🤩👇🏻❗️

Wonder what Angus MacGyver would think of our #cryoEM Dewar drying cycle setup @mpibp.bsky.social 🤔(lowest heat gun setting a little hotter than desired).

How do 2 meters of DNA fit inside a nucleus you can barely see? 🧬 Our new study mapped individual nucleosomes inside human cells.

What is the best way to distribute the electron dose across your tilt series in cryo ET? Thanks to Maarten Tuijtel, we finally know --> head over to eLife for the publication! doi.org/10.7554/eLif...

3/3: Across reconstruction, template matching, and subtomogram averaging, datasets acquired with 1°, 2°, and 3° all performed robustly—with 3° tilt steps showing the best performance in final refinement. @elife.bsky.social 📄 Read the full study: 👉 elifesciences.org/reviewed-pre...

1/3: We are excited to share a new study by Maarten Tuijtel from @becklab.bsky.social, published in eLife. 🔬 🎉 The work addresses a key question in cryo-electron tomography: how to best distribute the limited electron dose across a tilt series while balancing angular sampling and image quality. 💥

The paper is out which means the MD trajectories are finally available! #MolecularNodes #b3d #GeometryNodes

Thought I had discovered a new #cryoEM “hole size gradient” feature. Turns out E.coli in ice creates optical illusions ☹️. Or it’s just me hallucinating.

Wouldn’t be surprised if this is what we’ll find at a German-run train station on planet Mars one day 🚀🚇

It's finally out now in @natcomms.nature.com! We used cryo-EM + simulations to watch the Na⁺/H⁺ antiporter NhaA in action across a wide range of pH—and uncover how pH, Na⁺ binding, and structural changes are coupled. Read here 🔗 www.nature.com/articles/s41...

Excited to see POPSICLE out! 🍦 A combined benchmark for cryoET and evaluations with common segmentation models. Find the full dataset here: huggingface.co/datasets/bio...

Better vitrification = better cryo-ET. We've opened an RFA for two-year grants to advance vitrification techniques for biological samples—welcoming applications from researchers in heat transfer, cryogenics, and materials science. Apply here: bit.ly/4uip6eJ

@mgflast.bsky.social showing us how to do cellular structural biology on easymode thanks to his collection of pretrained nets 😎 Particularly cool: he demonstrates custom tomo picking workflows e.g. yTuRC at the minus end of MTs, restricting picks to specific cellular compartments Check it out!

First international VISION symposium on Integrated Structural Virology 📅 8 – 9 September 2026 📍 @cssbhamburg.bsky.social , Hamburg, Germany 📝 Registration Open| Deadline: 19 July 2026 🔗

PhD: defended ✅🎉 My work used in situ cryo-ET #teamtomo to investigate cellular machines from ribosome translation and HIV capsid at the nuclear pore to membrane association of vault, and the molecular architecture of heterochromatin. Huge thanks to @becklab.bsky.social. What a wonderful ride!

If it fits, it sits, #cryoEM version. Rear door of Krios at @mpibp.bsky.social has a cat flap now🚪

Komm’ am 12. Juni auf die Night of Science✨! Erlebe, wie aus Stickstoff leckeres Eis🍦wird und welche Aufgaben verschiedene Proteine in unserem Körper übernehmen! Erfahre in Vorträgen und bei einer Elektronenmikroskopie-Tour 🔬 mehr über unsere Forschung! Infos: 👉 www.biophys.mpg.de/de/night-of-...

Sub-cellular chemical mapping using correlated cryogenic electron and mass spectrometry imaging online @natmethods.nature.com, led by Hannah Ochner, collaboration with @catfranco.bsky.social and @kiranrpatil.bsky.social labs doi.org/10.1038/s415...

If you love phages and CryoEM, the deadline to apply for a PhD studentship in my lab is 8th June!

GBM Lunch on May 20, 2026 (12.30 pm) Speaker: @dodonova-sveta.bsky.social (EMBL Heidelberg) Title: "Insights into nsights into Chromatin Architecture in Archaea by Cryo-EM and Cryo-ET" Chair: Janosch Hennig (University of Bayreuth) Organizer: GBM Study Group "Structural Biology" #GBMLunch

Banksy's rat with suitcase resurfaced after 16 years at a research center near Tokyo? 🙃

Join a rising star and very friendly colleague! #PhDposition

www.biorxiv.org/content/10.1... In situ cryo-ET defines the ultrastructure of ER exit sites in human cells

If you’re looking for a dream combo postdoc position that includes #cryoET plus #virology plus a scientifically and geographically very appealing lab: please consider applying 👇🏻🤩

That’s a wrap on the @embo.org Practical Course on “In-situ structural biology by #cryoFIB and #cryoET” @mpibp.bsky.social! Our students tutored 18 participants for an intensive, hands-on course covering the full workflow! It was an incredible week of learning, collaboration, and shared expertise! 🤩

Preprint 🧵! I’m really excited to introduce BIGSMALL, an interleaved multi-magnification cryo-ET scheme bridging molecular and cellular scales in a single acquisition! BIGSMALL = 𝐁road 𝐈nformation 𝐆athering 𝐒trategy by 𝐌ultiscale 𝐀cquisition of lame𝐋𝐋a www.biorxiv.org/content/10.6... (1/6)

New preprint 🚀 ❄️ We developed Autogrid-compatible HPF planchettes that enable direct freezing of clipped EM grids and streamline integration with cryo-FIB workflows ✔️ improved grid stability ✔️ reduced handling ✔️ robust vitrification (🦠 🧫 🧠) A step toward routine HPF for complex samples #teamtomo

That’s a wrap on our @embo.org #cryoFIB & #cryoET course! It was an incredible week of hands-on learning, collaboration, and shared expertise, made possible by dedicated organizers, incredible trainers, and an engaged group of participants.

