategy by 𝐌ultiscale 𝐀cquisition of lame𝐋𝐋a www.biorxiv.org/content/10.6... (1/6)

New preprint 🚀 ❄️ We developed Autogrid-compatible HPF planchettes that enable direct freezing of clipped EM grids and streamline integration with cryo-FIB workflows ✔️ improved grid stability ✔️ reduced handling ✔️ robust vitrification (🦠 🧫 🧠) A step toward routine HPF for complex samples #teamtomo

That’s a wrap on our @embo.org #cryoFIB & #cryoET course! It was an incredible week of hands-on learning, collaboration, and shared expertise, made possible by dedicated organizers, incredible trainers, and an engaged group of participants.

We are having a very hands-on week at the @embo.org #cryoFIB & #cryoET course 🔬 Our participants are learning about sample vitrification, lamella milling, FLM, lift-out, data acquisition and more! We are learning by doing, troubleshooting, and sharing expertise across labs. 🧪

Participants shared their work and ideas in our poster session at the @embo.org Practical Course on “In-situ structural biology by Cryo-FIB and Cryo-ET” at our institute! It was a great chance to connect, discuss, and get new perspectives on #cryoFIB and #cryoET. 🌍

We’ve kicked off our @embo.org Practical Course on #cryoFIB & #cryoET! Participants from around the world are joining us this week for hands-on training, from lamella milling to tomogram reconstruction 🔬

The cartwheel was first visualized ~70 years ago in the symbiont Trichonympha in the wood termite gut. We’ve discovered the cartwheel’s secret: a unique zigzag stacking of SAS-6 tetramers that facilitates the iconic 9-fold symmetry of cilia. #cellbiology #teamtomo #SAS6 #cartwheel

Unintentional staring contest with the FIB-SEM chamber (I won).

Little bit surprised to see most microscopy facilities now have dedicated image analysis support, but 1.0 FTE on average is nowhere near enough. And more than half don't charge for analysis services?!? 🤨 onlinelibrary.wiley.com/doi/10.1111/...

Using Cryogenic Electron Tomography (cryoET) to Determine Rubisco Polymerization Constants in α-Carboxysomes www.biorxiv.org/content/10.6...

New Title Alert: easymode- a collection of general pretrained networks for cellular cryoET. Learn more here: buff.ly/mLbcUbZ #SBGrid #SBGridSoftware

TIL what "unload sample from Compustage" of a cryo-EM actually looks like. Neat 🙂.

A consortium of group leaders from IMP, IMBA (Vienna BioCenter) and ISTA has been awarded an FWF Emerging Fields grant to study how germ cells safeguard and pass on genetic information across generations.

Cryo-EM question of the day: You want jam on it, too, do you? 🤦🏻‍♀️

The Trojan Horse is real, and it’s microscopic! 🐴🦠 Our paper is out today in @cellcellpress.bsky.social! We discovered that deltaviruses physically hide INSIDE helper viruses to sneak into new cells. And to prove it, we had to image them from every angle. 🧵👇 www.sciencedirect.com/science/arti...

Interested in protein mislocalisation and aggregation in neurodegenerative disease? 🧠 Check out the research of the Dormann Group (@dormannlab.bsky.social, @unimainz.bsky.social). 🗓 Application deadline: March 11 👉 imprs-cbp.mpg.de/call-for-applications #imprs_cbp #neurodegeneration #biophysics

We are on the home stretch! 🏁 Only 1.5 weeks left to #apply for our #gradschool! Don't miss this opportunity to get a #PhD position in the life sciences! 👉 imprs-cbp.mpg.de/call-for-app...

We’re still at the @biophysicalsoc.bsky.social #bps2026 Meeting in San Francisco! Come visit us at Booth 630 and take a #cellfie with us! 📸! Interested in a fully funded PhD through IMPRS-CBP? This is your chance to meet us, ask questions, and learn more about #PhDpositions in Germany. #biophysics

📷 (1) Kim Group, (3, 4) Shau Chung Shin / Max Planck Institute of Biophysics 🎶 Melek Özdemir / Max Planck Institute of Biophysics

Come visit our @mpibp.bsky.social booth at the @biophysicalsoc.bsky.social #bps2026 meeting in San Francisco! We’re looking forward to chat about our research, PhD opportunities, and international career paths! 🥳 We’d love to connect and take your #cellfie! 🦠 Find us in booth 630! #imprs #imprs_cbp

📷/🎥 (1) MrsKirk72 Pixabay, (2-4) Bernhard Hampölz / Max Planck Institute of Biophysics, (5) Shau Chung Shin / Max Planck Institute of Biophysics . 🎵 Melek Özdemir

Ribosomes in pairs: A survival strategy inside stressed cells. When nutrients drop or temperatures shift, cells switch to survival mode. New work by @erin-schuman.bsky.social & colleagues shows that inactive ribosomes pair up via a ribosomal RNA link @andschwarz.bsky.social @muellermara.bsky.social

Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA www.science.org/doi/10.1126/... co-first with: @andschwarz.bsky.social with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more 🧵 0/6 #MolBio 🧪

Why should you join our #gradschool? Check out our 10 #keyfeatures and find out how we support you during your #phdjourney! Apply by March 11! imprs-cbp.mpg.de/key-features

Into single-particle cryoEM and redox biology? Meet the Murphy Group in our First IMPRSsion video on YouTube. ( @bjmurphylab.bsky.social , @mpibp.bsky.social ) Watch it on our YouTube channel and apply to IMPRS-CBP: youtube.com/watch?v=aecFlDKjKzo #imprs_cbp #cryoEM #biophysics #phd

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...

❗️Highly recommended - please consider applying, 3 weeks to go👇🏻

Mosquitoes like Aedes aegypti spread viruses that cause major global diseases. We decided to have a closer look at a family of mosquito carbohydrate-binding proteins involved in infecting these vector species. We found some unexpected things 😁 Preprint out now 🦟🦟🦟 www.biorxiv.org/content/10.6...

Seeing mechanisms of disease Now online: “Seeing the mechanisms of disease with cryoEM” on Penn Medicine—how near-atomic views of molecules help us decode what goes wrong in illness. #cryoEM #SciComm www.pennmedicine.org/news/seeing-... @yiweichang.bsky.social @jrocereta.bsky.social

📢Paper alert📢 Now out in @bmc.springernature.com with open access: our very cool collaboration with @chlandalab.bsky.social on FIB-milling designs for cryoET rdcu.be/e2nXE Here you can see different designs for the stress relief cuts for dual-axis tomography. Read the paper for more details😀

🤔 ah, the German language and its compound words. This one’s messing even with native-speaker synapses 🤦🏻‍♀️

Thinking of applying to IMPRS-CBP? 👣 Here’s a quick look at our application process to guide you along the way. 🗓️ Deadline: March 11 Apply here 👉 imprs-cbp.mpg.de/call-for-app... #gradschool @mpibp.bsky.social @goetheuni.bsky.social @unimainz.bsky.social

Reminder with <2 weeks to deadline:

We are running the cryo-ET image processing workshop again this year! Come learn everything tomo: STA, segmentation, heterogeneity analysis from @baradlab.com @williamnwan.bsky.social and others! Apply!

I am super happy to share this paper in its final form. We used FIB milling to "dig in to" cell lines and mouse brains infected with tick-borne flaviviruses, followed by cryo-ET to study the virus replication. It's open access, so have a look! #virology #teamtomo www.nature.com/articles/s41...

10 years since I took this photo under a bridge in Tartu, Estonia. Still in keeping with the times, I’d say.