LLM spam is getting too sophisticated 🫠

and we wonder how he can be so productive...

Thrilled, and admittedly relieved, to see this major investment in Dutch #cryoEM become reality! 🇳🇱🔬 Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠 www.uu.nl/en/news/33-m...

Our new preprint is out 🥳🥳🥳 Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence? 👇

“Bell's research needs to be aligned with the company's needs.” Where is Bell Labs now? www.nature.com/articles/454...

how do people see new cryo-EM papers these days? Twitter was pretty universal back in the day and Bluesky still feels much smaller, feel like I’m missing things 🤔

Image of the Sun. Taken at night. Not looking up at sky but down through 8000 miles of rock to the other side of the Earth. Not with light but neutrinos.

The Wilkinson Lab is open for science! @mskcancercenter.bsky.social 🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬 annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)

My quote of the day Abraham Lincoln

🥳 Today marks the start of the lab of former postdoc @florianwollweber.bsky.social at @embl.org Grenoble! www.embl.org/groups/wollw... Florian-- we will miss you dearly and wish you much success! With us, Florian applied multiscale imaging 🔬to Asgard archaea ...👇

Happy logical operator Halloween! 🎃

worth understanding

I'll help spread the word—Stan's a gem.

my friend and wonderful colleague Stan is hiring at Genentech in South San Francisco! 🧬 🌉 Biochemist/structural biologist looking for your first position in industry? I can’t recommend working with Stan enough ☺️ please repost for visibility www.linkedin.com/posts/stanis...

It was a fantastic opportunity to finally meet the people behind this software that I have been using for years and is so important for my work! A big thank you to all core developers who were so welcoming, and patiently guided participants in their attempts to contribute back to napari!

Happy Halloween from the napari team!

I truly appreciate the organizers, core contributors, and all attendees for this wonderful opportunity! I enjoyed learning and working on napari in a welcoming environment. Those interested in talking about and contributing to napari, let’s join the regular community meeting together!

The Genentech headcrab is being fed a steady stream of amazing scientists! Lovely visit from Bluesky-less Johannes Elferich this morning

Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️ Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...

I saw someone recently advocating for dismantling UK Research and Innovation to save £25bn… our society has already been hollowed out - thankful to have a strong economic argument against this for the future

Our experience of time is powerfully shaped by boundaries between events (i.e., going from one meeting to the next). But what about time *within an event*? In new work, we find reliable distortions of time based on internal event structure (e.g., beginnings, middles, and ends)! tinyurl.com/n8mn2sn7

@proteincapsid.bsky.social has great taste in git commit messages

Saw and loved this from one of my favorite mountaineers this morning, food for thought "Super weakness sometimes manifests itself as super strength (normal people don’t strive to be extraordinary)." - Andy Kirkpatrick

Happy to see this out :) How close does single-particle cryo-EM get to in situ structure determination? In this review, @tzviyazbm.bsky.social and I explore recent examples of studies that we believe push the boundaries of what's possible. #cryo-EM

Respect - knowing when to put your foot down is hard, I hope this move ends up creating alternative opportunities to fill the gap

No matter which party is in charge, the shots are being called by powerful donors, not ordinary voters. No wonder most people feel so cynical about politics – they’re dealing with a cost-of-living crisis, while politicians from both parties are on the take. substack.com/home/post/p-...

recently discovered that wikipedia volunteers have a hilariously high bar for what constitutes "unusual death"

“The rational response to paralysis would be to acknowledge it and seek support. Yet most institutions resort to symbolic gestures to maintain the appearance of relevance.”

supporting cryo-EM software is socially complex ☹️ please read this fantastic blog post by @mrocklin.bsky.social and keep it in mind when requesting support matthewrocklin.com/support-comp...

A class like no other!! From #AI structure hallucination 🤖 to #CryoEM structure reality 🔬 by @biozentrum.unibas.ch @unibas.ch undergraduate students👩‍🔬👩‍🎓 in just a few weeks! One of their creations is this beautiful flower-shaped tetrameric pore 🌼, a brand new member of the #ProteinCosmos 🧶🧬 🧪

The sad truth is that we all use proxies for quality as cognitive shortcuts in many areas of our lives - for the things we care about we need to engage, think more deeply and not use rely on these proxies en.wikipedia.org/wiki/Princip...

That merely being “under review” by a Nature family journal is offered as a quality proxy for a paper is a tragic illustration of the extent to which academia is addicted to brands and outsources evaluation

That’s a wrap of the 2nd edition of our one of a kind structural biology block course at the @biozentrum.unibas.ch! In just 6 short weeks students designed protein oligomers; rotated in cryo-ET, cryo-EM SPA, AFM, and NMR labs; and expressed, purified, and structurally characterized their designs

The German company that makes the mechanical ladder used in the Louvre heist has used the image to advertise, with the text 'When you need to move fast' 10/10 response, no notes

Our colleagues Vinith Kishore and Valentin Debarnot from the @ivandokmanic.bsky.social lab have come up with an amazing deep learning tool for denoising and filling the missing wedge in #cryoET data. I'm pleased to introduce Icecream🍧

Excited to share a new chapter of my scientific journey in Chris Russo's group — developing a way to freeze proteins faster than they diffuse, paving the way for cryo-EM without air–water interface damage.

Chris Russo and Anastasiia Gusach have developed a new method to prepare #cryoEM samples that avoids protein damage during freezing Read more: www2.mrc-lmb.cam.ac.uk/a-new-method... #LMBResearch

Last Friday (17th), we had an amazing first Young Swiss Tomo meeting in Bern, organized with Elda Bauda, Zanetta Kechagia, and @leonieanton.bsky.social! Over 70 people from 🇨🇭 gathered to talk about cryo-electron tomography 🔬. Huge thanks to the DCI for making the event possible! See you next year! 👋

Excellent recommendation, thanks @alisterburt.bsky.social! 🙏 🤓

Huge! Congratulations Joe, looks like those months of manual picking worked out 😉

Check out our preprint! With new molecular mechanisms, 140 subtomogram averages, and ~600 annotated cells under different conditions, we @embl.org were able to describe bacterial populations with in-cell #cryoET. And there’s a surprise at the end 🕵️ www.biorxiv.org/content/10.1... #teamtomo

An insightful read. I hadn’t appreciated the links between feudalism and privatization. The author’s evocation of how future historians may look back on our era in that respect felt important, and a fruitful way to think, to me. I’m hopeful the pendulum will swing back towards effective government.

Don Fawcett’s big red book The Cell is available for free online!! There are a bajillion cryo-ET projects in there, recommend a physical copy if you can find one - it’s my favourite coffee table book

This is one thing the ML folks are doing right, the blog post + arxiv combo is all you (should) need, wish it was more normalised for bio too

the GNE headcrab went for its latest victim today, a wild @sjorsscheres.bsky.social… Thankfully @przemekdut.bsky.social was there to save the day!

A utopian future is still possible (just) on.ft.com/46PEDsw | opinion

1/9 🚀 Big news! As a result of 5 years of my PhD, building on a 30-year dream of my PI Dr. Nancy Carrasco, we think we've found a new way to treat cancer! We’ve released our preprint & I'm so excited to share this story! 🧵 www.biorxiv.org/content/10.1... #Science #proteinengineering #proteindesing

Incredible video. I suspect I will end up watching every video on the channel.

It’s terrifying to watch the UK be so easily pushed into spending more on drugs… youtu.be/_xdYrg3G_00?...