We are having a very hands-on week at the @embo.org #cryoFIB & #cryoET course 🔬 Our participants are learning about sample vitrification, lamella milling, FLM, lift-out, data acquisition and more! We are learning by doing, troubleshooting, and sharing expertise across labs. 🧪

Participants shared their work and ideas in our poster session at the @embo.org Practical Course on “In-situ structural biology by Cryo-FIB and Cryo-ET” at our institute! It was a great chance to connect, discuss, and get new perspectives on #cryoFIB and #cryoET. 🌍

We’ve kicked off our @embo.org Practical Course on #cryoFIB & #cryoET! Participants from around the world are joining us this week for hands-on training, from lamella milling to tomogram reconstruction 🔬

The cartwheel was first visualized ~70 years ago in the symbiont Trichonympha in the wood termite gut. We’ve discovered the cartwheel’s secret: a unique zigzag stacking of SAS-6 tetramers that facilitates the iconic 9-fold symmetry of cilia. #cellbiology #teamtomo #SAS6 #cartwheel

Unintentional staring contest with the FIB-SEM chamber (I won).

Little bit surprised to see most microscopy facilities now have dedicated image analysis support, but 1.0 FTE on average is nowhere near enough. And more than half don't charge for analysis services?!? 🤨 onlinelibrary.wiley.com/doi/10.1111/...

Using Cryogenic Electron Tomography (cryoET) to Determine Rubisco Polymerization Constants in α-Carboxysomes www.biorxiv.org/content/10.6...

New Title Alert: easymode- a collection of general pretrained networks for cellular cryoET. Learn more here: buff.ly/mLbcUbZ #SBGrid #SBGridSoftware

TIL what "unload sample from Compustage" of a cryo-EM actually looks like. Neat 🙂.

A consortium of group leaders from IMP, IMBA (Vienna BioCenter) and ISTA has been awarded an FWF Emerging Fields grant to study how germ cells safeguard and pass on genetic information across generations.

Cryo-EM question of the day: You want jam on it, too, do you? 🤦🏻‍♀️

The Trojan Horse is real, and it’s microscopic! 🐴🦠 Our paper is out today in @cellcellpress.bsky.social! We discovered that deltaviruses physically hide INSIDE helper viruses to sneak into new cells. And to prove it, we had to image them from every angle. 🧵👇 www.sciencedirect.com/science/arti...

Interested in protein mislocalisation and aggregation in neurodegenerative disease? 🧠 Check out the research of the Dormann Group (@dormannlab.bsky.social, @unimainz.bsky.social). 🗓 Application deadline: March 11 👉 imprs-cbp.mpg.de/call-for-applications #imprs_cbp #neurodegeneration #biophysics

We are on the home stretch! 🏁 Only 1.5 weeks left to #apply for our #gradschool! Don't miss this opportunity to get a #PhD position in the life sciences! 👉 imprs-cbp.mpg.de/call-for-app...

We’re still at the @biophysicalsoc.bsky.social #bps2026 Meeting in San Francisco! Come visit us at Booth 630 and take a #cellfie with us! 📸! Interested in a fully funded PhD through IMPRS-CBP? This is your chance to meet us, ask questions, and learn more about #PhDpositions in Germany. #biophysics

📷 (1) Kim Group, (3, 4) Shau Chung Shin / Max Planck Institute of Biophysics 🎶 Melek Özdemir / Max Planck Institute of Biophysics

Come visit our @mpibp.bsky.social booth at the @biophysicalsoc.bsky.social #bps2026 meeting in San Francisco! We’re looking forward to chat about our research, PhD opportunities, and international career paths! 🥳 We’d love to connect and take your #cellfie! 🦠 Find us in booth 630! #imprs #imprs_cbp

📷/🎥 (1) MrsKirk72 Pixabay, (2-4) Bernhard Hampölz / Max Planck Institute of Biophysics, (5) Shau Chung Shin / Max Planck Institute of Biophysics . 🎵 Melek Özdemir

Ribosomes in pairs: A survival strategy inside stressed cells. When nutrients drop or temperatures shift, cells switch to survival mode. New work by @erin-schuman.bsky.social & colleagues shows that inactive ribosomes pair up via a ribosomal RNA link @andschwarz.bsky.social @muellermara.bsky.social

Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA www.science.org/doi/10.1126/... co-first with: @andschwarz.bsky.social with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more 🧵 0/6 #MolBio 🧪

Why should you join our #gradschool? Check out our 10 #keyfeatures and find out how we support you during your #phdjourney! Apply by March 11! imprs-cbp.mpg.de/key-features

Into single-particle cryoEM and redox biology? Meet the Murphy Group in our First IMPRSsion video on YouTube. ( @bjmurphylab.bsky.social , @mpibp.bsky.social ) Watch it on our YouTube channel and apply to IMPRS-CBP: youtube.com/watch?v=aecFlDKjKzo #imprs_cbp #cryoEM #biophysics #phd